| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Meaghan Morris, Akihiko Koyama, Eliezer Masliah, Lennart Muck. Tau reduction does not prevent motor deficits in two mouse models of Parkinson's disease. PloS one. vol 6. issue 12. 2012-04-23. PMID:22206005. |
tau reduction also did not prevent 6-ohda-induced loss of dopaminergic terminals in the striatum. |
2012-04-23 |
2023-08-12 |
mouse |
| Thomas Haggerty, Joel Credle, Olga Rodriguez, Jonathan Wills, Adam W Oaks, Eliezer Masliah, Anita Sidh. Hyperphosphorylated Tau in an α-synuclein-overexpressing transgenic model of Parkinson's disease. The European journal of neuroscience. vol 33. issue 9. 2011-09-16. PMID:21453448. |
in human postmortem striatum of parkinson's disease (pd) and pd with dementia, we have recently described elevated levels of tauopathy, indexed as increased hyperphosphorylated tau (p-tau). |
2011-09-16 |
2023-08-12 |
mouse |
| Casper Jansen, Piero Parchi, Sabina Capellari, Rosaria Strammiello, Elise G P Dopper, John C van Swieten, Wouter Kamphorst, Annemieke J M Rozemulle. A second case of Gerstmann-Sträussler-Scheinker disease linked to the G131V mutation in the prion protein gene in a Dutch patient. Journal of neuropathology and experimental neurology. vol 70. issue 8. 2011-09-16. PMID:21760536. |
in addition, there were tau accumulations around numerous amyloid deposits in the cerebral cortex, striatum, hippocampal formation, and midbrain. |
2011-09-16 |
2023-08-12 |
Not clear |
| Taiki Kambe, Yumiko Motoi, Ran Inoue, Nobuhiko Kojima, Norihiro Tada, Tetsuya Kimura, Naruhiko Sahara, Shunji Yamashita, Tatsuya Mizoroki, Akihiko Takashima, Kohei Shimada, Koichi Ishiguro, Hiroshi Mizuma, Hirotaka Onoe, Yoshikuni Mizuno, Nobutaka Hattor. Differential regional distribution of phosphorylated tau and synapse loss in the nucleus accumbens in tauopathy model mice. Neurobiology of disease. vol 42. issue 3. 2011-08-23. PMID:21324362. |
in the striatum of old tg601, the level of at8- or at180-positive tau was decreased compared with that of other regions, while phf-1-positive tau levels remained equal. |
2011-08-23 |
2023-08-12 |
mouse |
| Jose A Rodríguez-Navarro, Laura Rodríguez, María J Casarejos, Rosa M Solano, Ana Gómez, Juan Perucho, Ana María Cuervo, Justo García de Yébenes, María A Men. Trehalose ameliorates dopaminergic and tau pathology in parkin deleted/tau overexpressing mice through autophagy activation. Neurobiology of disease. vol 39. issue 3. 2010-11-16. PMID:20546895. |
the treatment with trehalose for 4 months of 3-month-old pk(-/-)/tau(vlw) mice maintained the amelioration of the tau pathology and astrogliosis but failed to revert da-related pathology in the striatum. |
2010-11-16 |
2023-08-12 |
mouse |
| Matthias Höllerhage, Andreas Matusch, Pierre Champy, Anne Lombès, Merle Ruberg, Wolfgang H Oertel, Günter U Höglinge. Natural lipophilic inhibitors of mitochondrial complex I are candidate toxins for sporadic neurodegenerative tau pathologies. Experimental neurology. vol 220. issue 1. 2009-11-13. PMID:19682988. |
we determined their lipophilicity, their effect on complex i activity in submitochondrial particles, and their effect on cellular atp levels, neuronal cell death and somatodendritic redistribution of phosphorylated tau protein (ad2 antibody against ps396/ps404-tau) in primary cultures of fetal rat striatum. |
2009-11-13 |
2023-08-12 |
rat |
| Ronald L Klein, Robert D Dayton, Tracee L Terry, Chris Vascoe, John J Sunderland, Kerrie H Tainte. PET imaging in rats to discern temporal onset differences between 6-hydroxydopamine and tau gene vector neurodegeneration models. Brain research. vol 1259. 2009-07-02. PMID:19368808. |
6-ohda reduced uptake on the ipsilateral side relative to the untreated contralateral side at both 1 and 4 weeks after lesioning, while the aav9 tau led to reduced uptake of the tracer in the striatum at 4 weeks, but not 1 week after treatment. |
