| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Laurent Bardi. The complex role of serotonin and 5-HT receptors in chronic pain. Behavioural pharmacology. vol 22. issue 5-6. 2011-12-13. PMID:21808193. |
the purpose of this study is to provide an analysis of the recent developments in understanding the role of 5-ht both within the periphery and at the level of the spinal dorsal horn. |
2011-12-13 |
2023-08-12 |
Not clear |
| Ming Gu, Kan Miyoshi, Ronald Dubner, Wei Guo, Shiping Zou, Ke Ren, Koichi Noguchi, Feng We. Spinal 5-HT(3) receptor activation induces behavioral hypersensitivity via a neuronal-glial-neuronal signaling cascade. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 36. 2011-10-31. PMID:21900561. |
recent studies indicate that the descending serotonin (5-ht) system from the rostral ventromedial medulla (rvm) in the brainstem and the 5-ht(3) receptor subtype in the spinal dorsal horn are involved in enhanced descending pain facilitation after tissue and nerve injury. |
2011-10-31 |
2023-08-12 |
rat |
| Ming Gu, Kan Miyoshi, Ronald Dubner, Wei Guo, Shiping Zou, Ke Ren, Koichi Noguchi, Feng We. Spinal 5-HT(3) receptor activation induces behavioral hypersensitivity via a neuronal-glial-neuronal signaling cascade. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 36. 2011-10-31. PMID:21900561. |
in addition, exogenous brain-derived neurotrophic factor-induced descending pain facilitation was accompanied by upregulation of cd11b and gfap expression in the spinal dorsal horn after microinjection in the rvm, and these events were significantly prevented by functional blockade of spinal 5-ht(3) receptors. |
2011-10-31 |
2023-08-12 |
rat |
| Jian-jun Chen, Qin Yang, Xin-zhi L. [5-HT descending expressing in the dorsal horn of cat spinal cord after deafferentation]. Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition. vol 41. issue 5. 2011-09-29. PMID:21302446. |
[5-ht descending expressing in the dorsal horn of cat spinal cord after deafferentation]. |
2011-09-29 |
2023-08-12 |
cat |
| Jian-jun Chen, Qin Yang, Xin-zhi L. [5-HT descending expressing in the dorsal horn of cat spinal cord after deafferentation]. Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition. vol 41. issue 5. 2011-09-29. PMID:21302446. |
to investigate the serotonin (5-ht) expression in dorsal horn of cat spinal cord and the atypical complex terminal (act) after complete dorsal rhizotomy. |
2011-09-29 |
2023-08-12 |
cat |
| Hua Yin, Seon Ah Park, Seong Kyu Han, Soo Joung Par. Effects of 5-hydroxytryptamine on substantia gelatinosa neurons of the trigeminal subnucleus caudalis in immature mice. Brain research. vol 1368. 2011-06-30. PMID:20971089. |
serotonin (5-hydroxytryptamine, 5-ht) is involved in the descending modulation of nociceptive transmission in the spinal dorsal horn. |
2011-06-30 |
2023-08-12 |
mouse |
| Christopher M Peters, Ken-ichiro Hayashida, Eric E Ewan, Kunie Nakajima, Hideaki Obata, Qinghao Xu, Tony L Yaksh, James C Eisenac. Lack of analgesic efficacy of spinal ondansetron on thermal and mechanical hypersensitivity following spinal nerve ligation in the rat. Brain research. vol 1352. 2010-12-22. PMID:20637741. |
in addition, snl did not alter the density of serotonergic fibers or 5-ht3 receptor immunoreactivity or spinal tissue content of 5-ht within the dorsal horn. |
2010-12-22 |
2023-08-12 |
rat |
| Alex Brenchat, Xavier Nadal, Luz Romero, Sergio Ovalle, Asunción Muro, Ricard Sánchez-Arroyos, Enrique Portillo-Salido, Marta Pujol, Ana Montero, Xavier Codony, Javier Burgueño, Daniel Zamanillo, Michel Hamon, Rafael Maldonado, José Miguel Vel. Pharmacological activation of 5-HT7 receptors reduces nerve injury-induced mechanical and thermal hypersensitivity. Pain. vol 149. issue 3. 2010-11-29. PMID:20399562. |
