| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Carlos M Hernandez, Rachel E Barkey, Kristen M Craven, Karin A Pedemonte, Bernadette Alisantosa, Jonathan O Sanchez, Jane M Flin. Transfusion with Blood Plasma from Young Mice Affects rTg4510 Transgenic Tau Mice Modeling of Alzheimer's Disease. Brain sciences. vol 13. issue 6. 2023-06-28. PMID:37371321. |
we found that tau mice injected with plasma had lower expression of phosphorylated tau (ptau) in the brain, accompanied by fewer tau tangles in the cortex and ca1 region of the hippocampus and smaller tau tangles in the cortex, when compared to tau mice injected with saline. |
2023-06-28 |
2023-08-14 |
mouse |
| Fan Chen, Na Wang, Xinyan Tian, Juan Su, Yan Qin, Rongqiao He, Xiaping H. The Protective Effect of Mangiferin on Formaldehyde-Induced HT22 Cell Damage and Cognitive Impairment. Pharmaceutics. vol 15. issue 6. 2023-06-28. PMID:37376018. |
the results in murine hippocampal cells (ht22) revealed that co-treatment with mgf significantly decreased fa-induced cytotoxicity and inhibited tau hyperphosphorylation in a dose-dependent manner. |
2023-06-28 |
2023-08-14 |
Not clear |
| Maryam Hossein Rezaei, Elham Madadizadeh, Mohsen Aminaei, Mehdi Abbaspoor, Janis Schierbauer, Othmar Moser, Kayvan Khoramipour, Karim Chamar. Leptin Signaling Could Mediate Hippocampal Decumulation of Beta-Amyloid and Tau Induced by High-Intensity Interval Training in Rats with Type 2 Diabetes. Cellular and molecular neurobiology. 2023-06-28. PMID:37378849. |
leptin signaling could mediate hippocampal decumulation of beta-amyloid and tau induced by high-intensity interval training in rats with type 2 diabetes. |
2023-06-28 |
2023-08-14 |
rat |
| Lan Xiao, Xuyu Yang, Vinay Kumar Sharma, Daniel Abebe, Y Peng Lo. Hippocampal delivery of neurotrophic factor-α1/carboxypeptidase E gene prevents neurodegeneration, amyloidosis, memory loss in Alzheimer's Disease male mice. Molecular psychiatry. 2023-06-27. PMID:37369719. |
here we report that viral-(aav) delivery of neurotrophic factor-α1/carboxypeptidase e (nf-α1/cpe) gene in hippocampus at an early age prevented later development of cognitive deficits as assessed by morris water maze and novel object recognition assays, neurodegeneration, and tau hyperphosphorylation in male 3xtg-ad mice. |
2023-06-27 |
2023-08-14 |
mouse |
| Ron Balczon, Chung-Sik Choi, Althea deWeever, Chun Zhou, Meredith S Gwin, Claire Kolb, C Michael Francis, Mike T Lin, Troy Steven. Infection promotes Ser-214 phosphorylation important for generation of cytotoxic tau variants. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 37. issue 7. 2023-06-26. PMID:37358817. |
however, in the brain, both the ser-214 phosphorylated tau and the mutant ser-214-ala tau, which cannot be phosphorylated, disrupted hippocampal long-term potentiation suggesting that inhibition of long-term potentiation was relatively insensitive to the phosphorylation status of ser-214. |
2023-06-26 |
2023-08-14 |
Not clear |
| Manuel Schweighauser, Holly J Garringer, Therése Klingstedt, K Peter R Nilsson, Masami Masuda-Suzukake, Jill R Murrell, Shannon L Risacher, Ruben Vidal, Sjors H W Scheres, Michel Goedert, Bernardino Ghetti, Kathy L Newel. Mutation ∆K281 in MAPT causes Pick's disease. Acta neuropathologica. 2023-06-23. PMID:37351604. |
at autopsy, numerous inclusions of hyperphosphorylated 3r tau were present in neurons and glial cells of neocortex and some subcortical regions, including hippocampus, caudate/putamen and globus pallidus. |
2023-06-23 |
2023-08-14 |
Not clear |
| Dianne Marquez Lopez, Connor J Maltby, Hannah Warming, Nullin Divecha, Mariana Vargas-Caballero, Mark J Coldwell, Katrin Deinhard. A luminescence-based reporter to study tau secretion reveals overlapping mechanisms for the release of healthy and pathological tau. Frontiers in neuroscience. vol 17. 2023-06-22. PMID:37342467. |
here, we established a sensitive bioluminescence-based assay to assess mechanisms underlying the secretion of pseudohyperphosphorylated and wild-type tau in cultured murine hippocampal neurons. |
2023-06-22 |
2023-08-14 |
Not clear |
