| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Brendan E Depue, Gregory C Burgess, Erik G Willcutt, L Cinnamon Bidwell, Luka Ruzic, Marie T Banic. Symptom-correlated brain regions in young adults with combined-type ADHD: their organization, variability, and relation to behavioral performance. Psychiatry research. vol 182. issue 2. 2010-07-01. PMID:20399622. |
the results implicated a broad array of brain regions that are linked to behaviors compromised in adhd, including executive function/cognitive control (prefrontal cortex, dorsal striatum), reward and motivational circuitry (ventral striatum), and stimulus representation and timing (posterior cortex and cerebellum). |
2010-07-01 |
2023-08-12 |
Not clear |
| L A Ruocco, U A Gironi Carnevale, C Treno, A G Sadile, D Melisi, C Arra, M Ibba, C Schirru, E Carbon. Prepuberal subchronic methylphenidate and atomoxetine induce different long-term effects on adult behaviour and forebrain dopamine, norepinephrine and serotonin in Naples high-excitability rats. Behavioural brain research. vol 210. issue 1. 2010-06-30. PMID:20156489. |
the high-performance liquid chromatography (hplc) tissue content assessment of dopamine, norepinephrine, serotonin and relative metabolites in the prefrontal cortex (pfc), cortical motor area (mc), dorsal striatum (ds), ventral striatum (vs), hippocampus and mesencephalon indicated that methylphenidate decreased (i) dopamine, dopac, norepinephrine, mhpg, 5-ht and 5-hiaa in the pfc, (ii) dopamine, dopac, hva, serotonin, 5-hiaa in the ds, (iii) dopamine, dopac, hva and mhpg (but increased norepinephrine) in the vs and (iv) norepinephrine, mhpg, serotonin and 5-hiaa in the hippocampus. |
2010-06-30 |
2023-08-12 |
rat |
| Xiangrui Li, Zhong-Lin Lu, Arnaud D'Argembeau, Marie Ng, Antoine Bechar. The Iowa Gambling Task in fMRI images. Human brain mapping. vol 31. issue 3. 2010-05-06. PMID:19777556. |
specifically, a neural circuitry involving the dorsolateral prefrontal cortex (for working memory), the insula and posterior cingulate cortex (for representations of emotional states), the mesial orbitofrontal and ventromedial prefrontal cortex (for coupling the two previous processes), the ventral striatum and anterior cingulate/sma (supplementary motor area) for implementing behavioral decisions was engaged. |
2010-05-06 |
2023-08-12 |
Not clear |
| Ralph Adolph. What does the amygdala contribute to social cognition? Annals of the New York Academy of Sciences. vol 1191. 2010-04-20. PMID:20392275. |
the amygdala processes a psychological stimulus dimension related to saliency or relevance; mechanisms have been identified to link it to processing unpredictability; and insights from reward learning have situated it within a network of structures that include the prefrontal cortex and the ventral striatum in processing the current value of stimuli. |
2010-04-20 |
2023-08-12 |
Not clear |
| Leah H Somerville, Rebecca M Jones, B J Case. A time of change: behavioral and neural correlates of adolescent sensitivity to appetitive and aversive environmental cues. Brain and cognition. vol 72. issue 1. 2010-04-07. PMID:19695759. |
this review discusses the emotional and incentive-driven behavioral changes in adolescents and their associated neural mechanisms, focusing on the dynamic interactions between the amygdala, ventral striatum, and prefrontal cortex. |
2010-04-07 |
2023-08-12 |
Not clear |
| George F Koob, Nora D Volko. Neurocircuitry of addiction. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 35. issue 1. 2010-02-24. PMID:19710631. |
animal and human imaging studies have revealed discrete circuits that mediate the three stages of the addiction cycle with key elements of the ventral tegmental area and ventral striatum as a focal point for the binge/intoxication stage, a key role for the extended amygdala in the withdrawal/negative affect stage, and a key role in the preoccupation/anticipation stage for a widely distributed network involving the orbitofrontal cortex-dorsal striatum, prefrontal cortex, basolateral amygdala, hippocampus, and insula involved in craving and the cingulate gyrus, dorsolateral prefrontal, and inferior frontal cortices in disrupted inhibitory control. |
2010-02-24 |
2023-08-12 |
human |
