| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sarah Thomas Broome, Alessandro Castorin. Systemic Rotenone Administration Causes Extra-Nigral Alterations in C57BL/6 Mice. Biomedicines. vol 10. issue 12. 2022-12-23. PMID:36551930. |
molecular analyses showed reductions of both th and dat expression in the midbrain, striatum and spinal cord, accompanied by altered expression of dopamine receptors and brain-derived neurotrophic factor (bdnf). |
2022-12-23 |
2023-08-14 |
mouse |
| Pardeep Yadav, Pratik Chakraborty, Niraj Kumar Jha, Saikat Dewanjee, Abhimanyu Kumar Jha, Siva Prasad Panda, Prabhu Chandra Mishra, Abhijit Dey, Saurabh Kumar Jh. Molecular Mechanism and Role of Japanese Encephalitis Virus Infection in Central Nervous System-Mediated Diseases. Viruses. vol 14. issue 12. 2022-12-23. PMID:36560690. |
however, jev enters human brain microvascular endothelial cells via an endocytic pathway mediated by caveolae and the ezrin protein and also targets dopamine-rich areas for infection of the midbrain via altering dopamine levels. |
2022-12-23 |
2023-08-14 |
human |
| Jun Li, Nan Li, Jingkuan Wei, Chun Feng, Yanying Chen, Tingwei Chen, Zongyong Ai, Xiaoqing Zhu, Weizhi Ji, Tianqing L. Genetically engineered mesenchymal stem cells with dopamine synthesis for Parkinson's disease in animal models. NPJ Parkinson's disease. vol 8. issue 1. 2022-12-22. PMID:36550118. |
importantly, after grafting into the caudate and putamen, dopa-mscs provide homotopic reconstruction of midbrain dopamine pathways by restoring striatal dopamine levels, and safely and long-term (up to 51 months) correct motor disorders and nonmotor deficits in acute and chronic pd rhesus monkey models of pd even with advanced pd symptoms. |
2022-12-22 |
2023-08-14 |
rat |
| Bina Lee, Ingabire Ines, Jihyun Je, Eun Jung Park, Hyemin Seong, Min Gi Jo, Hwajin Kim, Seon-Hee Kim, Seong Jae Kim, Hye Jung Kim, Minkyeong Kim, Sang Won Park, Seung Pil Yu. Effect of Renal Ischemia Reperfusion on Brain Neuroinflammation. Biomedicines. vol 10. issue 11. 2022-11-26. PMID:36428560. |
the striatum and ventral midbrain, known to control overall movement, secrete the neurotransmitter dopamine. |
2022-11-26 |
2023-08-14 |
Not clear |
| Gurvir S Virdi, Minee L Choi, James R Evans, Zhi Yao, Dilan Athauda, Stephanie Strohbuecker, Raja S Nirujogi, Anna I Wernick, Noelia Pelegrina-Hidalgo, Craig Leighton, Rebecca S Saleeb, Olga Kopach, Haya Alrashidi, Daniela Melandri, Jimena Perez-Lloret, Plamena R Angelova, Sergiy Sylantyev, Simon Eaton, Simon Heales, Dmitri A Rusakov, Dario R Alessi, Tilo Kunath, Mathew H Horrocks, Andrey Y Abramov, Rickie Patani, Sonia Gandh. Protein aggregation and calcium dysregulation are hallmarks of familial Parkinson's disease in midbrain dopaminergic neurons. NPJ Parkinson's disease. vol 8. issue 1. 2022-11-24. PMID:36424392. |
our small molecule-based protocol generates highly enriched midbrain dopaminergic (mda) neurons: molecular identity was confirmed using single-cell rna sequencing and proteomics, and functional identity was established through dopamine synthesis, and measures of electrophysiological activity. |
2022-11-24 |
2023-08-14 |
human |
| Samuel Rantataro, Laura Ferrer Pascual, Tomi Lauril. Ascorbic acid does not necessarily interfere with the electrochemical detection of dopamine. Scientific reports. vol 12. issue 1. 2022-11-23. PMID:36418489. |
