| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ryunosuke Amo, Naoshige Uchida, Mitsuko Watabe-Uchid. Glutamate inputs send prediction error of reward but not negative value of aversive stimuli to dopamine neurons. bioRxiv : the preprint server for biology. 2023-11-21. PMID:37986868. |
midbrain dopamine neurons are thought to signal reward prediction errors (rpes) but the mechanisms underlying rpe computation, particularly contributions of different neurotransmitters, remain poorly understood. |
2023-11-21 |
2023-11-29 |
Not clear |
| Hye Yun Kim, Jieun Lee, Hyun-Jin Kim, Byeong Eun Lee, Jaewook Jeong, Eun Jeong Cho, Hyun-Jun Jang, Kyeong Jin Shin, Min Ji Kim, Young Chan Chae, Seung Eun Lee, Kyungjae Myung, Ja-Hyun Baik, Pann-Ghill Suh, Jae-Ick Ki. PLCγ1 in dopamine neurons critically regulates striatal dopamine release via VMAT2 and synapsin III. Experimental & molecular medicine. 2023-11-01. PMID:37907739. |
we found that cell type-specific deletion of plcγ1 does not adversely affect the development and cellular morphology of midbrain dopamine neurons but does facilitate dopamine release from dopaminergic axon terminals in the striatum. |
2023-11-01 |
2023-11-08 |
mouse |
| Yun-Feng Zhang, Jialiang Wu, Yingqi Wang, Natalie L Johnson, Janardhan P Bhattarai, Guanqing Li, Wenqiang Wang, Camilo Guevara, Hannah Shoenhard, Marc V Fuccillo, Daniel W Wesson, Minghong M. Ventral striatal islands of Calleja neurons bidirectionally mediate depression-like behaviors in mice. Nature communications. vol 14. issue 1. 2023-10-30. PMID:37898623. |
finally, we propose a model that explains how ot d3 neurons may influence dopamine release via synaptic connections with ot spiny projection neurons (spns) that project to midbrain dopamine neurons. |
2023-10-30 |
2023-11-08 |
mouse |
| Daniel L Albaugh, Aryn H Gitti. Basal ganglia: Appreciating the 'value' of the GPe. Current biology : CB. vol 33. issue 20. 2023-10-26. PMID:37875082. |
a newly discovered cell type, the slow pacemaker, robustly encodes reward value and generates prediction errors in a manner remarkably similar to midbrain dopamine neurons. |
2023-10-26 |
2023-11-08 |
Not clear |
| Alice Petty, Anna Garcia-Hidalgo, Els F Halff, Sridhar Natesan, Dominic J Withers, Elaine E Irvine, Michelle Kokkinou, Lisa A Wells, David R Bonsall, Sac-Pham Tang, Mattia Veronese, Oliver D Howe. Sub-Chronic Ketamine Administration Increases Dopamine Synthesis Capacity in the Mouse Midbrain: a Preclinical In Vivo PET Study. Molecular imaging and biology. 2023-10-23. PMID:37872462. |
sub-chronic ketamine administration increases dopamine synthesis capacity in the mouse midbrain: a preclinical in vivo pet study. |
2023-10-23 |
2023-11-08 |
mouse |
| Pol Bech, Sylvain Crochet, Robin Dard, Parviz Ghaderi, Yanqi Liu, Meriam Malekzadeh, Carl C H Petersen, Mauro Pulin, Anthony Renard, Christos Sourmpi. Striatal Dopamine Signals and Reward Learning. Function (Oxford, England). vol 4. issue 6. 2023-10-16. PMID:37841525. |
neuronal circuits of the basal ganglia have been strongly implicated in action selection, as well as the learning and execution of goal-directed behaviors, with accumulating evidence supporting the hypothesis that midbrain dopamine neurons might encode a reward signal useful for learning. |
2023-10-16 |
2023-11-08 |
Not clear |
