| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yasuhiko Sato, Shoko Saito, Makiko Nakayama, Sunao Sugita, Akihiko Kudo, Hiroshi Kein. Genetic Ablation of Nrf2 Exacerbates Neuroinflammation in Ocular Autoimmunity. International journal of molecular sciences. vol 23. issue 19. 2022-10-14. PMID:36233013. |
gfap positive cells (astrocytes) and iba-1 positive cells (microglia cells) in the retina were more numerous in nrf2 ko mice compared to wt mice. |
2022-10-14 |
2023-08-14 |
mouse |
| Yu Huan, Xiu-Quan Wu, Tao Chen, Ya-Nan Dou, Bo Jia, Xin He, Dong-Yu Wei, Zhou Fei, Fei Fe. Necroptosis plays a crucial role in the exacerbation of retinal injury after blunt ocular trauma. Neural regeneration research. vol 18. issue 4. 2022-10-07. PMID:36204864. |
additionally, blunt ocular trauma induced nerve regeneration and müller glial hyperplasia; it also resulted in the recruitment of microglia to the retina and polarization of those microglia to the m1 phenotype. |
2022-10-07 |
2023-08-14 |
Not clear |
| Zizhu Tan, Yinjie Guo, Maleeka Shrestha, Daniel Sun, Meredith Gregory-Ksander, Tatjana C Jakob. Microglia depletion exacerbates retinal ganglion cell loss in a mouse model of glaucoma. Experimental eye research. 2022-10-07. PMID:36206859. |
plx5622 efficiently depleted microglia in the retina and the optic nerve head, but about 20% of microglia persisted in the myelinated optic nerve proper even after prolonged exposure to the drug. |
2022-10-07 |
2023-08-14 |
mouse |
| Qinyuan Alis Xu, Pierre Boerkoel, Veronica Hirsch-Reinshagen, Ian R Mackenzie, Ging-Yuek Robin Hsiung, Geoffrey Charm, Elliott F To, Alice Q Liu, Katerina Schwab, Kailun Jiang, Marinko Sarunic, Mirza Faisal Beg, Wellington Pham, Jing Cui, Eleanor To, Sieun Lee, Joanne A Matsubar. Müller cell degeneration and microglial dysfunction in the Alzheimer's retina. Acta neuropathologica communications. vol 10. issue 1. 2022-10-05. PMID:36199154. |
this study focused on the relationship of aβ with macroglia and microglia, as these glial cells are hypothesized to play important roles in homeostasis and clearance of aβ in the ad retina. |
2022-10-05 |
2023-08-14 |
Not clear |
| Isabella Palazzo, Lisa Kelly, Lindsay Koenig, Andy J Fische. Patterns of NFkB activation resulting from damage, reactive microglia, cytokines, and growth factors in the mouse retina. Experimental neurology. 2022-09-29. PMID:36174748. |
patterns of nfkb activation resulting from damage, reactive microglia, cytokines, and growth factors in the mouse retina. |
2022-09-29 |
2023-08-14 |
mouse |
| Bingsheng Lou, Lei Zeng, Xinbo Gao, Xiaobing Qian, Jing Jing Li, Xinyu Gu, Zheng Liu, Keli Liu, Xun Chen, Xiaofeng Lin, Feng Zhan. A single-cell transcriptomic atlas of the human ciliary body. Cellular and molecular life sciences : CMLS. vol 79. issue 10. 2022-09-26. PMID:36163311. |
importantly, we discovered the transitional states that probably contribute to the transition of ciliary macrophage into retina microglia and verified no lymphatics in the ciliary body. |
2022-09-26 |
2023-08-14 |
human |
| Kangjia Lv, Hui Ying, Guangyi Hu, Jing Hu, Qizhi Jian, Fang Zhan. Integrated multi-omics reveals the activated retinal microglia with intracellular metabolic reprogramming contributes to inflammation in STZ-induced early diabetic retinopathy. Frontiers in immunology. vol 13. 2022-09-19. PMID:36119084. |
these findings suggest that activated microglia with intracellular metabolic reprogramming in retina may contribute to pro-inflammation in the early dr. |
2022-09-19 |
2023-08-14 |
mouse |
