| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhengshi Yang, Jefferson W Kinney, Dietmar Cordes, The Alzheimer's Disease Neuroimaging Initiativ. Uptake of 18F-AV45 in the Putamen Provides Additional Insights into Alzheimer's Disease beyond the Cortex. Biomolecules. vol 14. issue 2. 2024-02-24. PMID:38397394. |
cortical uptake in brain amyloid positron emission tomography (pet) is increasingly used for the biological diagnosis of alzheimer's disease (ad); however, the clinical and biological relevance of the striatum beyond the cortex in amyloid pet scans remains unclear. |
2024-02-24 |
2024-02-26 |
human |
| Lucia Aa Giannini, Merel O Mol, Ana Rajicic, Renee van Buuren, Lana Sarkar, Sanaz Arezoumandan, Daniel T Ohm, David J Irwin, Annemieke Jm Rozemuller, John C van Swieten, Harro Seelaa. Presymptomatic and early pathological features of MAPT-associated frontotemporal lobar degeneration. Acta neuropathologica communications. vol 11. issue 1. 2023-08-02. PMID:37533060. |
the 68-year-old presymptomatic l315r carrier (ftld-cdr = 0) had limited tau burden morphologically similar to l315r end-stage carriers in middle frontal, antero-inferior temporal, amygdala, (para-)hippocampus and striatum, along with age-related alzheimer's disease neuropathological change. |
2023-08-02 |
2023-08-14 |
Not clear |
| Livia La Barbera, Marcello D'Ameli. Alzheimer's Disease and Sex-Dependent Alterations in the Striatum: A Lesson from a Mouse Model. Journal of Alzheimer's disease : JAD. 2023-07-31. PMID:37522213. |
alzheimer's disease and sex-dependent alterations in the striatum: a lesson from a mouse model. |
2023-07-31 |
2023-08-14 |
mouse |
| Hao Chen, Yajie Li, Jingwen Gao, Qi Cheng, Lei Liu, Rong Ca. Activation of Pgk1 Results in Reduced Protein Aggregation in Diverse Neurodegenerative Conditions. Molecular neurobiology. 2023-05-30. PMID:37249790. |
through in vivo studies, we examined neuron-specific overexpression of tau in drosophila, mouse models of app/ps1 alzheimer's disease (ad), and a rat model of multiple system atrophy (msa) via the viral expression of α-synuclein in the striatum. |
2023-05-30 |
2023-08-14 |
mouse |
| Li Liu, Shaozhen Yan, Min Chu, Binbin Nie, Kexin Xie, Yue Cui, Deming Jiang, Zhongyun Chen, Haitian Nan, Pedro Rosa-Neto, Jie Lu, Liyong W. Involvement of specific striatal subregion contributes to executive deficits in Alzheimer disease. Journal of psychiatry & neuroscience : JPN. vol 48. issue 2. 2023-04-12. PMID:37045477. |
however, it remains unclear whether and how the striatum contributes specifically to executive deficits in alzheimer disease (ad). |
2023-04-12 |
2023-08-14 |
Not clear |
| Ji Eun Kim, Dong-Kyun Lee, Ji Hye Hwang, Chan-Mi Kim, Yeji Kim, Jae-Hong Lee, Jong-Min Lee, Jee Hoon Ro. Regional Comparison of Imaging Biomarkers in the Striatum between Early- and Late-onset Alzheimer's Disease. Experimental neurobiology. vol 31. issue 6. 2023-01-11. PMID:36631848. |
regional comparison of imaging biomarkers in the striatum between early- and late-onset alzheimer's disease. |
2023-01-11 |
2023-08-14 |
human |
| Tae Kyoo Kim, Sangjoon Lee, Heh-In I. Quantitative Sequencing Analysis of the Striatal Transcriptome in a Mouse Model of Alzheimer Disease. International neurourology journal. vol 26. issue Suppl 2. 2022-12-12. PMID:36503214. |
the purpose of this study was to analyze the transcriptomic changes in the striatum of amyloid precursor protein/presenilin 1 (app/ps1) transgenic mice and uncover its association with the methyl-cpg binding protein 2 (mecp2) mediated-changes in striatal epigenetic signature during alzheimer disease (ad) pathological progression. |
2022-12-12 |
2023-08-14 |
mouse |
