| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Michy P Kell. Cyclic nucleotide signaling changes associated with normal aging and age-related diseases of the brain. Cellular signalling. vol 42. 2018-07-18. PMID:29175000. |
among the most reproducible findings are 1) elevated circulating anp and bnp levels being associated with cognitive dysfunction or dementia independent of cardiovascular effects, 2) reduced basal and/or nmda-stimulated cgmp levels in brain with aging or alzheimer's disease (ad), 3) reduced adenylyl cyclase activity in hippocampus and specific cortical regions with aging or ad, 4) reduced expression/activity of pka in temporal cortex and hippocampus with ad, 5) reduced phosphorylation of creb in hippocampus with aging or ad, 6) reduced expression/activity of the pde4 family in brain with aging, 7) reduced expression of pde10a in the striatum with huntington's disease (hd) or parkinson's disease, and 8) beneficial effects of select pde inhibitors, particularly pde10 inhibitors in hd models and pde4 and pde5 inhibitors in aging and ad models. |
2018-07-18 |
2023-08-13 |
human |
| Gwenn S Smith, Frederick S Barrett, Jin Hui Joo, Najlla Nassery, Alena Savonenko, Devin J Sodums, Christopher M Marano, Cynthia A Munro, Jason Brandt, Michael A Kraut, Yun Zhou, Dean F Wong, Clifford I Workma. Molecular imaging of serotonin degeneration in mild cognitive impairment. Neurobiology of disease. vol 105. 2018-04-18. PMID:28511918. |
reduced serotonin transporter availability was observed in mild cognitive impairment compared to controls in cortical and limbic areas typically affected by alzheimer's disease pathology, as well as in sensory and motor areas, striatum and thalamus that are relatively spared in alzheimer's disease. |
2018-04-18 |
2023-08-13 |
human |
| Manon Thierry, Serge Marty, Susana Boluda, Charles Duyckaert. Alzheimer's senile plaque as shown by microcryodissection, a new technique for dissociating tissue structures. Journal of neural transmission (Vienna, Austria : 1996). vol 124. issue 6. 2018-03-20. PMID:28386671. |
samples of neocortex, hippocampus and striatum were taken from formalin-fixed brains (one control case; three cases with severe alzheimer disease). |
2018-03-20 |
2023-08-13 |
Not clear |
| Heikki Pentikäinen, Tiia Ngandu, Yawu Liu, Kai Savonen, Pirjo Komulainen, Merja Hallikainen, Miia Kivipelto, Rainer Rauramaa, Hilkka Soinine. Cardiorespiratory fitness and brain volumes in men and women in the FINGER study. Age and ageing. vol 46. issue 2. 2017-11-20. PMID:28064170. |
we investigated whether the association of crf with total grey matter (gm) and white matter volumes as well as medial temporal lobe and striatum volumes is different between men and women at increased risk for alzheimer's disease (ad). |
2017-11-20 |
2023-08-13 |
Not clear |
| Tiina Annus, Liam R Wilson, Julio Acosta-Cabronero, Arturo Cardenas-Blanco, Young T Hong, Tim D Fryer, Jonathan P Coles, David K Menon, Shahid H Zaman, Anthony J Holland, Peter J Nesto. The Down syndrome brain in the presence and absence of fibrillar β-amyloidosis. Neurobiology of aging. vol 53. 2017-11-16. PMID:28192686. |
in the presence of amyloid neuropathology, the ds brains demonstrated a strikingly similar pattern of posterior dominant cortical thinning and subcortical atrophy in the hippocampus, thalamus, and striatum, to that observed in non-ds alzheimer's disease. |
2017-11-16 |
2023-08-13 |
Not clear |
| Qingxi Zhang, Wanling Chen, Sheng Tan, Tongxiang Li. Stem Cells for Modeling and Therapy of Parkinson's Disease. Human gene therapy. vol 28. issue 1. 2017-08-23. PMID:27762639. |
parkinson's disease (pd) is the second most frequent neurodegenerative disease after alzheimer's disease, which is characterized by a low level of dopamine being expressing in the striatum and a deterioration of dopaminergic neurons (dan) in the substantia nigra pars compacta. |
2017-08-23 |
2023-08-13 |
human |