| Haoshen Shi, Zhuoran Yin, Yosef Koronyo, Dieu-Trang Fuchs, Julia Sheyn, Miyah R Davis, Jered W Wilson, Milica A Margeta, Kristen M Pitts, Shawn Herron, Seiko Ikezu, Tsuneya Ikezu, Stuart L Graham, Vivek K Gupta, Keith L Black, Mehdi Mirzaei, Oleg Butovsky, Maya Koronyo-Hamaou. Regulating microglial miR-155 transcriptional phenotype alleviates Alzheimer's-induced retinal vasculopathy by limiting Clec7a/Galectin-3 Acta neuropathologica communications. vol 10. issue 1. 2022-09-08. PMID:36076283. |
despite growing interest in studying manifestations of alzheimer's disease (ad) in the retina, a cns organ accessible to noninvasive high-resolution imaging, to date mgnd microglia have not been studied in the ad retina. |
2022-09-08 |
2023-08-14 |
Not clear |
| Cheng-Rong Yu, Manoj Kumar Yadav, Minkyung Kang, Yingyos Jittayasothorn, Lijin Dong, Charles E Egwuag. Photoreceptor Cells Constitutively Express IL-35 and Promote Ocular Immune Privilege. International journal of molecular sciences. vol 23. issue 15. 2022-07-28. PMID:35897732. |
interleukin-27 is constitutively secreted by microglia in the retina or brain, and upregulation of il-27 during neuroinflammation suppresses encephalomyelitis and autoimmune uveitis. |
2022-07-28 |
2023-08-14 |
mouse |
| Yan Tao, Yusuke Murakami, Demetrios G Vavvas, Koh-Hei Sonod. Necroptosis and Neuroinflammation in Retinal Degeneration. Frontiers in neuroscience. vol 16. 2022-07-18. PMID:35844208. |
receptor-interacting protein kinase (ripk) plays a pivotal role in the induction of necroptosis in various cell types, including microglia, and it is implicated in diverse neurodegenerative diseases in the central nervous system and the retina. |
2022-07-18 |
2023-08-14 |
Not clear |
| Jacob K Sterling, Bailey Baumann, Sierra Foshe, Andrew Voigt, Samyuktha Guttha, Ahab Alnemri, Sam J McCright, Mingyao Li, Randy J Zauhar, Sandra R Montezuma, Rebecca J Kapphahn, Venkata R M Chavali, David A Hill, Deborah A Ferrington, Dwight Stambolian, Robert F Mullins, David Merrick, Joshua L Dunaie. Inflammatory adipose activates a nutritional immunity pathway leading to retinal dysfunction. Cell reports. vol 39. issue 11. 2022-06-15. PMID:35705048. |
rna sequencing (rna-seq) analysis of choroid and retina from human donors revealed that hallmarks of this pathway are present in amd microglia and macrophages. |
2022-06-15 |
2023-08-14 |
human |
| Marco Puthenparampil, Tommaso Torresin, Silvia Franciotta, Annachiara Marin, Federica De Napoli, Valentina Annamaria Mauceri, Silvia Miante, Elisabetta Pilotto, Edoardo Midena, Paolo Gall. Hyper-Reflecting Foci in Multiple Sclerosis Retina Associate With Macrophage/Microglia-Derived Cytokines in Cerebrospinal Fluid. Frontiers in immunology. vol 13. 2022-06-06. PMID:35664007. |
since microglia are widespread activated in multiple sclerosis (ms) brain, its evaluation in retina may help to understand and monitor ms-related pathology. |
2022-06-06 |
2023-08-14 |
Not clear |
| Assraa Hassan Jassim, Nana Yaa Nsiah, Denise M Inma. Ocular Hypertension Results in Hypoxia within Glia and Neurons throughout the Visual Projection. Antioxidants (Basel, Switzerland). vol 11. issue 5. 2022-05-28. PMID:35624752. |
hypoxia was detected primarily in müller glia in the retina, and microglia and astrocytes in the on and optic nerve head (onh). |
2022-05-28 |
2023-08-13 |
mouse |