| Pol Bech, Sylvain Crochet, Robin Dard, Parviz Ghaderi, Yanqi Liu, Meriam Malekzadeh, Carl C H Petersen, Mauro Pulin, Anthony Renard, Christos Sourmpi. Striatal Dopamine Signals and Reward Learning. Function (Oxford, England). vol 4. issue 6. 2023-10-16. PMID:37841525. |
we focus on phasic increases in action potential firing of midbrain dopamine neurons in response to unexpected rewards. |
2023-10-16 |
2023-11-08 |
Not clear |
| Hao Liu, Haibin Dong, Chunxiao Wang, Wenjuan Jia, Guangqiang Wang, Hua Wang, Lin Zhong, Lei Gon. Key Subdomains of Cerebral Dopamine Neurotrophic Factor Regulate Its Protective Function in 6-Hydroxydopamine-Lesioned PC12 Cells. DNA and cell biology. 2023-10-10. PMID:37815547. |
cerebral dopamine neurotrophic factor (cdnf) is a unique neurotrophic factor (ntf) that has shown significant neuroprotective and neurorestorative functions on midbrain dopaminergic neurons. |
2023-10-10 |
2023-10-15 |
human |
| Kai Xu, Peng Huang, Yixuan Wu, Teng Liu, Ningyi Shao, Lulu Zhao, Xiaoyan Hu, Junlei Chang, Yongbo Peng, Shaogang Q. Engineered Selenium/Human Serum Albumin Nanoparticles for Efficient Targeted Treatment of Parkinson's Disease via Oral Gavage. ACS nano. 2023-10-09. PMID:37807265. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by the degeneration of dopamine (da) neurons in the midbrain substantia nigra pars compacta (snpc). |
2023-10-09 |
2023-10-15 |
human |
| Shweta Jain, Andrew G Yee, James Maas, Sarah Gierok, Hongfei Xu, Jasmine Stansil, Jacob Eriksen, Alexandra B Nelson, Katlin Silm, Christopher P Ford, Robert H Edward. Adaptor protein-3 produces synaptic vesicles that release phasic dopamine. Proceedings of the National Academy of Sciences of the United States of America. vol 120. issue 42. 2023-10-09. PMID:37812725. |
the burst firing of midbrain dopamine neurons releases a phasic dopamine signal that mediates reinforcement learning. |
2023-10-09 |
2023-10-15 |
Not clear |
| Kelsey Barcomb, Christopher P For. Alterations in neurotransmitter co-release in Parkinson's disease. Experimental neurology. 2023-10-06. PMID:37802381. |
parkinson's disease is a neurological disorder characterized by degeneration of midbrain dopamine neurons, which results in numerous adaptations in basal ganglia circuits. |
2023-10-06 |
2023-10-15 |
Not clear |
| Kelsey Barcomb, Christopher P For. Alterations in neurotransmitter co-release in Parkinson's disease. Experimental neurology. 2023-10-06. PMID:37802381. |
research over the past twenty-five years has identified that midbrain dopamine neurons of the substantia nigra pars compacta (snc) and ventral tegmental area (vta) co-release multiple other transmitters including glutamate and gaba, in addition to their canonical transmitter, dopamine. |
2023-10-06 |
2023-10-15 |
Not clear |
| Aastha Singh, Anne Panhelainen, Merja H Voutilaine. Feasibility of combining alpha-synuclein aggregation and 6-OHDA in embryonic midbrain culture for modeling dopamine neuron degeneration. Neuroscience letters. 2023-10-06. PMID:37802418. |
feasibility of combining alpha-synuclein aggregation and 6-ohda in embryonic midbrain culture for modeling dopamine neuron degeneration. |
2023-10-06 |
2023-10-15 |
mouse |
| Jie Zhang, Jia Li, Cheng-Xi Liu, Huan Gui, Cheng-Dong Yuan, Yi Zhan. The role of intracerebral dopamine D1 and D2 receptors in sleep-wake cycles and general anesthesia. Ibrain. vol 8. issue 1. 2023-10-03. PMID:37786416. |
dopamine (da), a monoamine neurotransmitter, is synthesized and released mainly by neurons in the ventral tegmental area and the substantia nigra (sn) pars compacta of the midbrain. |