| Anastasie Mate De Gerando, Lindsay A Welikovitch, Anita Khasnavis, Caitlin Commins, Calina Glynn, Joshua E Chun, Romain Perbet, Bradley T Hyma. Tau seeding and spreading in vivo is supported by both AD-derived fibrillar and oligomeric tau. Acta neuropathologica. 2023-06-21. PMID:37341831. |
sarkosyl-insoluble and hmw tau are nearly equivalent in potency in hek cell bioactivity assay for seeding aggregates, and their injection reveals similar local uptake into hippocampal neurons in ps19 tau transgenic mice. |
2023-06-21 |
2023-08-14 |
mouse |
| Stephanie A Schultz, Zahra Shirzadi, Aaron P Schultz, Lei Liu, Colleen D Fitzpatrick, Eric McDade, Nicolas R Barthelemy, Alan Renton, Bianca Esposito, Nelly Joseph-Mathurin, Carlos Cruchaga, Charles D Chen, Alison Goate, Ricardo Francisco Allegri, Tammie L S Benzinger, Sarah Berman, Helena C Chui, Anne M Fagan, Martin R Farlow, Nick C Fox, Brian A Gordon, Gregory S Day, Neill R Graff-Radford, Jason J Hassenstab, Bernard J Hanseeuw, Anna Hofmann, Clifford R Jack, Mathias Jucker, Celeste M Karch, Robert A Koeppe, Jae-Hong Lee, Allan I Levey, Johannes Levin, Ralph N Martins, Hiroshi Mori, John C Morris, James Noble, Richard J Perrin, Pedro Rosa-Neto, Stephen P Salloway, Raquel Sanchez-Valle, Peter R Schofield, Chengjie Xiong, Keith A Johnson, Randall J Bateman, Reisa A Sperling, Jasmeer P Chhatwa. Location of pathogenic variants in PSEN1 impacts progression of cognitive, clinical, and neurodegenerative measures in autosomal-dominant Alzheimer's disease. Aging cell. 2023-06-09. PMID:37291760. |
while both the cy and tm groups were found to have similarly elevated aβ compared to nc, tm carriers had greater cognitive impairment, smaller hippocampal volume, and elevated phosphorylated tau levels across the spectrum of pre-symptomatic and symptomatic phases of disease as compared to cy, using both cross-sectional and longitudinal data. |
2023-06-09 |
2023-08-14 |
Not clear |
| Anika Wuestefeld, Hannah Baumeister, Jenna N Adams, Robin de Flores, Carl Hodgetts, Negar Mazloum-Farzaghi, Rosanna K Olsen, Vyash Puliyadi, Tammy T Tran, Arnold Bakker, Kelsey L Canada, Marshall A Dalton, Ana M Daugherty, Renaud La Joie, Lei Wang, Madigan Bedard, Esther Buendia, Amanda Denning, David J Irwin, Ranjit Ittyerah, Edward B Lee, Sydney Lim, Maria Mercedes Iñiguez de Onzoño Martin, Monica Munoz Lopez, Theresa Schuck, Winifred Trotman, Alicia Vela, Paul Yushkevich, Katrin Amunts, Jean C Augustinack, Song-Lin Ding, Ricardo Insausti, Olga Kedo, David Berron, Laura E M Wiss. Comparison of histological delineations of medial temporal lobe cortices by four independent neuroanatomy laboratories. bioRxiv : the preprint server for biology. 2023-06-09. PMID:37292729. |
the medial temporal lobe (mtl) cortex, located adjacent to the hippocampus, is crucial for memory and prone to the accumulation of certain neuropathologies such as alzheimer's disease neurofibrillary tau tangles. |
2023-06-09 |
2023-08-14 |
human |
| Tatiana M Corey, Oscar Illanes, Matthew Lawrence, Sylvia E Perez, Shervin Liddie, John J Callana. Naturally occurring histological findings and Alzheimer's-like pathology in the brain of aging African green monkeys (Chlorocebus sabaeus). The Journal of comparative neurology. 2023-06-06. PMID:37279778. |
in 12 animals, 11 over the age of 10 years, phosphorylated tau cp13-immunoreactive neurons, neuropil, and oligodendrocyte-like cells were seen in the prefrontal, frontal, cingulate, orbital, temporal, and entorhinal cortices as well as the hippocampus; no neurofibrillary tangles were observed. |
2023-06-06 |
2023-08-14 |
monkey |
| Yunfang Su, Dahui Wang, Ningning Liu, Jiajia Yang, Ruiqin Sun, Zhenqiang Zhan. Clostridium butyricum improves cognitive dysfunction in ICV-STZ-induced Alzheimer's disease mice via suppressing TLR4 signaling pathway through the gut-brain axis. PloS one. vol 18. issue 6. 2023-06-02. PMID:37267300. |
the pharmacological effect of cb was assessed by behavior test, brain tissue h&e staining and tau protein phosphorylation levels of hippocampus tissues. |
2023-06-02 |
2023-08-14 |
mouse |
| Mengjuan Zhu, Bin Xiao, Tao Xue, Sifei Qin, Jiuyang Ding, Yue Wu, Qingqiu Tang, Mengfan Huang, Na Zhao, Yingshan Ye, Yuning Zhang, Boya Zhang, Juan Li, Fukun Guo, Yong Jiang, Lin Zhang, Lu Zhan. Cdc42GAP deficiency contributes to the Alzheimer's disease phenotype. Brain : a journal of neurology. 2023-05-31. PMID:37254741. |