| Brittany N Dugger, Geidy E Serrano, Lucia I Sue, Douglas G Walker, Charles H Adler, Holly A Shill, Marwan N Sabbagh, John N Caviness, Jose Hidalgo, Megan Saxon-Labelle, Glenn Chiarolanza, Monica Mariner, Jonette Henry-Watson, Thomas G Beac. Presence of Striatal Amyloid Plaques in Parkinson's Disease Dementia Predicts Concomitant Alzheimer's Disease: Usefulness for Amyloid Imaging. Journal of Parkinson's disease. vol 2. issue 1. 2021-10-21. PMID:22924088. |
the spread of amyloid plaques to the striatum has been reported to be a sensitive and specific indicator of dementia due to alzheimer's disease (ad). |
2021-10-21 |
2023-08-12 |
human |
| Qi Qin, Liping Fu, Ruimin Wang, Jihui Lyu, Huixuan Ma, Minmin Zhan, Aihong Zhou, Fen Wang, Xiumei Zuo, Cuibai We. Prominent Striatum Amyloid Retention in Early-Onset Familial Alzheimer's Disease With PSEN1 Mutations: A Pilot PET/MR Study. Frontiers in aging neuroscience. vol 13. 2021-10-05. PMID:34603009. |
prominent striatum amyloid retention in early-onset familial alzheimer's disease with psen1 mutations: a pilot pet/mr study. |
2021-10-05 |
2023-08-13 |
Not clear |
| Santosh R D'Mell. When Good Kinases Go Rogue: GSK3, p38 MAPK and CDKs as Therapeutic Targets for Alzheimer's and Huntington's Disease. International journal of molecular sciences. vol 22. issue 11. 2021-06-23. PMID:34072862. |
alzheimer's disease (ad) is a mostly sporadic brain disorder characterized by cognitive decline resulting from selective neurodegeneration in the hippocampus and cerebral cortex whereas huntington's disease (hd) is a monogenic inherited disorder characterized by motor abnormalities and psychiatric disturbances resulting from selective neurodegeneration in the striatum. |
2021-06-23 |
2023-08-13 |
Not clear |
| Yuksel Caki. Hybrid modeling of alpha rhythm and the amplitude of low-frequency fluctuations abnormalities in the thalamocortical region and basal ganglia in Alzheimer's disease. The European journal of neuroscience. vol 52. issue 2. 2021-06-21. PMID:31887242. |
a hybrid computational model of thalamocortical circuitry and basal ganglia is proposed to investigate the relation between the fractional amplitude of low-frequency fluctuations (falff) in the resting-state functional magnetic resonance imaging (rs-fmri) in the striatum and electroencephalogram (eeg) changes within the alpha frequency bands in thalamic region in the case of alzheimer's disease (ad). |
2021-06-21 |
2023-08-13 |
Not clear |
| Milos D Ikonomovic, Christopher J Buckley, Eric E Abrahamson, Julia K Kofler, Chester A Mathis, William E Klunk, Gill Farra. Post-mortem analyses of PiB and flutemetamol in diffuse and cored amyloid-β plaques in Alzheimer's disease. Acta neuropathologica. vol 140. issue 4. 2021-05-31. PMID:32772265. |
however, imaging-to-autopsy validation studies of amyloid pet radioligands have identified several false positive cases all of which had mainly diffuse aβ plaques (i.e., plaques without neuritic pathology or dense amyloid core), and high amyloid pet signal was reported in the striatum where diffuse plaques predominate in alzheimer's disease (ad). |
2021-05-31 |
2023-08-13 |
Not clear |
| Won-Jun Jang, Taekwon Son, Sang-Hoon Song, In Soo Ryu, Sooyeun Lee, Chul-Ho Jeon. Transcriptional Profiling of Whisker Follicles and of the Striatum in Methamphetamine Self-Administered Rats. International journal of molecular sciences. vol 21. issue 22. 2021-03-03. PMID:33238484. |
statistically significant degs were found to belong to the classes of genes involved in nicotine addiction, cocaine addiction, and amphetamine addiction in the striatum as well as in parkinson's, huntington's, and alzheimer's diseases in whisker follicles. |
2021-03-03 |
2023-08-13 |
rat |
