| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiaowen Zhuang, Julia Lemak, Sadhana Sridhar, Alexandra B Nelso. Inhibition of Indirect Pathway Activity Causes Abnormal Decision-Making In a Mouse Model of Impulse Control Disorder in Parkinson's Disease. bioRxiv : the preprint server for biology. 2024-11-18. PMID:39554037. |
in parkinson's disease (pd), in which loss of midbrain dopamine neurons is associated with progressive motor and cognitive deficits, this coordination is disrupted. |
2024-11-18 |
2024-11-22 |
mouse |
| Chengxue Du, Jiachen Wang, Huihui Tan, Nannan Han, Xiaobo Li, Baihua Sun, Gejuan Zhang, Mingze Chan. Dopamine D Brain research bulletin. vol 219. 2024-11-13. PMID:39521183. |
dopamine d although the output of the lateral habenula (lhb) controls the activity of midbrain dopamine (da) and 5-hydroxytryptamine (5-ht) containing systems, which are implicated in the pathophysiology of anxiety, it is not clear how activation and blockade of lhb d |
2024-11-13 |
2024-11-17 |
Not clear |
| Tomohiko Yoshizawa, Makoto Funahash. Dopamine release in striatal striosome compartments in response to rewards and aversive outcomes during classical conditioning in mice. Neuroscience research. 2024-11-09. PMID:39515479. |
the striatum consists of two anatomically and neurochemically distinct compartments, striosomes and the matrix, which receive dopaminergic inputs from the midbrain and exhibit distinct dopamine release dynamics in acute brain slices. |
2024-11-09 |
2024-11-17 |
mouse |
| Sonia Aroni, Claudia Sagheddu, Marco Pistis, Anna Lisa Munton. Functional Adaptation in the Brain Habenulo-Mesencephalic Pathway During Cannabinoid Withdrawal. Cells. vol 13. issue 21. 2024-11-08. PMID:39513916. |
the mesolimbic reward system originating from dopamine neurons in the ventral tegmental area (vta) of the midbrain shows a profound reduction in function during cannabinoid withdrawal. |
2024-11-08 |
2024-11-16 |
Not clear |
| Harris E Blankenship, Kelsey A Carter, Kevin D Pham, Nina T Cassidy, Andrea N Markiewicz, Michael I Thellmann, Amanda L Sharpe, Willard M Freeman, Michael J Beckstea. VTA dopamine neurons are hyperexcitable in 3xTg-AD mice due to casein kinase 2-dependent SK channel dysfunction. Nature communications. vol 15. issue 1. 2024-11-08. PMID:39516200. |
here, we investigated the role of midbrain dopamine (da) neurons in ad using the amyloid + tau-driven 3xtg-ad mouse model. |
2024-11-08 |
2024-11-17 |
mouse |
| Wisberty J Gordián-Vélez, Kevin D Browne, Jonathan H Galarraga, Dimple Chouhan, John E Duda, Rodrigo A España, H Isaac Chen, Jason A Burdick, D Kacy Culle. Dopaminergic Axon Tracts Within a Hyaluronic Acid Hydrogel Encasement to Restore the Nigrostriatal Pathway. Advanced healthcare materials. 2024-11-04. PMID:39494983. |
using rat ventral midbrain neurons, it is found that te-nsps exhibited improved neurite growth with ha relative to agarose, with no differences in electrically-evoked dopamine release. |
2024-11-04 |
2024-11-06 |
rat |
| Mohd Yaseen Malik, Fei Guo, Aman Asif-Malik, Vasileios Eftychidis, Nikolaos Barkas, Elena Eliseeva, Kerstin N Timm, Aleksandra Wolska, David Bergin, Barbara Zonta, Veronika Ratz-Wirsching, Stephan von Hörsten, Mark E Walton, Peter J Magill, Claus Nerlov, Liliana Minichiell. Impaired striatal glutathione-ascorbate metabolism induces transient dopamine increase and motor dysfunction. Nature metabolism. 2024-10-29. PMID:39468205. |
here, we demonstrate that genetic disruption of ispns function by ntrk2/trkb deletion in mice results in increased striatal dopamine and midbrain dopaminergic neurons, preceding hyperkinetic dysfunction. |
2024-10-29 |
2024-10-31 |
mouse |
| Jasmine L Carter, Julian A N M Halmai, Jennifer J Waldo, Paula A Vij, Maribel Anguiano, Isaac J Villegas, Yu Xin Du, Jan Nolta, Kyle D Fin. A de novo Missense Mutation in PPP2R5D Alters Dopamine Pathways and Morphology of iPSC-derived Midbrain Neurons. Stem cells (Dayton, Ohio). 2024-10-26. PMID:39460716. |
a de novo missense mutation in ppp2r5d alters dopamine pathways and morphology of ipsc-derived midbrain neurons. |
2024-10-26 |
2024-10-29 |
human |
| Tate A Pollock, Alexander V Margetts, Samara J Vilca, Luis M Tuest. Cocaine taking and craving produce distinct transcriptional profiles in dopamine neurons. bioRxiv : the preprint server for biology. 2024-10-17. PMID:39416214. |
the adaptive responses from midbrain dopamine neurons to artificial rewards such as drugs of abuse are therefore important for understanding the development of substance use disorders. |
2024-10-17 |
2024-10-19 |
mouse |
| Huifang Wu, Minghao Yan, Tong Wu, Xiaodong Ha. MC-LR disrupts dopamine synthesis in the substantia nigra of midbrain by enhancing the chaperone-mediated autophagy pathway through direct binding to ERK2. Journal of hazardous materials. vol 480. 2024-10-16. PMID:39413523. |
