| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Feng Zhou, Xian Wang, Baoyu Han, Xiaohui Tang, Ru Liu, Qing Ji, Zhiqiang Zhou, Lidong Zhan. Short-chain fatty acids contribute to neuropathic pain via regulating microglia activation and polarization. Molecular pain. vol 17. 2021-10-14. PMID:33626986. |
the results showed that cci produced mechanical allodynia and thermal hyperalgesia, and also increased the expressions of microglia markers (iba1, cd11b) and pro-inflammatory phenotype markers (cd68, il-1β, and tnf-α), but not anti-inflammatory phenotype marker (cd206, il-4) in the hippocampus and spinal cord, accompanied by increased scfas in the gut. |
2021-10-14 |
2023-08-13 |
mouse |
| Yishun Hong, Wenyao Wu, Shuo Wang, Quanshui Hao, Hua Zheng, Shiyong Li, Xianwei Zhang, Rao Su. Angiotensin II type 1 receptor blockade attenuates posttraumatic stress disorder-related chronic pain by inhibiting glial activation in the spinal cord. Neuropharmacology. vol 196. 2021-10-01. PMID:34252405. |
our results showed that sps exposure increased the levels of angiotensin ii in the hippocampus, prefrontal cortex (pfc) and spinal cord; intraperitoneal injection of losartan attenuated sps-induced mechanical allodynia, and suppressed sps-induced glial activation (both microglia and astrocytes) and proinflammatory cytokine expression in the pfc and spinal cord, but not in the hippocampus. |
2021-10-01 |
2023-08-13 |
rat |
| Hamid Soltani Zangbar, Tahereh Ghadiri, Manuchehr Seyedi Vafaee, Abbas Ebrahimi Kalan, Mohammad Karimipour, Solmaz Fallahi, Meysam Ghorbani, Parviz Shahab. A potential entanglement between the spinal cord and hippocampus: Theta rhythm correlates with neurogenesis deficiency following spinal cord injury in male rats. Journal of neuroscience research. vol 98. issue 12. 2021-09-17. PMID:32875652. |
herein we used 24 male wistar rats (sham/sci = 12) and examined the effect of spinal cord contusion on hippocampal theta rhythm, spatial memory, and neurodegeneration. |
2021-09-17 |
2023-08-13 |
human |
| Vishal Kumar, Satyabrata Kundu, Arti Singh, Shamsher Sing. Understanding the role of histone deacetylase and their inhibitors in neurodegenerative disorders: Current targets and future perspective. Current neuropharmacology. 2021-06-21. PMID:34151764. |
hdacs are localized in different parts of the brain- hdac1 (hippocampus and cortex), hdac2 (nucleus), hdac3, 4, 5, 7 and 9 (nucleus and cytoplasm), hdac6 & hdac7 (cytoplasm) and hdac11 (nucleus, cornus ammonis 1 and spinal cord). |
2021-06-21 |
2023-08-13 |
Not clear |
| Vishal Kumar, Satyabrata Kundu, Arti Singh, Shamsher Sing. Understanding the role of histone deacetylase and their inhibitors in neurodegenerative disorders: Current targets and future perspective. Current neuropharmacology. 2021-06-21. PMID:34151764. |
sirtuins are localized in the different parts of the brain and neuron -sirt1 (nucleus), sirt2 (cortex, striatum, hippocampus and spinal cord), sirt3 (mitochondria and cytoplasm), sirt4, sirt5 & sirt6 (mitochondria), sirt7 (nucleus) and sirt8 (nucleolus). |
2021-06-21 |
2023-08-13 |
Not clear |
| Pablo Ferreira-Chamorro, Alejandro Redondo, Gabriela Riego, Olga Po. Treatment with 5-fluoro-2-oxindole Increases the Antinociceptive Effects of Morphine and Inhibits Neuropathic Pain. Cellular and molecular neurobiology. vol 41. issue 5. 2021-05-28. PMID:32880099. |
in c57bl/6 mice with neuropathic pain provoked by the total constriction of sciatic nerve we studied the effects of 10 mg/kg 5-fluoro-2-oxindole in: (i) the allodynia and hyperalgesia caused by the injury; (ii) the anxiety- and depressive-like behaviors; (iii) the local antinociceptive actions of morphine; (iv) the expression of cd11b/c (a microglial marker), the antioxidant and detoxificant enzymes nrf2, heme oxygenase 1 (ho-1) and nad(p)h:quinone oxidoreductase-1 (nqo1), and of mor in the spinal cord and hippocampus. |
2021-05-28 |
2023-08-13 |
mouse |
