| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Valeria Parrales-Macias, Patrick P Michel, Aurore Tourville, Rita Raisman-Vozari, Stéphane Haïk, Stéphane Hunot, Nicolas Bizat, Annie Lannuze. The Pesticide Chlordecone Promotes Parkinsonism-like Neurodegeneration with Tau Lesions in Midbrain Cultures and Cells. vol 12. issue 9. 2023-05-14. PMID:37174736. |
for that, we used culture systems of mouse midbrain dopamine (da) neurons and glial cells, together with the nematode |
2023-05-14 |
2023-08-14 |
mouse |
| Benjamin D Hobson, Adrien T Stanley, Mark B De Los Santos, Bruce Culbertson, Eugene V Mosharov, Peter A Sims, David Sulze. Conserved and cell type-specific transcriptional responses to IFN-γ in the ventral midbrain. Brain, behavior, and immunity. 2023-04-26. PMID:37100211. |
we find that ifn-γ induces transcription of mhc class i antigen processing and presentation machinery in all major parenchymal cell types in the ventral midbrain in vivo; however, neuronal responses are low amplitude and limited to a small set of genes, mhc class ii expression and cellular proliferation are restricted to microglia, and dopamine neuronal responses require cell autonomous expression of ifngr1. |
2023-04-26 |
2023-08-14 |
mouse |
| Malika S Datta, Yannan Chen, Shradha Chauhan, Jing Zhang, Estanislao Daniel De La Cruz, Cheng Gong, Raju Tome. Whole-brain mapping reveals the divergent impact of ketamine on the dopamine system. bioRxiv : the preprint server for biology. 2023-04-24. PMID:37090584. |
here, we develop and utilize a high-resolution whole-brain phenotyping approach to show that repeated ketamine administration leads to a dosage-dependent decrease of dopamine (da) neurons in the behavior state-related midbrain regions and, conversely, an increase within the hypothalamus. |
2023-04-24 |
2023-08-14 |
Not clear |
| Hanna K Isotalus, Will J Carr, Jonathan Blackman, George G Averill, Oliver Radtke, James Selwood, Rachel Williams, Elizabeth Ford, Liz McCullagh, James McErlane, Cian O'Donnell, Claire Durant, Ullrich Bartsch, Matt W Jones, Carlos Muñoz-Neira, Alfie R Wearn, John P Grogan, Elizabeth J Coulthar. L-DOPA increases slow-wave sleep duration and selectively modulates memory persistence in older adults. Frontiers in behavioral neuroscience. vol 17. 2023-04-24. PMID:37091594. |
dopamine projections between the midbrain and hippocampus potentially support memory processes during slow wave sleep. |
2023-04-24 |
2023-08-14 |
Not clear |
| Ying S Chao, Jeffrey Parrilla-Carrero, Maya Eid, Oliver P Culver, Tyler B Jackson, Rachel Lipat, Makoto Taniguchi, Thomas C Jho. Innate cocaine-seeking vulnerability arising from loss of serotonin-mediated aversive effects of cocaine in rats. Cell reports. vol 42. issue 5. 2023-04-21. PMID:37083325. |
however, cocaine also blocks serotonin uptake, which we show drives, in rats, individually variable aversive effects that depend on serotonin 2c receptors (5-ht2crs) in the rostromedial tegmental nucleus (rmtg), a major gabaergic afferent to midbrain dopamine neurons. |
2023-04-21 |
2023-08-14 |
rat |
| Jyoti C Patel, Kenneth D Carr, Margaret E Ric. Actions and Consequences of Insulin in the Striatum. Biomolecules. vol 13. issue 3. 2023-03-29. PMID:36979453. |
in the brain, insulin has well-established actions in the hypothalamus, as well as at the level of mesolimbic dopamine neurons in the midbrain. |
2023-03-29 |
2023-08-14 |
Not clear |
