| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Meaghan Morris, Gabrielle I Coste, Javier Redding-Ochoa, Haidan Guo, Austin R Graves, Juan C Troncoso, Richard L Hugani. Hippocampal synaptic alterations associated with tau pathology in primary age-related tauopathy. Journal of neuropathology and experimental neurology. 2023-08-23. PMID:37595576. |
in this study, the hippocampal ca2 region showed loss of synaptophysin puncta and intensity in cases of part with either a high stage (braak iv) or a high burden of neuritic tau pathology. |
2023-08-23 |
2023-09-07 |
Not clear |
| Meaghan Morris, Gabrielle I Coste, Javier Redding-Ochoa, Haidan Guo, Austin R Graves, Juan C Troncoso, Richard L Hugani. Hippocampal synaptic alterations associated with tau pathology in primary age-related tauopathy. Journal of neuropathology and experimental neurology. 2023-08-23. PMID:37595576. |
these novel findings suggest the presence of synaptic loss associated with either a high hippocampal tau burden or a braak stage iv in part. |
2023-08-23 |
2023-09-07 |
Not clear |
| Hamed Alizadeh Pahlavan. Exercise therapy to prevent and treat Alzheimer's disease. Frontiers in aging neuroscience. vol 15. 2023-08-21. PMID:37600508. |
while in animals moderate-intensity exercise restores hippocampal and amygdala memory through increased levels of p-akt, p-trkb, and p-pkc and decreased levels of aβ, tau phosphorylation, and amyloid precursor proteins (app) in ad. |
2023-08-21 |
2023-09-07 |
human |
| Grace Minogue, Allegra Kawles, Antonia Zouridakis, Rachel Keszycki, Alyssa Macomber, Vivienne Lubbat, Nathan Gill, Qinwen Mao, Margaret E Flanagan, Hui Zhang, Rudolph Castellani, Eileen H Bigio, M-Marsel Mesulam, Changiz Geula, Tamar Gefe. Distinct Patterns of Hippocampal Pathology in Alzheimer's Disease with TDP-43. Annals of neurology. 2023-08-18. PMID:37592884. |
here, we investigated neuronal integrity and pathologic burden of tdp-43 and tau along the well-charted trisynaptic hippocampal circuit [dentate gyrus (dg), ca3, and ca1] in participants with amnestic dementia due to ad/tdp, amnestic dementia due to ad alone, or non-amnestic dementia due to tdp-43 proteinopathy associated with frontotemporal lobar degeneration (ftld-tdp). |
2023-08-18 |
2023-09-07 |
human |
| Rebecca L Noel, Samantha L Gorman, Alec J Batts, Elisa E Konofago. Getting ahead of Alzheimer's disease: early intervention with focused ultrasound. Frontiers in neuroscience. vol 17. 2023-08-14. PMID:37575309. |
finally, fus-bbbo reduced hippocampal accumulation of aβ40, aβ42, and total tau in females by 12.54, 13.05, and 3.57%, respectively, and reduced total tau in males by 18.98%. |
2023-08-14 |
2023-08-16 |
mouse |
| Eliot J Davidowitz, Patricia Lopez, Heidy Jimenez, Leslie Adrien, Peter Davies, James G Mo. Small molecule inhibitor of tau self-association in a mouse model of tauopathy: A preventive study in P301L tau JNPL3 mice. PloS one. vol 18. issue 8. 2023-08-09. PMID:37556474. |
biochemical methods were used to evaluate self-associated tau, insoluble tau aggregates, total tau, and phosphorylated tau in the hindbrain, cortex, and hippocampus. |
2023-08-09 |
2023-08-16 |
mouse |
| Debashis Dutta, Malabendu Jana, Ramesh Kumar Paidi, Moumita Majumder, Sumita Raha, Sridevi Dasarathy, Kalipada Paha. Tau fibrils induce glial inflammation and neuropathology via TLR2 in Alzheimer's disease-related mouse models. The Journal of clinical investigation. 2023-08-08. PMID:37552543. |
nasal administration of wttidm in p301s tau-expressing ps19 mice was found to inhibit gliosis and inflammatory markers, along with reduction of pathogenic tau in the hippocampus, resulting in improved cognitive behavior in ps19 mice. |
2023-08-08 |
2023-08-16 |
mouse |
