| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Christopher A Guevara, Kumayl Alloo, Swati Gupta, Romario Thomas, Pamela Del Valle, Alexandra R Magee, Deanna L Benson, George W Huntle. Parkinson's LRRK2-G2019S risk gene mutation drives sex-specific behavioral and cellular adaptations to chronic variable stress. Frontiers in behavioral neuroscience. vol 18. 2024-09-27. PMID:39328984. |
anxiety is a psychiatric non-motor symptom of parkinson's that can appear in the prodromal period, prior to significant loss of midbrain dopamine neurons and motor symptoms. |
2024-09-27 |
2024-09-29 |
mouse |
| Mingxin Ding, Porter L Tomsick, Ryan A Young, Shantanu P Jadha. Ventral tegmental area dopamine neural activity switches simultaneously with rule representations in the prefrontal cortex and hippocampus. bioRxiv : the preprint server for biology. 2024-09-24. PMID:39314328. |
midbrain dopamine (da) activity is key in reward seeking behavior and learning. |
2024-09-24 |
2024-09-26 |
rat |
| Lidia Miguel Telega, Danesh Ashouri Vajari, Chockalingam Ramanathan, Volker A Coenen, Máté D Döbröss. Chronic in vivo sequelae of repetitive acute mfb-DBS on accumbal dopamine and midbrain neuronal activity. Journal of neurochemistry. 2024-09-23. PMID:39308085. |
chronic in vivo sequelae of repetitive acute mfb-dbs on accumbal dopamine and midbrain neuronal activity. |
2024-09-23 |
2024-09-26 |
Not clear |
| Yi-Ming Li, Xiao-Hu Xu, Li-Na Ren, Xiao-Fan Xu, Yi-Long Dai, Rui-Rui Yang, Cheng-Qiang Ji. The diagnostic value of neutrophil to lymphocyte ratio, albumin to fibrinogen ratio, and lymphocyte to monocyte ratio in Parkinson's disease: a retrospective study. Frontiers in neurology. vol 15. 2024-09-18. PMID:39286804. |
parkinson's disease (pd) is a prevalent disorder of the central nervous system, marked by the degeneration of dopamine (da) neurons in the ventral midbrain. |
2024-09-18 |
2024-09-20 |
Not clear |
| Sofia Ines Garcia Moreno, Fabian Limani, Iina Ludwig, Catherine Gilbert, Christian Pifl, Thomas S Hnasko, Thomas Steinkellne. Viral overexpression of human alpha-synuclein in mouse substantia nigra dopamine neurons results in hyperdopaminergia but no neurodegeneration. Experimental neurology. 2024-09-17. PMID:39288832. |
loss of select neuronal populations such as midbrain dopamine (da) neurons is a pathological hallmark of parkinson's disease (pd). |
2024-09-17 |
2024-09-20 |
mouse |
| Daniel F Hill, Robert W Hickman, Alaa Al-Mohammad, Arkadiusz Stasiak, Wolfram Schult. Dopamine neurons encode trial-by-trial subjective reward value in an auction-like task. Nature communications. vol 15. issue 1. 2024-09-17. PMID:39289338. |
in these highly experienced animals, responses of midbrain dopamine neurons followed the trial-by-trial variations of bids despite constant, explicitly predicted reward amounts. |
2024-09-17 |
2024-09-20 |
human |
| Fanshi Zhang, Zhuofan Ye, Yuanyang Xie, Mei Liu, Li Zhang, Jun Zhang, Zucai X. Levodopa-induced dyskinesia: brain iron deposition as a new hypothesis. Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine. 2024-08-30. PMID:39212870. |
the main pathological change in pd is the degenerative death of dopamine (da) neurons in the midbrain substantia nigra, which causes a significant decrease in the da content of the striatum. |
2024-08-30 |
2024-09-04 |
Not clear |
