| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chunying Guo, Ting Wang, Haiyan Huang, Xiaolu Wang, Yugui Jiang, Jinan L. Plasminogen degrades α-synuclein, Tau and TDP-43 and decreases dopaminergic neurodegeneration in mouse models of Parkinson's disease. Scientific reports. vol 14. issue 1. 2024-04-13. PMID:38615036. |
the in vitro, ex vivo and in vivo results showed that the administered plasminogen crossed the blood‒brain barrier (bbb), entered cells, and migrated to the nucleus, increased plasmin activity intracellularly, bound to α-syn through lysine binding sites, significantly promoted α-syn, tau and tdp-43 clearance intracellularly and even intranuclearly in the brain, decreased dopaminergic neurodegeneration and increased the tyrosine hydroxylase levels in the substantia nigra and striatum, and improved motor function in pd mouse models. |
2024-04-13 |
2024-04-16 |
mouse |
| Hadeer O Abou-Hany, Mohamed El-Sherbiny, Sally Elshaer, Eman Said, Tarek Moustaf. Neuro-modulatory impact of felodipine against experimentally-induced Parkinson's disease: Possible contribution of PINK1-Parkin mitophagy pathway. Neuropharmacology. 2024-03-17. PMID:38494124. |
nrf2 content significantly decreased with the accumulation of α-synuclein and tau proteins in both the substantia nigra and striatum. |
2024-03-17 |
2024-03-20 |
Not clear |
| Kurt A Jellinge. The enigma of depression in corticobasal degeneration, a frequent but poorly understood co-morbidity. Journal of neural transmission (Vienna, Austria : 1996). 2024-01-12. PMID:38216704. |
this 4-repeat (4r) tauopathy is morphologically featured by asymmetric frontoparietal atrophy, neuronal loss, and gliosis in cortex and subcortex including substantia nigra, ballooned/achromatic neurons with filamentous 4r tau aggregates in cortex and striatum, widespread thread-like structures, pathognomonic "astroglial plaques", "tufted astrocytes", and numerous "coiled bodies" (in astrocytes and oligodendroglia) in cerebral white matter. |
2024-01-12 |
2024-01-15 |
Not clear |
| Lucia Aa Giannini, Merel O Mol, Ana Rajicic, Renee van Buuren, Lana Sarkar, Sanaz Arezoumandan, Daniel T Ohm, David J Irwin, Annemieke Jm Rozemuller, John C van Swieten, Harro Seelaa. Presymptomatic and early pathological features of MAPT-associated frontotemporal lobar degeneration. Acta neuropathologica communications. vol 11. issue 1. 2023-08-02. PMID:37533060. |
the 68-year-old presymptomatic l315r carrier (ftld-cdr = 0) had limited tau burden morphologically similar to l315r end-stage carriers in middle frontal, antero-inferior temporal, amygdala, (para-)hippocampus and striatum, along with age-related alzheimer's disease neuropathological change. |
2023-08-02 |
2023-08-14 |
Not clear |
| Minji Kim, Hiroaki Sekiya, Gary Yao, Nicholas B Martin, Monica Castanedes-Casey, Dennis W Dickson, Tae Hyun Hwang, Shunsuke Kog. Diagnosis of Alzheimer Disease and Tauopathies on Whole-Slide Histopathology Images Using a Weakly Supervised Deep Learning Algorithm. Laboratory investigation; a journal of technical methods and pathology. vol 103. issue 6. 2023-06-26. PMID:36889541. |
three sections (a: motor cortex; b: cingulate gyrus and superior frontal gyrus; and c: corpus striatum) that had been immunostained for phosphorylated tau were scanned and converted to wsis. |
2023-06-26 |
2023-12-23 |
Not clear |
| Hao Chen, Yajie Li, Jingwen Gao, Qi Cheng, Lei Liu, Rong Ca. Activation of Pgk1 Results in Reduced Protein Aggregation in Diverse Neurodegenerative Conditions. Molecular neurobiology. 2023-05-30. PMID:37249790. |
through in vivo studies, we examined neuron-specific overexpression of tau in drosophila, mouse models of app/ps1 alzheimer's disease (ad), and a rat model of multiple system atrophy (msa) via the viral expression of α-synuclein in the striatum. |
2023-05-30 |
2023-08-14 |
mouse |
| Isaline Mees, Rebecca Nisbet, Anthony Hannan, Thibault Renoi. Implications of Tau Dysregulation in Huntington's Disease and Potential for New Therapeutics. Journal of Huntington's disease. 2023-04-24. PMID:37092231. |
