| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T Kanazawa, F Akiyama, S Kakizaki, Y Takashima, Y Set. Delivery of siRNA to the brain using a combination of nose-to-brain delivery and cell-penetrating peptide-modified nano-micelles. Biomaterials. vol 34. issue 36. 2014-03-25. PMID:23992922. |
we also studied the intranasal transfer of mpeg-pcl-tat to the brain via the olfactory and trigeminal nerves, the putative pathways to the brain from the nasal cavity. |
2014-03-25 |
2023-08-12 |
Not clear |
| T Kanazawa, F Akiyama, S Kakizaki, Y Takashima, Y Set. Delivery of siRNA to the brain using a combination of nose-to-brain delivery and cell-penetrating peptide-modified nano-micelles. Biomaterials. vol 34. issue 36. 2014-03-25. PMID:23992922. |
we found that mpeg-pcl-tat accelerated transport along the olfactory and trigeminal nerve pathway because of its high permeation across the nasal mucosa. |
2014-03-25 |
2023-08-12 |
Not clear |
| David Dunston, Sarah Ashby, Kurt Krosnowski, Tatsuya Ogura, Weihong Li. An effective manual deboning method to prepare intact mouse nasal tissue with preserved anatomical organization. Journal of visualized experiments : JoVE. issue 78. 2014-03-11. PMID:23963491. |
the nasal cavity is lined with various epithelia such as olfactory, respiratory, and squamous epithelia which differ markedly in anatomical locations, morphology, and functions. |
2014-03-11 |
2023-08-12 |
mouse |
| Paolo Emanuele Forni, Kapil Bharti, Ellen M Flannery, Tomomi Shimogori, Susan Wra. The indirect role of fibroblast growth factor-8 in defining neurogenic niches of the olfactory/GnRH systems. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 50. 2014-03-07. PMID:24336726. |
fgf8 hypomorph mouse models, fgf8(neo/neo) and fgf8(neo/null), displayed severe craniofacial defects together with overlapping defects in the olfactory pit including (1) lack of neuronal formation ventrally, where gnrh neurons normally form, and (2) altered expression of bmp4 and nog, with nog ectopically expressed in the nasal mesenchyme and no longer defining the gnrh and vomeronasal neurogenic border. |
2014-03-07 |
2023-08-12 |
mouse |
| Paolo Emanuele Forni, Kapil Bharti, Ellen M Flannery, Tomomi Shimogori, Susan Wra. The indirect role of fibroblast growth factor-8 in defining neurogenic niches of the olfactory/GnRH systems. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 50. 2014-03-07. PMID:24336726. |
together our data show that (1) fgf8 is not sufficient to induce ectodermal progenitors of the olfactory pit to acquire neural fate and (2) altered neurogenesis and lack of gnrh neuron specification after chronically reduced fgf8 expression reflected dysgenesis of the nasal region and loss of a specific neurogenic permissive milieu that was defined by mesenchymal signals. |
2014-03-07 |
2023-08-12 |
mouse |
| François Féron, Chris Perry, Stéphane D Girard, Alan Mackay-Si. Isolation of adult stem cells from the human olfactory mucosa. Methods in molecular biology (Clifton, N.J.). vol 1059. 2014-02-25. PMID:23934838. |
the olfactory mucosa, located in the nasal cavity, is the only nervous tissue that is exposed to the external environment and easily accessible in every living individual. |
2014-02-25 |
2023-08-12 |
human |
| François Féron, Chris Perry, Stéphane D Girard, Alan Mackay-Si. Isolation of adult stem cells from the human olfactory mucosa. Methods in molecular biology (Clifton, N.J.). vol 1059. 2014-02-25. PMID:23934838. |
here, we describe a method for biopsying olfactory mucosa from human nasal cavities and isolating multipotent adult stem cells that can be used to either identify biomarkers in brain disorders or repair the pathological/traumatized nervous system. |