| Jordan E Elum, Eric R Szelenyi, Barbara Juarez, Alexandria D Murry, Grigory Loginov, Catalina A Zamorano, Pan Gao, Ginny Wu, Scott Ng-Evans, Joshua X Yee, Xiangmin Xu, Sam A Golden, Larry S Zweife. Distinct dynamics and intrinsic properties in ventral tegmental area populations mediate reward association and motivation. Cell reports. vol 43. issue 9. 2024-08-29. PMID:39207900. |
here, we compare the contribution of two primarily dopaminergic and largely non-overlapping vta subpopulations, all vta dopamine neurons and vta gabaergic neurons of the mouse midbrain, to these processes. |
2024-08-29 |
2024-09-04 |
mouse |
| James D Howard, Donnisa Edmonds, Geoffrey Schoenbaum, Thorsten Kahn. Distributed midbrain responses signal the content of positive identity prediction errors. Current biology : CB. 2024-08-28. PMID:39197457. |
recent work across species has shown that midbrain dopamine neurons signal not only errors in the prediction of reward value but also in the prediction of value-neutral sensory features. |
2024-08-28 |
2024-09-01 |
human |
| Triana Acevedo-Huergo, Jonathan Sánchez-Yépez, María Soledad Mendoza-Trejo, Isela Hernández-Plata, Magda Giordano, Verónica Mireya Rodrígue. Hypoactivity and neurochemical alterations in the basal ganglia of female Sprague-Dawley rats after repeated exposure to atrazine. Frontiers in toxicology. vol 6. 2024-08-20. PMID:39161789. |
the atr administration increased dopamine and dopac content in the nucleus accumbens and the dopamine and dopac and serotonin and 5-hiaa content in the ventral midbrain. |
2024-08-20 |
2024-08-22 |
rat |
| Gerardo Mendez-Victoriano, Yunting Zhu, Frank Middleton, Paul T Massa, Kachikwulu Ajulu, Maree J Webster, Cynthia S Weicker. Increased Parenchymal Macrophages are associated with decreased Tyrosine Hydroxylase mRNA levels in the Substantia Nigra of people with Schizophrenia and Bipolar Disorder. Psychiatry research. vol 340. 2024-08-17. PMID:39153291. |
the relationship of midbrain macrophages to dopamine neurons has not been explored, nor is it known if changes in midbrain macrophages are also present in bipolar disorder (bd) or major depressive disorder (mdd). |
2024-08-17 |
2024-08-20 |
Not clear |
| Mateja Rybiczka-Tešulov, Oxana Garritsen, Morten T Venø, Laura Wieg, Roland van Dijk, Karim Rahimi, Andreia Gomes-Duarte, Marina de Wit, Lieke L van de Haar, Lars Michels, Nicky C H van Kronenburg, Christiaan van der Meer, Jørgen Kjems, Vamshidhar R Vangoor, R Jeroen Pasterkam. Circular RNAs regulate neuron size and migration of midbrain dopamine neurons during development. Nature communications. vol 15. issue 1. 2024-08-08. PMID:39117691. |
circular rnas regulate neuron size and migration of midbrain dopamine neurons during development. |
2024-08-08 |
2024-08-12 |
mouse |
| Mateja Rybiczka-Tešulov, Oxana Garritsen, Morten T Venø, Laura Wieg, Roland van Dijk, Karim Rahimi, Andreia Gomes-Duarte, Marina de Wit, Lieke L van de Haar, Lars Michels, Nicky C H van Kronenburg, Christiaan van der Meer, Jørgen Kjems, Vamshidhar R Vangoor, R Jeroen Pasterkam. Circular RNAs regulate neuron size and migration of midbrain dopamine neurons during development. Nature communications. vol 15. issue 1. 2024-08-08. PMID:39117691. |
midbrain dopamine (mda) neurons play an essential role in cognitive and motor behaviours and are linked to different brain disorders. |
2024-08-08 |
2024-08-12 |
mouse |
| Hirotoshi Iguchi, Takumi Katsuzawa, Chihiro Saruta, Tetsushi Sadakata, Shota Kobayashi, Yumi Sato, Akira Sato, Yoshitake Sano, So Maezawa, Yo Shinoda, Teiichi Furuich. Calcium-dependent activator protein for secretion 2 is involved in dopamine release in mouse midbrain neurons. Frontiers in molecular neuroscience. vol 17. 2024-08-02. PMID:39092202. |
