| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bingbing Song, Wenling Chen, Juan Carlos G Marvizó. Inhibition of opioid release in the rat spinal cord by serotonin 5-HT(1A) receptors. Brain research. vol 1158. 2007-10-12. PMID:17555728. |
these results show that 5-ht(1a) receptors inhibit opioid release in the spinal dorsal horn, probably from a subpopulation of enkephalin-containing presynaptic terminals. |
2007-10-12 |
2023-08-12 |
rat |
| Yan Lu, Edward R Per. Selective action of noradrenaline and serotonin on neurones of the spinal superficial dorsal horn in the rat. The Journal of physiology. vol 582. issue Pt 1. 2007-08-09. PMID:17463043. |
selective action of noradrenaline and serotonin on neurones of the spinal superficial dorsal horn in the rat. |
2007-08-09 |
2023-08-12 |
rat |
| Feng-Yu Liu, Guo-Gang Xing, Xiao-Xiu Qu, Isabella S Xu, Ji-Sheng Han, You Wa. Roles of 5-hydroxytryptamine (5-HT) receptor subtypes in the inhibitory effects of 5-HT on C-fiber responses of spinal wide dynamic range neurons in rats. The Journal of pharmacology and experimental therapeutics. vol 321. issue 3. 2007-07-30. PMID:17329553. |
these results suggest that, under basal conditions, there is no tonic serotonergic inhibition on the c-responses of dorsal horn neurons, and multiple 5-ht receptor subtypes including 1b, 2a, 2c, 3, and 4 may be involved in mediating the inhibitory effects of 5-ht. |
2007-07-30 |
2023-08-12 |
rat |
| Hideaki Obata, Naomi Ito, Masayuki Sasaki, Shigeru Saito, Fumio Got. Possible involvement of spinal noradrenergic mechanisms in the antiallodynic effect of intrathecally administered 5-HT2C receptor agonists in the rats with peripheral nerve injury. European journal of pharmacology. vol 567. issue 1-2. 2007-07-27. PMID:17451674. |
taken together, these findings suggest that 5-ht(2a) and 5-ht(2c) receptors in the dorsal horn of the spinal cord might be involved in alleviating neuropathic pain by different mechanisms. |
2007-07-27 |
2023-08-12 |
rat |
| David W Hampton, John D Steeves, James W Fawcett, Matt S Rame. Spinally upregulated noggin suppresses axonal and dendritic plasticity following dorsal rhizotomy. Experimental neurology. vol 204. issue 1. 2007-05-10. PMID:17258709. |
in the deafferented dorsal horn, noggin-fbab treatment induced significant increases in the density of sp, calcitonin gene-related peptide (cgrp)- and 5-hydroxytryptamine (5-ht)-positive axons. |
2007-05-10 |
2023-08-12 |
Not clear |
| Camilla I Svensson, Thao K Tran, Bethany Fitzsimmons, Tony L Yaksh, Xiao-Ying Hu. Descending serotonergic facilitation of spinal ERK activation and pain behavior. FEBS letters. vol 580. issue 28-29. 2007-01-19. PMID:17113581. |
serotonin (5-ht) derived from bulbo-spinal projection is released by nociceptive input into the spinal dorsal horn. |
2007-01-19 |
2023-08-12 |
rat |
| José A Lopez-Garci. Serotonergic modulation of spinal sensory circuits. Current topics in medicinal chemistry. vol 6. issue 18. 2006-11-30. PMID:17017969. |
according to these reports, 5-ht triggers depressant effects on synaptic transmission limiting the release of neurotransmitters from afferent terminals or the responsiveness of nmda receptors located in dorsal horn neurones. |
2006-11-30 |
2023-08-12 |
Not clear |
| Hajime Tanaka, Satoshi Amamiya, Nao Miura, Akiko Araki, Junko Ohinata, Kenji Fujied. Postnatal development of brainstem serotonin-containing neurons projecting to lumbar spinal cord in rats. Brain & development. vol 28. issue 9. 2006-11-28. PMID:16730936. |
previous studies have shown that the 5-ht neurons in b3 send fibers mainly to the dorsal horn, while those in b1 and b2 send fibers mainly to the ventral horn at all spinal cord levels. |
2006-11-28 |
2023-08-12 |
rat |
| Hajime Tanaka, Satoshi Amamiya, Nao Miura, Akiko Araki, Junko Ohinata, Kenji Fujied. Postnatal development of brainstem serotonin-containing neurons projecting to lumbar spinal cord in rats. Brain & development. vol 28. issue 9. 2006-11-28. PMID:16730936. |
taken together, the present findings suggest that the brainstem 5-ht systems influence the ventral horn of the spinal cord, where spinal motoneurons exist earlier than in the dorsal horn. |
2006-11-28 |
2023-08-12 |
rat |
| Xuejiao Chen, Feihong Bing, Peifang Dai, Yanguo Hon. Involvement of protein kinase C in 5-HT-evoked thermal hyperalgesia and spinal fos protein expression in the rat. Pharmacology, biochemistry, and behavior. vol 84. issue 1. 2006-10-02. PMID:16730785. |
5-ht and alpha-m-5-ht also evoked numerous expressions of c-fos-like immunoreactivity (c-fos-li) in the ipsilateral dorsal horn (predominantly laminae i-ii) of the lumbar spinal cord. |
2006-10-02 |
2023-08-12 |
rat |
| Wahida Rahman, Rie Suzuki, Mark Webber, Stephen P Hunt, Anthony H Dickenso. Depletion of endogenous spinal 5-HT attenuates the behavioural hypersensitivity to mechanical and cooling stimuli induced by spinal nerve ligation. Pain. vol 123. issue 3. 2006-08-09. PMID:16644129. |