to validate this claim, we used unmodified single-wall carbon nanotube electrode to measure dopamine at physiologically relevant concentration range (25-1000 nm) from human midbrain organoid medium with highly linear response. |
2022-11-23 |
2023-08-14 |
human |
| Suyun Hahn, Ki Bum Um, So Woon Kim, Hyun Jin Kim, Myoung Kyu Par. Proximal dendritic localization of NALCN channels underlies tonic and burst firing in nigral dopaminergic neurons. The Journal of physiology. 2022-11-18. PMID:36398712. |
midbrain dopamine (da) neurons are slow pacemakers that can generate tonic and burst firings and the highly excitable proximal dendritic compartments (pdcs) and two na |
2022-11-18 |
2023-08-14 |
Not clear |
| Hongyan Zhang, Lulu Xu, Junwei Xiong, Xinxin Li, Yindong Yang, Yong Liu, Chunfeng Zhang, Qiyu Wang, Jiajia Wang, Pengyu Wang, Xiaobin Wu, Xue Wang, Xiaofeng Zhu, Yanzhong Gua. Role of KCC2 in the Regulation of Brain-Derived Neurotrophic Factor on Ethanol Consumption in Rats. Molecular neurobiology. 2022-11-18. PMID:36401060. |
the mesocorticolimbic dopamine (da) system, originating from the ventral tegmental area (vta) in the midbrain, is involved in the rewarding effect of ethanol. |
2022-11-18 |
2023-08-14 |
rat |
| Jinwen Xue, Dandan Qian, Bingqian Zhang, Jingxuan Yang, Wei Li, Yifei Bao, Shi Qiu, Yi Fu, Shaoli Wang, Ti-Fei Yuan, Wei L. Midbrain dopamine neurons arbiter OCD-like behavior. Proceedings of the National Academy of Sciences of the United States of America. vol 119. issue 46. 2022-11-07. PMID:36343236. |
midbrain dopamine neurons arbiter ocd-like behavior. |
2022-11-07 |
2023-08-14 |
Not clear |
| Marcella Birtele, Petter Storm, Yogita Sharma, Janko Kajtez, Jenny Nelander Wahlestedt, Edoardo Sozzi, Fredrik Nilsson, Simon Stott, Xiaoling L He, Bengt Mattsson, Daniella Rylander Ottosson, Roger A Barker, Alessandro Fiorenzano, Malin Parma. Single-cell transcriptional and functional analysis of dopaminergic neurons in organoid-like cultures derived from human fetal midbrain. Development (Cambridge, England). 2022-10-28. PMID:36305490. |
significant efforts are ongoing to develop refined differentiation protocols to generate midbrain dopamine (da) neurons from pluripotent stem cells (pscs) for application in disease modeling, diagnostics, drug screening, and cell-based therapies for parkinson's disease (pd). |
2022-10-28 |
2023-08-14 |
human |
| Na Zhao, Jian Song, Shenquan Li. Multi-timescale analysis of midbrain dopamine neuronal firing activities. Journal of theoretical biology. 2022-10-24. PMID:36279959. |
multi-timescale analysis of midbrain dopamine neuronal firing activities. |
2022-10-24 |
2023-08-14 |
Not clear |
| Na Zhao, Jian Song, Shenquan Li. Multi-timescale analysis of midbrain dopamine neuronal firing activities. Journal of theoretical biology. 2022-10-24. PMID:36279959. |
midbrain dopamine (da) neurons exhibit spiking and bursting patterns under physiological conditions. |
2022-10-24 |
2023-08-14 |
Not clear |
| Karolina Farrell, Armin Lak, Aman B Salee. Midbrain dopamine neurons signal phasic and ramping reward prediction error during goal-directed navigation. Cell reports. vol 41. issue 2. 2022-10-12. PMID:36223748. |
midbrain dopamine neurons signal phasic and ramping reward prediction error during goal-directed navigation. |
2022-10-12 |