| Mia A Thomaidou, Kaya J Peerdeman, Melissa I Koppeschaar, Andrea W M Evers, Dieuwke S Veldhuijze. How Negative Experience Influences the Brain: A Comprehensive Review of the Neurobiological Underpinnings of Nocebo Hyperalgesia. Frontiers in neuroscience. vol 15. 2021-04-13. PMID:33841092. |
structural and functional neuroimaging findings demonstrated that nocebo hyperalgesia amplified pain signals in the spinal cord and brain regions involved in sensory and cognitive-affective processing including the prefrontal cortex, insula, amygdala, and hippocampus. |
2021-04-13 |
2023-08-13 |
Not clear |
| Arno Wünschmann, Robert Lopez-Astacio, Aníbal G Armién, Leslie Reed, Colin R Parris. Parvovirus-induced encephalitis in a juvenile raccoon. Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc. vol 33. issue 1. 2021-03-10. PMID:33100176. |
histologic evaluation demonstrated nonsuppurative encephalitis in thalamus, brainstem, and hippocampus, cerebellar purkinje cell loss, as well as poliomyelitis and demyelination of the spinal cord. |
2021-03-10 |
2023-08-13 |
Not clear |
| Motoi Yoshimura, Hiroyuki Honda, Naokazu Sasagasako, Shinichiro Mori, Hideomi Hamasaki, Satoshi O Suzuki, Takashi Ishii, Toshiharu Ninomiya, Jun-Ichi Kira, Toru Iwak. PCBP2 Is Downregulated in Degenerating Neurons and Rarely Observed in TDP-43-Positive Inclusions in Sporadic Amyotrophic Lateral Sclerosis. Journal of neuropathology and experimental neurology. vol 80. issue 3. 2021-02-23. PMID:33313661. |
notably, one case with ftld-tdp subtype b pathology had marked colocalization of tdp-43 and pcbp2 in the cytoplasmic inclusions and dystrophic neurites of the cerebral cortex, hippocampus, and spinal cord. |
2021-02-23 |
2023-08-13 |
human |
| Samar S Elblehi, Omnia I El Euony, Yasser S El-Saye. Apoptosis and astrogliosis perturbations and expression of regulatory inflammatory factors and neurotransmitters in acrylamide-induced neurotoxicity under ω3 fatty acids protection in rats. Neurotoxicology. vol 76. 2021-01-20. PMID:31647937. |
histopathologically, acr caused various degenerative changes, necrosis and glial cell activation in the cerebrum, cerebellum, hippocampus, spinal cord and sciatic nerve. |
2021-01-20 |
2023-08-13 |
rat |
| Yu Wang, Chun-Mei Li, Rui Han, Zhe-Zhe Wang, Yong-Lin Gao, Xiao-Yin Zhu, Xin Yu, Guang-Ying Du, Hong-Bo Wang, Jing-Wei Tian, Feng-Hua F. PCC0208009, an indirect IDO1 inhibitor, alleviates neuropathic pain and co-morbidities by regulating synaptic plasticity of ACC and amygdala. Biochemical pharmacology. vol 177. 2020-12-14. PMID:32217098. |
some studies have indicated that ido1 expression increased after neuropathic pain in hippocampus and spinal cord, whether these changes existing in anterior cingulate cortex (acc) and amygdala remains obscure and how ido1 inhibition leads to analgesia is largely unknown. |
2020-12-14 |
2023-08-13 |
Not clear |
| Xi Fang, Chun Yang, Shan Li, Gaofeng Zhan, Jie Zhang, Niannian Huang, Xiangxi Du, Hui Xu, Kenji Hashimoto, Ailin Lu. Brain-derived neurotrophic factor-TrkB signaling in the medial prefrontal cortex plays a role in the anhedonia-like phenotype after spared nerve injury. European archives of psychiatry and clinical neuroscience. vol 270. issue 2. 2020-11-06. PMID:29882089. |
furthermore, tissue levels of bdnf in the hippocampus, l2-5 spinal cord, muscle, and liver from both rats with or without anhedonia-like phenotype were lower compared with those of sham-operated rats. |
2020-11-06 |
2023-08-13 |
rat |
| James Fraser, Alexandra Essebier, Alexander S Brown, Raul Ayala Davila, Danyon Harkins, Oressia Zalucki, Lauren P Shapiro, Peter Penzes, Brandon J Wainwright, Matthew P Scott, Richard M Gronostajski, Mikael Bodén, Michael Piper, Tracey J Harve. Common Regulatory Targets of NFIA, NFIX and NFIB during Postnatal Cerebellar Development. Cerebellum (London, England). vol 19. issue 1. 2020-10-23. PMID:31838646. |
for instance, transcription factors from the nuclear factor i (nfi) family have been shown to co-ordinate neural stem and progenitor cell differentiation within multiple regions of the embryonic nervous system, including the neocortex, hippocampus, spinal cord and cerebellum. |
2020-10-23 |