| Matthew H Higgs, James A Jones, Charles J Wilson, Michael J Beckstea. SK and Kv4 channels limit spike timing perturbations in pacemaking dopamine neurons. eNeuro. 2023-03-27. PMID:36973012. |
midbrain dopamine (da) neurons are among the best characterized pacemaker neurons, having intrinsic, rhythmic firing activity even in the absence of synaptic input. |
2023-03-27 |
2023-08-14 |
mouse |
| Zheng-Xiong Xi, Briana Hempel, Madeline Crissman, Sruti Pari, Benjamin Klein, Guo-Hua Bi, Hannah Alto. PPARα and PPARγ are expressed in midbrain dopamine neurons and modulate dopamine- and cannabinoid-mediated behavior in mice. Research square. 2023-03-13. PMID:36909477. |
pparα and pparγ are expressed in midbrain dopamine neurons and modulate dopamine- and cannabinoid-mediated behavior in mice. |
2023-03-13 |
2023-08-14 |
mouse |
| N Shashaank, Mahalakshmi Somayaji, Mattia Miotto, Eugene V Mosharov, Emily A Makowicz, David A Knowles, Giancarlo Ruocco, David L Sulze. Computational models of dopamine release measured by fast scan cyclic voltammetry in vivo. PNAS nexus. vol 2. issue 3. 2023-03-13. PMID:36909827. |
ventral midbrain dopamine neurons exhibit ongoing tonic firing that produces low extrasynaptic levels of dopamine below the detection of conventional extrasynaptic cyclic voltammetry (∼10-20 nanomolar), with superimposed bursts that can saturate the dopamine uptake transporter and produce transient micromolar concentrations. |
2023-03-13 |
2023-08-14 |
mouse |
| Baile Ning, Zhifang Wang, Qian Wu, Qiyue Deng, Qing Yang, Jing Gao, Wen Fu, Ying Deng, Bingxin Wu, Xichang Huang, Jilin Mei, Wenbin F. Acupuncture inhibits autophagy and repairs synapses by activating the mTOR pathway in Parkinson's disease depression model rats. Brain research. 2023-03-13. PMID:36914042. |
firstly, observing the behavioral changes of the dpd rat model, the regulation of monoamine neurotransmitters dopamine (da) and 5-hydroxytryptamine (5-ht) in the midbrain, the change of α-synuclein (α-syn) in the striatum, the efficacy of acupuncture in the treatment of dpd was discussed. |
2023-03-13 |
2023-08-14 |
rat |
| William Shao-Tsu Chen, Tzu-Ying Lin, Chia-Hua Kuo, Dennis Jine-Yuan Hsieh, Wei-Wen Kuo, Shih-Chieh Liao, Hui-Chuan Kao, Da-Tong Ju, Yu-Jung Lin, Chih-Yang Huan. Ginkgolide A improves the pleiotropic function and reinforces the neuroprotective effects by mesenchymal stem cell-derived exosomes in 6-OHDA-induced cell model of Parkinson's disease. Aging. vol 15. 2023-03-02. PMID:36863713. |
parkinson's disease (pd) is a common disorder attributed to the loss of midbrain dopamine (mda) neurons and reduced dopamine secretion. |
2023-03-02 |
2023-08-14 |
Not clear |
| M J Corenblum, A McRobbie-Johnson, E Carruth, K Bernard, M Luo, L J Mandarino, S Peterson, D Billheimer, T Maley, E D Eggers, L Madhava. Parallel Neurodegenerative Phenotypes in Sporadic Parkinson's Disease Fibroblasts and Midbrain Dopamine Neurons. bioRxiv : the preprint server for biology. 2023-02-17. PMID:36798207. |
parallel neurodegenerative phenotypes in sporadic parkinson's disease fibroblasts and midbrain dopamine neurons. |
2023-02-17 |
2023-08-14 |
human |
| M J Corenblum, A McRobbie-Johnson, E Carruth, K Bernard, M Luo, L J Mandarino, S Peterson, D Billheimer, T Maley, E D Eggers, L Madhava. Parallel Neurodegenerative Phenotypes in Sporadic Parkinson's Disease Fibroblasts and Midbrain Dopamine Neurons. bioRxiv : the preprint server for biology. 2023-02-17. PMID:36798207. |
