| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Niyanta N Kumar, Mohan Gautam, Jeffrey J Lochhead, Daniel J Wolak, Vamsi Ithapu, Vikas Singh, Robert G Thorn. Relative vascular permeability and vascularity across different regions of the rat nasal mucosa: implications for nasal physiology and drug delivery. Scientific reports. vol 6. 2018-05-15. PMID:27558973. |
here, we determined that the relative capillary permeability to hydrophilic macromolecule tracers is significantly greater in nasal respiratory regions than in olfactory regions. |
2018-05-15 |
2023-08-13 |
rat |
| Niyanta N Kumar, Mohan Gautam, Jeffrey J Lochhead, Daniel J Wolak, Vamsi Ithapu, Vikas Singh, Robert G Thorn. Relative vascular permeability and vascularity across different regions of the rat nasal mucosa: implications for nasal physiology and drug delivery. Scientific reports. vol 6. 2018-05-15. PMID:27558973. |
mean capillary density in the nasal mucosa was also approximately 5-fold higher in nasal respiratory regions than in olfactory regions. |
2018-05-15 |
2023-08-13 |
rat |
| Niyanta N Kumar, Mohan Gautam, Jeffrey J Lochhead, Daniel J Wolak, Vamsi Ithapu, Vikas Singh, Robert G Thorn. Relative vascular permeability and vascularity across different regions of the rat nasal mucosa: implications for nasal physiology and drug delivery. Scientific reports. vol 6. 2018-05-15. PMID:27558973. |
applying capillary pore theory and normalization to our permeability data yielded mean pore diameter estimates ranging from 13-17 nm for the nasal respiratory vasculature compared to <10 nm for the vasculature in olfactory regions. |
2018-05-15 |
2023-08-13 |
rat |
| Yi Zhuo, Lei Wang, Lite Ge, Xuan Li, Da Duan, Xiaohua Teng, Miao Jiang, Kai Liu, Ting Yuan, Pei Wu, Hao Wang, Yujia Deng, Huali Xie, Ping Chen, Ying Xia, Ming L. Hypoxic Culture Promotes Dopaminergic-Neuronal Differentiation of Nasal Olfactory Mucosa Mesenchymal Stem Cells via Upregulation of Hypoxia-Inducible Factor-1α. Cell transplantation. vol 26. issue 8. 2018-05-08. PMID:28901191. |
hypoxic culture promotes dopaminergic-neuronal differentiation of nasal olfactory mucosa mesenchymal stem cells via upregulation of hypoxia-inducible factor-1α. |
2018-05-08 |
2023-08-13 |
Not clear |
| Manjunath Dammalli, Gourav Dey, Anil K Madugundu, Manish Kumar, Benvil Rodrigues, Harsha Gowda, Bychapur Gowrishankar Siddaiah, Anita Mahadevan, Susarla Krishna Shankar, Thottethodi Subrahmanya Keshava Prasa. Proteomic Analysis of the Human Olfactory Bulb. Omics : a journal of integrative biology. vol 21. issue 8. 2018-04-26. PMID:28816642. |
in this context, the olfactory bulb is a vital component of the olfactory system receiving sensory information from the axons of the olfactory receptor neurons located in the nasal cavity and the first place that processes the olfactory information. |
2018-04-26 |
2023-08-13 |
human |
| T Hummel, K L Whitcroft, P Andrews, A Altundag, C Cinghi, R M Costanzo, M Damm, J Frasnelli, H Gudziol, N Gupta, A Haehne, E Holbrook, S C Hong, D Hornung, K B Hüttenbrink, R Kamel, M Kobayashi, I Konstantinidis, B N Landis, D A Leopold, A Macchi, T Miwa, R Moesges, J Mullol, C A Mueller, G Ottaviano, G C Passali, C Philpott, J M Pinto, V J Ramakrishnan, P Rombaux, Y Roth, R A Schlosser, B Shu, G Soler, P Stjärne, B A Stuck, J Vodicka, A Welge-Luesse. Position paper on olfactory dysfunction. Rhinology. Supplement. vol 54. issue 26. 2018-04-12. PMID:29528615. |
