| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xian Ding, Xiang Gao, Zhichun Wang, Xuliang Jiang, Shunmei Lu, Jingjing Xu, Guowei Qin, Zhengfeng Gu, Dongxiao Huan. Preoperative Chronic and Acute Pain Affects Postoperative Cognitive Function Mediated by Neurotransmitters. Journal of molecular neuroscience : MN. vol 71. issue 3. 2021-10-04. PMID:32901371. |
like anxiety, cci increased 5-hydroxytryptamine (5-ht) levels in the prefrontal cortex and hippocampus. |
2021-10-04 |
2023-08-13 |
mouse |
| Daniel R Fregoso, Yasmin Hadian, Anthony C Gallegos, Doniz Degovics, John Maaga, Ciara E Keogh, Isaiah Kletenik, Melanie G Gareau, R Rivkah Isserof. Skin-brain axis signaling mediates behavioral changes after skin wounding. Brain, behavior, & immunity - health. vol 15. 2021-10-01. PMID:34589779. |
prefrontal cortex serotonin and dopamine turnover were increased on day six post-wounding. |
2021-10-01 |
2023-08-13 |
mouse |
| Iulia Zoicas, Sabine E Huber, Liubov S Kalinichenko, Erich Gulbins, Christian P Müller, Johannes Kornhube. Ceramides affect alcohol consumption and depressive-like and anxiety-like behavior in a brain region- and ceramide species-specific way in male mice. Addiction biology. vol 25. issue 6. 2021-09-28. PMID:31828921. |
our results revealed that c16, but not c8 and c20, ceramide altered alcohol drinking and emotional behavior in a brain region-specific way without altering tissue noradrenaline, dopamine, and serotonin levels in the prefrontal cortex, ventral striatum, and dorsal mesencephalon. |
2021-09-28 |
2023-08-13 |
mouse |
| Sofi da Cunha-Bang, Gitte Moos Knudse. The Modulatory Role of Serotonin on Human Impulsive Aggression. Biological psychiatry. vol 90. issue 7. 2021-09-27. PMID:34266672. |
interventions that (presumably) alter serotonin levels have effects on brain activity within brain regions involved in impulsive aggression, notably the amygdala, dorsal striatum, anterior cingulate, insula, and prefrontal cortex. |
2021-09-27 |
2023-08-13 |
human |
| Takahiro Ito, Yuka Hiramatsu, Akihiro Mouri, Takuya Yoshigai, Ayaki Takahashi, Akira Yoshimi, Takayoshi Mamiya, Norio Ozaki, Yukihiro Nod. Involvement of PKCβI-SERT activity in stress vulnerability of mice exposed to twice-swim stress. Neuroscience research. vol 171. 2021-09-06. PMID:33460682. |
phosphorylated pkcβi or sert and 5-ht levels were decreased in the prefrontal cortex of twice-stressed mice. |
2021-09-06 |
2023-08-13 |
mouse |
| Marzia Maiolati, Valeria Tarmati, Claudio Latagliata, Simona Cabib, Cristina Orsin. Opposite genotype-specific effects of serotoninergic treatments on Pavlovian Conditioned Approach in mice of two inbred strains C57 BL/6J and DBA/2J. Behavioural pharmacology. vol 32. issue 5. 2021-09-06. PMID:33709985. |
we have recently demonstrated that whereas young adult mice of both strains develop sign-tracking in a pavlovian conditioned approach (pca), a trait associated with dysfunctional behavior in rat models, in full adult c57 mice acquisition of this phenotype is inhibited by pre-frontal cortical (pfc) serotonin (5ht) transmission. |
2021-09-06 |
2023-08-13 |
mouse |
| Marzia Maiolati, Valeria Tarmati, Claudio Latagliata, Simona Cabib, Cristina Orsin. Opposite genotype-specific effects of serotoninergic treatments on Pavlovian Conditioned Approach in mice of two inbred strains C57 BL/6J and DBA/2J. Behavioural pharmacology. vol 32. issue 5. 2021-09-06. PMID:33709985. |
these findings confirm the strain-specific inhibitory role of pfc 5-ht transmission on sign-tracking development by mice of the c57 strain and support the hypothesis that different genotype-specific neurobiological substrates of dysfunctional phenotypes contribute to variable effects of pharmacotherapies. |
2021-09-06 |
2023-08-13 |
mouse |
| Gerly Tamm, Kairi Kreegipuu, Jaanus Harr. Platelet MAO activity and COMT Val158Met genotype interaction predicts visual working memory updating efficiency. Behavioural brain research. vol 407. 2021-09-02. PMID:33745984. |