here, we report cellular and molecular alterations in skin fibroblasts of late-onset sporadic pd subjects, that were recapitulated in matched induced pluripotent stem cell (ipsc)-derived midbrain dopamine (da) neurons, reprogrammed from the same fibroblasts. |
2023-02-17 |
2023-08-14 |
human |
| Alexander Allen, Elizabeth Heisler, J Matthew Kittelberge. Dopamine Injections to the Midbrain Periaqueductal Gray Inhibit Vocal-Motor Production in a Teleost Fish. Physiology & behavior. 2023-02-16. PMID:36796532. |
dopamine injections to the midbrain periaqueductal gray inhibit vocal-motor production in a teleost fish. |
2023-02-16 |
2023-08-14 |
Not clear |
| Daniel F Hill, Robert W Hickman, Alaa Al-Mohammad, Arkadiusz Stasiak, Wolfram Schult. Dopamine signals encode internally determined subjective value regardless of externally indicated reward attributes. bioRxiv : the preprint server for biology. 2023-01-30. PMID:36711724. |
responses of midbrain dopamine neurons followed the trial-by-trial variation of bids despite constant, explicitly predicted reward amounts; correspondingly, the dopamine responses were similar when the animal placed similar bids for different reward amounts. |
2023-01-30 |
2023-08-14 |
human |
| Jean Paul Selten, Johan Orme. Low status, humiliation, dopamine and risk of schizophrenia. Psychological medicine. 2023-01-25. PMID:36695070. |
since most individuals exposed to low status do not develop schizophrenia, we propose that this risk factor increases the risk of disorder in the presence of a poor homeostatic control of dopamine neurons in midbrain and dorsal striatum. |
2023-01-25 |
2023-08-14 |
human |
| Jean Paul Selten, Johan Orme. Low status, humiliation, dopamine and risk of schizophrenia. Psychological medicine. 2023-01-25. PMID:36695070. |
in this new version of the social defeat hypothesis we propose that the combination of low status, repeated humiliation and poor homeostatic control of dopamine neurons in midbrain and dorsal striatum leads to increased striatal dopamine activity and thereby to an increased risk of schizophrenia. |
2023-01-25 |
2023-08-14 |
human |
| Eva Troyano-Rodriguez, Harris E Blankenship, Kylie Handa, Sarah Y Branch, Michael J Beckstea. Preservation of dendritic D2 receptor transmission in substantia nigra dopamine neurons with age. Scientific reports. vol 13. issue 1. 2023-01-19. PMID:36658269. |
in the midbrain, d2-type dopamine receptors located at dendrodendritic synapses between dopamine neurons control cell firing through g protein-activated potassium (girk) channels. |
2023-01-19 |
2023-08-14 |
mouse |
| Oxana Garritsen, Eljo Y van Battum, Laurens M Grossouw, R Jeroen Pasterkam. Development, wiring and function of dopamine neuron subtypes. Nature reviews. Neuroscience. 2023-01-18. PMID:36653531. |
the midbrain dopamine (mda) system is composed of molecularly and functionally distinct neuron subtypes that mediate specific behaviours and are linked to various brain diseases. |
2023-01-18 |
2023-08-14 |
Not clear |
| Joseph J Lebowitz, Aditi Banerjee, Claire Qiao, James R Bunzow, John T Williams, Pascal S Kaese. Synaptotagmin-1 is a Ca Cell reports. vol 42. issue 1. 2023-01-14. PMID:36640316. |
somatodendritic dopamine secretion in the midbrain leads to d2 receptor-induced modulation of dopamine neurons on the timescale of seconds. |
2023-01-14 |
2023-08-14 |
Not clear |