mc-lr disrupts dopamine synthesis in the substantia nigra of midbrain by enhancing the chaperone-mediated autophagy pathway through direct binding to erk2. |
2024-10-16 |
2024-10-19 |
mouse |
| Huifang Wu, Minghao Yan, Tong Wu, Xiaodong Ha. MC-LR disrupts dopamine synthesis in the substantia nigra of midbrain by enhancing the chaperone-mediated autophagy pathway through direct binding to ERK2. Journal of hazardous materials. vol 480. 2024-10-16. PMID:39413523. |
mc-lr could penetrate the blood-brain barrier of mice and accumulate in the substantia nigra (sn) of the midbrain, leading to a reduction in dopamine levels and parkinson's disease (pd)-like motor dysfunction in mice. |
2024-10-16 |
2024-10-19 |
mouse |
| Zhewei Zhang, Yuji K Takahashi, Marlian Montesinos-Cartegena, Thorsten Kahnt, Angela J Langdon, Geoffrey Schoenbau. Expectancy-related changes in firing of dopamine neurons depend on hippocampus. Nature communications. vol 15. issue 1. 2024-10-16. PMID:39414794. |
we recorded midbrain dopamine neurons as rats performed an odor-based choice task, in which expected rewards were manipulated across blocks. |
2024-10-16 |
2024-10-19 |
rat |
| Xóchitl Flores-Ponce, Iván Velasc. Dopaminergic neuron metabolism: relevance for understanding Parkinson's disease. Metabolomics : Official journal of the Metabolomic Society. vol 20. issue 6. 2024-10-13. PMID:39397188. |
dopaminergic neurons from the substantia nigra pars compacta (snc) have a higher susceptibility to aging-related degeneration, compared to midbrain dopaminergic cells present in the ventral tegmental area (vta); the death of dopamine neurons in the snc results in parkinson´s disease (pd). |
2024-10-13 |
2024-10-16 |
Not clear |
| Greg Perlman, Kenneth Wengler, Scott J Moeller, Roman Kotov, Daniel N Klein, Jodi J Weinstein, Guillermo Horga, Anissa Abi-Dargha. Association of Neuromelanin-Sensitive MRI Signal With Lifetime Substance Use in Young Women. The American journal of psychiatry. 2024-10-09. PMID:39380373. |
midbrain dopamine function plays a key role in translational models of substance use disorders. |
2024-10-09 |
2024-10-11 |
Not clear |
| Greg Perlman, Kenneth Wengler, Scott J Moeller, Roman Kotov, Daniel N Klein, Jodi J Weinstein, Guillermo Horga, Anissa Abi-Dargha. Association of Neuromelanin-Sensitive MRI Signal With Lifetime Substance Use in Young Women. The American journal of psychiatry. 2024-10-09. PMID:39380373. |
whether midbrain dopamine function is associated with substance use frequency and severity or reward function in 20-24 year-olds remains a critical gap in knowledge. |
2024-10-09 |
2024-10-11 |
Not clear |
| Samuel J Gershman, Armin La. Policy complexity suppresses dopamine responses. bioRxiv : the preprint server for biology. 2024-09-30. PMID:39345642. |
in support of this hypothesis, we find that policy complexity suppresses midbrain dopamine responses to reward outcomes, thereby reducing behavioral sensitivity to these outcomes. |
2024-09-30 |
2024-10-02 |
Not clear |
| Valentina Basso, Máté D Döbrössy, Lachlan H Thompson, Deniz Kirik, Heidi R Fuller, Monte A Gate. State of the Art in Sub-Phenotyping Midbrain Dopamine Neurons. Biology. vol 13. issue 9. 2024-09-28. PMID:39336117. |
state of the art in sub-phenotyping midbrain dopamine neurons. |
2024-09-28 |
2024-10-01 |
human |
| Daria S Gorina, Anastasiya V Lastovka, Artem D Rogachev, Alexandra V Podturkina, Alla V Pavlova, Oleg V Ardashov, Nikolai S Li-Zhulanov, Tatyana G Tolstikova, Konstantin P Volcho, Nariman F Salakhutdino. Pharmacokinetics and Dose Proportionality Study of a Novel Antiparkinsonian Agent, a 1 Molecules (Basel, Switzerland). vol 29. issue 18. 2024-09-28. PMID:39339493. |
pa-96 supported the survival of cultured naïve dopamine neurons, alleviated motor deficits in mptp and haloperidol-based mice models of parkinson's disease, and increased the density of tyrosine hydroxylase positive neurons and dopamine concentration in the midbrain of an mptp-damaged brain. |
2024-09-28 |
2024-10-01 |
mouse |
| Zhe Chen, Naiyan Lu, Xu Li, Qingrun Liu, Yujie Li, Xiyue Li, Ximiao Yu, Haotian Zhao, Chang Liu, Xue Tang, Xun Wang, Weisun Huan. The Effect of a Caffeine and Nicotine Combination on Nicotine Withdrawal Syndrome in Mice. Nutrients. vol 16. issue 18. 2024-09-28. PMID:39339647. |
the changes in dopamine release in the prefrontal cortex (pfc) and ventral tegmental area (vta) in the midbrain were analyzed using elisa. |
2024-09-28 |
2024-10-01 |
mouse |
| Alain Rios, Kyohei Fujita, Yoshikazu Isomura, Nobuya Sat. Adaptive circuits for action and value information in rodent operant learning. Neuroscience research. 2024-09-28. PMID:39341460. |
we include insights from recent studies, which reveals the intricate roles of midbrain dopamine neurons in integrating action initiation and reward feedback, thereby enhancing movement-related activities in the dorsal striatum. |
2024-09-28 |
2024-10-01 |
Not clear |