| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zachary Gaertner, Cameron Oram, Amanda Schneeweis, Elan Schonfeld, Cyril Bolduc, Chuyu Chen, Daniel Dombeck, Loukia Parisiadou, Jean Francois Poulin, Rajeshwar Awatraman. Molecular and spatial transcriptomic classification of midbrain dopamine neurons and their alterations in a LRRK2 bioRxiv : the preprint server for biology. 2024-06-19. PMID:38895448. |
molecular and spatial transcriptomic classification of midbrain dopamine neurons and their alterations in a lrrk2 several studies have revealed that midbrain dopamine (da) neurons, even within a single neuroanatomical area, display heterogeneous properties. |
2024-06-19 |
2024-06-21 |
mouse |
| Pingping Song, Dimitri Krain. Diverse Functions of Parkin in Midbrain Dopaminergic Neurons. Movement disorders : official journal of the Movement Disorder Society. 2024-06-11. PMID:38858837. |
in pd patient neurons, disruption of this pathway on loss of parkin leads to defective recycling of synaptic vesicles and accumulation of toxic oxidized dopamine that at least in part explains preferential vulnerability of midbrain dopaminergic neurons. |
2024-06-11 |
2024-06-14 |
human |
| Tania Arora, Gaurav Sharma, Vikash Prashar, Randeep Singh, Arti Sharma, Harish Changotra, Jyoti Parkas. Mechanistic Evaluation of miRNAs and Their Targeted Genes in the Pathogenesis and Therapeutics of Parkinson's Disease. Molecular neurobiology. 2024-06-01. PMID:38823001. |
pd is mainly caused by the demolition of the primary dopamine neurotransmitter secretory cells and dopaminergic or dopamine secretory neurons in the substantia nigra pars compacta of the midbrain, which are majorly responsible for motor functions. |
2024-06-01 |
2024-06-03 |
Not clear |
| Eric Garr, Yifeng Cheng, Huijeong Jeong, Sara Brooke, Laia Castell, Aneesh Bal, Robin Magnard, Vijay Mohan K Namboodiri, Patricia H Jana. Mesostriatal dopamine is sensitive to changes in specific cue-reward contingencies. Science advances. vol 10. issue 22. 2024-05-29. PMID:38809978. |
conditioned responding was attenuated for the cue-reward contingency that was degraded, as was dopamine neuron activity in the midbrain and dopamine release in the ventral striatum in response to the cue and subsequent reward. |
2024-05-29 |
2024-06-02 |
rat |
| Minryung R Song, Sang Wan Le. Rethinking dopamine-guided action sequence learning. The European journal of neuroscience. 2024-05-27. PMID:38798086. |
previous research has demonstrated that midbrain dopamine and its major projection target, the striatum, play crucial roles in these processes. |
2024-05-27 |
2024-05-31 |
Not clear |
| Tae-Yoon Park, Jeha Jeon, Young Cha, Kwang-Soo Ki. Past, present, and future of cell replacement therapy for parkinson's disease: a novel emphasis on host immune responses. Cell research. 2024-05-22. PMID:38777859. |
central to the pathophysiology of pd is the specific degeneration of midbrain dopamine neurons (mdans) in the substantia nigra. |
2024-05-22 |
2024-05-27 |
human |
| Fares J P Sayegh, Lionel Mouledous, Catherine Macri, Juliana Pi Macedo, Camille Lejards, Claire Rampon, Laure Verret, Lionel Daha. Ventral tegmental area dopamine projections to the hippocampus trigger long-term potentiation and contextual learning. Nature communications. vol 15. issue 1. 2024-05-21. PMID:38773091. |
here, we used optogenetic manipulation of midbrain dopamine neurons in male dat::cre mice, and discovered that stimulating the schaffer collaterals - the glutamatergic axons connecting ca3 and ca1 regions - of the dorsal hippocampus concomitantly with midbrain dopamine terminals within a 200 millisecond time-window triggers ltp at glutamatergic synapses. |