tau hyperphosphorylation, the main feature of tau pathology, has also been investigated and our own published results suggest that the protein phosphorylation machinery is dysregulated in the early stages of hd in r6/1 transgenic mice, primarily in the cortex and striatum. |
2023-04-24 |
2023-08-14 |
mouse |
| Chaitali Anand, Pedro D Maia, Justin Torok, Christopher Mezias, Ashish Ra. The effects of microglia on tauopathy progression can be quantified using Nexopathy in silico (Nexis) models. Scientific reports. vol 12. issue 1. 2022-12-08. PMID:36477076. |
trem2 appears to reduce tau accumulation rate while increasing its interregional spread from the hippocampal seed area, causing higher tau burden in the striatum, pallidum, and contralateral hippocampus. |
2022-12-08 |
2023-08-14 |
Not clear |
| Lucia A A Giannini, Daniel T Ohm, Annemieke J M Rozemuller, Laynie Dratch, EunRan Suh, Vivianna M van Deerlin, John Q Trojanowski, Edward B Lee, John C van Swieten, Murray Grossman, Harro Seelaar, David J Irwi. Isoform-specific patterns of tau burden and neuronal degeneration in MAPT-associated frontotemporal lobar degeneration. Acta neuropathologica. 2022-09-06. PMID:36066634. |
in contrast, the regions with the highest tau burden differed in isoform groups (3r: striatum; 3r + 4r: striatum, inferior parietal lobule, middle frontal cortex, anterior cingulate cortex; 4r: transentorhinal cortex, anterior temporal cortex, fusiform gyrus). |
2022-09-06 |
2023-08-14 |
Not clear |
| Kaidong Wang, Baofu Zhang, Tian Tian, Bingyang Zhang, Ge Shi, Chunhui Zhang, Guoliang Li, Min Huan. Taurine protects dopaminergic neurons in paraquat-induced Parkinson's disease mouse model through PI3K/Akt signaling pathways. Amino acids. 2021-11-27. PMID:34837554. |
our study showed that pd mice with tau intervention recovered motor and non-motor functions to some extent, and the number of dopaminergic (dac) neurons in the substantia nigra and the level of dopamine (da) secretion in the striatum were also significantly increased compared with the pq-dyed group, and the protein content of pi3k and pdk-1 and the phosphorylation level of akt were reduced in parallel with the reduction in the expression of microglia and related inflammatory factors. |
2021-11-27 |
2023-08-13 |
mouse |
| Michael Ohene-Nyako, Sara R Nass, Yun K Hahn, Pamela E Knapp, Kurt F Hause. Morphine and HIV-1 Tat interact to cause region-specific hyperphosphorylation of tau in transgenic mice. Neuroscience letters. vol 741. 2021-05-04. PMID:33202259. |
the pathological phospho-isotypes of tau (pser396, pser404, pthr205, pser202, and pthr181) and the tau kinases gsk3β and cdk5/p35 were explored in the striatum, hippocampus, and prefrontal cortex of inducible male and female hiv-1 tat-transgenic mice, with some receiving escalating doses of morphine for 2 weeks. |
2021-05-04 |
2023-08-13 |
mouse |
| Justyna Zareba-Paslawska, Kalicharan Patra, Luca Kluzer, Tamas Revesz, Per Svenningsso. Tau Isoform-Driven CBD Pathology Transmission in Oligodendrocytes in Humanized Tau Mice. Frontiers in neurology. vol 11. 2021-02-02. PMID:33519674. |
next, we demonstrate the spread of tau pathology from striatum to the overlaying corpus callosum and further to the contralateral side. |
2021-02-02 |
2023-08-13 |
mouse |
| Wen Hu, Feng Wu, Yanchong Zhang, Cheng-Xin Gong, Khalid Iqbal, Fei Li. Expression of Tau Pathology-Related Proteins in Different Brain Regions: A Molecular Basis of Tau Pathogenesis. Frontiers in aging neuroscience. vol 9. 2020-10-01. PMID:29021756. |
in the rat brain, the expression level of tau with three microtubule-binding repeats (3r-tau) was comparable in the hippocampus, ec, fc, parietal-temporal cortex (ptc), occipital-temporal cortex (otc), striatum, thalamus, olfactory bulb (ob) and cerebellum. |
2020-10-01 |
2023-08-13 |
human |
| Keqing Zhu, Xin Wang, Bing Sun, Juanli Wu, Hui Lu, Xiaoling Zhang, Huazheng Liang, Dandan Zhang, Chong Li. Primary Age-Related Tauopathy in Human Subcortical Nuclei. Frontiers in neuroscience. vol 13. 2020-10-01. PMID:31191227. |
