| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tao Yang, Zheng Zha, Xiao Yang, YueZhi Kang, Xin Wang, Yanping Tong, XueSong Zhao, Lei Wang, YongPing Fa. Neuroprotective Effects of Fingolimod Supplement on the Retina and Optic Nerve in the Mouse Model of Experimental Autoimmune Encephalomyelitis. Frontiers in neuroscience. vol 15. 2021-05-14. PMID:33981197. |
microglia were hyperactivated in the retina and optic nerve in the eae mice compared to controls, which could be alleviated by fingolimod treatment. |
2021-05-14 |
2023-08-13 |
mouse |
| Michael A Dixon, Ursula Greferath, Erica L Fletcher, Andrew I Joblin. The Contribution of Microglia to the Development and Maturation of the Visual System. Frontiers in cellular neuroscience. vol 15. 2021-05-13. PMID:33967697. |
the retina is an easily accessible part of the central nervous system and therefore much has been learned about the function of microglia from studies in the retina and visual system. |
2021-05-13 |
2023-08-13 |
Not clear |
| Michael A Dixon, Ursula Greferath, Erica L Fletcher, Andrew I Joblin. The Contribution of Microglia to the Development and Maturation of the Visual System. Frontiers in cellular neuroscience. vol 15. 2021-05-13. PMID:33967697. |
anatomically, microglia have processes that contact all synapses within the retina, as well as blood vessels in the major vascular plexuses. |
2021-05-13 |
2023-08-13 |
Not clear |
| Yuta Moriuchi, Toshiro Iwagawa, Asano Tsuhako, Hideto Koso, Yasuyuki Fujita, Sumiko Watanab. RasV12 Expression in Microglia Initiates Retinal Inflammation and Induces Photoreceptor Degeneration. Investigative ophthalmology & visual science. vol 61. issue 13. 2021-05-07. PMID:33231622. |
here, we investigated the primary consequences of microglial activation by the specific expression of constitutively active ras in microglia in a transgenic mouse model before the onset of any degenerative changes in the retina. |
2021-05-07 |
2023-08-13 |
mouse |
| Neil F Ash, Michael T Massengill, Lindsey Harmer, Ahmed Jafri, Alfred S Lewi. Automated segmentation and analysis of retinal microglia within ImageJ. Experimental eye research. vol 203. 2021-04-23. PMID:33359513. |
while algorithms seeking to automate microglia counts and morphological analysis are becoming increasingly popular, few exist that are adequate for use within the retina and manual analysis remains prevalent. |
2021-04-23 |
2023-08-13 |
Not clear |
| Pilar Rojas, Ana I Ramírez, Manuel Cadena, José A Fernández-Albarral, Elena Salobrar-García, Inés López-Cuenca, Irene Santos-García, Eva de Lago, José L Urcelay-Segura, José M Ramírez, Rosa de Hoz, Juan J Salaza. Retinal Ganglion Cell Loss and Microglial Activation in a SOD1G93A Mouse Model of Amyotrophic Lateral Sclerosis. International journal of molecular sciences. vol 22. issue 4. 2021-04-12. PMID:33562231. |
for sod1g93a animals (compared to the wild-type), we found, in microglial cells, (i) a significant increase in the area occupied by each microglial cell in the total area of the retina; (ii) a significant increase in the arbor area in the outer plexiform layer (opl) inferior sector; (iii) the presence of cells with retracted processes; (iv) areas of cell groupings in some sectors; (v) no significant increase in the number of microglial cells; (vi) the expression of ifn-γ and il-1β; and (vii) the non-expression of il-10 and arginase-i. |
2021-04-12 |
2023-08-13 |
mouse |
| Kjell Johansson, Linnéa Allevang Svensson, Camilla Mohli. Morphological analyzes of microglia heterogeneity and dynamics during photoreceptor degeneration in vitro: Presumptive dark microglia in porcine retina. Experimental eye research. vol 200. 2021-03-02. PMID:32896534. |
morphological analyzes of microglia heterogeneity and dynamics during photoreceptor degeneration in vitro: presumptive dark microglia in porcine retina. |
2021-03-02 |
2023-08-13 |
human |
| Kjell Johansson, Linnéa Allevang Svensson, Camilla Mohli. Morphological analyzes of microglia heterogeneity and dynamics during photoreceptor degeneration in vitro: Presumptive dark microglia in porcine retina. Experimental eye research. vol 200. 2021-03-02. PMID:32896534. |
in the adult retina, ramifying microglia interact with the outer plexiform layer (opl) monitoring the synaptic integrity between photoreceptors and post-synaptic target cells. |
2021-03-02 |
2023-08-13 |
human |
| Kjell Johansson, Linnéa Allevang Svensson, Camilla Mohli. Morphological analyzes of microglia heterogeneity and dynamics during photoreceptor degeneration in vitro: Presumptive dark microglia in porcine retina. Experimental eye research. vol 200. 2021-03-02. PMID:32896534. |
the iba1-and cd11b-immunoreactive microglia in degenerating retina may be of two separate subtypes, which differ in localization, subcellular morphology and perhaps function. |
2021-03-02 |
2023-08-13 |