2024-05-21 |
2024-05-27 |
mouse |
| Fares J P Sayegh, Lionel Mouledous, Catherine Macri, Juliana Pi Macedo, Camille Lejards, Claire Rampon, Laure Verret, Lionel Daha. Ventral tegmental area dopamine projections to the hippocampus trigger long-term potentiation and contextual learning. Nature communications. vol 15. issue 1. 2024-05-21. PMID:38773091. |
thus, activation of midbrain dopamine can operate as a teaching signal that triggers neohebbian ltp and promotes supervised learning. |
2024-05-21 |
2024-05-27 |
mouse |
| Megan Caldwell, Josue Criollo Mendoza, Xin Yan Zhu Jiang, Colin Alarcon, Vanessa Ayo-Jibunoh, Shelby Louis, Daniel Maronna, Rania Darwish, Jaquelyn Tomaio, Susana Mingote, Leora Yetnikof. Reorganization of dopamine circuitry in the anterior corpus callosum between early adolescence and adulthood in the mouse. The European journal of neuroscience. vol 59. issue 10. 2024-05-21. PMID:38720367. |
we recently demonstrated in the adult mouse brain that axon terminals arising from midbrain dopamine neurons innervate the anterior corpus callosum and that oligodendrocyte lineage cells in this white matter tract express dopamine receptor transcripts. |
2024-05-21 |
2024-05-27 |
mouse |
| Dominik Szabó, Vedran Franke, Simona Bianco, Mykhailo Y Batiuk, Eleanor J Paul, Alexander Kukalev, Ulrich G Pfisterer, Ibai Irastorza-Azcarate, Andrea M Chiariello, Samuel Demharter, Luna Zea-Redondo, Jose P Lopez-Atalaya, Mario Nicodemi, Altuna Akalin, Konstantin Khodosevich, Mark A Ungless, Warren Winick-Ng, Ana Pomb. A single dose of cocaine rewires the 3D genome structure of midbrain dopamine neurons. bioRxiv : the preprint server for biology. 2024-05-20. PMID:38766140. |
midbrain dopamine neurons (dns) respond to a first exposure to addictive drugs and play key roles in chronic drug usage |
2024-05-20 |
2024-05-27 |
Not clear |
| Dominik Szabó, Vedran Franke, Simona Bianco, Mykhailo Y Batiuk, Eleanor J Paul, Alexander Kukalev, Ulrich G Pfisterer, Ibai Irastorza-Azcarate, Andrea M Chiariello, Samuel Demharter, Luna Zea-Redondo, Jose P Lopez-Atalaya, Mario Nicodemi, Altuna Akalin, Konstantin Khodosevich, Mark A Ungless, Warren Winick-Ng, Ana Pomb. A single dose of cocaine rewires the 3D genome structure of midbrain dopamine neurons. bioRxiv : the preprint server for biology. 2024-05-20. PMID:38766140. |
a single dose of cocaine rewires the 3d genome structure of midbrain dopamine neurons. |
2024-05-20 |
2024-05-27 |
Not clear |
| Kenta Abe, Yuki Kambe, Kei Majima, Zijing Hu, Makoto Ohtake, Ali Momennezhad, Hideki Izumi, Takuma Tanaka, Ashley Matunis, Emma Stacy, Takahide Itokazu, Takashi R Sato, Tatsuo Sat. Functional diversity of dopamine axons in prefrontal cortex during classical conditioning. eLife. vol 12. 2024-05-15. PMID:38747563. |
midbrain dopamine neurons impact neural processing in the prefrontal cortex (pfc) through mesocortical projections. |
2024-05-15 |
2024-05-27 |
mouse |
| Sofia Ines Garcia Moreno, Fabian Limani, Iina Ludwig, Catherine Gilbert, Christian Pifl, Thomas S Hnasko, Thomas Steinkellne. Viral overexpression of human alpha-synuclein in mouse substantia nigra dopamine neurons results in hyperdopaminergia but no neurodegeneration. bioRxiv : the preprint server for biology. 2024-05-15. PMID:38746104. |
loss of select neuronal populations such as midbrain dopamine (da) neurons is a pathological hallmark of parkinson's disease (pd). |