2023-08-14 |
mouse |
| Karolina Farrell, Armin Lak, Aman B Salee. Midbrain dopamine neurons signal phasic and ramping reward prediction error during goal-directed navigation. Cell reports. vol 41. issue 2. 2022-10-12. PMID:36223748. |
midbrain dopamine neurons are involved in reward value learning and have been linked to reward location learning. |
2022-10-12 |
2023-08-14 |
mouse |
| Karolina Farrell, Armin Lak, Aman B Salee. Midbrain dopamine neurons signal phasic and ramping reward prediction error during goal-directed navigation. Cell reports. vol 41. issue 2. 2022-10-12. PMID:36223748. |
our results suggest that midbrain dopamine neurons encode phasic and ramping reward prediction error signals to improve goal-directed navigation. |
2022-10-12 |
2023-08-14 |
mouse |
| Sofía Puvogel, Astrid Alsema, Laura Kracht, Maree J Webster, Cynthia Shannon Weickert, Iris E C Sommer, Bart J L Egge. Single-nucleus RNA sequencing of midbrain blood-brain barrier cells in schizophrenia reveals subtle transcriptional changes with overall preservation of cellular proportions and phenotypes. Molecular psychiatry. 2022-10-03. PMID:36192459. |
the midbrain is an extensively studied brain region in schizophrenia, in view of its reported dopamine pathophysiology and neuroimmune changes associated with this disease. |
2022-10-03 |
2023-08-14 |
Not clear |
| Alice Servonnet, Saleem M Nicol. Dips in dopamine say "no" to nicotine. Neuron. vol 110. issue 18. 2022-09-22. PMID:36137519. |
show that nicotine aversion depends on both desensitization of high-affinity nicotinic acetylcholine receptors (nachrs) that activate midbrain dopamine neurons and activation of low-affinity nachrs that inhibit dopamine neurons via the laterodorsal tegmental nucleus (ldt). |
2022-09-22 |
2023-08-14 |
Not clear |
| Bernardo Lopez-Torres, Irma Ares, Marta Martínez, Jorge-Enrique Maximiliano, María-Rosa Martínez-Larrañaga, Arturo Anadón, María-Aránzazu Martíne. Neurotoxicity induced by the pyrethroid lambda-cyhalothrin: Alterations in monoaminergic systems and dopaminergic and serotoninergic pathways in the rat brain. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2022-09-20. PMID:36126889. |
the effects of type ii pyrethroid lambda-cyhalothrin on dopamine (da) and serotonin (5-ht) synthesis in rat brain regions (striatum, hippocampus, prefrontal cortex, hypothalamus and midbrain) were studied. |
2022-09-20 |
2023-08-14 |
rat |
| Edoardo Sozzi, Fredrik Nilsson, Janko Kajtez, Malin Parmar, Alessandro Fiorenzan. Generation of Human Ventral Midbrain Organoids Derived from Pluripotent Stem Cells. Current protocols. vol 2. issue 9. 2022-09-19. PMID:36121202. |
parkinson's disease (pd) is the second most common neurodegenerative disorder worldwide and is caused by the degeneration and loss of dopamine (da) neurons in the ventral midbrain (vm). |
2022-09-19 |
2023-08-14 |
human |
| Seong Shoon Yoon, Bong Hyo Lee, Seong Ho Lee, Seong Hun Choi, Seon-Ju Jeong, Sang Chan Kim, Chae Ha Yan. Effects of isoflurane anesthesia on addictive behaviors in rats. Psychopharmacology. 2022-09-15. PMID:36109391. |
recently, it has been suggested that isoflurane might reduce dopamine release from rat midbrain dopaminergic neurons, the neurobiological substrate implicated in the reinforcing effects of abused drugs and nondrug rewards. |
2022-09-15 |
2023-08-14 |
rat |