| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mary Beth Genter, Eric L Kendig, Mitchell D Knutso. Uptake of materials from the nasal cavity into the blood and brain: are we finally beginning to understand these processes at the molecular level? Annals of the New York Academy of Sciences. vol 1170. 2009-09-25. PMID:19686203. |
we summarize here a representative sample of transporter proteins found in olfactory mucosa and/or nasal respiratory mucosa and the substrates that they transport into the brain and/or bloodstream. |
2009-09-25 |
2023-08-12 |
Not clear |
| Steven D Munger, Trese Leinders-Zufall, Frank Zufal. Subsystem organization of the mammalian sense of smell. Annual review of physiology. vol 71. 2009-09-22. PMID:18808328. |
the olfactory system is composed of a number of distinct subsystems that can be distinguished by the location of their sensory neurons in the nasal cavity, the receptors they use to detect chemosensory stimuli, the signaling mechanisms they employ to transduce those stimuli, and their axonal projections to specific regions of the olfactory forebrain. |
2009-09-22 |
2023-08-12 |
Not clear |
| Sándor Horvát, András Fehér, Hartwig Wolburg, Péter Sipos, Szilvia Veszelka, Andrea Tóth, Lóránd Kis, Anita Kurunczi, Gábor Balogh, Levente Kürti, István Eros, Piroska Szabó-Révész, Mária A Del. Sodium hyaluronate as a mucoadhesive component in nasal formulation enhances delivery of molecules to brain tissue. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. vol 72. issue 1. 2009-09-21. PMID:19007885. |
the highest concentrations of fd-4 could be detected in the olfactory bulbs, frontal and parietal cortex 4h after nasal administration in the mucoadhesive formulation. |
2009-09-21 |
2023-08-12 |
rat |
| Vassilios Danielides, Michael Katotomichelakis, Dimitrios Balatsouras, Maria Riga, Maria Simopoulou, Elias Kantas, Nikolaos Nikoletto. Evaluation of prognostic factors for olfaction in nasal polyposis treated by endoscopic sinus surgery. Rhinology. vol 47. issue 2. 2009-08-20. PMID:19593975. |
this prospective study aimed to assess treatment outcome on olfaction in patients undergoing endoscopic sinus surgery (ess) for nasal polyposis, and to evaluate the role of previous sinus surgery and the duration of olfactory deficit as prognostic factors for olfaction improvement. |
2009-08-20 |
2023-08-12 |
Not clear |
| Michael Katotomichelakis, Maria Riga, Spyridon Davris, Gregorios Tripsianis, Maria Simopoulou, Nikolaos Nikolettos, Konstantinos Simopoulos, Vasilios Danielide. Allergic rhinitis and aspirin-exacerbated respiratory disease as predictors of the olfactory outcome after endoscopic sinus surgery. American journal of rhinology & allergy. vol 23. issue 3. 2009-07-30. PMID:19490814. |
allergic rhinitis and aspirin-exacerbated respiratory disease (aerd) are examined as potential confounding factors of the olfactory outcome in patients with extensive nasal polyposis and rhinosinusitis treated with functional endoscopic sinus surgery (fess). |
2009-07-30 |
2023-08-12 |
Not clear |
| Siyi Zhang, Mingyao Wang, Peter W Villalta, Bruce R Lindgren, Pramod Upadhyaya, Yanbin Lao, Stephen S Hech. Analysis of pyridyloxobutyl and pyridylhydroxybutyl DNA adducts in extrahepatic tissues of F344 rats treated chronically with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and enantiomers of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol. Chemical research in toxicology. vol 22. issue 5. 2009-07-21. PMID:19358518. |
pob- and phb-dna adducts were quantified in nasal olfactory mucosa, nasal respiratory mucosa, oral mucosa, and pancreas of treated rats. |
2009-07-21 |
2023-08-12 |
rat |