2023-08-13 |
Not clear |
| Pablo Ferreira-Chamorro, Alejandro Redondo, Gabriela Riego, Sergi Leánez, Olga Po. Sulforaphane Inhibited the Nociceptive Responses, Anxiety- and Depressive-Like Behaviors Associated With Neuropathic Pain and Improved the Anti-allodynic Effects of Morphine in Mice. Frontiers in pharmacology. vol 9. 2020-09-29. PMID:30542282. |
the protein levels of nrf2, heme oxygenase 1 (ho-1), nad(p)h:quinone oxidoreductase-1 (nqo1), cd11b/c (a microglial activator marker), mitogen-activated protein kinases (mapk) and μ opioid receptors (mor) in the spinal cord, prefrontal cortex and hippocampus from mice, at 28 days after cci, were also evaluated. |
2020-09-29 |
2023-08-13 |
mouse |
| Pablo Ferreira-Chamorro, Alejandro Redondo, Gabriela Riego, Sergi Leánez, Olga Po. Sulforaphane Inhibited the Nociceptive Responses, Anxiety- and Depressive-Like Behaviors Associated With Neuropathic Pain and Improved the Anti-allodynic Effects of Morphine in Mice. Frontiers in pharmacology. vol 9. 2020-09-29. PMID:30542282. |
interestingly, treatment with sfn also potentiated the antiallodynic effects of morphine in sciatic nerve-injured mice by regularizing the down regulation of mor in the spinal cord and/or hippocampus. |
2020-09-29 |
2023-08-13 |
mouse |
| Jing-Hui Feng, Hee-Jung Lee, Hong-Won Su. The Molecular Signatures of Acute-immobilization-induced Antinociception and Chronic-immobilization-induced Antinociceptive Tolerance. Experimental neurobiology. vol 28. issue 6. 2020-09-28. PMID:31902155. |
the cox-2 in drg, p-jnk, p-ampkα1, and p-mtor in the spinal cord, p-p38 in the hippocampus, and p-ampkα1 in the hypothalamus were elevated in acute immobilization stress, but were reduced gradually after 3, 7 and 14 days of immobilization stress. |
2020-09-28 |
2023-08-13 |
mouse |
| Jing-Hui Feng, Hee-Jung Lee, Hong-Won Su. The Molecular Signatures of Acute-immobilization-induced Antinociception and Chronic-immobilization-induced Antinociceptive Tolerance. Experimental neurobiology. vol 28. issue 6. 2020-09-28. PMID:31902155. |
in addition, the cox-2 in drg, p-jnk, p-ampkα1, and p-mtor in the spinal cord, p-p38 in the hippocampus, and p-ampkα1 in the hypothalamus may play important roles in the regulation of antinociception induced by acute immobilization stress and the tolerance development induced by chronic immobilization stress. |
2020-09-28 |
2023-08-13 |
mouse |
| Xuejun Chai, Wei Zhang, Lingling Li, Yongji Wu, Xiaoyan Zhu, Shanting Zha. Profile of MIF in Developing Hippocampus: Association With Cell Proliferation and Neurite Outgrowth. Frontiers in molecular neuroscience. vol 13. 2020-09-28. PMID:32903462. |
previous studies have shown that mif is expressed in neocortex, hippocampus, hypothalamus, cerebellum, and spinal cord in adult mice. |
2020-09-28 |
2023-08-13 |
mouse |
| Nira de la Vega Gallardo, Rosana Penalva, Marie Dittmer, Michelle Naughton, John Falconer, Jill Moffat, Alerie G de la Fuente, José R Hombrebueno, Zhiyong Lin, Bernard Perbal, Rebecca J Ingram, Emma Evergren, Denise C Fitzgeral. Dynamic CCN3 expression in the murine CNS does not confer essential roles in myelination or remyelination. Proceedings of the National Academy of Sciences of the United States of America. vol 117. issue 30. 2020-09-17. PMID:32651278. |
we found ccn3 to be expressed predominantly by neurons in distinct areas of the cns, primarily the cerebral cortex, hippocampus, amygdala, suprachiasmatic nuclei, anterior olfactory nuclei, and spinal cord gray matter. |
2020-09-17 |
2023-08-13 |
mouse |
| Giorgia Moschetti, Giada Amodeo, Maria Serena Paladini, Raffaella Molteni, Gianfranco Balboni, Alberto Panerai, Paola Sacerdote, Silvia Franch. Prokineticin 2 promotes and sustains neuroinflammation in vincristine treated mice: Focus on pain and emotional like behavior. Brain, behavior, and immunity. vol 82. 2020-09-16. PMID:31525509. |
pk2, pk-rs, cytokines, neuroinflammatory markers (cd68, cd11b, gfap, tlr4) and atf3 were evaluated in drg, spinal cord, prefrontal cortex and hippocampus. |
2020-09-16 |
2023-08-13 |
mouse |