| Wei-Ti Hsu, Yi-Hung Chen, Han-Bin Yang, Jaung-Geng Lin, Shih-Ya Hun. Electroacupuncture Improves Motor Symptoms of Parkinson's Disease and Promotes Neuronal Autophagy Activity in Mouse Brain. The American journal of Chinese medicine. vol 48. issue 7. 2021-02-09. PMID:33202151. |
we report that ea improves pd motor symptoms in mice and enhances (1) autophagy initiation (increased beclin 1), (2) autophagosome biogenesis (increased atg5, atg7, atg9a, atg12, atg16l, atg3, and lc3-ii), (3) autophagy flux/substrate degradation (decreased p62), and (4) mitophagy (increased pink1 and dj-1) in neurons of the substantia nigra, striatum, hippocampus, and cortex (affected brain areas of pd, huntington disease, and alzheimer's disease). |
2021-02-09 |
2023-08-13 |
mouse |
| Meina Quan, Tan Zhao, Yi Tang, Ping Luo, Wei Wang, Qi Qin, Tingting Li, Qigeng Wang, Jiliang Fang, Jianping Ji. Effects of gene mutation and disease progression on representative neural circuits in familial Alzheimer's disease. Alzheimer's research & therapy. vol 12. issue 1. 2021-01-11. PMID:31937364. |
although structural and functional changes of the striatum and hippocampus are present in familial alzheimer's disease, little is known about the effects of specific gene mutation or disease progression on their related neural circuits. |
2021-01-11 |
2023-08-13 |
Not clear |
| Kathryn L Van Pelt, Lisa Koehl, Allison Caban-Holt, Amelia Anderson-Mooney, Elizabeth Head, Frederick A Schmit. Feasibility of dual-task gait to estimate Alzheimer's related cognitive decline in Down syndrome. Alzheimer's & dementia (Amsterdam, Netherlands). vol 12. issue 1. 2020-11-30. PMID:32875058. |
the striatum and frontal lobes have been shown to have early alzheimer's disease (ad) neuropathology and are critical for motor and cognitive function. |
2020-11-30 |
2023-08-13 |
Not clear |
| Yoo Hyun Um, Woo Hee Choi, Won Sang Jung, Young Ha Park, Chang-Uk Lee, Hyun Kook Li. A Case Report of a 37-Year-Old Alzheimer's Disease Patient with Prominent Striatum Amyloid Retention. Psychiatry investigation. vol 14. issue 4. 2020-09-29. PMID:28845182. |
a case report of a 37-year-old alzheimer's disease patient with prominent striatum amyloid retention. |
2020-09-29 |
2023-08-13 |
Not clear |
| Meguro, Yamaguchi, Shimada, Itoh, Yamador. Striatal dopaminergic transmission and neocortical glucose utilization in Alzheimer's disease: a triple-tracer positron emission tomography study. Archives of gerontology and geriatrics. vol 31. issue 2. 2019-11-20. PMID:11090909. |
for alzheimer's disease (ad), using pet and the ligands of dopa, d2 receptor antagonist, and deoxyglucose, we previously found that dopa uptake into the striatum (the ki value) was correlated with the mini-mental state (mms) score. |
2019-11-20 |
2023-08-12 |
human |
| Chiung-Chih Chang, Shih-Jen Tsai, Nai-Ching Chen, Chi-Wei Huang, Shih-Wei Hsu, Ya-Ting Chang, Mu-En Liu, Wen-Neng Chang, Wan-Chen Tsai, Chen-Chang Le. Catechol-O-Methyltransferase Val158Met Polymorphism on Striatum Structural Covariance Networks in Alzheimer's Disease. Molecular neurobiology. vol 55. issue 6. 2019-02-26. PMID:28707072. |
catechol-o-methyltransferase val158met polymorphism on striatum structural covariance networks in alzheimer's disease. |
2019-02-26 |
2023-08-13 |
human |
| Douglas W Scharre, Emily Weichart, Dylan Nielson, Jun Zhang, Punit Agrawal, Per B Sederberg, Michael V Knopp, Ali R Reza. Deep Brain Stimulation of Frontal Lobe Networks to Treat Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 62. issue 2. 2019-02-08. PMID:29400666. |
the study objective was to evaluate the safety and efficacy of deep brain stimulation (dbs) at the ventral capsule/ventral striatum (vc/vs) region to specifically modulate frontal lobe behavioral and cognitive networks as a novel treatment approach for alzheimer's disease (ad) patients. |
2019-02-08 |
2023-08-13 |
human |