| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Marcia G Honig, Nobel A Del Mar, Desmond L Henderson, Dylan O'Neal, Meghna Yammanur, Rachel Cox, Chunyan Li, Aaron M Perry, Bob M Moore, Anton Reine. Raloxifene, a cannabinoid type-2 receptor inverse agonist, mitigates visual deficits and pathology and modulates microglia after ocular blast. Experimental eye research. 2022-02-10. PMID:35143834. |
blast forces frequently damage the retina and optic nerves, and work on experimental animals has shown the pro-inflammatory actions of microglia can further exacerbate such injuries. |
2022-02-10 |
2023-08-13 |
mouse |
| Luoziyi Wang, Yiwen Qian, Xin Che, Jing Jiang, Jinshan Suo, Zhiliang Wan. Isolation and Characterization of Primary Retinal Microglia From the Human Post-mortem Eyes for Future Studies of Ocular Diseases. Frontiers in cellular neuroscience. vol 15. 2022-01-31. PMID:35095423. |
microglia, the primary resident immunocytes in the retina, continuously function as immune system supervisors in sustaining intraocular homeostasis. |
2022-01-31 |
2023-08-13 |
human |
| Ema Ozaki, Conor Delaney, Matthew Campbell, Sarah L Doyl. Minocycline suppresses disease-associated microglia (DAM) in a model of photoreceptor cell degeneration. Experimental eye research. 2022-01-29. PMID:35090890. |
as the resident immune cells in the retina, microglia play important homeostatic roles in retinal immune regulation and neuroprotection. |
2022-01-29 |
2023-08-13 |
mouse |
| Ema Ozaki, Conor Delaney, Matthew Campbell, Sarah L Doyl. Minocycline suppresses disease-associated microglia (DAM) in a model of photoreceptor cell degeneration. Experimental eye research. 2022-01-29. PMID:35090890. |
in this study we examine the kinetics of microglia infiltration towards the outer retina of rhodopsin knockout mice (rho |
2022-01-29 |
2023-08-13 |
mouse |
| Sujith Kumar Pulukool, Sai Krishna Srimadh Bhagavatham, Vishnu Kannan, Brahmanaidu Parim, Sivateja Challa, Vidya Karnatam, Datta Darshan V M, Irfan Ahmad Mir, Piruthivi Sukumar, Vijayalakshmi Venkateshan, Anuj Sharma, Venketesh Sivaramakrishna. Elevated ATP, cytokines and potential microglial inflammation distinguish exfoliation glaucoma from exfoliation syndrome. Cytokine. vol 151. 2022-01-25. PMID:35074716. |
microglia are immune cells in the retina implicated in glaucoma. |
2022-01-25 |
2023-08-13 |
Not clear |
| Nobuhiko Shiraki, Kazuichi Maruyama, Ryuhei Hayashi, Akiko Oguchi, Yasuhiro Murakawa, Tomohiko Katayama, Toru Takigawa, Susumu Sakimoto, Andrew J Quantock, Motokazu Tsujikawa, Kohji Nishid. PAX6-positive microglia evolve locally in hiPSC-derived ocular organoids. Stem cell reports. 2022-01-14. PMID:35030319. |
they govern the immunogenicity of the retina, which is considered to be part of the cns; however, it is not known how microglia develop in the eye. |
2022-01-14 |
2023-08-13 |
human |
| Mengmeng Jiang, Hai Xie, Chaoyang Zhang, Tianqin Wang, Haibin Tian, Lixia Lu, Jing-Ying Xu, Guo-Tong Xu, Lin Liu, Jingfa Zhan. Enhancing fractalkine/CX3CR1 signalling pathway can reduce neuroinflammation by attenuating microglia activation in experimental diabetic retinopathy. Journal of cellular and molecular medicine. 2022-01-13. PMID:35023309. |
in conclusion, the results demonstrated that fkn deactivated microglia via inhibiting nf-κb pathway and activating nrf2 pathway, thus to reduce the production of inflammation-related cytokines and ros, and protect the retina from diabetes insult. |
2022-01-13 |
2023-08-13 |
rat |
| Xiaokun Han, Xuan Liu, Jiejie Zhuang, Xida Liang, Qian Luo, Pei Chen, Ye Wen, Xiao Wang, Juan Peng, Ying Yang, Xiangyin Sha, Jing Zhuan. A modified high-yield method for primary culture of rat retinal microglial cells. Experimental eye research. 2022-01-03. PMID:34979098. |
here, we described a modified protocol of a microglial cell culture from the neonatal rat retina. |
2022-01-03 |
2023-08-13 |
rat |
| Ni Jin, Weiwei Sha, Lixiong Ga. Shaping the Microglia in Retinal Degenerative Diseases Using Stem Cell Therapy: Practice and Prospects. Frontiers in cell and developmental biology. vol 9. 2021-12-30. PMID:34966736. |
microglia are immune cells in the retina that have two activation phenotypes, namely, pro-inflammatory m1 and anti-inflammatory m2 phenotypes. |
2021-12-30 |
2023-08-13 |
Not clear |
| Yuanfei Ji, Bo Yu, Yikui Zhang, Wencan W. The change of microglia numbers within the mice retina, optic nerve and chiasm following intravitreal AAV2-GFP injection. European journal of ophthalmology. 2021-12-30. PMID:34967226. |
the change of microglia numbers within the mice retina, optic nerve and chiasm following intravitreal aav2-gfp injection. |
2021-12-30 |
2023-08-13 |
mouse |
