| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Julian Cheron, Leonardo Beccari, Perrine Hagué, Romain Icick, Chloé Despontin, Teresa Carusone, Matthieu Defrance, Sagar Bhogaraju, Elena Martin-Garcia, Roberto Capellan, Rafael Maldonado, Florence Vorspan, Jérôme Bonnefont, Alban de Kerchove d'Exaerd. USP7/Maged1-mediated H2A monoubiquitination in the paraventricular thalamus: an epigenetic mechanism involved in cocaine use disorder. Nature communications. vol 14. issue 1. 2023-12-20. PMID:38123574. |
while histone modifications such as methylation and acetylation have been studied in the ventral tegmental area and nucleus accumbens (nac), the role of h2a monoubiquitination remains unknown. |
2023-12-20 |
2023-12-23 |
Not clear |
| Oyku Dinckol, Noah Harris Wenger, Jennifer E Zachry, Munir Gunes Kutl. Nucleus accumbens core single cell ensembles bidirectionally respond to experienced versus observed aversive events. Scientific reports. vol 13. issue 1. 2023-12-19. PMID:38114559. |
in this study, we recorded single cell activity patterns of nucleus accumbens (nac) core neurons using in vivo optical imaging of calcium transients via miniature scopes. |
2023-12-19 |
2023-12-23 |
Not clear |
| Shingo Nakajima, Geneviève Demers, Arturo Israel Machuca-Parra, Zahra Dashtehei Pour, Diane Bairamian, Khalil Bouyakdan, Alexandre Fisette, Anita Kabahizi, Josephine Robb, Demetra Rodaros, Cyril Laurent, Guillaume Ferreira, Nathalie Arbour, Thierry Alquier, Stephanie Fulto. Central activation of the fatty acid sensor GPR120 suppresses microglia reactivity and alleviates sickness- and anxiety-like behaviors. Journal of neuroinflammation. vol 20. issue 1. 2023-12-19. PMID:38111048. |
we found gpr120 mrna to be enriched in both murine and human microglia, and in situ hybridization revealed gpr120 expression in microglia of the nucleus accumbens (nac) in mice. |
2023-12-19 |
2023-12-21 |
mouse |
| Brandon Taraku, Joana R Loureiro, Ashish K Sahib, Artemis Zavaliangos-Petropulu, Noor Al-Sharif, Amber Leaver, Benjamin Wade, Shantanu Joshi, Roger P Woods, Randall Espinoza, Katherine L Nar. Ketamine treatment modulates habenular and nucleus accumbens static and dynamic functional connectivity in major depression. medRxiv : the preprint server for health sciences. 2023-12-18. PMID:38106178. |
dysfunctional reward processing in major depressive disorder (mdd) involves functional circuitry of the habenula (hb) and nucleus accumbens (nac). |
2023-12-18 |
2023-12-21 |
human |
| Li Niu, Mengnan Hao, Yanhong Wang, Kai Wu, Chengdong Yuan, Yu Zhang, Jie Zhang, Xiaoli Liang, Yi Zhan. Dopamine D2-receptor neurons in nucleus accumbens regulate sevoflurane anesthesia in mice. Frontiers in molecular neuroscience. vol 16. 2023-12-13. PMID:38089676. |
as a result, this study aimed to explore the involvement of dopamine d2 receptor (d2r) expressing neurons located in the nucleus accumbens (nac), a critical nucleus governing sleep-wake regulation, in sevoflurane anesthesia. |
2023-12-13 |
2023-12-17 |
mouse |
| Caroline S Johnson, Andrew D Chapp, Erin B Lind, Mark J Thomas, Paul G Mermelstei. Sex differences in mouse infralimbic cortex projections to the nucleus accumbens shell. Biology of sex differences. vol 14. issue 1. 2023-12-12. PMID:38082417. |
the nucleus accumbens (nac) is an important region in motivation and reward. |
2023-12-12 |
2023-12-17 |
mouse |
| Oualid Abboussi, Zmarak Ahmad Khan, Hind Ibork, Simo S Zulu, William Daniels, Khalid Taghzouti, Tim G Hale. CB2 agonist mitigates cocaine-induced reinstatement of place preference and modulates the inflammatory response in mice. Behavioural pharmacology. 2023-12-12. PMID:38085651. |
specifically, jwh-133 administration was found to upregulate Δ-fosb expression in the nucleus accumbens (nac), elevate cx3cl1 levels in both the ventral tegmental area and prefrontal cortex (pfc), and concurrently reduce il-1β expression in the pfc and nac among cocaine-treated animals. |