the findings support the view that serotonin modulates dopaminergic activation in updating and contribute to understanding the role of serotonin in pfc, top-down inhibitory signals, and its interactions with dopamine in wm processes. |
2021-09-02 |
2023-08-13 |
human |
| Claudia Villani, Giuseppina Sacchetti, Mirjana Carli, Roberto W Invernizz. Fluoxetine rescues rotarod motor deficits in Mecp2 heterozygous mouse model of Rett syndrome via brain serotonin. Neuropharmacology. vol 176. 2021-08-13. PMID:32652084. |
mecp2 null mice, which responded poorly to fluoxetine in the rotarod, showed reduced 5-ht synthesis in the prefrontal cortex, hippocampus and striatum, and reduced efficacy of fluoxetine in raising extracellular 5-ht as compared to female mutants. |
2021-08-13 |
2023-08-13 |
mouse |
| Yunxia Niu, Tao Wang, Shan Liang, Wei Li, Xu Hu, Xiaoli Wu, Feng Ji. Sex-dependent aberrant PFC development in the adolescent offspring rats exposed to variable prenatal stress. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 80. issue 6. 2021-08-12. PMID:32358823. |
the study tested the concentration of brain-derived neurotrophic factor (bdnf), cluster of differentiation 68 (cd68), synaptotagmin-1(syt-1), 5-hydroxytryptamine (5-ht), dopamine (da), glucocorticoid receptors (grs) and oestrogen receptors (ers) in the pfc (prefrontal cortex). |
2021-08-12 |
2023-08-13 |
rat |
| Zhicheng Jin, Jianer Ling, Jing Yu, Mengzi He, Pingping Ni, Fang Zhang, Yizhen Wan. Serotonin 2A receptor function and depression-like behavior in rats model of hypothyroidism. Experimental brain research. vol 239. issue 8. 2021-08-12. PMID:34106297. |
tt[formula: see text] and tt[formula: see text] levels were measured after the behavior tests and the expression levels of 5-ht[formula: see text] receptor and 5-ht[formula: see text] receptor proteins were analyzed in the hippocampus and prefrontal cortex. |
2021-08-12 |
2023-08-13 |
rat |
| Johan Alsiö, Olivia Lehmann, Colin McKenzie, David E Theobald, Lydia Searle, Jing Xia, Jeffrey W Dalley, Trevor W Robbin. Serotonergic Innervations of the Orbitofrontal and Medial-prefrontal Cortices are Differentially Involved in Visual Discrimination and Reversal Learning in Rats. Cerebral cortex (New York, N.Y. : 1991). vol 31. issue 2. 2021-08-11. PMID:33043981. |
these findings extend our understanding of serotonin in cognitive flexibility by revealing differential effects within two subregions of the prefrontal cortex in visual discrimination and reversal learning. |
2021-08-11 |
2023-08-13 |
rat |
| Luana Olegário da Silva, Raquel da Silva Aragão, Manuella da Luz Duarte Barros, Kelli Nogueira Ferraz-Pereira, Isabeli Lins Pinheiro, Lígia Cristina Monteiro Galind. Maternal exposure to high-fat diet modifies anxiety-like/depression-like behaviors and compounds of Serotonergic System in offspring: A preclinical systematic review. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 81. issue 5. 2021-08-06. PMID:33788300. |
maternal consumption of hfd was found to be associated with an inconsistent pattern of the expression of tph2 as well as reduced the immunoreactivity of 5-ht in the prefrontal cortex and increased 5-ht1a receptor expression in the dorsal raphe of offspring. |
2021-08-06 |
2023-08-13 |
Not clear |
| Basem H Elesawy, Walaa F Alsanie, Mubarak Ali Algahtany, Jawaher M Al-Ashkhari, Aya K Alyarobi, Hussein F Sak. Whole and refined grains change behavior and reduce brain derived neurotrophic factor and neurotrophin-3 in rats. Journal of food biochemistry. 2021-07-19. PMID:34278588. |
the rats on a diet of whole and refined grains had low bdnf, nt-3, norepinephrine, dopamine and serotonin significantly (p < .01) in both the hippocampus and prefrontal cortex as compared to control rats. |
2021-07-19 |
2023-08-13 |
rat |