| George F Koob, Nora D Volko. Neurocircuitry of addiction. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 35. issue 1. 2010-02-24. PMID:19710631. |
the transition to addiction involves neuroplasticity in all of these structures that may begin with changes in the mesolimbic dopamine system and a cascade of neuroadaptations from the ventral striatum to dorsal striatum and orbitofrontal cortex and eventually dysregulation of the prefrontal cortex, cingulate gyrus, and extended amygdala. |
2010-02-24 |
2023-08-12 |
human |
| Suzanne N Haber, Brian Knutso. The reward circuit: linking primate anatomy and human imaging. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 35. issue 1. 2010-02-24. PMID:19812543. |
the key structures in this network are the anterior cingulate cortex, the orbital prefrontal cortex, the ventral striatum, the ventral pallidum, and the midbrain dopamine neurons. |
2010-02-24 |
2023-08-12 |
human |
| Konrad Lehmann, Thorsten Grund, Anja Bagorda, Francesco Bagorda, Keren Grafen, York Winter, Gertraud Teuchert-Nood. Developmental effects on dopamine projections and hippocampal cell proliferation in the rodent model of postweaning social and physical deprivation can be triggered by brief changes of environmental context. Behavioural brain research. vol 205. issue 1. 2010-01-12. PMID:19631238. |
in experimental animals as compared to deprived controls, dopamine fibre densities were increased in the pfc and basolateral amygdala, decreased in the central amygdala, but not altered in the ventral striatum. |
2010-01-12 |
2023-08-12 |
Not clear |
| Giovanna Zamboni, Marta Gozzi, Frank Krueger, Jean-René Duhamel, Angela Sirigu, Jordan Grafma. Individualism, conservatism, and radicalism as criteria for processing political beliefs: a parametric fMRI study. Social neuroscience. vol 4. issue 5. 2009-11-24. PMID:19562629. |
we found that three independent dimensions explained the variability of a set of statements expressing political beliefs and that each dimension was reflected in a distinctive pattern of neural activation: individualism (medial prefrontal cortex and temporoparietal junction), conservatism (dorsolateral prefrontal cortex), and radicalism (ventral striatum and posterior cingulate). |
2009-11-24 |
2023-08-12 |
human |
| Moritz de Greck, Alexander Supady, Rene Thiemann, Claus Tempelmann, Bernhard Bogerts, Lukas Forschner, Klaus V Ploetz, Georg Northof. Decreased neural activity in reward circuitry during personal reference in abstinent alcoholics--a fMRI study. Human brain mapping. vol 30. issue 5. 2009-07-02. PMID:18711709. |
alcoholic patients showed slightly reduced signal changes in the brain stem adjacent to ventral tegmental area (vta) and in the ventromedial prefrontal cortex (vmpfc) during the reward task, while we found no alterations in the right and left ventral striatum (vs). |
2009-07-02 |
2023-08-12 |
human |
| Robert K McNamara, Jessica Able, Ronald Jandacek, Therese Rider, Patrick Ts. Inbred C57BL/6J and DBA/2J mouse strains exhibit constitutive differences in regional brain fatty acid composition. Lipids. vol 44. issue 1. 2009-05-22. PMID:18923861. |
after correction for multiple comparisons, c57bl/6j mice exhibited significantly lower dha composition in the hippocampus and ventral striatum, but not prefrontal cortex or midbrain, and significantly greater regional arachidonic acid (ara, 20:4n-6):dha ratios, relative to dba/2j mice. |
2009-05-22 |
2023-08-12 |
mouse |
| Petra Schweinhardt, David A Seminowicz, Erik Jaeger, Gary H Duncan, M Catherine Bushnel. The anatomy of the mesolimbic reward system: a link between personality and the placebo analgesic response. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 15. 2009-05-12. PMID:19369556. |
similarly, gmd in ventral striatum and prefrontal cortex is related to dopamine-related personality traits. |
2009-05-12 |
2023-08-12 |
human |
| Robert K McNamara, Juliana Sullivan, Neil M Richtand, Ronald Jandacek, Therese Rider, Patrick Tso, Nick Campbell, Jack Lipto. Omega-3 fatty acid deficiency augments amphetamine-induced behavioral sensitization in adult DBA/2J mice: relationship with ventral striatum dopamine concentrations. Synapse (New York, N.Y.). vol 62. issue 10. 2009-04-21. PMID:18651642. |