| Stephen Lippi, Rachel Barkey, Mya Rodrigue. The cognitive and noncognitive behavioral effects of a high-fat diet in the rTg4510 tau mouse model. Physiology & behavior. 2023-08-05. PMID:37543107. |
two hallmark proteins in ad, amyloid-beta plaques and tau neurofibrillary tangles, accumulate in regions of the brain critical for learning and memory, including the hippocampus. |
2023-08-05 |
2023-08-14 |
mouse |
| Stephen Lippi, Rachel Barkey, Mya Rodrigue. The cognitive and noncognitive behavioral effects of a high-fat diet in the rTg4510 tau mouse model. Physiology & behavior. 2023-08-05. PMID:37543107. |
in the brain, tau mice had greater levels of glial fibrillary acidic protein (gfap) (p < 0.05) and significantly less hippocampal cell density than wt mice (p < 0.001). |
2023-08-05 |
2023-08-14 |
mouse |
| Lucia Aa Giannini, Merel O Mol, Ana Rajicic, Renee van Buuren, Lana Sarkar, Sanaz Arezoumandan, Daniel T Ohm, David J Irwin, Annemieke Jm Rozemuller, John C van Swieten, Harro Seelaa. Presymptomatic and early pathological features of MAPT-associated frontotemporal lobar degeneration. Acta neuropathologica communications. vol 11. issue 1. 2023-08-02. PMID:37533060. |
the 68-year-old presymptomatic l315r carrier (ftld-cdr = 0) had limited tau burden morphologically similar to l315r end-stage carriers in middle frontal, antero-inferior temporal, amygdala, (para-)hippocampus and striatum, along with age-related alzheimer's disease neuropathological change. |
2023-08-02 |
2023-08-14 |
Not clear |
| Asmaa Gaber, Osama M Ahmed, Yasser A Khadrawy, Khairy M A Zoheir, Rasha E Abo-ELeneen, Mohamed A Alblihed, Ahlam M Elbakr. Mesenchymal Stem Cells and Begacestat Mitigate Amyloid-β 25-35-Induced Cognitive Decline in Rat Dams and Hippocampal Deteriorations in Offspring. Biology. vol 12. issue 7. 2023-07-29. PMID:37508337. |
additionally, bm-msc or gsi-953 therapy reduced aβ 25-35-induced increases in tau phosphorylation and amyloid precursor protein levels in the neonates' hippocampus and elevated the lower levels of glycogen synthase kinase-3 and brain-derived neurotrophic factor; moreover, reversed aβ 25-35-induced alterations in gene expression in the neonatal hippocampus. |
2023-07-29 |
2023-08-14 |
rat |
| Pingting Liu, Md Razaul Karim, Ana Covelo, Yuan Yue, Michael K Lee, Wensheng Li. The UPR Maintains Proteostasis and the Viability and Function of Hippocampal Neurons in Adult Mice. International journal of molecular sciences. vol 24. issue 14. 2023-07-29. PMID:37511300. |
these results suggest that the upr is required for maintaining neuronal proteostasis (particularly tau and aβ homeostasis) and the viability and function of neurons in the hippocampus of adult mice. |
2023-07-29 |
2023-08-14 |
mouse |
| Kaiming Guo, Wenting Huang, Kun Chen, Pengkai Huang, Wenshuo Peng, Ruiqing Shi, Tao He, Mulan Zhang, Hao Wang, Jian Hu, Xinshi Wang, Yangping Shentu, Huiqin Xu, Li Li. Fibroblast growth factor 10 ameliorates neurodegeneration in mouse and cellular models of Alzheimer's disease via reducing tau hyperphosphorylation and neuronal apoptosis. Aging cell. 2023-07-28. PMID:37503695. |
additionally, fgf10 treatment reduced tau hyperphosphorylation and neuronal apoptosis, thereby mitigating neuronal cell damage and synaptic deficits in the cortex and hippocampus of 3xtg-ad mice, as well as appswe-transfected ht22 cells. |
2023-07-28 |
2023-08-14 |
mouse |
| Kaiming Guo, Wenting Huang, Kun Chen, Pengkai Huang, Wenshuo Peng, Ruiqing Shi, Tao He, Mulan Zhang, Hao Wang, Jian Hu, Xinshi Wang, Yangping Shentu, Huiqin Xu, Li Li. Fibroblast growth factor 10 ameliorates neurodegeneration in mouse and cellular models of Alzheimer's disease via reducing tau hyperphosphorylation and neuronal apoptosis. Aging cell. 2023-07-28. PMID:37503695. |
similarly, endogenous fgf10 overexpression ameliorated tau hyperphosphorylation and neuronal apoptosis in the cortex and hippocampus of 3xtg-ad mice. |