the 5-ht(7) receptor co-localized with gabaergic cells in the dorsal horn of the spinal cord, suggesting that the activation of spinal inhibitory gabaergic interneurons could contribute to the analgesic effects of 5-ht(7) receptor agonists. |
2010-11-29 |
2023-08-12 |
mouse |
| Alex Brenchat, Xavier Nadal, Luz Romero, Sergio Ovalle, Asunción Muro, Ricard Sánchez-Arroyos, Enrique Portillo-Salido, Marta Pujol, Ana Montero, Xavier Codony, Javier Burgueño, Daniel Zamanillo, Michel Hamon, Rafael Maldonado, José Miguel Vel. Pharmacological activation of 5-HT7 receptors reduces nerve injury-induced mechanical and thermal hypersensitivity. Pain. vol 149. issue 3. 2010-11-29. PMID:20399562. |
in addition, a significant increase of 5-ht(7) receptors was found by immunohistochemistry in the ipsilateral dorsal horn of the spinal cord after nerve injury, suggesting a "pain"-triggered regulation of receptor expression. |
2010-11-29 |
2023-08-12 |
mouse |
| Hideaki Obata, Masafumi Kimura, Kunie Nakajima, Masaru Tobe, Koichi Nishikawa, Shigeru Sait. Monoamine-dependent, opioid-independent antihypersensitivity effects of intrathecally administered milnacipran, a serotonin noradrenaline reuptake inhibitor, in a postoperative pain model in rats. The Journal of pharmacology and experimental therapeutics. vol 334. issue 3. 2010-09-23. PMID:20558774. |
microdialysis studies of the dorsal horn of the lumbar spinal cord were also performed to measure 5-ht and na levels after systemic injection of milnacipran. |
2010-09-23 |
2023-08-12 |
rat |
| Hideaki Obata, Masafumi Kimura, Kunie Nakajima, Masaru Tobe, Koichi Nishikawa, Shigeru Sait. Monoamine-dependent, opioid-independent antihypersensitivity effects of intrathecally administered milnacipran, a serotonin noradrenaline reuptake inhibitor, in a postoperative pain model in rats. The Journal of pharmacology and experimental therapeutics. vol 334. issue 3. 2010-09-23. PMID:20558774. |
microdialysis studies revealed that milnacipran increased both 5-ht and na levels in the spinal dorsal horn. |
2010-09-23 |
2023-08-12 |
rat |
| Z Aira, I Buesa, M Salgueiro, J Bilbao, L Aguilera, M Zimmermann, J J Azku. Subtype-specific changes in 5-HT receptor-mediated modulation of C fibre-evoked spinal field potentials are triggered by peripheral nerve injury. Neuroscience. vol 168. issue 3. 2010-09-21. PMID:20412834. |
neurotransmitter serotonin (5-ht) released from descending pain modulation pathways to the dorsal horn is crucial to spinal nociception processing. |
2010-09-21 |
2023-08-12 |
rat |
| Li-na Qiao, Jun-ying Wang, Shu-ping Chen, Yong-hui Gao, Yong-sheng Yang, Jun-ling Li. [Effects of electroacupuncture at "Futu" (LI 18) on the immunoactivity of substance P, 5-HT 1 AR, etc. of the cervical spinal dorsal horn in rats with neck incision pain]. Zhen ci yan jiu = Acupuncture research. vol 35. issue 2. 2010-08-17. PMID:20626139. |
to observe the effect of electroacupuncture(ea) of bilateral "futu" (li 18) on the immunoactivity of substance p (sp), nk-1 receptor (r), cyclooxygenase-1 (cox-1), 5-ht 1 ar and 5-ht2 ar in the cervical spinal dorsal horn of rats with neck incision pain, so as to explore its underlying mechanism in relieving incision pain. |
2010-08-17 |
2023-08-12 |
rat |
| Feng-Yu Liu, Xiao-Xiu Qu, Xu Ding, Jie Cai, Hong Jiang, You Wan, Ji-Sheng Han, Guo-Gang Xin. Decrease in the descending inhibitory 5-HT system in rats with spinal nerve ligation. Brain research. vol 1330. 2010-08-02. PMID:20230801. |
