| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Miriam Matamales, Alice E McGovern, Jia Dai Mi, Stuart B Mazzone, Bernard W Balleine, Jesus Bertran-Gonzale. Local D2- to D1-neuron transmodulation updates goal-directed learning in the striatum. Science (New York, N.Y.). vol 367. issue 6477. 2020-04-08. PMID:32001651. |
local d2- to d1-neuron transmodulation updates goal-directed learning in the striatum. |
2020-04-08 |
2023-08-13 |
mouse |
| Miriam Matamales, Alice E McGovern, Jia Dai Mi, Stuart B Mazzone, Bernard W Balleine, Jesus Bertran-Gonzale. Local D2- to D1-neuron transmodulation updates goal-directed learning in the striatum. Science (New York, N.Y.). vol 367. issue 6477. 2020-04-08. PMID:32001651. |
although such learning is thought to depend on dopamine signals in the striatum, the way the circuits that mediate goal-directed control are reorganized during new learning remains unknown. |
2020-04-08 |
2023-08-13 |
mouse |
| Miriam Matamales, Alice E McGovern, Jia Dai Mi, Stuart B Mazzone, Bernard W Balleine, Jesus Bertran-Gonzale. Local D2- to D1-neuron transmodulation updates goal-directed learning in the striatum. Science (New York, N.Y.). vol 367. issue 6477. 2020-04-08. PMID:32001651. |
here, by mapping a dopamine-dependent transcriptional activation marker in large ensembles of spiny projection neurons (spns) expressing dopamine receptor type 1 (d1-spns) or 2 (d2-spns) in mice, we demonstrate an extensive and dynamic d2- to d1-spn transmodulation across the striatum that is necessary for updating previous goal-directed learning. |
2020-04-08 |
2023-08-13 |
mouse |
| Jacob A Nadel, Sean S Pawelko, Della Copes-Finke, Maya Neidhart, Christopher D Howar. Lesion of striatal patches disrupts habitual behaviors and increases behavioral variability. PloS one. vol 15. issue 1. 2020-03-31. PMID:31914121. |
habitual responding is thought to be mediated by the striatum, with medial striatum guiding goal-directed action and lateral striatum promoting habits. |
2020-03-31 |
2023-08-13 |
mouse |
| Jiayi Lu, Yifeng Cheng, Xuehua Wang, Kayla Woodson, Craig Kemper, Emily Disney, Jun Wan. Alcohol intake enhances glutamatergic transmission from D2 receptor-expressing afferents onto D1 receptor-expressing medium spiny neurons in the dorsomedial striatum. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 44. issue 6. 2019-12-20. PMID:30733568. |
this modulation is mainly mediated by dopamine d1 receptors (d1rs) and d2rs, which are highly expressed in medium spiny neurons (msns) of the dorsomedial striatum (dms), a brain region essential for goal-directed behaviors and addiction. |
2019-12-20 |
2023-08-13 |
mouse |
| Andre F Marquand, Koen V Haak, Christian F Beckman. Functional corticostriatal connection topographies predict goal directed behaviour in humans. Nature human behaviour. vol 1. issue 8. 2019-11-20. PMID:28804783. |
we show that striatal topography is preserved in regions not previously known to have topographic connections with the striatum and that many goal-directed behaviours can be mapped precisely onto individual variations in the spatial layout of striatal connectivity. |
2019-11-20 |
2023-08-13 |
human |
| Elizabeth G Pitts, Dan C Li, Shannon L Gourle. Bidirectional coordination of actions and habits by TrkB in mice. Scientific reports. vol 8. issue 1. 2019-09-30. PMID:29540698. |
for example, the orbitofrontal cortex and dorsomedial striatum are critical for goal-directed action, while the dorsolateral striatum supports habits. |
2019-09-30 |
2023-08-13 |
mouse |
| Laura A Bradfield, Genevra Hart, Bernard W Ballein. Inferring action-dependent outcome representations depends on anterior but not posterior medial orbitofrontal cortex. Neurobiology of learning and memory. vol 155. 2019-09-23. PMID:30243849. |
we first used retrograde tracing to compare the density of efferents from mofc to several structures known to contribute to goal-directed action: the mediodorsal thalamus, basolateral amygdala, posterior dorsomedial striatum, nucleus accumbens core and ventral tegmental area. |
2019-09-23 |
2023-08-13 |
rat |
| Teri M Furlong, Laura H Corbit, Robert A Brown, Bernard W Ballein. Methamphetamine promotes habitual action and alters the density of striatal glutamate receptor and vesicular proteins in dorsal striatum. Addiction biology. vol 23. issue 3. 2019-08-28. PMID:28707389. |
in the dorsomedial striatum, a structure critical for goal-directed action, meth exposure was associated with a reduction in glutamate receptor and glutamate vesicular proteins, whereas in the dorsolateral striatum, a region that has previously been implicated in habit learning, there was an increase in these proteins. |
2019-08-28 |
2023-08-13 |
Not clear |
| Elodie Perrin, Laurent Venanc. Bridging the gap between striatal plasticity and learning. Current opinion in neurobiology. vol 54. 2019-08-22. PMID:30321866. |
the striatum, the main input nucleus of the basal ganglia, controls goal-directed behavior and procedural learning. |
2019-08-22 |
2023-08-13 |
Not clear |
| Sten Grillne. The Enigmatic "Indirect Pathway" of the Basal Ganglia: A New Role. Neuron. vol 99. issue 6. 2019-07-25. PMID:30236279. |