whilst the full set of recommendations are outlined in the main document, points include the following:• patients with suspected olfactory loss should undergo a full examination of the head and neck, including rigid nasal endoscopywith small diameter endoscopes.• subjective olfactory assessment should not be undertaken in isolation, given its poor reliability.• psychophysical assessment tools used in clinical and research settings should include reliable and validated tests of odourthreshold, and/or one of odour identification or discrimination.• comprehensive chemosensory assessment should include gustatory screening.• smell training can be helpful in patients with olfactory loss of several aetiologies. |
2018-04-12 |
2023-08-13 |
Not clear |
| Angélica González-Maciel, Rafael Reynoso-Robles, Ricardo Torres-Jardón, Partha S Mukherjee, Lilian Calderón-Garcidueña. Combustion-Derived Nanoparticles in Key Brain Target Cells and Organelles in Young Urbanites: Culprit Hidden in Plain Sight in Alzheimer's Disease Development. Journal of Alzheimer's disease : JAD. vol 59. issue 1. 2018-04-06. PMID:28598844. |
mexico city (mc) children exhibit systemic and brain inflammation, low cerebrospinal fluid (csf) aβ1-42, breakdown of nasal, olfactory, alveolar-capillary, duodenal, and blood-brain barriers, volumetric and metabolic brain changes, attention and short-term memory deficits, and hallmarks of ad and parkinson's disease. |
2018-04-06 |
2023-08-13 |
Not clear |
| Julianna J Tomlinson, Bojan Shutinoski, Li Dong, Fanyi Meng, Dina Elleithy, Nathalie A Lengacher, Angela P Nguyen, Greg O Cron, Qiubo Jiang, Erik D Roberson, Robert L Nussbaum, Nour K Majbour, Omar M El-Agnaf, Steffany A Bennett, Diane C Lagace, John M Woulfe, Subash Sad, Earl G Brown, Michael G Schlossmache. Holocranohistochemistry enables the visualization of α-synuclein expression in the murine olfactory system and discovery of its systemic anti-microbial effects. Journal of neural transmission (Vienna, Austria : 1996). vol 124. issue 6. 2018-03-20. PMID:28477284. |
this technique permits the visualization of the olfactory system from the nasal cavity to mitral cells and dopamine-producing interneurons of glomeruli in the olfactory bulb. |
2018-03-20 |
2023-08-13 |
mouse |
| Nobuko Hada, William Joseph Netzer, Fanny Belhassan, Lawrence Paul Wennogle, Sveinbjörn Gizurarso. Nose-to-brain transport of imatinib mesylate: A pharmacokinetic evaluation. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. vol 102. 2018-03-02. PMID:28238945. |
one approach is intranasal administration, where the olfactory region of the nasal cavity extends up to the cranial cavity and provides direct access to the brain. |
2018-03-02 |
2023-08-13 |
Not clear |
| Marie-Hortense Sonnet, Duc Trung Nguyen, Phi-Linh Nguyen-Thi, Fabien Arous, Roger Jankowski, Cécile Rumea. Fine-tuned evaluation of olfactory function in patients operated for nasal polyposis. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery. vol 274. issue 7. 2018-02-27. PMID:28447155. |
fine-tuned evaluation of olfactory function in patients operated for nasal polyposis. |
2018-02-27 |
2023-08-13 |
Not clear |
| Romal Stewart, Gautam Wali, Chris Perry, Martin F Lavin, Francois Féron, Alan Mackay-Sim, Ratneswary Sutharsa. A Patient-Specific Stem Cell Model to Investigate the Neurological Phenotype Observed in Ataxia-Telangiectasia. Methods in molecular biology (Clifton, N.J.). vol 1599. 2018-02-20. PMID:28477134. |
the occurrence of continuous neurogenesis and easy access make the multipotent adult stem cells from the olfactory mucosa within the nasal cavity a potential cellular model. |
2018-02-20 |
2023-08-13 |
Not clear |
| Jasmina Topcagic, Rebecca Feldman, Anatole Ghazalpour, Jeffrey Swensen, Zoran Gatalica, Semir Vrani. Comprehensive molecular profiling of advanced/metastatic olfactory neuroblastomas. PloS one. vol 13. issue 1. 2018-02-20. PMID:29324814. |
olfactory neuroblastoma (onb) is a rare, locally aggressive, malignant neoplasm originating in the olfactory epithelium in the nasal vault. |