2014-02-25 |
2023-08-12 |
human |
| Adlane Ould-Yahoui, Oualid Sbai, Kévin Baranger, Anne Bernard, Yatma Gueye, Eliane Charrat, Benoît Clément, Didier Gigmes, Vincent Dive, Stéphane D Girard, François Féron, Michel Khrestchatisky, Santiago River. Role of matrix metalloproteinases in migration and neurotrophic properties of nasal olfactory stem and ensheathing cells. Cell transplantation. vol 22. issue 6. 2014-02-20. PMID:23043957. |
role of matrix metalloproteinases in migration and neurotrophic properties of nasal olfactory stem and ensheathing cells. |
2014-02-20 |
2023-08-12 |
human |
| Adlane Ould-Yahoui, Oualid Sbai, Kévin Baranger, Anne Bernard, Yatma Gueye, Eliane Charrat, Benoît Clément, Didier Gigmes, Vincent Dive, Stéphane D Girard, François Féron, Michel Khrestchatisky, Santiago River. Role of matrix metalloproteinases in migration and neurotrophic properties of nasal olfactory stem and ensheathing cells. Cell transplantation. vol 22. issue 6. 2014-02-20. PMID:23043957. |
adult olfactory ectomesenchymal stem cells (oe-mscs) and olfactory ensheathing cells (oecs), both from the nasal olfactory lamina propria, display robust regenerative properties when transplanted into the nervous system, but the mechanisms supporting such therapeutic effects remain unknown. |
2014-02-20 |
2023-08-12 |
human |
| Bo Wang, Yanli D. Cadmium and its neurotoxic effects. Oxidative medicine and cellular longevity. vol 2013. 2014-02-19. PMID:23997854. |
cd can be uptaken from the nasal mucosa or olfactory pathways into the peripheral and central neurons; for the latter, cd can increase the blood brain barrier (bbb) permeability. |
2014-02-19 |
2023-08-12 |
Not clear |
| A SELLARI-FRANCESCHIN. [Possible relation between olfactory acuity and sulfocyanate concentration of the nasal mucus]. La Clinica otorinolaringoiatrica. vol 2. issue 6. 2014-02-18. PMID:24540015. |
[possible relation between olfactory acuity and sulfocyanate concentration of the nasal mucus]. |
2014-02-18 |
2023-08-12 |
Not clear |
| Onder Göktas, Larissa Lau, Franca Fleine. Effect of laser treatment on olfactory dysfunction. Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India. vol 66. issue Suppl 1. 2014-02-17. PMID:24533379. |
subjective nasal airflow (na) and the olfactory function were rated by means of visual analogue scales (vas). |
2014-02-17 |
2023-08-12 |
Not clear |
| Somani Sham, Naik Chetan. Nasal endoscopic and anterior craniotomy resection for esthesioneuroblastoma: how we did it. Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India. vol 66. issue Suppl 1. 2014-02-17. PMID:24533412. |
the objective of this study was to report and present an approach to combine functional and esthetic technique of endoscopic nasal tumor resection with anterior cranial fossa extension resection in a case of esthesioneuroblastoma (enb), a rare slow growing malignant neoplasm of the olfactory mucosa. |
2014-02-17 |
2023-08-12 |
Not clear |
| Bradley J Goldstein, Joshua M Hare, Seth Lieberman, Roy Casian. Adult human nasal mesenchymal stem cells have an unexpected broad anatomic distribution. International forum of allergy & rhinology. vol 3. issue 7. 2014-02-11. PMID:23423973. |
little is known about the function of this nasal msc, or its relationship to the olfactory lineage, but there is considerable interest in using the nasal msc for cell-based therapies. |
2014-02-11 |
2023-08-12 |
human |
