| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rajas P Kale, Thanh Thanh L Nguyen, J Blair Price, Nathanael J Yates, Ken Walder, Michael Berk, Roy V Sillitoe, Abbas Z Kouzani, Susannah J Ty. Mood Regulatory Actions of Active and Sham Nucleus Accumbens Deep Brain Stimulation in Antidepressant Resistant Rats. Frontiers in human neuroscience. vol 15. 2021-08-06. PMID:34349629. |
we investigated the antidepressant-like effects of chronic nucleus accumbens (nac) dbs and its association with change in glycogen synthase kinase 3 (gsk3) and mammalian target of rapamycin (mtor) expression in the infralimbic cortex (il), and the dorsal (dhip) and ventral (vhip) subregions of the hippocampus of antidepressant resistant rats. |
2021-08-06 |
2023-08-13 |
rat |
| Yasaman Razavi, Sara Karimi, Saeideh Karimi-Haghighi, Soghra Hesam, Abbas Haghparas. Changes in c-fos and p-CREB signaling following exposure to forced swim stress or exogenous corticosterone during morphine-induced place preference are dependent on glucocorticoid receptor in the basolateral amygdala. Canadian journal of physiology and pharmacology. vol 98. issue 11. 2021-08-02. PMID:32574519. |
neural circuitry comprising the nucleus accumbens (nac), prefrontal cortex (pfc), amygdala (amy), and hippocampus (hip) are the main components of the reward circuit. |
2021-08-02 |
2023-08-13 |
rat |
| Mi Yang, Chang-Hao Luo, Ying-Qi Zhu, Yuan-Chu Liu, Ye-Juan An, Javed Iqbal, Zhe-Zhi Wang, Xin-Ming M. 7, 8-Dihydroxy-4-methylcoumarin reverses depression model-induced depression-like behaviors and alteration of dendritic spines in the mood circuits. Psychoneuroendocrinology. vol 119. 2021-07-21. PMID:32563935. |
the aim of this study was to investigate whether dhmc alleviates chronic unpredictable mild stress (cums)-induced depression-like behaviors and reverses cums-induced alterations in dendritic spines of principal neurons in brain areas of the emotional circuits including the hippocampus, medial prefrontal cortex (mpfc), nucleus accumbens (nac) and basolateral amygdala (bla) in male rats. |
2021-07-21 |
2023-08-13 |
rat |
| Andrew Chih Wei Huang, Ying Hao Yu, Alan Bo Han He, Chen Yin O. Interactions between prelimbic cortex and basolateral amygdala contribute to morphine-induced conditioned taste aversion in conditioning and extinction. Neurobiology of learning and memory. vol 172. 2021-07-14. PMID:32407964. |
the consequences of exciting or destroying the prelimbic cortex (prl) or the basolateral amygdala (bla) remain unclear, including the effects on morphine-induced conditioned taste aversion (cta) in the conditioning and extinction phases, plasma corticosterone (cort) levels, and c-fos/p-erk expressions in the subareas of the medial prefrontal cortex (i.e., prl, infralimbic cortex [il], cingulate cortex 1 [cg1]), basolateral amygdala (bla), central amygdala (cea), hippocampus (i.e., ca1, ca2, ca3, and dentate gyrus [dg]), nucleus accumbens (nac), lateral hypothalamus (lh), and piriform cortex (pc). |
2021-07-14 |
2023-08-13 |
Not clear |
| Caroline E Strong, Mohamed Kabba. Neural Mechanisms Underlying the Rewarding and Therapeutic Effects of Ketamine as a Treatment for Alcohol Use Disorder. Frontiers in behavioral neuroscience. vol 14. 2021-07-08. PMID:33362485. |
to do this, the focus will be on reward-related brain regions such as the nucleus accumbens (nac), dorsal striatum, prefrontal cortex (pfc), hippocampus, and ventral tegmental area (vta) to understand how acute vs. chronic exposure will alter reward signaling over time. |
2021-07-08 |
2023-08-13 |
human |
| David de Sa Nogueira, Romain Bourdy, Dominique Filliol, Gaëlle Awad, Virginie Andry, Yannick Goumon, Mary C Olmstead, Katia Befor. Binge sucrose-induced neuroadaptations: A focus on the endocannabinoid system. Appetite. vol 164. 2021-06-28. PMID:33864862. |
importantly, this group also exhibited alterations in ecs transcripts and endocannabinoid levels in brain reward regions, including an increase in cannabinoid receptor 1 (cb1r) mrna in the nucleus accumbens as well as changes in endocannabinoid levels in the prefrontal cortex and hippocampus. |
2021-06-28 |
2023-08-13 |
rat |
