| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| F Vahid-Ansari, Y Nakabeppu, G S Robertso. Contrasting effects of chronic clozapine, Seroquel(TM) (ICI 204,636) and haloperidol administration of deltaFosB-like immunoreactivity in the rodent forebrain. The European journal of neuroscience. vol 8. issue 5. 1996-11-06. PMID:8743740. |
these results suggest that a preferential action on limbic structures such as the prefrontal cortex, ventral striatum and lateral septal nucleus may account for the ability of chronic clozapine and ici 204, 636 administration to reduce the symptoms of schizophrenia without generating extrapyramidal side effects. |
1996-11-06 |
2023-08-12 |
rat |
| M B Knable, D R Weinberge. Limbic-prefrontal connectivity and clozapine. The Journal of clinical psychiatry. vol 55 Suppl B. 1994-11-28. PMID:7961578. |
future in vivo studies of cerebral blood flow and glucose metabolism in human patients may help to elucidate the specificity and reproducibility of the effects of clozapine in the ventral striatum and prefrontal cortex. |
1994-11-28 |
2023-08-12 |
human |
| M Mintz, L Reyneke, A de Villiers, R Allin, V Russell, W Daniels, G van der Spuy, A Jaffer, L Kellaway, R Dougla. Effect of amygdaloid kindling on [3H]dopamine and [14C]acetylcholine release from rat prefrontal cortex and striatal slices. Brain research. vol 592. issue 1-2. 1993-01-06. PMID:1450903. |
sections of the bilateral prefrontal cortex and dorsal and ventral striatum were dissected either 2 hours or 21 days after the final seizure and the electrically stimulated release of [3h]da and [14c]acetylcholine (ach) determined. |
1993-01-06 |
2023-08-11 |
rat |
| M Mintz, L Reyneke, A de Villiers, R Allin, V Russell, W Daniels, G van der Spuy, A Jaffer, L Kellaway, R Dougla. Effect of amygdaloid kindling on [3H]dopamine and [14C]acetylcholine release from rat prefrontal cortex and striatal slices. Brain research. vol 592. issue 1-2. 1993-01-06. PMID:1450903. |
long-term effects of kindling consisted of facilitation of ach release in the ventral striatum contralateral to the kindled amygdala and bilateral depression of da release in the prefrontal cortex. |
1993-01-06 |
2023-08-11 |
rat |
| M Mintz, L Reyneke, A de Villiers, R Allin, V Russell, W Daniels, G van der Spuy, A Jaffer, L Kellaway, R Dougla. Effect of amygdaloid kindling on [3H]dopamine and [14C]acetylcholine release from rat prefrontal cortex and striatal slices. Brain research. vol 592. issue 1-2. 1993-01-06. PMID:1450903. |
kindling therefore produced area specific changes in neurotransmitter systems giving rise to increased pro-convulsive cholinergic activity in the ventral striatum and decreased anti-convulsive dopaminergic activity in the prefrontal cortex. |
1993-01-06 |
2023-08-11 |
rat |
| P J McKenn. Pathology, phenomenology and the dopamine hypothesis of schizophrenia. The British journal of psychiatry : the journal of mental science. vol 151. 1988-03-04. PMID:3322465. |
the basal ganglia, ventral striatum, septo-hippocampal system, and prefrontal cortex, sites of mesotelencephalic dopamine innervation, are examined and it is argued that their dysfunction could form the basis of particular schizophrenic symptom classes. |
1988-03-04 |
2023-08-11 |
Not clear |