we previously demonstrated that neuropathic pain is associated with an enhanced descending facilitatory drive onto the mechanical evoked responses of dorsal horn neurones, mediated by 5-ht acting at spinal 5-ht3 receptors. |
2006-08-09 |
2023-08-12 |
Not clear |
| Wahida Rahman, Rie Suzuki, Mark Webber, Stephen P Hunt, Anthony H Dickenso. Depletion of endogenous spinal 5-HT attenuates the behavioural hypersensitivity to mechanical and cooling stimuli induced by spinal nerve ligation. Pain. vol 123. issue 3. 2006-08-09. PMID:16644129. |
depletion of spinal 5-ht in normal animals leads to reductions in mechanical and thermal evoked responses of deep dorsal horn neurones implying that spinal 5-ht has a predominant facilitatory function. |
2006-08-09 |
2023-08-12 |
Not clear |
| N J Langman, C G S Smith, K J Whitehea. Selective serotonin re-uptake inhibition attenuates evoked glutamate release in the dorsal horn of the anaesthetised rat in vivo. Pharmacological research. vol 53. issue 2. 2006-02-27. PMID:16280247. |
selective serotonin re-uptake inhibition attenuates evoked glutamate release in the dorsal horn of the anaesthetised rat in vivo. |
2006-02-27 |
2023-08-12 |
rat |
| Rie Suzuki, Wahida Rahman, Lars J Rygh, Mark Webber, Stephen P Hunt, Anthony H Dickenso. Spinal-supraspinal serotonergic circuits regulating neuropathic pain and its treatment with gabapentin. Pain. vol 117. issue 3. 2006-01-25. PMID:16150546. |
substance p-saporin (sp-sap) was used to selectively ablate superficial dorsal horn neurons expressing the neurokinin-1 receptor for substance p. these neurons project to the brain as shown by retrograde labelling and engage descending brainstem serotonergic influences that enhance spinal excitability via a facilitatory action on 5ht(3) receptors. |
2006-01-25 |
2023-08-12 |
Not clear |
| J E Holden, E Naleway Farah, Y Jeon. Stimulation of the lateral hypothalamus produces antinociception mediated by 5-HT1A, 5-HT1B and 5-HT3 receptors in the rat spinal cord dorsal horn. Neuroscience. vol 135. issue 4. 2006-01-11. PMID:16165284. |
these results suggest that the lateral hypothalamus modifies nociception in part by activating spinally projecting serotonin neurons that act at 5-ht1a, 5-ht1b, and 5-ht3 receptors in the dorsal horn. |
2006-01-11 |
2023-08-12 |
rat |
| D Conte, E D Legg, A C McCourt, E Silajdzic, G G Nagy, D J Maxwel. Transmitter content, origins and connections of axons in the spinal cord that possess the serotonin (5-hydroxytryptamine) 3 receptor. Neuroscience. vol 134. issue 1. 2005-12-02. PMID:15975728. |
3) what is the chemical nature of dorsal horn cells that possess 5-ht(3) receptors? |
2005-12-02 |
2023-08-12 |
Not clear |
| D Conte, E D Legg, A C McCourt, E Silajdzic, G G Nagy, D J Maxwel. Transmitter content, origins and connections of axons in the spinal cord that possess the serotonin (5-hydroxytryptamine) 3 receptor. Neuroscience. vol 134. issue 1. 2005-12-02. PMID:15975728. |
the results suggest that 5-ht(3) receptors are present principally on terminals of excitatory axons, and at least some of these originate from dorsal horn interneurons. |
2005-12-02 |
2023-08-12 |
Not clear |
| Veronique G J M Vanderhorst, Jan-Ake Gustafsson, Brun Ulfhak. Estrogen receptor-alpha and -beta immunoreactive neurons in the brainstem and spinal cord of male and female mice: relationships to monoaminergic, cholinergic, and spinal projection systems. The Journal of comparative neurology. vol 488. issue 2. 2005-08-30. PMID:15924341. |
fibers ir for vesicular acetylcholine transporter (vacht), th, and 5ht were located among er-alpha-ir neurons in the dorsal horn and spinal autonomic regions. |
2005-08-30 |
2023-08-12 |
mouse |
| Kimberly J Dougherty, B Anne Bannatyne, Elzbieta Jankowska, Piotr Krutki, David J Maxwel. Membrane receptors involved in modulation of responses of spinal dorsal horn interneurons evoked by feline group II muscle afferents. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 3. 2005-08-18. PMID:15659594. |
modulatory actions of a metabotropic 5-ht1a&7 membrane receptor agonist and antagonist [(+/-)-8-hydroxy-2-(di-n-propylamino)-tetralin; n-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-n-(2-pyridinyl) cyclohexane-carboxamide] and an ionotropic 5-ht3 membrane receptor agonist and antagonist [2-methyl-serotonin (2-me 5-ht); n-(1-azabicyclo[2.2.2]oct-3-yl)-6-chloro-4-methyl-3-oxo-3,4-dihydro-2h-1,4-benzoxazine-8-carboxamide hydrochloride] were investigated on dorsal horn interneurons mediating reflex actions of group ii muscle afferents. |
2005-08-18 |
2023-08-12 |
Not clear |
| Kimberly J Dougherty, B Anne Bannatyne, Elzbieta Jankowska, Piotr Krutki, David J Maxwel. Membrane receptors involved in modulation of responses of spinal dorsal horn interneurons evoked by feline group II muscle afferents. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 3. 2005-08-18. PMID:15659594. |
the relationship between 5-ht axons and axons immunoreactive for the 5-ht3a receptor subunit, which contact dorsal horn interneurons, was analyzed using immunofluorescence and confocal microscopy. |
2005-08-18 |
2023-08-12 |
Not clear |