| G X Papacharalampous, P V Vlastarakos, A Chrysovergis, P K Saravakos, G P Kotsis, D I Davili. Olfactory neuroblastoma (esthesioneuroblastoma): towards minimally invasive surgery and multi-modality treatment strategies - an updated critical review of the current literature. Journal of B.U.ON. : official journal of the Balkan Union of Oncology. vol 18. issue 3. 2014-02-11. PMID:24065464. |
the tumor arises from the specialized sensory epithelial olfactory cells, normally situated at the upper part of the nasal cavity, including the superior nasal concha, the roof of the nose and the cribriform plate. |
2014-02-11 |
2023-08-12 |
Not clear |
| Ada Salvetti Cavalcanti Caldas, Vera Lúcia Dutra Facundes, Daniele Andrade da Cunha, Patrícia Maria Mendes Balata, Leila Bastos Leal, Hilton Justino da Silv. Gustatory and olfactory dysfunction in laryngectomized patients. Brazilian journal of otorhinolaryngology. vol 79. issue 5. 2014-02-07. PMID:24141667. |
after total laryngectomy surgery, nasal airflow is moved permanently to the tracheostomy opening, compromising the contact of odorant molecules with the nasal cavity, which may reflect changes in the olfactory and gustatory perception in these individuals. |
2014-02-07 |
2023-08-12 |
Not clear |
| Ana Novo, Isabel Couto Guerra, Felisbela Rocha, Susana Gama-de-Sousa, Teresa Borges, Rita Cerqueira, Purificação Tavares, Paula Fonsec. Kallmann syndrome in a female adolescent: a new mutation in the FGFR1 gene. BMJ case reports. vol 2012. 2014-02-04. PMID:22751423. |
the authors present the case of a female adolescent with hypogonadotropic hypogonadism and impaired olfactory acuity in the presence of hypoplasia of the nasal sulcus and agenesis of the olfactory bulbs. |
2014-02-04 |
2023-08-12 |
Not clear |
| Lauren E Howard, William M Holmes, Sara Ferrando, James S Maclaine, Robert N Kelsh, Andrew Ramsey, Richard L Abel, Jonathan P L Co. Functional nasal morphology of chimaerid fishes. Journal of morphology. vol 274. issue 9. 2014-02-03. PMID:23630172. |
the nasal region of chimaerid fishes shows at least two adaptations to a benthic lifestyle, and suggests good olfactory sensitivity, with secondary folding enhancing the hypothetical flat sensory surface area by up to 70%. |
2014-02-03 |
2023-08-12 |
Not clear |
| Jean-Jacques Braun, Sophie Riehm, Gerlinde Averous, Alain Billing, Francis Veillo. MRI in respiratory epithelial adenomatoid hamartoma of nasal cavities. Journal of neuroradiology = Journal de neuroradiologie. vol 40. issue 3. 2014-01-30. PMID:23228477. |
this is a report of six cases of respiratory epithelial adenomatoid hamartoma of the nasal cavities that were characterized by: symptoms of nasal obstruction and dysosmia; endoscopic appearances of bilateral nasal polyposis affecting the olfactory clefts; ct imaging showing enlargement of the olfactory clefts; mri (rarely reported in the literature) revealing clearly delineated cerebriform tissue filling in the olfactory clefts; histological confirmation in all cases; and recovery after surgical endoscopic resection without the need for associated sinus surgery. |
2014-01-30 |
2023-08-12 |
Not clear |
| Zhen-Zhen Yang, Yan-Qing Zhang, Zhan-Zhang Wang, Kai Wu, Jin-Ning Lou, Xian-Rong Q. Enhanced brain distribution and pharmacodynamics of rivastigmine by liposomes following intranasal administration. International journal of pharmaceutics. vol 452. issue 1-2. 2014-01-16. PMID:23680731. |
the data suggest that rivastigmine liposomes especially cpp-lp improve the brain delivery and enhance pharmacodynamics which respect to bbb penetration and nasal olfactory pathway into brain after in administration, and simultaneously decrease the hepatic first pass metabolism and gastrointestinal adverse effects. |
2014-01-16 |
2023-08-12 |
Not clear |