in addition, overexpression of dominant-negative cdc42 in the primary hippocampal and cortical neurons of heterozygous cdc42gap mice reversed synaptic loss and tau hyperphosphorylation. |
2023-05-31 |
2023-08-14 |
mouse |
| Hannah Walgrave, Amber Penning, Giorgia Tosoni, Sarah Snoeck, Kristofer Davie, Emma Davis, Leen Wolfs, Annerieke Sierksma, Mayte Mars, Taofeng Bu, Nicola Thrupp, Lujia Zhou, Diederik Moechars, Renzo Mancuso, Mark Fiers, Andrew J M Howden, Bart De Strooper, Evgenia Salt. microRNA-132 regulates gene expression programs involved in microglial homeostasis. iScience. vol 26. issue 6. 2023-05-30. PMID:37250784. |
increasing mir-132 in ad mouse brain ameliorates amyloid and tau pathologies, and also restores adult hippocampal neurogenesis and memory deficits. |
2023-05-30 |
2023-08-14 |
mouse |
| Carlos G Ardanaz, Amaia Ezkurdia, Arantza Bejarano, Beatriz Echarte, Cristian Smerdou, Eva Martisova, Iván Martínez-Valbuena, María-Rosario Luquin, María J Ramírez, Maite Sola. JNK3 Overexpression in the Entorhinal Cortex Impacts on the Hippocampus and Induces Cognitive Deficiencies and Tau Misfolding. ACS chemical neuroscience. 2023-05-26. PMID:37236204. |
jnk3 overexpression in the entorhinal cortex impacts on the hippocampus and induces cognitive deficiencies and tau misfolding. |
2023-05-26 |
2023-08-14 |
human |
| Li Liang, Pengzheng Zhou, Chenfei Ye, Qi Yang, Ting M. Spatial-temporal patterns of brain disconnectome in Alzheimer's disease. Human brain mapping. 2023-05-25. PMID:37227021. |
our analysis suggests that brain wmh-related structural disconnectome contributes to ad evolution mainly through attacking connections between: (1) parahippocampal gyrus and superior frontal gyrus, orbital gyrus, and lateral occipital cortex; and (2) hippocampus and cingulate gyrus, which are also vulnerable to aβ and tau confirmed by other researches. |
2023-05-25 |
2023-08-14 |
human |
| Jafar Sadeghzadeh, Jaber Jafarzadeh, Pezhman Hadinezhad, Ahmad Nazari, Saeedeh Sohrabi, Vali Musazadeh, Ali Barzegar, Parviz Shahab. Profiling inflammatory mechanisms, hyperphosphorylated tau of hippocampal tissue and spatial memory following vitamin D3 treatment in the mice model of vascular dementia. International immunopharmacology. vol 120. 2023-05-23. PMID:37220695. |
profiling inflammatory mechanisms, hyperphosphorylated tau of hippocampal tissue and spatial memory following vitamin d3 treatment in the mice model of vascular dementia. |
2023-05-23 |
2023-08-14 |
mouse |
| Jafar Sadeghzadeh, Jaber Jafarzadeh, Pezhman Hadinezhad, Ahmad Nazari, Saeedeh Sohrabi, Vali Musazadeh, Ali Barzegar, Parviz Shahab. Profiling inflammatory mechanisms, hyperphosphorylated tau of hippocampal tissue and spatial memory following vitamin D3 treatment in the mice model of vascular dementia. International immunopharmacology. vol 120. 2023-05-23. PMID:37220695. |
the aim of this study was to investigate the effect of vitamin d3 (vitd3) on inflammatory mechanisms, hyperphosphorylated tau (p-tau) in the hippocampus, and cognitive impairment of the mouse model of vascular dementia (vad). |
2023-05-23 |
2023-08-14 |
mouse |
| Carola Tapia-Monsalves, Margrethe A Olesen, Francisca Villavicencio-Tejo, Rodrigo A Quintanill. Cyclosporine A (CsA) prevents synaptic impairment caused by truncated tau by caspase-3. Molecular and cellular neurosciences. 2023-05-14. PMID:37182572. |
we used mature hippocampal mice neurons to express a reporter protein (gfp, mcherry), coupled to full-length human tau protein (gfp-t4, mcherry-t4), and coupled to human tau protein cleaved at d421 by caspase-3 (gfp-t4c3, mcherry-t4c3) and synaptic elements were evaluated. |
2023-05-14 |
2023-08-14 |
mouse |
| Jianfeng Wu, Yi Su, Yanxi Chen, Wenhui Zhu, Eric M Reiman, Richard J Caselli, Kewei Chen, Paul M Thompson, Junwen Wang, Yalin Wan. A Surface-Based Federated Chow Test Model for Integrating APOE Status, Tau Deposition Measure, and Hippocampal Surface Morphometry. Journal of Alzheimer's disease : JAD. 2023-05-14. PMID:37182882. |
a surface-based federated chow test model for integrating apoe status, tau deposition measure, and hippocampal surface morphometry. |
2023-05-14 |
2023-08-14 |
Not clear |