| Siyi Zhang, Mingyao Wang, Peter W Villalta, Bruce R Lindgren, Pramod Upadhyaya, Yanbin Lao, Stephen S Hech. Analysis of pyridyloxobutyl and pyridylhydroxybutyl DNA adducts in extrahepatic tissues of F344 rats treated chronically with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and enantiomers of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol. Chemical research in toxicology. vol 22. issue 5. 2009-07-21. PMID:19358518. |
for example, in the nasal olfactory mucosa, pob-dna adduct levels in the nnk and (s)-nnal groups were not significantly different from each other, while (r)-nnal treatment generated 6-33 times lower amounts of pob-dna adducts than did nnk treatment. |
2009-07-21 |
2023-08-12 |
rat |
| Siyi Zhang, Mingyao Wang, Peter W Villalta, Bruce R Lindgren, Yanbin Lao, Stephen S Hech. Quantitation of pyridyloxobutyl DNA adducts in nasal and oral mucosa of rats treated chronically with enantiomers of N'-nitrosonornicotine. Chemical research in toxicology. vol 22. issue 5. 2009-07-21. PMID:19405515. |
in the present study, we have used liquid chromatography-electrospray ionization-tandem mass spectrometry (lc-esi-ms/ms) to analyze specific pob-dna adducts in the nasal olfactory, nasal respiratory, and oral mucosa of f344 rats treated chronically with (r)-nnn or (s)-nnn in the drinking water (10 ppm, 1-20 weeks). |
2009-07-21 |
2023-08-12 |
rat |
| Siyi Zhang, Mingyao Wang, Peter W Villalta, Bruce R Lindgren, Yanbin Lao, Stephen S Hech. Quantitation of pyridyloxobutyl DNA adducts in nasal and oral mucosa of rats treated chronically with enantiomers of N'-nitrosonornicotine. Chemical research in toxicology. vol 22. issue 5. 2009-07-21. PMID:19405515. |
adduct levels in the nasal respiratory mucosa exceeded those in the nasal olfactory and oral mucosa. |
2009-07-21 |
2023-08-12 |
rat |
| Siyi Zhang, Mingyao Wang, Peter W Villalta, Bruce R Lindgren, Yanbin Lao, Stephen S Hech. Quantitation of pyridyloxobutyl DNA adducts in nasal and oral mucosa of rats treated chronically with enantiomers of N'-nitrosonornicotine. Chemical research in toxicology. vol 22. issue 5. 2009-07-21. PMID:19405515. |
(r)-nnn treatment generated 2-4 times more adducts in the nasal olfactory and respiratory mucosa than did (s)-nnn at most time points. |
2009-07-21 |
2023-08-12 |
rat |
| Siyi Zhang, Mingyao Wang, Peter W Villalta, Bruce R Lindgren, Yanbin Lao, Stephen S Hech. Quantitation of pyridyloxobutyl DNA adducts in nasal and oral mucosa of rats treated chronically with enantiomers of N'-nitrosonornicotine. Chemical research in toxicology. vol 22. issue 5. 2009-07-21. PMID:19405515. |
o(2)-[4-(3-pyridyl)-4-oxobut-1-yl]thymidine (o(2)-pob-dthd, 11) predominated in the nasal olfactory and respiratory mucosa, followed by 7-[4-(3-pyridyl)-4-oxobut-1-yl]guanine (7-pob-gua, 14). |
2009-07-21 |
2023-08-12 |
rat |
| Siyi Zhang, Mingyao Wang, Peter W Villalta, Bruce R Lindgren, Yanbin Lao, Stephen S Hech. Quantitation of pyridyloxobutyl DNA adducts in nasal and oral mucosa of rats treated chronically with enantiomers of N'-nitrosonornicotine. Chemical research in toxicology. vol 22. issue 5. 2009-07-21. PMID:19405515. |
overall, pob-dna adduct formation in the nasal olfactory and nasal respiratory mucosa was similar to that previously observed in the lung, whereas in the oral mucosa, the trend resembled that in the esophagus. |
2009-07-21 |
2023-08-12 |
rat |
| M B Genter, B M Warner, M Medvedovic, M A Sarto. Comparison of rat olfactory mucosal responses to carcinogenic and non-carcinogenic chloracetanilides. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 47. issue 6. 2009-07-16. PMID:19425180. |
the mechanism by which alachlor induces tumors is distinct from many other nasal carcinogens, in that alachlor induces a gradual de-differentiation of the olfactory mucosa (om) to a more respiratory-like epithelium, in contrast to other agents that induce cytotoxicity, followed by an aberrant regenerative response. |