calcium-dependent activator protein for secretion 2 is involved in dopamine release in mouse midbrain neurons. |
2024-08-02 |
2024-08-05 |
mouse |
| Yusuke Ichikawa, Bunpei Sato, Shin-Ichi Hirano, Yoshiyasu Takefuji, Fumitake Sato. Realizing brain therapy with "smart medicine": mechanism and case report of molecular hydrogen inhalation for Parkinson's disease. Medical gas research. vol 14. issue 3. 2024-07-29. PMID:39073335. |
in the midbrain of parkinson's disease patients, hydroxyl radicals generated by the fenton reaction cause a chain reaction of oxidation of dopamine, but hydrogen entering the midbrain can convert the hydroxyl radicals into water molecules and inhibit the oxidation of dopamine. |
2024-07-29 |
2024-08-02 |
Not clear |
| Christina A Nelson, James N Brundage, Benjamin M Williams, Jared K Baldridge, Alyssa L Stockard, Charlton H Bassett, Brandon J Burger, Bridger T Gunter, Andrew J Payne, Jordan T Yorgason, Scott C Steffensen, Kyle B Bill. Voluntary Exercise Ameliorates Chronic Ethanol Withdrawal-Induced Adaptations of Opioid Receptor Expression in the Nucleus Accumbens, Dopamine Release, and Ethanol Consumption. Biomedicines. vol 12. issue 7. 2024-07-27. PMID:39062166. |
chronic ethanol (etoh) exposure has been shown to upregulate and sensitize kappa opioid receptors (kors) in the nucleus accumbens (nac), which is innervated by dopamine (da) neurons in the midbrain ventral tegmental area (vta), which may contribute to aud-related behaviors. |
2024-07-27 |
2024-07-29 |
mouse |
| Roger A Barker, Anders Björklund, Malin Parma. The history and status of dopamine cell therapies for Parkinson's disease. BioEssays : news and reviews in molecular, cellular and developmental biology. 2024-07-26. PMID:39058892. |
the results of these trials are eagerly awaited although proof of principle data has already come from trials using human fetal midbrain dopamine cell transplants. |
2024-07-26 |
2024-07-29 |
human |
| Jingjing Yang, Hongjuan Wang, Huan Chen, Hongwei Hou, Qingyuan H. The association of genetic polymorphisms within the dopaminergic system with nicotine dependence: A narrative review. Heliyon. vol 10. issue 12. 2024-07-18. PMID:39021905. |
nicotine acts on the limbic dopamine reward loop in the midbrain by binding to nicotinic acetylcholine receptors, promoting the release of dopamine, and resulting in a rewarding effect or satisfaction. |
2024-07-18 |
2024-07-20 |
Not clear |
| Nina Rouhani, David Clewett, James W Anton. Building and Breaking the Chain: A Model of Reward Prediction Error Integration and Segmentation of Memory. Journal of cognitive neuroscience. 2024-07-11. PMID:38991138. |
here, we review the roles of midbrain dopamine, the locus coeruleus, and the hippocampus in event cognition to propose and simulate the theoretical influence of two prediction error signals in integrating versus segmenting events in memory. |
2024-07-11 |
2024-07-14 |
Not clear |
| Matthew H Higgs, Michael J Beckstea. Impact of unitary synaptic inhibition on spike timing in ventral tegmental area dopamine neurons. eNeuro. 2024-07-05. PMID:38969500. |
midbrain dopamine neurons receive convergent synaptic input from multiple brain areas, which perturbs rhythmic pacemaking to produce the complex firing patterns observed in vivo. |
2024-07-05 |
2024-07-08 |
mouse |