| Marta Fernández-Nogales, María Santos-Galindo, Jesús Merchán-Rubira, Jeroen J M Hoozemans, Alberto Rábano, Isidro Ferrer, Jesús Avila, Félix Hernández, José J Luca. Tau-positive nuclear indentations in P301S tauopathy mice. Brain pathology (Zurich, Switzerland). vol 27. issue 3. 2017-04-24. PMID:27338164. |
increased incidence of neuronal nuclear indentations is a well-known feature of the striatum of huntington's disease (hd) brains and, in alzheimer's disease (ad), neuronal nuclear indentations have recently been reported to correlate with neurotoxicity caused by improper cytoskeletal/nucleoskeletal coupling. |
2017-04-24 |
2023-08-13 |
mouse |
| Elena Rodriguez-Vieitez, Laure Saint-Aubert, Stephen F Carter, Ove Almkvist, Karim Farid, Michael Schöll, Konstantinos Chiotis, Steinunn Thordardottir, Caroline Graff, Anders Wall, Bengt Långström, Agneta Nordber. Diverging longitudinal changes in astrocytosis and amyloid PET in autosomal dominant Alzheimer's disease. Brain : a journal of neurology. vol 139. issue Pt 3. 2016-07-18. PMID:26813969. |
by using linear mixed-effects models, fibrillar amyloid-β plaque deposition was first observed in the striatum of presymptomatic autosomal dominant alzheimer's disease carriers from 17 years before expected symptom onset; at about the same time, astrocytosis was significantly elevated and then steadily declined. |
2016-07-18 |
2023-08-13 |
human |
| Maxime Bertoux, Claire O'Callaghan, Emma Flanagan, John R Hodges, Michael Hornberge. Fronto-Striatal Atrophy in Behavioral Variant Frontotemporal Dementia and Alzheimer's Disease. Frontiers in neurology. vol 6. 2015-07-20. PMID:26191038. |
behavioral variant frontotemporal dementia (bvftd) has only recently been associated with significant striatal atrophy, whereas the striatum appears to be relatively preserved in alzheimer's disease (ad). |
2015-07-20 |
2023-08-13 |
Not clear |
| Motoyasu Honma, Takeshi Kuroda, Akinori Futamura, Azusa Sugimoto, Mitsuru Kawamur. [Mental time dysfunction in Parkinson's and Alzheimer's diseases]. Brain and nerve = Shinkei kenkyu no shinpo. vol 67. issue 3. 2015-06-16. PMID:25846444. |
it is possible that the dysfunction of mental time in parkinson's disease is caused by the abnormal striatum acting as a pacemaker, while that in alzheimer's disease is caused by abnormal hippocampal memory. |
2015-06-16 |
2023-08-13 |
Not clear |
| Nazia Maroof, Srinivasarao Ravipati, Marie Christine Pardon, David A Barrett, David A Kendal. Reductions in endocannabinoid levels and enhanced coupling of cannabinoid receptors in the striatum are accompanied by cognitive impairments in the AβPPswe/PS1ΔE9 mouse model of Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 42. issue 1. 2015-05-11. PMID:24844690. |
reductions in endocannabinoid levels and enhanced coupling of cannabinoid receptors in the striatum are accompanied by cognitive impairments in the aβppswe/ps1Δe9 mouse model of alzheimer's disease. |
2015-05-11 |
2023-08-13 |
mouse |
| Hitoshi Shinoto. [Neuroimaging in corticobasal syndrome]. Rinsho shinkeigaku = Clinical neurology. vol 53. issue 11. 2015-04-13. PMID:24291869. |
in cbs due to frontotemporal lobar degeneration (ftld), atrophy extended into prefrontal cortex, striatum, and brainstem, whereas in cbs due to alzheimer's disease (ad), atrophy extended into temporoparietal cortex and precuneus.no functional imaging study in pathology-proven cbd or cbs with known histopathology has been published today. |
2015-04-13 |
2023-08-12 |
Not clear |
| Mitsuru Shinohara, Shinsuke Fujioka, Melissa E Murray, Aleksandra Wojtas, Matthew Baker, Anne Rovelet-Lecrux, Rosa Rademakers, Pritam Das, Joseph E Parisi, Neill R Graff-Radford, Ronald C Petersen, Dennis W Dickson, Guojun B. Regional distribution of synaptic markers and APP correlate with distinct clinicopathological features in sporadic and familial Alzheimer's disease. Brain : a journal of neurology. vol 137. issue Pt 5. 2014-06-09. PMID:24625695. |