2024-05-15 |
2024-05-27 |
mouse |
| Hee Jae Jang, Royall McMahon Ward, Carla E M Golden, Christine M Constantinopl. Acetylcholine demixes heterogeneous dopamine signals for learning and moving. bioRxiv : the preprint server for biology. 2024-05-15. PMID:38746300. |
midbrain dopamine neurons promote reinforcement learning and movement vigor. |
2024-05-15 |
2024-05-27 |
rat |
| Samuel J Millard, Ivy B Hoang, Savannah Sherwood, Masakazu Taira, Vanessa Reyes, Zara Greer, Shayna L O'Connor, Kate M Wassum, Morgan H James, David J Barker, Melissa J Sharp. Cognitive representations of intracranial self-stimulation of midbrain dopamine neurons depend on stimulation frequency. Nature neuroscience. 2024-05-13. PMID:38741021. |
cognitive representations of intracranial self-stimulation of midbrain dopamine neurons depend on stimulation frequency. |
2024-05-13 |
2024-05-27 |
Not clear |
| Wolfram Schult. A dopamine mechanism for reward maximization. Proceedings of the National Academy of Sciences of the United States of America. vol 121. issue 20. 2024-05-08. PMID:38717856. |
midbrain dopamine neurons code reward prediction errors (rpe) of subjective reward value suitable for rl. |
2024-05-08 |
2024-05-27 |
monkey |
| Yilin Tang, Yuting Li, Peiyu Cao, Yingbo Dong, Guoxin Xu, Qi Si, Runda Li, Yuxiu Su. Striatum and globus pallidus structural abnormalities in schizophrenia: A retrospective study of the different stages of the disease. Progress in neuro-psychopharmacology & biological psychiatry. 2024-05-01. PMID:38692473. |
the basal ganglia are important structures for the release of dopamine in the limbic circuits of the midbrain, and the striatum and globus pallidus are the major nuclei of the basal ganglia, and the dysfunction of these regions has been the basis of many models that have attempted to explain the underlying mechanisms of schizophrenia symptoms. |
2024-05-01 |
2024-05-04 |
Not clear |
| Suraj Cherian, Gabriel Simms, Liqiang Chen, Hong-Yuan Ch. Loss of Midbrain Dopamine Neurons Does Not Alter GABAergic Inhibition Mediated by Parvalbumin-Expressing Interneurons in Mouse Primary Motor Cortex. eNeuro. 2024-04-24. PMID:38658137. |
loss of midbrain dopamine neurons does not alter gabaergic inhibition mediated by parvalbumin-expressing interneurons in mouse primary motor cortex. |
2024-04-24 |
2024-04-28 |
mouse |
| Katerina Rademacher, Zak Doric, Dominik Haddad, Aphroditi Mamaligas, Szu-Chi Liao, Rose B Creed, Kohei Kano, Zac Chatterton, Yuhong Fu, Joseph H Garcia, Victoria Vance, Yoshitaka Sei, Anatol Kreitzer, Glenda M Halliday, Alexandra B Nelson, Elyssa B Margolis, Ken Nakamur. Chronic hyperactivation of midbrain dopamine neurons causes preferential dopamine neuron degeneration. bioRxiv : the preprint server for biology. 2024-04-22. PMID:38645054. |
chronic hyperactivation of midbrain dopamine neurons causes preferential dopamine neuron degeneration. |
2024-04-22 |
2024-04-24 |
mouse |
| Ewa Galaj, Guo-Hua Bi, Zheng-Xiong X. β-caryophyllene inhibits heroin self-administration, but does not alter opioid-induced antinociception in rodents. Neuropharmacology. 2024-04-17. PMID:38631564. |
in this study, we found that systemic administration of bcp dose-dependently reduced heroin self-administration in rats under an fr2 schedule of reinforcement and partially blocked heroin-enhanced brain stimulation reward in dat-cre mice, maintained by optical stimulation of midbrain dopamine neurons at high frequencies. |
2024-04-17 |
2024-04-20 |
mouse |