| Marta Pengo, Silvia Miante, Silvia Franciotta, Marta Ponzano, Tommaso Torresin, Francesca Bovis, Francesca Rinaldi, Paola Perini, Martina Saiani, Monica Margoni, Alessandra Bertoldo, Maria Pia Sormani, Elisabetta Pilotto, Edoardo Midena, Paolo Gallo, Marco Puthenparampi. Retinal Hyperreflecting Foci Associate With Cortical Pathology in Multiple Sclerosis. Neurology(R) neuroimmunology & neuroinflammation. vol 9. issue 4. 2022-05-23. PMID:35606113. |
microglia, the resident immune cell of the brain and retina, is widespread activated in the white and gray matter (gm) in multiple sclerosis (ms). |
2022-05-23 |
2023-08-13 |
Not clear |
| Margarete M Karg, May Moorefield, Emma Hoffmann, Daisy Shu, Drenushe Krasniqi, Hannah Philipose, Bruce R Ksander, Magali Saint-Genie. Microglia Prevent the Loss of Visual Function in the Aging Retina by Maintaining the Health of Retinal Pigment Epithelial Cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35557419. |
microglia prevent the loss of visual function in the aging retina by maintaining the health of retinal pigment epithelial cells. |
2022-05-13 |
2023-08-13 |
mouse |
| Margarete M Karg, May Moorefield, Emma Hoffmann, Daisy Shu, Drenushe Krasniqi, Hannah Philipose, Bruce R Ksander, Magali Saint-Genie. Microglia Prevent the Loss of Visual Function in the Aging Retina by Maintaining the Health of Retinal Pigment Epithelial Cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35557419. |
interestingly, aging also coincides with the migration of microglia from the inner to the outer retina where they reside in the subretinal space between photoreceptor outer segments and the apical surface of rpe. |
2022-05-13 |
2023-08-13 |
mouse |
| Margarete M Karg, May Moorefield, Emma Hoffmann, Daisy Shu, Drenushe Krasniqi, Hannah Philipose, Bruce R Ksander, Magali Saint-Genie. Microglia Prevent the Loss of Visual Function in the Aging Retina by Maintaining the Health of Retinal Pigment Epithelial Cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35557419. |
healthy young microglia act as the immune sentinels of the retina, and thus are protective and maintain retinal homeostasis. |
2022-05-13 |
2023-08-13 |
mouse |
| Margarete M Karg, May Moorefield, Emma Hoffmann, Daisy Shu, Drenushe Krasniqi, Hannah Philipose, Bruce R Ksander, Magali Saint-Genie. Microglia Prevent the Loss of Visual Function in the Aging Retina by Maintaining the Health of Retinal Pigment Epithelial Cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35557419. |
we conclude that microglia in aging mice migrate to the subretinal space of the outer retina to support and maintain rpe cell functions that preserves vision. |
2022-05-13 |
2023-08-13 |
mouse |
| Anne Klotzsche-von Ameln, David Sprot. Harnessing retinal phagocytes to combat pathological neovascularization in ischemic retinopathies? Pflugers Archiv : European journal of physiology. 2022-05-07. PMID:35524802. |
during the manifestation of ir, the retina, normally an immune privileged tissue, encounters enhanced levels of cellular stress and inflammation that attract mononuclear phagocytes (mps) from the blood stream and activate resident mps (microglia). |
2022-05-07 |
2023-08-13 |
Not clear |
| Sarah Rose Anderson, Jacqueline M Roberts, Nathaniel Ghena, Emmalyn A Irvin, Joon Schwakopf, Isabelle B Cooperstein, Alejandra Bosco, Monica L Vette. Neuronal apoptosis drives remodeling states of microglia and shifts in survival pathway dependence. eLife. vol 11. 2022-04-28. PMID:35481836. |
using early postnatal mouse retina, a cns region undergoing significant developmental remodeling, we performed scrnaseq on microglia from mice that are wild-type, lack neuronal apoptosis (bax ko), or are treated with csf1r inhibitor (plx3397). |
2022-04-28 |
2023-08-13 |
mouse |