| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Laura W de Jong, Luca Ferrarini, Jeroen van der Grond, Julien R Milles, Johan H C Reiber, Rudi G J Westendorp, Edward L E M Bollen, Huub A M Middelkoop, Mark A van Buche. Shape abnormalities of the striatum in Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 23. issue 1. 2011-05-05. PMID:20930298. |
postmortem studies show pathological changes in the striatum in alzheimer's disease (ad). |
2011-05-05 |
2023-08-12 |
Not clear |
| Sheng Chen, Philip Seeman, Fang Li. Antipsychotic drug binding in the substantia nigra: an examination of high metoclopramide binding in the brains of normal, Alzheimer's disease, Huntington's disease, and Multiple Sclerosis patients, and its relation to tardive dyskinesia. Synapse (New York, N.Y.). vol 65. issue 2. 2011-04-01. PMID:20524177. |
using rat striatum as baseline to define antipsychotic binding to nonnigral tissue, the excess amount of binding to the alzheimer nigral tissue under clinical conditions would be 209, 19, 0, 3.4 and 0.8 fmole/mg for metoclopramide, clozapine, raclopride, haloperidol, and olanzapine, respectively, with a similar pattern for nigral tissues from huntington and multiple sclerosis patients. |
2011-04-01 |
2023-08-12 |
human |
| Jinte Middeldorp, Simone A van den Berge, Eleonora Aronica, Dave Speijer, Elly M Ho. Specific human astrocyte subtype revealed by affinity purified GFAP antibody; unpurified serum cross-reacts with neurofilament-L in Alzheimer. PloS one. vol 4. issue 11. 2010-04-26. PMID:19888461. |
these large astrocytes are present throughout the brain, e.g., along the subventricular zone, in the hippocampus, in the striatum and in the spinal cord of controls, alzheimer, and parkinson patients. |
2010-04-26 |
2023-08-12 |
human |
| Gil D Rabinovici, Ansgar J Furst, Adi Alkalay, Caroline A Racine, James P O'Neil, Mustafa Janabi, Suzanne L Baker, Neha Agarwal, Stephen J Bonasera, Elizabeth C Mormino, Michael W Weiner, Maria L Gorno-Tempini, Howard J Rosen, Bruce L Miller, William J Jagus. Increased metabolic vulnerability in early-onset Alzheimer's disease is not related to amyloid burden. Brain : a journal of neurology. vol 133. issue Pt 2. 2010-03-16. PMID:20080878. |
compared to normal controls, both early-onset and late-onset alzheimer's disease patient groups showed increased [(11)c]-labelled pittsburgh compound-b uptake throughout frontal, parietal and lateral temporal cortices and striatum on voxel-wise and region of interest comparisons (p < 0.05). |
2010-03-16 |
2023-08-12 |
Not clear |
| Tatsurou Yagami, Yukio Takahara, Chiyomi Ishibashi, Gaku Sakaguchi, Naohiro Itoh, Keiichi Ueda, Hitoshi Nakazato, Noboru Okamura, Yoshiharu Hiramatsu, Tsunetoshi Honma, Akinori Arimura, Toshiyuki Sakaeda, Goro Katsuur. Amyloid beta protein impairs motor function via thromboxane A2 in the rat striatum. Neurobiology of disease. vol 16. issue 3. 2004-09-24. PMID:15262259. |
amyloid beta protein (abeta) deposits are found in the striatum of patients with alzheimer disease (ad) showing extrapyramidal motor dysfunction, but neuronal cell loss has not yet been detected. |
2004-09-24 |
2023-08-12 |
rat |
| M Schumacher, S Weill-Engerer, P Liere, F Robert, R J M Franklin, L M Garcia-Segura, J J Lambert, W Mayo, R C Melcangi, A Parducz, U Suter, C Carelli, E E Baulieu, Y Akw. Steroid hormones and neurosteroids in normal and pathological aging of the nervous system. Progress in neurobiology. vol 71. issue 1. 2004-01-16. PMID:14611864. |
the conversion of dehydroepiandrosterone to delta5-androstene-3beta,17beta-diol and to 7alpha-oh-dehydroepiandrosterone occurred in frontal cortex, hippocampus, amygdala, cerebellum and striatum of both alzheimer's patients and controls. |
2004-01-16 |
2023-08-12 |
human |
| Zhong Xie, Todd E Morgan, Irina Rozovsky, Caleb E Finc. Aging and glial responses to lipopolysaccharide in vitro: greater induction of IL-1 and IL-6, but smaller induction of neurotoxicity. Experimental neurology. vol 182. issue 1. 2003-08-06. PMID:12821383. |