2023-12-12 |
2023-12-17 |
mouse |
| Shelley M Warlow, Sarthak M Singhal, Nick G Hollon, Lauren Faget, Dina S Dowlat, Vivien Zell, Avery C Hunker, Larry S Zweifel, Thomas S Hnask. Mesoaccumbal glutamate neurons drive reward via glutamate release but aversion via dopamine co-release. Neuron. 2023-12-12. PMID:38086374. |
ventral tegmental area (vta) projections to the nucleus accumbens (nac) drive reward-related motivation. |
2023-12-12 |
2023-12-17 |
mouse |
| Yann Ehinger, Sophie Laguesse, Khanhky Phamluong, Alexandra Salvi, Zachary W Hoisington, Drishti Soneja, Yoshitaka J Sei, Ken Nakamura, Dorit Ro. Paradoxical mTORC1-Dependent microRNA-mediated Translation Repression in the Nucleus Accumbens of Mice Consuming Alcohol Attenuates Glycolysis. bioRxiv : the preprint server for biology. 2023-12-11. PMID:38076984. |
we report that activation of mtorc1 in the nucleus accumbens (nac) of mice consuming alcohol promotes the translation of microrna (mir) machinery components and the upregulation of micrornas (mirs) expression including mir34a-5p. |
2023-12-11 |
2023-12-17 |
mouse |
| Bryan Strange, Svenja Treu, Juan Barcia, Cristina Torres Diaz, Javier Gonzalez Rosa, Cristina Nombela, Jose Pineda, Daniel Torres, Lukas Kunz, Robin Hellerstedt, Josue Avecillas-Chasin, Monica Lara, Marta Navas, Ana Galarza, Julia Garcia, Antonio Oliviero, Fernando Seijo, Andreas Horn, Ningfei Li, Nikolai Axmacher, Santiago Canals, Blanca Reneses, Anne Bierbraue. Deep-brain stimulation of the human nucleus accumbens-medial septum enhances memory formation. Research square. 2023-12-04. PMID:38045279. |
however, an alternative strategy is to stimulate brain areas providing modulatory inputs to medial temporal memory-related structures, such as the nucleus accumbens (nac), which is implicated in enhancing episodic memory encoding. |
2023-12-04 |
2023-12-10 |
human |
| Bing Huang, Zifei Chen, Fang Huang, Fenfei Gao, Jieling Chen, Peipei Liu, Zhijie Lu, Weiyuan Chen, Jie W. Demyelination in the medial prefrontal cortex by withdrawal from chronic nicotine causes impaired cognitive memory. Progress in neuro-psychopharmacology & biological psychiatry. 2023-11-30. PMID:38036034. |
we found no effect of nicotine withdrawal on the myelination in both of the ventral tegmental area (vta) and nucleus accumbens (nac) regions, but unexpectedly, we observed a demyelination phenomenon in the medial prefrontal cortex (mpfc) after withdrawal from chronic nicotine. |
2023-11-30 |
2023-12-10 |
Not clear |
| Amy M Gancarz, Raveena Parmar, Treefa Shwani, Moriah M Cobb, Michelle N Crawford, Jacob R Watson, Lisa Evans, Michael A Kausch, Craig T Werner, David M Diet. Adolescent exposure to sucrose increases cocaine-mediated behaviours in adulthood via Smad3. Addiction biology. vol 28. issue 12. 2023-11-29. PMID:38017636. |
to determine the neurobiological mechanisms leading to such behavioural adaptations, we find that adolescent sucrose exposure results in an upregulation of the transcription factor smad3 in the nucleus accumbens (nac) when compared with water-exposed controls. |
2023-11-30 |
2023-12-07 |
rat |
| Amy M Gancarz, Raveena Parmar, Treefa Shwani, Moriah M Cobb, Michelle N Crawford, Jacob R Watson, Lisa Evans, Michael A Kausch, Craig T Werner, David M Diet. Adolescent exposure to sucrose increases cocaine-mediated behaviours in adulthood via Smad3. Addiction biology. vol 28. issue 12. 2023-11-29. PMID:38017636. |
to determine the neurobiological mechanisms leading to such behavioural adaptations, we find that adolescent sucrose exposure results in an upregulation of the transcription factor smad3 in the nucleus accumbens (nac) when compared with water-exposed controls. |
2023-11-29 |
2023-12-07 |
rat |
| Neir Eshel, Gavin C Touponse, Allan R Wang, Amber K Osterman, Amei N Shank, Alexandra M Groome, Lara Taniguchi, Daniel F Cardozo Pinto, Jason Tucciarone, Brandon S Bentzley, Robert C Malenk. Striatal dopamine integrates cost, benefit, and motivation. Neuron. 2023-11-28. PMID:38016471. |