expression of tau was frequently found in subcortical nuclei including the substantia nigra, inferior colliculus, locus coeruleus, medulla oblongata in the brainstem, the caudate, putamen, nucleus globus pallidus in the striatum, the hypothalamus, thalamus, subthalamus in the diencephalon, and the cervical spinal cord in both part and ad, but not in the dentate nucleus of the cerebellum. |
2020-10-01 |
2023-08-13 |
human |
| Gabor Egervari, Diana Akpoyibo, Tanni Rahman, John F Fullard, James E Callens, Joseph A Landry, Annie Ly, Xianxiao Zhou, Noël Warren, Mads E Hauberg, Gabriel Hoffman, Randy Ellis, Jacqueline-Marie N Ferland, Michael L Miller, Eva Keller, Bin Zhang, Panos Roussos, Yasmin L Hur. Chromatin accessibility mapping of the striatum identifies tyrosine kinase FYN as a therapeutic target for heroin use disorder. Nature communications. vol 11. issue 1. 2020-09-23. PMID:32929078. |
fyn expression, kinase activity and the phosphorylation of its target tau are increased by heroin use in the post-mortem human striatum, as well as in rats trained to self-administer heroin and primary striatal neurons treated with chronic morphine in vitro. |
2020-09-23 |
2023-08-13 |
human |
| C Dirk Keene, Angela M Wilson, Mitchell D Kilgore, Lauren T Bruner, Nadia O Postupna, Martin Darva. Luminex-based quantification of Alzheimer's disease neuropathologic change in formalin-fixed post-mortem human brain tissue. Laboratory investigation; a journal of technical methods and pathology. vol 99. issue 7. 2020-05-18. PMID:30573871. |
consistent with the neuropathologic assessment, luminex assay detected high amounts of amyloid beta in the frontal cortex and striatum, and high amounts of hyperphosphorylated tau in the frontal cortex and hippocampus, of cases with high ad neuropathologic change. |
2020-05-18 |
2023-08-13 |
human |
| Swikrity Upadhyay Baskota, Oscar L Lopez, J Timothy Greenamyre, Julia Kofle. Spectrum of tau pathologies in Huntington's disease. Laboratory investigation; a journal of technical methods and pathology. vol 99. issue 7. 2020-05-18. PMID:30573872. |
none of the cases showed significant tau pathology in the striatum. |
2020-05-18 |
2023-08-13 |
Not clear |
| Jeremy Koppel, Heidy Jimenez, Leslie Adrien, Eric H Chang, Anil K Malhotra, Peter Davie. Increased tau phosphorylation follows impeded dopamine clearance in a P301L and novel P301L/COMT-deleted (DM) tau mouse model. Journal of neurochemistry. vol 148. issue 1. 2019-10-28. PMID:30238463. |
in another experiment, acutely following reboxetine injections, tau phosphorylation was quantified in the frontal cortex, striatum, and hippocampus of the mice. |
2019-10-28 |
2023-08-13 |
mouse |
| Céline Laurencé, Narimane Zeghbib, Michael Rivard, Sonia Lehri-Boufala, Isabelle Lachaise, Caroline Barau, Philippe Le Corvoisier, Thierry Martens, Laure Garrigue-Antar, Christophe Mori. A new human pyridinium metabolite of furosemide, inhibitor of mitochondrial complex I, is a candidate inducer of neurodegeneration. Biochemical pharmacology. vol 160. 2019-09-09. PMID:30537467. |
moreover, in mice, pof induced neurodegenerative diseases hallmarks like phospho-serine129 alpha-synuclein, tyrosine hydroxylase decrease in striatum, tau accumulation in hippocampus. |
2019-09-09 |
2023-08-13 |
mouse |
| Bianca Seminotti, Ângela Zanatta, Rafael Teixeira Ribeiro, Mateus Struecker da Rosa, Angela T S Wyse, Guilhian Leipnitz, Moacir Wajne. Disruption of Brain Redox Homeostasis, Microglia Activation and Neuronal Damage Induced by Intracerebroventricular Administration of S-Adenosylmethionine to Developing Rats. Molecular neurobiology. vol 56. issue 4. 2019-08-06. PMID:30058022. |
therefore, we investigated the effects of intracerebroventricular administration of adomet on redox homeostasis, microglia activation, synaptophysin levels, and tau phosphorylation in cerebral cortex and striatum of young rats. |
2019-08-06 |
2023-08-13 |
rat |