mixed glia from f344 male rats, aged 3 and 24 months, cultured from cerebral cortex (cx), hippocampus (hc), and striatum (st), were assayed for cytokines implicated in alzheimer's disease: il-1alpha, il-1beta, il-6, and tnf-alpha. |
2003-08-06 |
2023-08-12 |
rat |
| E Anthony Jone. Ammonia, the GABA neurotransmitter system, and hepatic encephalopathy. Metabolic brain disease. vol 17. issue 4. 2003-07-03. PMID:12602504. |
tetrahydroprogesterone and tetrahydrodeoxycorticosterone levels were found to be increased in a mouse model of acute liver failure, and, when thp or thdoc was injected into normal mice, sedation and alzheimer type ii astrocytic changes in the cortex, striatum, and hypothalmus were induced. |
2003-07-03 |
2023-08-12 |
mouse |
| Sébastien Weill-Engerer, Jean Philippe David, Véronique Sazdovitch, Philippe Liere, Michael Schumacher, André Delacourte, Etienne Emile Baulieu, Yvette Akw. In vitro metabolism of dehydroepiandrosterone (DHEA) to 7alpha-hydroxy-DHEA and Delta5-androstene-3beta,17beta-diol in specific regions of the aging brain from Alzheimer's and non-demented patients. Brain research. vol 969. issue 1-2. 2003-07-02. PMID:12676372. |
under our experimental conditions, the synthesis of 7alpha-hydroxy-dhea and delta5-androstene-3beta,17beta-diol occurs in the frontal cortex, hippocampus, amygdala, cerebellum and striatum of both alzheimer's patients and non-demented controls. |
2003-07-02 |
2023-08-12 |
human |
| Yan Shen, Yi Yu, Hong Guo, Zhongshu Tang, Fu-Shin X Yu, Jiawei Zho. Identification and comparative analysis of differentially expressed proteins in rat striatum following 6-hydroxydopamine lesions of the nigrostriatal pathway: up-regulation of amyloid precursor-like protein 2 expression. The European journal of neuroscience. vol 16. issue 5. 2002-12-09. PMID:12372026. |
these results suggest that the expression of aplp2, a protein that has been thought to be associated with alzheimer's disease, is up-regulated in the striatum following dopaminergic denervation. |
2002-12-09 |
2023-08-12 |
rat |
| Sébastien Weill-Engerer, Jean-Philippe David, Véronique Sazdovitch, Philippe Liere, Bernard Eychenne, Antoine Pianos, Michael Schumacher, André Delacourte, Etienne-Emile Baulieu, Yvette Akw. Neurosteroid quantification in human brain regions: comparison between Alzheimer's and nondemented patients. The Journal of clinical endocrinology and metabolism. vol 87. issue 11. 2002-12-09. PMID:12414884. |
to investigate the physiopathological significance of neurosteroids in alzheimer's disease (ad), we compared the concentrations of pregnenolone, pregnenolone sulfate (pregs), dehydroepiandrosterone, dehydroepiandrosterone sulfate (dheas), progesterone, and allopregnanolone, measured by gas chromatography-mass spectrometry, in individual brain regions of ad patients and aged nondemented controls, including hippocampus, amygdala, frontal cortex, striatum, hypothalamus, and cerebellum. |
2002-12-09 |
2023-08-12 |
human |
| Masahiko Suzuki, Timothy J Desmond, Roger L Albin, Kirk A Fre. Striatal monoaminergic terminals in Lewy body and Alzheimer's dementias. Annals of neurology. vol 51. issue 6. 2002-08-09. PMID:12112084. |
vesicular monoamine transporter type 2 and benzodiazepine binding site expressions were each preserved in alzheimer's disease striatum. |
2002-08-09 |
2023-08-12 |
human |
| A Gjedd. [Receptor mapping in living human beings by means of positron emission tomography]. Ugeskrift for laeger. vol 163. issue 38. 2001-10-25. PMID:11577527. |