human |
| C Henrique Alves, Rosa Fernandes, Ana Raquel Santiago, António Francisco Ambrósi. Microglia Contribution to the Regulation of the Retinal and Choroidal Vasculature in Age-Related Macular Degeneration. Cells. vol 9. issue 5. 2021-02-24. PMID:32423062. |
a limited number of studies have suggested that microglia, the resident immune cells of the retina, have an important role not only in the pathology but also in the formation and physiology of the retinal vascular system. |
2021-02-24 |
2023-08-13 |
Not clear |
| Hongjun Wang, Xiangyuan Song, Mingzhe Li, Xuefei Wang, Yi Tao, Xiamu Xiya, Hui Liu, Yini Zhao, Dong Chang, Qian Sh. The role of TLR4/NF-κB signaling pathway in activated microglia of rats with chronic high intraocular pressure and vitro scratch injury-induced microglia. International immunopharmacology. vol 83. 2021-02-19. PMID:32199351. |
we aimed to explore the impacts of high intraocular pressure (iop) on rat microglia in retina and the regulation of tlr4/nf-κb signaling pathway in scratched microglia cells. |
2021-02-19 |
2023-08-13 |
rat |
| Hongjun Wang, Xiangyuan Song, Mingzhe Li, Xuefei Wang, Yi Tao, Xiamu Xiya, Hui Liu, Yini Zhao, Dong Chang, Qian Sh. The role of TLR4/NF-κB signaling pathway in activated microglia of rats with chronic high intraocular pressure and vitro scratch injury-induced microglia. International immunopharmacology. vol 83. 2021-02-19. PMID:32199351. |
we found the level of activated microglia cells were significantly increased in the retina of chronic high iop groups. |
2021-02-19 |
2023-08-13 |
rat |
| Dorothea R Morris, Sarah E Bounds, Huanhuan Liu, Wei-Qun Ding, Yan Chen, Yin Liu, Jiyang Ca. Exosomal MiRNA Transfer between Retinal Microglia and RPE. International journal of molecular sciences. vol 21. issue 10. 2021-02-08. PMID:32429541. |
these findings suggest that exosome-mediated mirna transfer is a signaling mechanism that contributes to the regulation of microglia function in the aging retina. |
2021-02-08 |
2023-08-13 |
Not clear |
| Andreas Reichenbach, Andreas Bringman. Glia of the human retina. Glia. vol 68. issue 4. 2021-02-02. PMID:31793693. |
the human retina contains three types of glial cells: microglia and two types of macroglia, astrocytes and müller cells. |
2021-02-02 |
2023-08-13 |
human |
| Luisa Dietrich, Ralph Lucius, Johann Roider, Alexa Klettne. Interaction of inflammatorily activated retinal pigment epithelium with retinal microglia and neuronal cells. Experimental eye research. vol 199. 2021-01-28. PMID:32735798. |
a primary suspect of this contribution is the microglia, the innate immune cell of the retina. |
2021-01-28 |
2023-08-13 |
human |
| Kimberly Garces, Tal Carmy, Placido Illiano, Roberta Brambilla, Abigail S Hacka. Increased Neuroprotective Microglia and Photoreceptor Survival in the Retina from a Peptide Inhibitor of Myeloid Differentiation Factor 88 (MyD88). Journal of molecular neuroscience : MN. vol 70. issue 6. 2021-01-22. PMID:32072483. |
increased neuroprotective microglia and photoreceptor survival in the retina from a peptide inhibitor of myeloid differentiation factor 88 (myd88). |
2021-01-22 |
2023-08-13 |
mouse |
| Alula R Yohannes, Christopher Yi Jung, Katherine I Shea, Wai T Wong, Alexander Beylin, Ethan D Cohe. The microglia response to electrical overstimulation of the retina imaged under a transparent stimulus electrode. Journal of neural engineering. 2021-01-08. PMID:33418555. |
the microglia response to electrical overstimulation of the retina imaged under a transparent stimulus electrode. |
2021-01-08 |
2023-08-13 |
Not clear |
| Giovanni Luca Romano, Rosario Amato, Francesca Lazzara, Vittorio Porciatti, Tsung-Han Chou, Filippo Drago, Claudio Bucol. P2X7 receptor antagonism preserves retinal ganglion cells in glaucomatous mice. Biochemical pharmacology. vol 180. 2020-12-31. PMID:32798466. |
further, microglia activation was assessed in flat-mounted retina by using iba-1 immunostaining. |
2020-12-31 |
2023-08-13 |
mouse |
| Verena Behnke, Thomas Langman. IFN-β signaling dampens microglia reactivity but does not prevent from light-induced retinal degeneration. Biochemistry and biophysics reports. vol 24. 2020-12-11. PMID:33299932. |
systemic treatment with ifn-β partially enhanced ifn-α/β receptor (ifnar) signaling in the retina and reduced the number of reactivated microglia in the subretinal space. |
2020-12-11 |
2023-08-13 |
mouse |
| Pia Grotegut, Sandra Kuehn, Wilhelm Meißner, H Burkhard Dick, Stephanie C Joachi. Intravitreal S100B Injection Triggers a Time-Dependent Microglia Response in a Pro-Inflammatory Manner in Retina and Optic Nerve. Molecular neurobiology. vol 57. issue 2. 2020-11-25. PMID:31705442. |
intravitreal s100b injection triggers a time-dependent microglia response in a pro-inflammatory manner in retina and optic nerve. |
2020-11-25 |
2023-08-13 |
rat |