2023-07-28 |
2023-08-14 |
mouse |
| Tomas Ondrejcak, Igor Klyubin, Neng-Wei Hu, Tiernan T O'Malley, Grant T Corbett, Róisín Winters, Michael S Perkinton, Andrew Billinton, Jack A Prenderville, Dominic M Walsh, Michael J Rowa. Tau and Aß in patient-derived aqueous brain extracts act concomitantly to disrupt LTP The Journal of neuroscience : the official journal of the Society for Neuroscience. 2023-07-25. PMID:37491315. |
here, we explore how intracerebral injection of aß and tau present in such aqueous extracts of patient brain contribute to disruption of synaptic plasticity in the ca1 area of the male rat hippocampus. |
2023-07-25 |
2023-08-14 |
rat |
| Wilber Romero-Fernandez, Cristian Carvajal-Tapia, Alex Prusky, Ketaki A Katdare, Emmeline Wang, Alena Shostak, Lissa Ventura-Antunes, Hannah J Harmsen, Ethan S Lippmann, Kjell Fuxe, Jason A MacGurn, Dasiel O Borroto-Escuela, Matthew S Schra. Detection, visualization and quantification of protein complexes in human Alzheimer's disease brains using proximity ligation assay. Scientific reports. vol 13. issue 1. 2023-07-24. PMID:37488165. |
we confirmed that phosphorylated microtubule-associated protein tau (serine202, threonine205) aggregates were modified by ubiquitin and that phospho-tau-ubiquitin complexes were increased in hippocampal and frontal cortex regions in ad compared to non-ad brains. |
2023-07-24 |
2023-08-14 |
human |
| A S Oreshko, A Ya Rodnyy, D V Bazovkina, V S Naumenk. Effects of central administration of the human Tau protein on the Bdnf, Trkb, p75, Mapt, Bax and Bcl-2 genes expression in the mouse brain. Vavilovskii zhurnal genetiki i selektsii. vol 27. issue 4. 2023-07-19. PMID:37465194. |
central administration of the tau protein did not affect the expression of the ntrk2, ngfr, mapt, bax and bcl-2 genes in the frontal cortex and hippocampus. |
2023-07-19 |
2023-08-14 |
mouse |
| Guang Yang, Yuting Tong, Xingyu Wang, Chenyi Zhao, Zongtao Ba, Reaila Ahelijiang, Xinjuan Liu, Waimao Gao, Yan Zhao, Yining Gu, Jianmei Yang, Ying X. Guizhi Fuling capsule relieves memory deficits by inhibition of microglial neuroinflammation through blocking JAK2/STAT3 pathway in presenilin1/2 conditional double knockout mice. Frontiers in immunology. vol 14. 2023-07-19. PMID:37465679. |
in addition, gzfl could inverse the tau hyperphosphorylation and the lessened expression of synaptic proteins in hippocampus of ps cdko mice. |
2023-07-19 |
2023-08-14 |
mouse |
| Shunsuke Koga, Aya Murakami, Alexandra I Soto-Beasley, Ronald L Walton, Matthew C Baker, Monica Castanedes-Casey, Keith A Josephs, Owen A Ross, Dennis W Dickso. Diffuse argyrophilic grain disease with TDP-43 proteinopathy and neuronal intermediate filament inclusion disease: FTLD with mixed tau, TDP-43 and FUS pathologies. Acta neuropathologica communications. vol 11. issue 1. 2023-07-06. PMID:37415197. |
tau immunohistochemistry showed numerous argyrophilic grains, pretangles, thorn-shaped astrocytes, and ballooned neurons in the amygdala, hippocampus, parahippocampal gyrus, anteromedial thalamus, insular cortex, superior temporal gyrus and cingulate gyrus, consistent with diffuse argyrophilic grain disease (agd). |
2023-07-06 |
2023-08-14 |
Not clear |
| Minli Qu, Linhui Zuo, Mengru Zhang, Peng Cheng, Zhanjun Guo, Junya Yang, Changjun Li, Jing W. High glucose induces tau hyperphosphorylation in hippocampal neurons via inhibition of ALKBH5-mediated Dgkh m Cell death & disease. vol 14. issue 6. 2023-06-29. PMID:37385994. |
high glucose induces tau hyperphosphorylation in hippocampal neurons via inhibition of alkbh5-mediated dgkh m tau hyperphosphorylation in hippocampal neurons has an important pathogenetic role in the development of diabetic cognitive dysfunction. |
2023-06-29 |
2023-08-14 |
Not clear |