All Relations between hippocampus and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Timna Hitrec, Fabio Squarcio, Emiliana Piscitiello, Matteo Cerri, Davide Martelli, Alessandra Occhinegro, Ludovico Taddei, Domenico Tupone, Roberto Amici, Marco Lupp. Sleep deprivation soon after recovery from synthetic torpor enhances tau protein dephosphorylation in the rat brain. Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology. 2023-10-09. PMID:37812305. the effects of sd were studied by assessing: (i) deep brain temperature (tb); (ii) immunofluorescent staining for at8 (phosphorylated tau) and tau-1 (non-phosphorylated tau), assessed in 19 brain structures; (iii) different phosphorylated forms of tau and the main cellular factors involved in tau phospho-regulation, including pro- and anti-apoptotic markers, assessed through western blot in the parietal cortex and hippocampus; (iv) systemic factors which are involved in natural torpor; (v) microglia activation state, by considering morphometric variations. 2023-10-09 2023-10-15 rat
Hongli Li, Bo-Lin Xiang, Xiao Li, Cong Li, Yu Li, Ying Miao, Guo-Lan Ma, Yu-Hua Ma, Jia-Qi Chen, Qing-Yu Zhang, Long-Bao Lv, Ping Zheng, Rui Bi, Yong-Gang Ya. Cognitive Deficits and Alzheimer's Disease-Like Pathologies in the Aged Chinese Tree Shrew. Molecular neurobiology. 2023-10-09. PMID:37814108. moreover, the aged tree shrews exhibited several age-related phenotypes that are associated with ad, including increased levels of amyloid-β (aβ) accumulation and phosphorylated tau protein, synaptic and neuronal loss, and reactive gliosis in the cortex and the hippocampal tissues. 2023-10-09 2023-10-15 Not clear
María José Pérez, Rodrigo Ibarra-García-Padilla, Maoping Tang, George A Porter, Gail V W Johnson, Rodrigo A Quintanill. Caspase-3 cleaved tau impairs mitochondrial function through the opening of the mitochondrial permeability transition pore. Biochimica et biophysica acta. Molecular basis of disease. 2023-09-29. PMID:37774936. to investigate the mechanism behind mitochondrial dysfunction caused by this tau form, we used transient transfection and pharmacological approaches in immortalized cortical neurons and mouse primary hippocampal neurons. 2023-09-29 2023-10-07 mouse
María José Pérez, Rodrigo Ibarra-García-Padilla, Maoping Tang, George A Porter, Gail V W Johnson, Rodrigo A Quintanill. Caspase-3 cleaved tau impairs mitochondrial function through the opening of the mitochondrial permeability transition pore. Biochimica et biophysica acta. Molecular basis of disease. 2023-09-29. PMID:37774936. moreover, the impairment of mitochondrial length and bioenergetics induced by caspase-3-cleaved tau were prevented in hippocampal neurons obtained from cypd knock-out mice. 2023-09-29 2023-10-07 mouse
Giovanna Morello, Maria Guarnaccia, Valentina La Cognata, Valentina Latina, Pietro Calissano, Giuseppina Amadoro, Sebastiano Cavallar. Transcriptomic Analysis in the Hippocampus and Retina of Tg2576 AD Mice Reveals Defective Mitochondrial Oxidative Phosphorylation and Recovery by Tau 12A12mAb Treatment. Cells. vol 12. issue 18. 2023-09-28. PMID:37759477. transcriptomic analysis in the hippocampus and retina of tg2576 ad mice reveals defective mitochondrial oxidative phosphorylation and recovery by tau 12a12mab treatment. 2023-09-28 2023-10-07 mouse
Chiara Prinzi, Anna Kostenko, Gioacchino de Leo, Rosario Gulino, Giampiero Leanza, Antonella Caccam. Selective Noradrenaline Depletion in the Neocortex and Hippocampus Induces Working Memory Deficits and Regional Occurrence of Pathological Proteins. Biology. vol 12. issue 9. 2023-09-28. PMID:37759663. at about 12 weeks post-lesion, dose-dependent working memory deficits were detected in these animals, associated with a marked increase in cortical and hippocampal levels of tdp-43 phosphorylated at ser 409/410 and tau phosphorylated at thr 217. 2023-09-28 2023-10-07 rat