| Chayaporn Reakkamnuan, Dania Cheaha, Nifareeda Samerphob, Nusaib Sa-Ih, Ekkasit Kumarnsi. Adaptive changes in local field potential oscillation associated with morphine conditioned place preference in mice. Physiology & behavior. vol 235. 2021-06-25. PMID:33757777. |
male swiss albino mice implanted with intracranial electrodes into the nucleus accumbens (nac), striatum (str) and hippocampus (hc) were used for recording of local field potentials (lfps). |
2021-06-25 |
2023-08-13 |
mouse |
| Kaili Du, Zhuoyi Wang, Huimin Zhang, Yaofang Zhang, Hongliang Su, Zhiwen Wei, Chao Zhang, Keming Yun, Bin Con. Levo-tetrahydropalmatine attenuates the acquisition of fentanyl-induced conditioned place preference and the changes in ERK and CREB phosphorylation expression in mice. Neuroscience letters. vol 756. 2021-06-22. PMID:34029649. |
western blot assays were used to dissect the accompanying changes in the phosphorylation of extracellular signal-regulated kinase (erk) and camp response element binding protein (creb) in related brain regions, including the hippocampus (hip), caudate putamen (cpu), prefrontal cortex (pfc), and nucleus accumbens (nac), which may mediate the effects of l-thp on fentanyl-induced cpp. |
2021-06-22 |
2023-08-13 |
mouse |
| Miguel Skirzewski, Marie E Cronin, Ricardo Murphy, Wambura Fobbs, Alexxai V Kravitz, Andres Buonann. ErbB4 Null Mice Display Altered Mesocorticolimbic and Nigrostriatal Dopamine Levels as well as Deficits in Cognitive and Motivational Behaviors. eNeuro. vol 7. issue 3. 2021-06-18. PMID:32354758. |
here, we report that extracellular steady-state levels of da are reduced in the medial prefrontal cortex (mpfc; -65%), hippocampus (-53%) and nucleus accumbens (nac; -35%), but are elevated in the dorsal striatum (+25%) of erbb4 knock-out mice (erbb4 kos) relative to wild-type controls. |
2021-06-18 |
2023-08-13 |
mouse |
| Luis A Trujillo-Villarreal, Viktor J Romero-Díaz, Iván Alberto Marino-Martínez, Lizeth Fuentes-Mera, Marco Antonio Ponce-Camacho, Gabriel A Devenyi, M Mallar Chakravarty, Alberto Camacho-Morales, Eduardo E Garza-Villarrea. Maternal cafeteria diet exposure primes depression-like behavior in the offspring evoking lower brain volume related to changes in synaptic terminals and gliosis. Translational psychiatry. vol 11. issue 1. 2021-06-18. PMID:33446642. |
macrostructural dbm analysis showed reduction in the frontomesocorticolimbic circuit volume including the nucleus accumbens (nac), hippocampus, and prefrontal cortex. |
2021-06-18 |
2023-08-13 |
rat |
| Keith A Misquitta, Amy Miles, Thomas D Prevot, Jaime K Knoch, Corey Fee, Dwight F Newton, Jacob Ellegood, Jason P Lerch, Etienne Sibille, Yuliya S Nikolova, Mounira Banas. Reduced anterior cingulate cortex volume induced by chronic stress correlates with increased behavioral emotionality and decreased synaptic puncta density. Neuropharmacology. vol 190. 2021-06-09. PMID:33864799. |
clinical and preclinical studies report that chronic stress induces behavioral deficits as well as volumetric and synaptic alterations in corticolimbic brain regions including the anterior cingulate cortex (acc), amygdala (amy), nucleus accumbens (nac) and hippocampus (hpc). |
2021-06-09 |
2023-08-13 |
Not clear |
| Pamela DeRosse, Anita D Barbe. Overlapping Neurobiological Substrates for Early-Life Stress and Resilience to Psychosis. Biological psychiatry. Cognitive neuroscience and neuroimaging. vol 6. issue 2. 2021-06-03. PMID:33097471. |
exposure to early-life stress disrupts the neurodevelopment of widespread brain systems, including key components of the hypothalamic-pituitary-adrenal axis stress response, such as the amygdala, hippocampus, and medial prefrontal cortex, as well as key components of the brain's reward system, such as the nucleus accumbens and orbitofrontal cortex. |
2021-06-03 |
2023-08-13 |
Not clear |
| Carmen Freire-Cobo, Jun Wan. Dietary phytochemicals modulate experience-dependent changes in Neurexin gene expression and alternative splicing in mice after chronic variable stress exposure. European journal of pharmacology. vol 883. 2021-05-18. PMID:32663544. |