in the present study, we observed that the inhibitory effects of 5-ht and its receptor agonists including 1a, 1b, 3, 4, and probably 2c receptor agonists, on the c-fiber responses of dorsal horn wide dynamic range (wdr) neurons in the spinal cord decreased significantly following spinal nerve ligation (snl). |
2010-08-02 |
2023-08-12 |
rat |
| Feng Wei, Ronald Dubner, Shiping Zou, Ke Ren, Guang Bai, Dong Wei, Wei Gu. Molecular depletion of descending serotonin unmasks its novel facilitatory role in the development of persistent pain. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 25. 2010-07-15. PMID:20573908. |
compared to negative control shrna, tph-2 shrna induced significantly prolonged downregulation of tph-2 in the rvm and 5-ht in spinal dorsal horn. |
2010-07-15 |
2023-08-12 |
rat |
| Ning Lü, Mei Han, Zhi-Lan Yang, Yan-Qing Wang, Gen-Cheng Wu, Yu-Qiu Zhan. Nociceptin/Orphanin FQ in PAG modulates the release of amino acids, serotonin and norepinephrine in the rostral ventromedial medulla and spinal cord in rats. Pain. vol 148. issue 3. 2010-04-30. PMID:20036056. |
the results showed that the microinjection of n/ofq into the vlpag produced robust decreases in 5-hydroxytryptamine (5-ht, serotonin), norepinephrine (ne), and gamma-aminobutyric acid (gaba), and increase in glutamate (glu) release in the spinal dorsal horn. |
2010-04-30 |
2023-08-12 |
rat |
| Chi-Sang Poo. Optimal interaction of respiratory and thermal regulation at rest and during exercise: role of a serotonin-gated spinoparabrachial thermoafferent pathway. Respiratory physiology & neurobiology. vol 169. issue 3. 2010-02-24. PMID:19770073. |
this optimization model of respiratory-thermoregulatory interaction is supported by a host of recent studies which demonstrate that animals with serotonin (5-ht) dysfunction at the spinal dorsal horn--due to 5-ht antagonism, genetic 5-ht defects or spinal cord injury--all display similar respiratory abnormalities that are consistent with hyperactivity of the spinoparabrachial thermoafferent (and pain) pathway. |
2010-02-24 |
2023-08-12 |
human |
| Zhiyang Song, Camilla Ultenius, Björn A Meyerson, Bengt Linderot. Pain relief by spinal cord stimulation involves serotonergic mechanisms: an experimental study in a rat model of mononeuropathy. Pain. vol 147. issue 1-3. 2010-02-23. PMID:19836134. |
immunohistochemical examination showed a high density of 5-ht stained terminals in the dorsal horn superficial laminae (i-ii) in scs responding rats following stimulation. |
2010-02-23 |
2023-08-12 |
rat |
| Teruyuki Fukushima, Toshiki Ohtsubo, Masayuki Tsuda, Yuchio Yanagawa, Yuuichi Hor. Facilitatory actions of serotonin type 3 receptors on GABAergic inhibitory synaptic transmission in the spinal superficial dorsal horn. Journal of neurophysiology. vol 102. issue 3. 2009-10-23. PMID:19369358. |
facilitatory actions of serotonin type 3 receptors on gabaergic inhibitory synaptic transmission in the spinal superficial dorsal horn. |
2009-10-23 |
2023-08-12 |
mouse |
| Teruyuki Fukushima, Toshiki Ohtsubo, Masayuki Tsuda, Yuchio Yanagawa, Yuuichi Hor. Facilitatory actions of serotonin type 3 receptors on GABAergic inhibitory synaptic transmission in the spinal superficial dorsal horn. Journal of neurophysiology. vol 102. issue 3. 2009-10-23. PMID:19369358. |
analgesic effects of serotonin (5-hydroxytryptamine [5-ht]) type 3 (5-ht3) receptors may involve the release of gamma-aminobutyric acid (gaba) in the spinal dorsal horn. |
2009-10-23 |
2023-08-12 |
mouse |