| Kate Beecher, Joshua Wang, Angela Jacques, Nicholas Chaaya, Fatemeh Chehrehasa, Arnauld Belmer, Selena E Bartlet. Sucrose Consumption Alters Serotonin/Glutamate Co-localisation Within the Prefrontal Cortex and Hippocampus of Mice. Frontiers in molecular neuroscience. vol 14. 2021-07-16. PMID:34262435. |
although serotonin and glutamate co-localisation has been implicated in reward processing, it is still unknown how chronic sucrose consumption changes this transmission in regions associated with executive control over feeding-such as the prefrontal cortex (pfc) and dentate gyrus (dg) of the hippocampus. |
2021-07-16 |
2023-08-13 |
mouse |
| Barbara Dos Santos, Ariana Ern Schmitz, Gudrian Ricardo Lopes de Almeida, Luiz Felipe de Souza, Jozimar Carlos Szczepanik, Everson Araújo Nunes, Henver Simionato Brunetta, Josiel Mileno Mack, Rui Daniel Prediger, Maurício Peña Cunha, Alcir Luiz Dafr. Fructose Intake Impairs Cortical Antioxidant Defenses Allied to Hyperlocomotion in Middle-Aged C57BL/6 Female Mice. Neurochemical research. vol 45. issue 12. 2021-07-12. PMID:32968860. |
fru intake did not alter serotonin, dopamine, and norepinephrine levels in the hippocampus, prefrontal cortex, and striatum. |
2021-07-12 |
2023-08-13 |
mouse |
| Anna-Lena Frey, Ciara McCab. Effects of serotonin and dopamine depletion on neural prediction computations during social learning. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 45. issue 9. 2021-06-23. PMID:32330925. |
on the neural level, computational modeling-based fmri analyses revealed that 5-ht depletion altered social reward prediction signals in the insula, temporal lobe, and prefrontal cortex, while da depletion affected social reward prediction encoding only in the prefrontal cortex. |
2021-06-23 |
2023-08-13 |
human |
| Kenichi Fukumoto, Manoela V Fogaça, Rong-Jian Liu, Catharine H Duman, Xiao-Yuan Li, Shigeyuki Chaki, Ronald S Duma. Medial PFC AMPA receptor and BDNF signaling are required for the rapid and sustained antidepressant-like effects of 5-HT Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 45. issue 10. 2021-06-23. PMID:32396921. |
medial pfc ampa receptor and bdnf signaling are required for the rapid and sustained antidepressant-like effects of 5-ht we previously reported that the serotonergic system is important for the antidepressant-like effects of ketamine, a non-competitive n-methyl-d-aspartate receptor antagonist, which produces rapid and long-lasting antidepressant effects in patients with major depressive disorder (mdd). |
2021-06-23 |
2023-08-13 |
Not clear |
| Frederick Adams Ekuban, Cai Zong, Madoka Takikawa, Kota Morikawa, Toshihiro Sakurai, Sahoko Ichihara, Ken Itoh, Masayuki Yamamoto, Seiichiroh Ohsako, Gaku Ichihar. Genetic ablation of Nrf2 exacerbates neurotoxic effects of acrylamide in mice. Toxicology. vol 456. 2021-06-22. PMID:33872730. |
the effects of acrylamide were examined by landing foot spread test, immunohistochemistry for noradrenaline (na) and serotonin (5-ht)-containing axons and iba1-positive microglia in the prefrontal cortex as well as quantitative real-time polymerase chain reaction (qrt-pcr) on antioxidant, proinflammatory and anti-inflammatory genes in the prefrontal cortex. |
2021-06-22 |
2023-08-13 |
mouse |
| Francis Rodriguez Bambico, Zhuoliang Li, Meaghan Creed, Danilo De Gregorio, Mustansir Diwan, Jessica Li, Sean McNeill, Gabriella Gobbi, Roger Raymond, José N Nobreg. A Key Role for Prefrontocortical Small Conductance Calcium-Activated Potassium Channels in Stress Adaptation and Rapid Antidepressant Response. Cerebral cortex (New York, N.Y. : 1991). vol 30. issue 3. 2021-06-21. PMID:31504265. |
this antidepressant-like effect was mediated via a muscarinic m1 receptor-skc pathway because it was mimicked by intra-medial prefrontal cortex (intra-mpfc) infusions of scopolamine, of the m1 antagonist pirenzepine or of the skc antagonist apamin, but not by the selective serotonin reuptake inhibitor (ssri) antidepressant fluoxetine. |
2021-06-21 |
2023-08-13 |
Not clear |