we found that cvs differentially triggers the region-specific gene expression of nrxns in mice nucleus accumbens (nac) and hippocampus (hipp). |
2021-05-18 |
2023-08-13 |
mouse |
| Milo Grotell, Bjørnar den Hollander, Aaro Jalkanen, Essi Törrönen, Jouni Ihalainen, Elena de Miguel, Mateusz Dudek, Mikko I Kettunen, Petri Hyytiä, Markus M Forsberg, Esko Kankuri, Esa R Korp. Alcohol Co-Administration Changes Mephedrone-Induced Alterations of Neuronal Activity. Frontiers in pharmacology. vol 12. 2021-05-18. PMID:33995109. |
these effects were most profound in brain regions which are known to have high dopamine and serotonin activities including hippocampus, nucleus accumbens and caudate-putamen. |
2021-05-18 |
2023-08-13 |
rat |
| Cheng Xue, Xiao-Hui Li, Meng-Qi Liu, Xing-Cheng Yang, Guo-Hai Li, Ru-Jing Xu, Jia Wang, Wei-Ning Zhan. Enhancing excitatory projections from the ventral subiculum to the nucleus accumbens shell contribute to the MK-801-induced impairment of prepulse inhibition. Neuroscience letters. vol 731. 2021-05-17. PMID:32380142. |
the neural circuits involving the hippocampus and nucleus accumbens (nac) have been studied in rats to uncover the neurochemical and neuroanatomical substrates that regulate ppi. |
2021-05-17 |
2023-08-13 |
rat |
| Katsumasa Muneoka, Yasunori Oda, Masaaki Iwata, Masaomi Iyo, Kenji Hashimoto, Yukihiko Shirayam. Monoaminergic balances predict non-depression-like phenotype in Learned Helplessness Paradigm. Neuroscience. vol 440. 2021-05-14. PMID:32222554. |
here, we measured the levels of monoamines, including noradrenaline (na), serotonin (5-ht), and dopamine (da), and their metabolites in the medial prefrontal cortex (mpfc), orbitofrontal cortex (ofc), hippocampus, nucleus accumbens (nac), amygdala, and striatum in lh, non-lh, and non-manipulated (naïve) rats. |
2021-05-14 |
2023-08-13 |
rat |
| Yanjun Meng, Hong Li, Junjie Wang, Yong Xu, Binquan Wan. Cognitive behavioral therapy for patients with mild to moderate depression: Treatment effects and neural mechanisms. Journal of psychiatric research. vol 136. 2021-05-14. PMID:33631654. |
at the baseline, mri data revealed abnormalities in the hippocampus and nucleus accumbens (nac) of patients with mmd, e.g., smaller gray matter volumes of the hippocampus and nucleus accumbens (nac), as well as weaker functional connectivity between nac and the posterior cingulate cortex/precuneus. |
2021-05-14 |
2023-08-13 |
Not clear |
| Serguei Liachenko, Jaivijay Ram. Sex differences in the effect of acute administration of nicotine on MRS-measured metabolic profile of the rat brain. Neuroscience research. vol 157. 2021-04-28. PMID:31381938. |
proton mrs was used to monitor changes of specific neurometabolites in hippocampus (hc), nucleus accumbens (nac), and anterior cingulate cortex (acc) of rats of both sexes after single intraperitoneal injection of nicotine. |
2021-04-28 |
2023-08-13 |
rat |
| Yolanda Campos-Jurado, Lucía Martí-Prats, Jose A Morón, Ana Polache, Luis Granero, Lucía Hipólit. Dose-dependent induction of CPP or CPA by intra-pVTA ethanol: Role of mu opioid receptors and effects on NMDA receptors. Progress in neuro-psychopharmacology & biological psychiatry. vol 100. 2021-04-28. PMID:31978422. |
finally, modifications of the expression of nmda receptor subunits in the nucleus accumbens (nac) and hippocampus after ethanol-induced cpp were analyzed at the proteomic and transcriptomic levels by western blot and in situ hybridation rnascope techniques, respectively. |
2021-04-28 |
2023-08-13 |
Not clear |
| Chiomah Ezeomah, Kathryn A Cunningham, Sonja J Stutz, Robert G Fox, Natalya Bukreyeva, Kelly T Dineley, Slobodan Paessler, Irma E Cisnero. Fentanyl self-administration impacts brain immune responses in male Sprague-Dawley rats. Brain, behavior, and immunity. vol 87. 2021-04-27. PMID:32165150. |
several innate immune markers, as well as opioid receptors (ors) and intracellular pattern recognition receptors (prrs), were interrogated within nodes of the neurocircuitry involved in oud processes, including the prefrontal cortex (pfc), nucleus accumbens (nac), caudate putamen (cpu), hippocampus (hip) and midbrain (mb). |
2021-04-27 |
2023-08-13 |
rat |