| Jamal Saada, Ryan J McAuley, Michela Marcatti, Tony Zifeng Tang, Massoud Motamedi, Bartosz Szczesn. Oxidative stress induces Z-DNA binding protein 1-dependent activation of microglia via mtDNA released from retinal pigment epithelial cells. The Journal of biological chemistry. 2021-12-26. PMID:34953858. |
oxidative stress, inflammation, and aberrant activation of microglia in the retina are commonly observed in ocular pathologies. |
2021-12-26 |
2023-08-13 |
Not clear |
| Jamal Saada, Ryan J McAuley, Michela Marcatti, Tony Zifeng Tang, Massoud Motamedi, Bartosz Szczesn. Oxidative stress induces Z-DNA binding protein 1-dependent activation of microglia via mtDNA released from retinal pigment epithelial cells. The Journal of biological chemistry. 2021-12-26. PMID:34953858. |
however, the molecular mechanisms that cause activation of microglia in the retina are not fully understood. |
2021-12-26 |
2023-08-13 |
Not clear |
| Anja Schlecht, Adrian Thien, Julian Wolf, Gabriele Prinz, Hansjürgen Agostini, Günther Schlunck, Peter Wieghofer, Stefaniya Boneva, Clemens Lang. Immunosenescence in Choroidal Neovascularization (CNV)-Transcriptional Profiling of Naïve and CNV-Associated Retinal Myeloid Cells during Aging. International journal of molecular sciences. vol 22. issue 24. 2021-12-24. PMID:34948115. |
however, age-related changes of myeloid cells (mcs), such as microglia and macrophages, in the healthy retina or during cnv formation are ill-defined. |
2021-12-24 |
2023-08-13 |
Not clear |
| Nishtha Ranawat, Ichiro Masa. Mechanisms underlying microglial colonization of developing neural retina in zebrafish. eLife. vol 10. 2021-12-12. PMID:34872632. |
the retina is one of the first brain regions to accommodate microglia. |
2021-12-12 |
2023-08-13 |
zebrafish |
| Pengfei Yang, Linchi Chen, Yongpeng Shi, Fangfang Zhou, Huanbing Tian, Jiande Li, Lan Ga. Progesterone alters the activation and typing of the microglia in the optic nerve crush model. Experimental eye research. vol 212. 2021-12-08. PMID:34699875. |
microglia have a protective effect on the central nervous system (cns), but their over-proliferation can cause secondary injury to the retina following optic nerve crush (onc). |
2021-12-08 |
2023-08-13 |
mouse |
| Pengfei Yang, Linchi Chen, Yongpeng Shi, Fangfang Zhou, Huanbing Tian, Jiande Li, Lan Ga. Progesterone alters the activation and typing of the microglia in the optic nerve crush model. Experimental eye research. vol 212. 2021-12-08. PMID:34699875. |
in general, this study elucidated the mechanism that progesterone prevented further damage on the retina by inhibiting proliferation, activation, and changing the type of microglia. |
2021-12-08 |
2023-08-13 |
mouse |
| Ling-Ping Cen, Tsz Kin Ng, Jia-Jian Liang, Ciyan Xu, Xi Zhuang, Yu-Fen Liu, Shao-Lang Chen, Yanxuan Xu, Qichen Yang, Xiang-Ling Yuan, Yong Jie Qin, Sun On Chan, Haoyu Chen, Mingzhi Zhang, Andrew V Schally, Chi Pui Pan. Agonist of growth hormone-releasing hormone enhances retinal ganglion cell protection induced by macrophages after optic nerve injury. Proceedings of the National Academy of Sciences of the United States of America. vol 118. issue 28. 2021-11-30. PMID:34244423. |
both the ghrh agonist and antagonist increased the phosphorylation of akt in the retina, but only agonist mr-409 promoted microglia activation in the retina. |
2021-11-30 |
2023-08-13 |
rat |
| Annelies Van Dyck, Ilse Bollaerts, An Beckers, Sophie Vanhunsel, Nynke Glorian, Jessie van Houcke, Tjakko J van Ham, Lies De Groef, Lien Andries, Lieve Moon. Müller glia-myeloid cell crosstalk accelerates optic nerve regeneration in the adult zebrafish. Glia. vol 69. issue 6. 2021-11-16. PMID:33502042. |
second, we demonstrated that acute depletion of both microglia and macrophages in the retina, using pharmacological treatments with both the csf1r inhibitor plx3397 and clodronate liposomes, compromised optic nerve regeneration. |
2021-11-16 |
2023-08-13 |
zebrafish |
| Annelies Van Dyck, Ilse Bollaerts, An Beckers, Sophie Vanhunsel, Nynke Glorian, Jessie van Houcke, Tjakko J van Ham, Lies De Groef, Lien Andries, Lieve Moon. Müller glia-myeloid cell crosstalk accelerates optic nerve regeneration in the adult zebrafish. Glia. vol 69. issue 6. 2021-11-16. PMID:33502042. |
moreover, we observed that csf1ra/b double mutant fish, lacking microglia in both retina and brain, displayed accelerated rgc axonal regrowth after onc, which was accompanied with unusual müller glia proliferative gliosis. |
2021-11-16 |
2023-08-13 |
zebrafish |
| Aby Joseph, Derek Power, Jesse Schalle. Imaging the dynamics of individual processes of microglia in the living retina Biomedical optics express. vol 12. issue 10. 2021-11-10. PMID:34745728. |
imaging the dynamics of individual processes of microglia in the living retina microglia are an essential population of resident immune cells in the central nervous system (cns) and retina. |
2021-11-10 |
2023-08-13 |
Not clear |