2009-07-02 |
2023-08-12 |
rat |
| Gabriel Santpere, Isidre Ferre. Delineation of early changes in cases with progressive supranuclear palsy-like pathology. Astrocytes in striatum are primary targets of tau phosphorylation and GFAP oxidation. Brain pathology (Zurich, Switzerland). vol 19. issue 2. 2009-05-01. PMID:18462470. |
astrocytes in striatum are primary targets of tau phosphorylation and gfap oxidation. |
2009-05-01 |
2023-08-12 |
Not clear |
| E B Shubenina, V S Kudrin, P M Klodt, A A Pokrovskiĭ, T A Gudasheva, T A Voronina, R U Ostrovskai. [Interstrain differences in the content of excitatory and inhibitory amino acids in the brain of DBA/2J, Balb/c and C57BL/6 mice: characteristics of the effect of a dipeptide antipsychotic drug dilept]. Eksperimental'naia i klinicheskaia farmakologiia. vol 71. issue 4. 2008-10-27. PMID:18819433. |
we have performed a comparative study of the content of glutamate (glu), aspartate (asp), taurine (tau), glycine (gly) and gamma-amino-butyric acid (gaba) in the cortex, hippocampus, and striatum of the dba/2j, balb/c and c57bl/6 mice brain. |
2008-10-27 |
2023-08-12 |
mouse |
| E B Shubenina, V S Kudrin, P M Klodt, A A Pokrovskiĭ, T A Gudasheva, T A Voronina, R U Ostrovskai. [Interstrain differences in the content of excitatory and inhibitory amino acids in the brain of DBA/2J, Balb/c and C57BL/6 mice: characteristics of the effect of a dipeptide antipsychotic drug dilept]. Eksperimental'naia i klinicheskaia farmakologiia. vol 71. issue 4. 2008-10-27. PMID:18819433. |
dilept induced a statistically significant increase in the levels of glu, tau and gaba in striatum of dba/2j, as well as insignificant increase in the levels of these amino acids in the cortex. |
2008-10-27 |
2023-08-12 |
mouse |
| Michail E Kalaitzakis, Manuel B Graeber, Stephen M Gentleman, Ronald K B Pearc. Striatal beta-amyloid deposition in Parkinson disease with dementia. Journal of neuropathology and experimental neurology. vol 67. issue 2. 2008-05-02. PMID:18219254. |
alpha-synuclein and tau deposition in the striatum were rare in both groups, but the abeta burden was significantly greater in the striatum of pd cases with dementia than present in the nondemented pd group. |
2008-05-02 |
2023-08-12 |
Not clear |
| Xiaodong Bie, Yueqing Chen, Jinn Han, Haibin Dai, Haitong Wan, Tongfeng Zha. Effects of gastrodin on amino acids after cerebral ischemia-reperfusion injury in rat striatum. Asia Pacific journal of clinical nutrition. vol 16 Suppl 1. 2007-06-14. PMID:17392124. |
the levels of glutamic acid (glu), aspartic acid (asp), gamma-aminobutyric acid (gaba), taurine (tau) in striatum in the rats of the 3 groups were measured with the method of microdialysis-hplc techniques. |
2007-06-14 |
2023-08-12 |
rat |
| Kurt A Jellinger, Johannes Attem. Does striatal pathology distinguish Parkinson disease with dementia and dementia with Lewy bodies? Acta neuropathologica. vol 112. issue 3. 2007-02-08. PMID:16804711. |
differences in as and abeta pathologies and much less of tau lesions in the striatum support a morphologic distinction between pdd and dlb, which may be of pathophysiologic importance, but the causes of these differences are unclear. |
2007-02-08 |
2023-08-12 |
Not clear |
| J Menéndez, J A Rodríguez-Navarro, R M Solano, M J Casarejos, I Rodal, R Guerrero, M P Sánchez, J Avila, M A Mena, J G de Yébene. Suppression of Parkin enhances nigrostriatal and motor neuron lesion in mice over-expressing human-mutated tau protein. Human molecular genetics. vol 15. issue 13. 2006-09-05. PMID:16698879. |
mice with combined homozygous mutations of these two genes show progressively abnormal walking already noticeable at 3 months of age, loss of dopamine and dopamine markers in striatum, nuclear tau immunoreactive deposits in motor neurons of the spinal cord, abnormal expression of glial markers and enhanced levels of pro-apoptotic proteins; findings that were absent or less pronounced in homozygote animals with deletions of parkin or over-expression of tau. |