recent studies suggest that subcortical structures, including striatum, are vulnerable to amyloid-β accumulation and other neuropathological features in familial alzheimer's disease due to autosomal dominant mutations. |
2014-06-09 |
2023-08-12 |
Not clear |
| Ching-Fen Jiang, Chiung-Chih Chang, Shu-Hua Huang, Chia-Hsiang W. Segmentation of the striatum from MR brain images to calculate the 99mTc-TRODAT-1 binding ratio in SPECT images. Computational and mathematical methods in medicine. vol 2013. 2014-01-21. PMID:23861724. |
quantification of regional (99m)tc-trodat-1 binding ratio in the striatum regions in spect images is essential for differential diagnosis between alzheimer's and parkinson's diseases. |
2014-01-21 |
2023-08-12 |
human |
| Michela Pievani, Martina Bocchetta, Marina Boccardi, Enrica Cavedo, Matteo Bonetti, Paul M Thompson, Giovanni B Frison. Striatal morphology in early-onset and late-onset Alzheimer's disease: a preliminary study. Neurobiology of aging. vol 34. issue 7. 2014-01-16. PMID:23428181. |
we investigated volume and shape changes in the striatum (caudate, putamen, and nucleus accumbens) of 18 early-onset (eoad) and 18 late-onset (load) alzheimer's disease patients compared with 2 control groups age- and sex-matched to each patient group, and explored the relationship between striatal atrophy and apolipoprotein e (apoe) genotype. |
2014-01-16 |
2023-08-12 |
Not clear |
| Jie Wu, Tingting Ding, Jiao Su. Neurotoxic potential of iron oxide nanoparticles in the rat brain striatum and hippocampus. Neurotoxicology. vol 34. 2013-07-09. PMID:22995439. |
the striatum and hippocampus are important structures in the brain and are associated with the development of parkinson's and alzheimer's diseases. |
2013-07-09 |
2023-08-12 |
rat |
| Natalie S Ryan, Shiva Keihaninejad, Timothy J Shakespeare, Manja Lehmann, Sebastian J Crutch, Ian B Malone, John S Thornton, Laura Mancini, Harpreet Hyare, Tarek Yousry, Gerard R Ridgway, Hui Zhang, Marc Modat, Daniel C Alexander, Martin N Rossor, Sebastien Ourselin, Nick C Fo. Magnetic resonance imaging evidence for presymptomatic change in thalamus and caudate in familial Alzheimer's disease. Brain : a journal of neurology. vol 136. issue Pt 5. 2013-06-24. PMID:23539189. |
amyloid imaging studies of presymptomatic familial alzheimer's disease have revealed the striatum and thalamus to be the earliest sites of amyloid deposition. |
2013-06-24 |
2023-08-12 |
human |
| Ross Zeitlin, Sagar Patel, Sarah Burgess, Gary W Arendash, Valentina Echeverri. Caffeine induces beneficial changes in PKA signaling and JNK and ERK activities in the striatum and cortex of Alzheimer's transgenic mice. Brain research. vol 1417. 2012-01-18. PMID:21907331. |
caffeine induces beneficial changes in pka signaling and jnk and erk activities in the striatum and cortex of alzheimer's transgenic mice. |
2012-01-18 |
2023-08-12 |
mouse |
| Taiki Kambe, Yumiko Motoi, Ran Inoue, Nobuhiko Kojima, Norihiro Tada, Tetsuya Kimura, Naruhiko Sahara, Shunji Yamashita, Tatsuya Mizoroki, Akihiko Takashima, Kohei Shimada, Koichi Ishiguro, Hiroshi Mizuma, Hirotaka Onoe, Yoshikuni Mizuno, Nobutaka Hattor. Differential regional distribution of phosphorylated tau and synapse loss in the nucleus accumbens in tauopathy model mice. Neurobiology of disease. vol 42. issue 3. 2011-08-23. PMID:21324362. |
in alzheimer's disease, basal forebrain and hippocampus are mainly involved, while frontotemporal lobar degeneration affects the frontal and temporal lobes and subcortical nuclei including striatum. |
2011-08-23 |
2023-08-12 |
mouse |
| Laura W de Jong, Luca Ferrarini, Jeroen van der Grond, Julien R Milles, Johan H C Reiber, Rudi G J Westendorp, Edward L E M Bollen, Huub A M Middelkoop, Mark A van Buche. Shape abnormalities of the striatum in Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 23. issue 1. 2011-05-05. PMID:20930298. |
shape abnormalities of the striatum in alzheimer's disease. |
2011-05-05 |
2023-08-12 |
Not clear |