2009-07-16 |
2023-08-12 |
rat |
| Richard S Kaye, Tarlochan S Purewal, Oya H Alpa. Development and testing of particulate formulations for the nasal delivery of antibodies. Journal of controlled release : official journal of the Controlled Release Society. vol 135. issue 2. 2009-07-15. PMID:19059291. |
the addition of leucine and aerosil resulted in a 10% increase in the deposition beyond the nasal vestibule, with approximately 45% of the delivered dose being deposited in the turbinates, olfactory region, and nasal-pharynx. |
2009-07-15 |
2023-08-12 |
human |
| Jeffery D Kocsis, Karen L Lankford, Masanori Sasaki, Christine Radtk. Unique in vivo properties of olfactory ensheathing cells that may contribute to neural repair and protection following spinal cord injury. Neuroscience letters. vol 456. issue 3. 2009-07-15. PMID:19429149. |
olfactory ensheathing cells (oecs) are specialized glial cells that guide olfactory receptor axons from the nasal mucosa into the brain where they make synaptic contacts in the olfactory bulb. |
2009-07-15 |
2023-08-12 |
Not clear |
| B R Grubb, T D Rogers, R C Boucher, L E Ostrowsk. Ion transport across CF and normal murine olfactory and ciliated epithelium. American journal of physiology. Cell physiology. vol 296. issue 6. 2009-07-09. PMID:19321738. |
this tissue is composed of approximately 50% olfactory (oe) and approximately 50% ciliated epithelium (ce), and on the basis of previous observations, we hypothesized that a significant fraction of the bioelectric signals from murine nasal tissue may arise from oe rather than ce, while ce is the target tissue for cf gene therapy. |
2009-07-09 |
2023-08-12 |
mouse |
| Valeria Franceschini, Simone Bettini, Simone Pifferi, Alfredo Rosellini, Anna Menini, Ricardo Saccardi, Emanuela Ognio, Rosemary Jeffery, Richard Poulsom, Roberto P Revoltell. Human cord blood CD133+ stem cells transplanted to nod-scid mice provide conditions for regeneration of olfactory neuroepithelium after permanent damage induced by dichlobenil. Stem cells (Dayton, Ohio). vol 27. issue 4. 2009-06-23. PMID:19350683. |
the herbicide dichlobenil selectively causes necrosis of the dorsomedial part of olfactory neuroepithelium (ne) with permanent damage to the underlying mucosa, whereas the lateral part of the olfactory region and the nasal respiratory mucosa remain undamaged. |
2009-06-23 |
2023-08-12 |
mouse |
| Lusine Danielyan, Richard Schäfer, Andreas von Ameln-Mayerhofer, Marine Buadze, Julia Geisler, Tim Klopfer, Ute Burkhardt, Barbara Proksch, Stephan Verleysdonk, Miriam Ayturan, Gayane H Buniatian, Christoph H Gleiter, William H Fre. Intranasal delivery of cells to the brain. European journal of cell biology. vol 88. issue 6. 2009-06-22. PMID:19324456. |
we hypothesized that intranasally administered cells could bypass the blood-brain barrier by migrating from the nasal mucosa through the cribriform plate along the olfactory neural pathway into the brain and cerebrospinal fluid (csf). |
2009-06-22 |
2023-08-12 |
mouse |
| Scott A White, Loïc Briand, David J Scott, Antoni J Borysi. Structure of rat odorant-binding protein OBP1 at 1.6 A resolution. Acta crystallographica. Section D, Biological crystallography. vol 65. issue Pt 5. 2009-06-22. PMID:19390145. |
the nasal mucosa is a specialist interfacial region sandwiched between the olfactory system and the gaseous chemical milieu. |
2009-06-22 |
2023-08-12 |
rat |
| Fiona J Wilkes, David G Laing, Ian Hutchinson, Anthony L Jinks, Erminio Monteleon. Temporal processing of olfactory stimuli during retronasal perception. Behavioural brain research. vol 200. issue 1. 2009-06-18. PMID:19162085. |
chemosense 2004;6:1-7; voirol e, daget n. comparative study of nasal and retronasal olfactory perception. |
2009-06-18 |
2023-08-12 |
Not clear |