here, we measure da release in the nucleus accumbens (nac) and dorsolateral striatum (dls) while independently varying costs and benefits and apply behavioral economic principles to determine a mouse's level of motivation. |
2023-11-28 |
2023-12-07 |
mouse |
| Pratap S Markam, Clément Bourguignon, Lei Zhu, Martin Darvas, Paul V Sabatini, Maia V Kokoeva, Bruno Giros, Kai-Florian Storc. The neurons that drive infradian sleep-wake and mania-like behavioral rhythms. bioRxiv : the preprint server for biology. 2023-11-28. PMID:38014299. |
this cycling capacity is abrogated upon genetic disruption of da production in da neurons of the ventral tegmental area (vta) or ablation of nucleus accumbens (nac) projecting, dopamine (da) neurons. |
2023-11-28 |
2023-11-29 |
mouse |
| Sero Toriano Parel, Shannon N Bennett, Cindy J Cheng, Olivia C Timmermans, Laura M Fiori, Gustavo Turecki, Catherine Jensen Peñ. Transcriptional signatures of early-life stress and antidepressant treatment efficacy. Proceedings of the National Academy of Sciences of the United States of America. vol 120. issue 49. 2023-11-27. PMID:38011563. |
here, we leveraged existing rna sequencing datasets from 1) blood samples from depressed female- and male-identifying patients treated with escitalopram or desvenlafaxine and assessed for treatment response or failure; 2) the nucleus accumbens (nac) of female and male mice exposed to els and/or adult stress; and 3) the nac of mice after adult stress, antidepressant treatment with imipramine or ketamine, and assessed for treatment response or failure. |
2023-11-27 |
2023-11-29 |
mouse |
| Austin Ganaway, Kousuke Tatsuta, Virgil Christian Garcia Castillo, Ryoma Okada, Yoshinori Sunaga, Yasumi Ohta, Jun Ohta, Masahiro Ohsawa, Metin Akay, Yasemin M Aka. Investigating the Influence of Morphine and Cocaine on the Mesolimbic Pathway Using a Novel Microimaging Platform. International journal of molecular sciences. vol 24. issue 22. 2023-11-25. PMID:38003493. |
specifically, the mesolimbic pathway connecting the ventral tegmental area (vta) and the nucleus accumbens (nac) is crucial in regulating memory, emotion, motivation, and behavior due to its responsibility to modulate dopamine. |
2023-11-25 |
2023-11-28 |
mouse |
| Miguel Á Luján, Dan P Covey, Reana Young-Morrison, LanYuan Zhang, Andrew Kim, Fiorella Morgado, Sachin Patel, Caroline E Bass, Carlos Paladini, Joseph F Chee. Mobilization of endocannabinoids by midbrain dopamine neurons is required for the encoding of reward prediction. Nature communications. vol 14. issue 1. 2023-11-24. PMID:37985770. |
brain levels of the endocannabinoid 2-arachidonoylglycerol (2-ag) shape motivated behavior and nucleus accumbens (nac) dopamine release. |
2023-11-24 |
2023-11-28 |
mouse |
| Madalyn Hafenbreidel, Surya Pandey, Sherri B Briggs, Meghana Arza, Shalakha Bonthu, Cadence Fisher, Annika Tiller, Alice B Hall, Shayna Reed, Natasha Mayorga, Li Lin, Susan Khan, Michael D Cameron, Gavin Rumbaugh, Courtney A Mille. Basolateral Amygdala Corticotropin Releasing Factor Receptor 2 Interacts with Nonmuscle Myosin II to Destabilize Memory in Males. Neurobiology of learning and memory. 2023-11-23. PMID:37995804. |
the effect is highly selective, as nmii inhibition has no effect in other relevant brain regions (e.g., dorsal hippocampus [dphc], nucleus accumbens [nac]), nor does it interfere with associations for other aversive or appetitive stimuli, including cocaine (coc). |
2023-11-23 |
2023-11-29 |
mouse |
| Rifka C Derman, Elizabeth C Bryda, Carrie R Ferrari. Role of Nucleus Accumbens D1-type Medium Spiny Neurons in the Expression and Extinction of Sign-tracking. Behavioural brain research. 2023-11-20. PMID:37984521. |
sign-tracking is dependent upon dopamine activity in the nucleus accumbens (nac). |
2023-11-20 |
2023-11-29 |
rat |