in the present study, we determined the effects of dietary-induced deficits in brain dha composition on amphetamine (amph)-induced locomotor activity and sensitization in dba/2j mice, an inbred strain previously found to be hyporesponsive to amph, as well as monoamine concentrations in the pfc and ventral striatum following the amph challenge. |
2009-04-21 |
2023-08-12 |
mouse |
| Robert K McNamara, Juliana Sullivan, Neil M Richtand, Ronald Jandacek, Therese Rider, Patrick Tso, Nick Campbell, Jack Lipto. Omega-3 fatty acid deficiency augments amphetamine-induced behavioral sensitization in adult DBA/2J mice: relationship with ventral striatum dopamine concentrations. Synapse (New York, N.Y.). vol 62. issue 10. 2009-04-21. PMID:18651642. |
dha-deficient mice exhibited significantly greater ventral striatum, but not pfc, da and da metabolite concentrations following the amph challenge, whereas serotonin and noradrenalin concentrations were not altered. |
2009-04-21 |
2023-08-12 |
mouse |
| Jean-Claude Dreher, Philip Kohn, Bhaskar Kolachana, Daniel R Weinberger, Karen Faith Berma. Variation in dopamine genes influences responsivity of the human reward system. Proceedings of the National Academy of Sciences of the United States of America. vol 106. issue 2. 2009-02-13. PMID:19104049. |
the results revealed a main effect of comt genotype in the ventral striatum and lateral prefrontal cortex during reward anticipation (p < 0.001, uncorrected) and in the orbitofrontal cortex at the time of reward delivery (p < 0.005), met/met individuals exhibiting the highest activation. |
2009-02-13 |
2023-08-12 |
human |
| Jean-Claude Dreher, Philip Kohn, Bhaskar Kolachana, Daniel R Weinberger, Karen Faith Berma. Variation in dopamine genes influences responsivity of the human reward system. Proceedings of the National Academy of Sciences of the United States of America. vol 106. issue 2. 2009-02-13. PMID:19104049. |
the main effect of dat1 genotype was seen in robust blood-oxygen-level-dependent response differences in the caudate nucleus and ventral striatum during reward anticipation (p < 0.001) and in the lateral prefrontal cortex and midbrain at the time of reward delivery, with carriers of the dat1 9-repeat allele showing the highest activity. |
2009-02-13 |
2023-08-12 |
human |
| Jean-Claude Dreher, Philip Kohn, Bhaskar Kolachana, Daniel R Weinberger, Karen Faith Berma. Variation in dopamine genes influences responsivity of the human reward system. Proceedings of the National Academy of Sciences of the United States of America. vol 106. issue 2. 2009-02-13. PMID:19104049. |
moreover, an interaction between the comt and dat1 genes was found in the ventral striatum and lateral prefrontal cortex during reward anticipation and in the lateral prefrontal and orbitofrontal cortices as well as in the midbrain at the time of reward delivery, with carriers of the dat1 9-repeat allele and comt met/met allele exhibiting the highest activation, presumably reflecting functional change consequent to higher synaptic dopamine availability. |
2009-02-13 |
2023-08-12 |
human |
| Michael X Cohen, Jan-Christoph Schoene-Bake, Christian E Elger, Bernd Webe. Connectivity-based segregation of the human striatum predicts personality characteristics. Nature neuroscience. vol 12. issue 1. 2009-01-29. PMID:19029888. |
whereas fiber tracts between a subcortical network, including the hippocampus and amygdala, and the ventral striatum predicted individual differences in novelty seeking, tracts between prefrontal cortex and the striatum predicted individual differences in reward dependence. |
2009-01-29 |
2023-08-12 |
human |
| Philip Gorwoo. Neurobiological mechanisms of anhedonia. Dialogues in clinical neuroscience. vol 10. issue 3. 2008-12-23. PMID:18979942. |
the analyses of anhedonic non-clinical subjects, nonanhedonic depressed patients, and depressed patients with various levels ofanhedonia seem to favor the hypothesis that the severity of anhedonia is associated with a deficit of activity of the ventral striatum (including the nucleus accumbens) and an excess of activity of ventral region of the prefrontal cortex (including the ventromedial prefrontal cortex and the orbitofrontal cortex), with a pivotal, but not exclusive, role of dopamine. |
2008-12-23 |
2023-08-12 |
human |