Aida Muntsant, Maria Del Mar Castillo-Ruiz, Lydia Giménez-Llor. Survival Bias, Non-Lineal Behavioral and Cortico-Limbic Neuropathological Signatures in 3xTg-AD Mice for Alzheimer's Disease from Premorbid to Advanced Stages and Compared to Normal Aging. International journal of molecular sciences. vol 24. issue 18. 2023-09-28. PMID:37762098. the underlying temporal and spatial progression of aβ and tau pathologies pointed to a relevant cortico-limbic substrate roadmap: premorbid intracellular aβ immunoreactivity and pser202/pthr205 tau phosphorylation in the amygdala and ventral hippocampus, and the entorhinal cortex and ventral hippocampus as the areas most affected by aβ plaques. 2023-09-28 2023-10-07 mouse
Meixiang Huang, Carolyn Tallon, Xiaolei Zhu, Kaitlyn D J Huizar, Silvia Picciolini, Ajit G Thomas, Lukas Tenora, Wathsala Liyanage, Francesca Rodà, Alice Gualerzi, Rangaramanujam M Kannan, Marzia Bedoni, Rana Rais, Barbara S Slushe. Microglial-Targeted nSMase2 Inhibitor Fails to Reduce Tau Propagation in PS19 Mice. Pharmaceutics. vol 15. issue 9. 2023-09-28. PMID:37765332. the progression of alzheimer's disease (ad) correlates with the propagation of hyperphosphorylated tau (ptau) from the entorhinal cortex to the hippocampus and neocortex. 2023-09-28 2023-10-07 mouse
Mohammad Amin Rajizadeh, Amirhossein Moslemizadeh, Mahdieh Sadat Hosseini, Forouzan Rafiei, Zahra Soltani, Kayvan Khoramipou. Adiponectin receptor 1 could explain the sex differences in molecular basis of cognitive improvements induced by exercise training in type 2 diabetic rats. Scientific reports. vol 13. issue 1. 2023-09-27. PMID:37758935. leptin and adiponectin levels in serum were measured along with hippocampal expression of leptin and adiponectin receptors, amp-activated protein kinase (ampk), dephosphorylated glycogen synthase kinase-3 beta (dep-gsk3β), tau, and beta-amyloid (aβ). 2023-09-27 2023-10-07 rat
Mohammad Amin Rajizadeh, Amirhossein Moslemizadeh, Mahdieh Sadat Hosseini, Forouzan Rafiei, Zahra Soltani, Kayvan Khoramipou. Adiponectin receptor 1 could explain the sex differences in molecular basis of cognitive improvements induced by exercise training in type 2 diabetic rats. Scientific reports. vol 13. issue 1. 2023-09-27. PMID:37758935. however, after 8 weeks of hiit, hippocampal levels of apnr1 and ampk as well as quicki were lower and hippocampal levels of gsk, tau, and aβ were higher in females compared to male rats (p < 0.05). 2023-09-27 2023-10-07 rat
Genevieve L Stein-O'Brien, Ryan Palaganas, Ernest M Meyer, Javier Redding-Ochoa, Olga Pletnikova, Haidan Guo, William R Bell, Juan C Troncoso, Richard L Huganir, Meaghan Morri. Transcriptional Signatures of Hippocampal Tau Pathology in Primary Age-Related Tauopathy and Alzheimer's Disease. medRxiv : the preprint server for health sciences. 2023-09-25. PMID:37745408. transcriptional signatures of hippocampal tau pathology in primary age-related tauopathy and alzheimer's disease. 2023-09-25 2023-10-07 Not clear
Feng Han, JiaQie Lee, Xi Chen, Jacob Ziontz, Tyler Ward, Susan M Landau, Suzanne L Baker, Theresa M Harrison, William J Jagus. Global brain activity and its coupling with cerebrospinal fluid flow is related to tau pathology. bioRxiv : the preprint server for biology. 2023-09-25. PMID:37745434. cortical tau deposits first in the entorhinal cortex and hippocampus and then propagates to neocortex in an aβ-dependent manner. 2023-09-25 2023-10-07 human
Suzanne D Lanooij, W H I M Drinkenburg, U L M Eisel, E A van der Zee, Martien J H Ka. The effects of social environment on AD-related pathology in hAPP-J20 mice and tau-P301L mice. Neurobiology of disease. 2023-09-25. PMID:37748620. in 12-week-old p301l mice, tau pathology was induced through seeding by injecting k18 into the dorsal hippocampus (p301l 2023-09-25 2023-10-07 mouse