2023-10-03 |
2023-10-07 |
Not clear |
| Yuji K Takahashi, Zhewei Zhang, Marlian Montesinos-Cartegena, Thorsten Kahnt, Angela J Langdon, Geoffrey Schoenbau. Expectancy-related changes in firing of dopamine neurons depend on hippocampus. bioRxiv : the preprint server for biology. 2023-10-02. PMID:37781610. |
we recorded midbrain dopamine neurons as rats performed an odor-based choice task, in which errors in the prediction of reward were induced by manipulating the number or timing of the expected rewards across blocks of trials. |
2023-10-02 |
2023-10-07 |
rat |
| Gavin C Jones, Christina A Small, Dallin Z Otteson, Caylor W Hafen, Jacob T Breinholt, Paul D Flora, Matthew D Burris, David W Sant, Tysum R Ruchti, Jordan T Yorgason, Scott C Steffensen, Kyle B Bill. Whole-Body Vibration Prevents Neuronal, Neurochemical, and Behavioral Effects of Morphine Withdrawal in a Rat Model. International journal of molecular sciences. vol 24. issue 18. 2023-09-28. PMID:37762450. |
peripheral mechanoreceptor-based treatments such as acupuncture and chiropractic manipulation have shown success in modulating the mesolimbic dopamine (da) system originating in the ventral tegmental area (vta) of the midbrain and projecting to the nucleus accumbens (nac) of the striatum. |
2023-09-28 |
2023-10-07 |
rat |
| Wen-Xiang Duan, Fen Wang, Jun-Yi Liu, Chun-Feng Li. Relationship Between Short-chain Fatty Acids and Parkinson's Disease: A Review from Pathology to Clinic. Neuroscience bulletin. 2023-09-27. PMID:37755674. |
parkinson's disease (pd) is a complicated neurodegenerative disease, characterized by the accumulation of α-synuclein (α-syn) in lewy bodies and neurites, and massive loss of midbrain dopamine neurons. |
2023-09-27 |
2023-10-07 |
Not clear |
| Long Din. Contributions of the Basal Ganglia to Visual Perceptual Decisions. Annual review of vision science. vol 9. 2023-09-15. PMID:37713277. |
from theoretical and experimental perspectives, the review focuses on four key stations in the bg network, namely, the striatum, pallidum, subthalamic nucleus, and midbrain dopamine neurons, which can have different roles and together support the decision process. |
2023-09-15 |
2023-10-07 |
Not clear |
| Nadine J Ortner, Anupam Sah, Enrica Paradiso, Josef Shin, Strahinja Stojanovic, Niklas Hammer, Maria Haritonova, Nadja T Hofer, Andrea Marcantoni, Laura Guarina, Petronel Tuluc, Tamara Theiner, Florian Pitterl, Karl Ebner, Herbert Oberacher, Emilio Carbone, Nadia Stefanova, Francesco Ferraguti, Nicolas Singewald, Jochen Roeper, Joerg Striessni. The human channel gating-modifying A749G CACNA1D (Cav1.3) variant induces a neurodevelopmental syndrome-like phenotype in mice. JCI insight. 2023-09-12. PMID:37698939. |
cav1.3ag mice confirm the pathogenicity of the a749g variant and point towards a pathogenetic role of altered signaling in the dopamine midbrain system. |
2023-09-12 |
2023-10-07 |
mouse |
| Jia-Xin Shi, Ke-Zhong Zhan. Advancements in autologous stem cell transplantation for Parkinson's Disease. Current stem cell research & therapy. 2023-09-11. PMID:37691194. |
parkinson's disease (pd) is a progressive neurodegenerative disease marked by comparatively focal dopaminergic neuron degeneration in the substantia nigra of the midbrain and dopamine loss in the striatum, which causes motor and non-motor symptoms. |
2023-09-11 |
2023-10-07 |
Not clear |