goal-directed behavior is processed in the dorsomedial striatum. |
2019-07-25 |
2023-08-13 |
Not clear |
| Tengfei Ma, Yifeng Cheng, Emily Roltsch Hellard, Xuehua Wang, Jiayi Lu, Xinsheng Gao, Cathy C Y Huang, Xiao-Yan Wei, Jun-Yuan Ji, Jun Wan. Bidirectional and long-lasting control of alcohol-seeking behavior by corticostriatal LTP and LTD. Nature neuroscience. vol 21. issue 3. 2019-05-15. PMID:29434375. |
we first induced ltp by pairing presynaptic glutamatergic stimulation with optogenetic postsynaptic depolarization in the dorsomedial striatum, a brain region known to control goal-directed behavior. |
2019-05-15 |
2023-08-13 |
Not clear |
| Charlotte Prévost, Hakwan Lau, Dean Mobb. How the Brain Converts Negative Evaluation into Performance Facilitation. Cerebral cortex (New York, N.Y. : 1991). vol 28. issue 2. 2019-05-08. PMID:28057723. |
concurrent functional magnetic resonance imaging revealed that the motivating effect of negative evaluation was represented in the insula and striatum, while the performance boost was associated with functional positive connectivity between the insula and a set of brain regions involved in goal-directed behavior and the orienting of attention. |
2019-05-08 |
2023-08-13 |
human |
| Ina Filla, Matthew R Bailey, Elke Schipani, Vanessa Winiger, Chris Mezias, Peter D Balsam, Eleanor H Simpso. Striatal dopamine D2 receptors regulate effort but not value-based decision making and alter the dopaminergic encoding of cost. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 43. issue 11. 2019-03-11. PMID:30082890. |
we have previously shown that upregulated dopamine d2 receptor expression within the striatum (d2r-oe mice) decreases goal-directed motivation. |
2019-03-11 |
2023-08-13 |
mouse |
| Ina Filla, Matthew R Bailey, Elke Schipani, Vanessa Winiger, Chris Mezias, Peter D Balsam, Eleanor H Simpso. Striatal dopamine D2 receptors regulate effort but not value-based decision making and alter the dopaminergic encoding of cost. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 43. issue 11. 2019-03-11. PMID:30082890. |
this shift away from choosing to repeatedly execute a response is accompanied by a dampening of extracellular dopamine in the striatum during goal-directed behavior. |
2019-03-11 |
2023-08-13 |
mouse |
| Emma N Cahill, George H Vousden, Marc T J Exton-McGuinness, Ian R C Beh, Casey B Swerner, Matej Macak, Sameera Abas, Cameron C Cole, Brian F Kelleher, Barry J Everitt, Amy L Milto. Knockdown of zif268 in the Posterior Dorsolateral Striatum Does Not Enduringly Disrupt a Response Memory of a Rewarded T-Maze Task. Neuroscience. vol 370. 2019-02-21. PMID:28736133. |
our previous, preliminary data identified that there was an increase in zif268 in the posterior dorsolateral striatum (pdls) after expression of an instrumental habit-like 'response' memory, but not an instrumental goal-directed 'place' memory on a t-maze task. |
2019-02-21 |
2023-08-13 |
rat |
| Poornima Kumar, Franziska Goer, Laura Murray, Daniel G Dillon, Miranda L Beltzer, Andrew L Cohen, Nancy H Brooks, Diego A Pizzagall. Impaired reward prediction error encoding and striatal-midbrain connectivity in depression. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 43. issue 7. 2019-02-08. PMID:29540863. |
preclinical studies have clarified that ventral tegmental area (vta) neurons encode rpe and habenular neurons encode punishment prediction error (ppe), which are then transmitted to the striatum and cortex to guide goal-directed behavior. |
2019-02-08 |
2023-08-13 |
Not clear |
| Elodie Fino, Marie Vandecasteele, Sylvie Perez, Frédéric Saudou, Laurent Venanc. Region-specific and state-dependent action of striatal GABAergic interneurons. Nature communications. vol 9. issue 1. 2018-12-17. PMID:30131490. |
striatum processes a wide range of functions including goal-directed behavior and habit formation, respectively encoded by the dorsomedial striatum (dms) and dorsolateral striatum (dls). |
2018-12-17 |
2023-08-13 |
Not clear |
| Iku Tsutsui-Kimura, Hiroyuki Takiue, Keitaro Yoshida, Ming Xu, Ryutaro Yano, Hiroyuki Ohta, Hiroshi Nishida, Youcef Bouchekioua, Hideyuki Okano, Motokazu Uchigashima, Masahiko Watanabe, Norio Takata, Michael R Drew, Hiromi Sano, Masaru Mimura, Kenji F Tanak. Dysfunction of ventrolateral striatal dopamine receptor type 2-expressing medium spiny neurons impairs instrumental motivation. Nature communications. vol 8. 2018-11-26. PMID:28145402. |
using a progressive, time-controllable, diphtheria toxin-mediated cell ablation/dysfunction technique, we find that loss-of-function of d2-msns within ventrolateral striatum (vls) is sufficient to reduce goal-directed behaviours without impairing reward preference or spontaneous behaviour. |
2018-11-26 |
2023-08-13 |
Not clear |
| Samantha R Santacruz, Erin L Rich, Joni D Wallis, Jose M Carmen. Caudate Microstimulation Increases Value of Specific Choices. Current biology : CB. vol 27. issue 21. 2018-08-08. PMID:29107551. |
the basal ganglia are highly implicated in action selection and goal-directed behavior [1-4], and the striatum in particular plays a critical role in arbitrating between competing choices [5-9]. |
2018-08-08 |
2023-08-13 |
monkey |