Lovedeep Singh, Harpreet Kaur, Girish Chandra Arya, Rajbir Bhatt. Neuroprotective potential of formononetin, a naturally occurring isoflavone phytoestrogen. Chemical biology & drug design. 2023-09-18. PMID:37722967. furthermore, formononetin also increases the expression of adam-10, which affects the pathology of neurodegenerative disease by lowering tau phosphorylation, maintaining synaptic plasticity, and boosting hippocampus neurogenesis. 2023-09-18 2023-10-07 Not clear
Khadga Raj Aran, G D Gupta, Shamsher Sing. Cladribine Induces Apoptosis, Neuroinflammation, Mitochondrial Oxidative Stress, Tau Phosphorylation and Aβ (1-42) Pathway in the Hippocampus: An In vivo Approach. Journal of chemical neuroanatomy. 2023-09-14. PMID:37708945. cladribine induces apoptosis, neuroinflammation, mitochondrial oxidative stress, tau phosphorylation and aβ (1-42) pathway in the hippocampus: an in vivo approach. 2023-09-14 2023-10-07 rat
Christopher G Schwarz, Walter K Kremers, Stephen D Weigand, Carl M Prakaashana, Matthew L Senjem, Scott A Przybelski, Val J Lowe, Jeffrey L Gunter, Kejal Kantarci, Prashanthi Vemuri, Jonathan Graff-Radford, Ronald C Petersen, David S Knopman, Clifford R Jac. Effects of de-facing software mri_reface on utility of imaging biomarkers used in Alzheimer's disease research. NeuroImage. Clinical. vol 40. 2023-09-13. PMID:37703605. we created a retrospective sample of participants from three age- and sex-matched clinical groups (cognitively unimpaired, mild cognitive impairment, and ad dementia, and we performed region- and voxel-wise analyses of: hippocampal volume (n), white matter hyperintensity volume (v), amyloid pet (a), and tau pet (t) measures, each from multiple software pipelines, on their ability to separate cognitively defined groups and their degrees of correlation with age and clinical dementia rating (cdr)-sum of boxes (cdr-sb). 2023-09-13 2023-10-07 human
Li Gao, Dongqing Wang, Jia Ren, Xue Tan, Jiayuan Chen, Zheng Kong, Yunan Nie, Ming Ya. Acteoside ameliorates learning and memory impairment in APP/PS1 transgenic mice by increasing Aβ degradation and inhibiting tau hyperphosphorylation. Phytotherapy research : PTR. 2023-09-04. PMID:37661763. we evaluated the levels of aβ40 and aβ42 in serum, cortex, and hippocampus, and aβ-related scavenging enzymes, phosphorylated gsk3β and hyperphosphorylated tau in the cortex and hippocampus of app/ps1 mice by western blotting. 2023-09-04 2023-09-07 mouse
Giulia Arenare, Riccardo Manca, Paolo Caffarra, Annalena Venneri, On Behalf Of The Alzheimer's Disease Neuroimaging Initiativ. Associations between Neuropsychiatric Symptoms and Alzheimer's Disease Biomarkers in People with Mild Cognitive Impairment. Brain sciences. vol 13. issue 8. 2023-08-26. PMID:37626552. this study aimed to investigate the association between nps severity and alzheimer's disease (ad) biomarkers, i.e., amyloid-β (aβ), phosphorylated tau protein (p-tau) and hippocampal volume ratio (hr), to characterise in more detail mci patients with a poor prognosis. 2023-08-26 2023-09-07 Not clear
Meaghan Morris, Gabrielle I Coste, Javier Redding-Ochoa, Haidan Guo, Austin R Graves, Juan C Troncoso, Richard L Hugani. Hippocampal synaptic alterations associated with tau pathology in primary age-related tauopathy. Journal of neuropathology and experimental neurology. 2023-08-23. PMID:37595576. hippocampal synaptic alterations associated with tau pathology in primary age-related tauopathy. 2023-08-23 2023-09-07 Not clear
Meaghan Morris, Gabrielle I Coste, Javier Redding-Ochoa, Haidan Guo, Austin R Graves, Juan C Troncoso, Richard L Hugani. Hippocampal synaptic alterations associated with tau pathology in primary age-related tauopathy. Journal of neuropathology and experimental neurology. 2023-08-23. PMID:37595576. high pathologic tau stage (braak stage) or a high burden of hippocampal tau pathology has been associated with cognitive impairment in part. 2023-08-23 2023-09-07 Not clear