2006-09-05 |
2023-08-12 |
mouse |
| Günter U Höglinger, Annie Lannuzel, Myriam Escobar Khondiker, Patrick P Michel, Charles Duyckaerts, Jean Féger, Pierre Champy, Annick Prigent, Fadia Medja, Anne Lombes, Wolfgang H Oertel, Merle Ruberg, Etienne C Hirsc. The mitochondrial complex I inhibitor rotenone triggers a cerebral tauopathy. Journal of neurochemistry. vol 95. issue 4. 2006-01-20. PMID:16219024. |
spherical deposits of alpha-synuclein were observed in a few cells, but cells with abnormal cytoplasmic accumulations of tau immunoreactivity were significantly more numerous in the striatum of severely lesioned rats. |
2006-01-20 |
2023-08-12 |
rat |
| Kazuyuki Noda, Tomonori Kobayashi, Shuji Matsuoka, Masashi Takanashi, Akira Kanazawa, Yoshikuni Mizun. [A 65-year-old man with rigid-bradykinetic parkinsonism, vertical gaze palsy, difficulty of eye-lid opening, and marked pseudo-bulbar palsy]. No to shinkei = Brain and nerve. vol 57. issue 1. 2005-04-08. PMID:15782604. |
with sliver (bodian and gallyas-braak) and anti-phsphorylated tau stain, abundant astrocytic plaques, neurofibrillary tangles, and argyrophilic threads on the frontal cortex, striatum, and substantia nigra were seen. |
2005-04-08 |
2023-08-12 |
human |
| Marion Hogg, Zoran M Grujic, Matt Baker, Serpil Demirci, Angela L Guillozet, Alison P Sweet, Laura L Herzog, Sandra Weintraub, M-Marsel Mesulam, Nichole E LaPointe, T C Gamblin, Robert W Berry, Lester I Binder, Rohan de Silva, Andrew Lees, Marisol Espinoza, Peter Davies, Andrew Grover, Naruhiko Sahara, Takashi Ishizawa, Dennis Dickson, Shu-Hui Yen, Michael Hutton, Eileen H Bigi. The L266V tau mutation is associated with frontotemporal dementia and Pick-like 3R and 4R tauopathy. Acta neuropathologica. vol 106. issue 4. 2003-12-17. PMID:12883828. |
et3, a four-repeat (4r) isoform-specific tau antibody, did not label pick bodies, but highlighted rare astrocytes, and threads in white matter bundles in the corpus striatum. |
2003-12-17 |
2023-08-12 |
Not clear |
| T L Wallace, C V Vorhees, F P Zemlan, G A Gudelsk. Methamphetamine enhances the cleavage of the cytoskeletal protein tau in the rat brain. Neuroscience. vol 116. issue 4. 2003-04-30. PMID:12617947. |
every 2 hours for a total of four injections) produced a time-dependent increase in the concentration of cleaved tau in the striatum. |
2003-04-30 |
2023-08-12 |
rat |
| Sébastien Weill-Engerer, Jean-Philippe David, Véronique Sazdovitch, Philippe Liere, Bernard Eychenne, Antoine Pianos, Michael Schumacher, André Delacourte, Etienne-Emile Baulieu, Yvette Akw. Neurosteroid quantification in human brain regions: comparison between Alzheimer's and nondemented patients. The Journal of clinical endocrinology and metabolism. vol 87. issue 11. 2002-12-09. PMID:12414884. |
a significant negative correlation was found between the levels of cortical beta-amyloid peptides and those of pregs in the striatum and cerebellum and between the levels of phosphorylated tau proteins and dheas in the hypothalamus. |
2002-12-09 |
2023-08-12 |
human |
| M Zielińska, W Hilgier, H D Borkowska, S S Oja, P Saransaari, P Goryński, J Albrech. Ammonia-induced extracellular accumulation of taurine in the rat striatum in vivo: role of ionotropic glutamate receptors. Neurochemical research. vol 27. issue 1-2. 2002-10-03. PMID:11926274. |
accumulation of taurine (tau), glutamate (glu) and glutamine (gln) was measured in vivo in microdialysates of the rat striatum following a direct application to the microdialysis tube of 60 mm ammonium chloride which renders the final ammonia concentration in the extracellular space to approximately 5 mm. |
2002-10-03 |
2023-08-12 |
rat |