2018-02-20 |
2023-08-13 |
Not clear |
| Kun Hwang, Seung Han Yeom, Suk Hyun Hwan. Complications of Nasal Bone Fractures. The Journal of craniofacial surgery. vol 28. issue 3. 2018-02-09. PMID:28468171. |
one patient of epiphora and 1 patient of diplopia were reportedamong the 77 patients with nasal bone fractures, 29 (37.7% ± 11.3%) complained of olfactory disturbances. |
2018-02-09 |
2023-08-13 |
Not clear |
| Tyler P Crowe, M Heather West Greenlee, Anumantha G Kanthasamy, Walter H Hs. Mechanism of intranasal drug delivery directly to the brain. Life sciences. vol 195. 2018-02-08. PMID:29277310. |
the intranasal route can thus transport drugs directly to the brain from the nasal cavity along the olfactory and trigeminal nerves. |
2018-02-08 |
2023-08-13 |
human |
| Yoojin Seo, Hyung-Sik Kim, Insung Kang, Soon Won Choi, Tae-Hoon Shin, Ji-Hee Shin, Byung-Chul Lee, Jin Young Lee, Jae-Jun Kim, Myung Geun Kook, Kyung-Sun Kan. Cathepsin S contributes to microglia-mediated olfactory dysfunction through the regulation of Cx3cl1-Cx3cr1 axis in a Niemann-Pick disease type C1 model. Glia. vol 64. issue 12. 2018-01-05. PMID:27687148. |
notably, nasal delivery of cx3cl1 neutralizing antibody or ctss inhibitor could inhibit the cx3cl1-cx3cr1 interaction and support neuronal survival through the suppression of microglial activation, leading to an improvement in the olfactory function in npc1 mice. |
2018-01-05 |
2023-08-13 |
mouse |
| Myriam Kossai, Sophie El Zein, Michel Wassef, Jean-Pierre Guichard, Christelle Pouliquen, Philippe Herman, Benjamin Vérillaud, Marion Class. Olfactory Epithelial Hamartoma: A New Subtype of Sinonasal Hamartoma. The American journal of surgical pathology. vol 42. issue 1. 2017-12-29. PMID:29076871. |
five of the lesions were unilateral solitary, polypoid, pedunculated masses, 38 to 80 mm in length, lodged in the nasal olfactory cleft. |
2017-12-29 |
2023-08-13 |
Not clear |
| Jinxiang Xi, Zhaoxuan Wang, Danielle Nevorski, Thomas White, Yue Zho. Nasal and Olfactory Deposition with Normal and Bidirectional Intranasal Delivery Techniques: In Vitro Tests and Numerical Simulations. Journal of aerosol medicine and pulmonary drug delivery. vol 30. issue 2. 2017-11-28. PMID:27977306. |
nasal and olfactory deposition with normal and bidirectional intranasal delivery techniques: in vitro tests and numerical simulations. |
2017-11-28 |
2023-08-13 |
Not clear |
| Jinxiang Xi, Zhaoxuan Wang, Danielle Nevorski, Thomas White, Yue Zho. Nasal and Olfactory Deposition with Normal and Bidirectional Intranasal Delivery Techniques: In Vitro Tests and Numerical Simulations. Journal of aerosol medicine and pulmonary drug delivery. vol 30. issue 2. 2017-11-28. PMID:27977306. |
furthermore, it is still challenging to quantify nasal deposition on a regional or local basis, which is crucial in assessing the performance of targeted olfactory drug delivery. |
2017-11-28 |
2023-08-13 |
Not clear |
| Heidi Hsieh, Michael C Horwath, Mary Beth Gente. Zinc gluconate toxicity in wild-type vs. MT1/2-deficient mice. Neurotoxicology. vol 58. 2017-11-24. PMID:27979773. |
in vivo studies using wild-type, mt1/2 knockout mice (mt ko), and heterozygotes administered zg by in instillation showed profound loss of the olfactory mucosa in the nasal cavity. |
2017-11-24 |
2023-08-13 |
mouse |
| Carolin Piotrowski, Vera Lede, Anne Butthof, Nicole Kaiser, Petra G Hirrlinger, Matthias H Tschöp, Torsten Schöneberg, Ingo Bechman. Open housing drives the expression of immune response genes in the nasal mucosa, but not the olfactory bulb. PloS one. vol 12. issue 10. 2017-11-20. PMID:29077773. |
nasal mucosa and olfactory bulb are separated by the cribriform plate which is perforated by olfactory nerves. |
2017-11-20 |
2023-08-13 |
mouse |