pet has revealed loss of dopaminergic terminals and dopamine synthetic capacity in parkinson's disease, mptp intoxication, and lesch-nyhan's syndrome; release of dopamine after administration of cocaine and amphetamine, and in motor activity and cognition; increased synaptic dopamine and release of dopamine, and the 70-90% neuroleptic occupancy of dopamine receptors in the striatum, in patients with schizophrenia; loss of muscarinic and nicotinergic receptors in alzheimer's disease, and benzodiazepine and opiate receptors in stroke, epilepsy, and huntington's chorea; altered opiate receptors in chronic pain and drug abuse; and release of opiates in analgesia; but changes in serotonin synthesis, transport, and binding in affective or psychotic disorders remain elusive. |
2001-10-25 |
2023-08-12 |
human |
| J Court, C Martin-Ruiz, M Piggott, D Spurden, M Griffiths, E Perr. Nicotinic receptor abnormalities in Alzheimer's disease. Biological psychiatry. vol 49. issue 3. 2001-06-07. PMID:11230868. |
in the striatum [(3)h]nicotine binding was reduced in alzheimer's disease, and although neuroleptic medication accentuated this change, it occurred in those free of neuroleptics. |
2001-06-07 |
2023-08-12 |
Not clear |
| E Hellström-Lindahl, J A Cour. Nicotinic acetylcholine receptors during prenatal development and brain pathology in human aging. Behavioural brain research. vol 113. issue 1-2. 2001-01-03. PMID:10942042. |
by contrast no loss in nachr binding with aging is observed in the thalamus and only after the 70th decade in the striatum, although in alzheimer's disease, parkinson's disease and lewy body dementia deficits in nachrs are observed in these areas and may be associated with specific disease-related processes. |
2001-01-03 |
2023-08-12 |
human |
| P Dubus, B Faucheux, F Boissière, A Groppi, C Vital, A Vital, Y Agid, E C Hirsch, J P Merli. Expression of Trk isoforms in brain regions and in the striatum of patients with Alzheimer's disease. Experimental neurology. vol 165. issue 2. 2000-10-26. PMID:10993689. |
expression of trk isoforms in brain regions and in the striatum of patients with alzheimer's disease. |
2000-10-26 |
2023-08-12 |
human |
| P Dubus, B Faucheux, F Boissière, A Groppi, C Vital, A Vital, Y Agid, E C Hirsch, J P Merli. Expression of Trk isoforms in brain regions and in the striatum of patients with Alzheimer's disease. Experimental neurology. vol 165. issue 2. 2000-10-26. PMID:10993689. |
thereafter, we studied the expression of trka isoforms in the striatum of five patients with alzheimer's disease (ad), four patients with non-ad dementia, seven patients with parkinson's disease, and six paired nondemented elderly control individuals. |
2000-10-26 |
2023-08-12 |
human |
| J A Court, M A Piggott, S Lloyd, N Cookson, C G Ballard, I G McKeith, R H Perry, E K Perr. Nicotine binding in human striatum: elevation in schizophrenia and reductions in dementia with Lewy bodies, Parkinson's disease and Alzheimer's disease and in relation to neuroleptic medication. Neuroscience. vol 98. issue 1. 2000-08-24. PMID:10858614. |
nicotine binding in human striatum: elevation in schizophrenia and reductions in dementia with lewy bodies, parkinson's disease and alzheimer's disease and in relation to neuroleptic medication. |
2000-08-24 |
2023-08-12 |
human |
| I Ferrer, R Blanc. N-myc and c-myc expression in Alzheimer disease, Huntington disease and Parkinson disease. Brain research. Molecular brain research. vol 77. issue 2. 2000-08-11. PMID:10837922. |
the present study examines n-myc and c-myc protein expression with western blotting and single and double-labeling immunohistochemistry in the hippocampus in alzheimer disease (ad), the striatum in huntington disease (hd) and the substantia nigra in parkinson disease (pd). |
2000-08-11 |
2023-08-12 |
human |
| E A Malecki, A G Devenyi, J L Beard, J R Conno. Existing and emerging mechanisms for transport of iron and manganese to the brain. Journal of neuroscience research. vol 56. issue 2. 2000-04-18. PMID:10777372. |
in addition, several neurological diseases such as alzheimer's disease, parkinson's disease, and huntington's disease are all associated with fe mismanagement in the brain, particularly in the striatum and basal ganglia. |
2000-04-18 |
2023-08-12 |
Not clear |