| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Pranav Vemula, Yu Jing, Hu Zhang, Jerry B Hunt, Leslie A Sandusky-Beltran, Daniel C Lee, Ping Li. Altered brain arginine metabolism in a mouse model of tauopathy. Amino acids. vol 51. issue 3. 2019-07-24. PMID:30604097. |
using high-performance liquid chromatographic and mass spectrometric assays, the present study systematically determined the tissue concentrations of l-arginine and its nine downstream metabolites in the frontal cortex, hippocampus, parahippocampal region, striatum, thalamus, and cerebellum in male ps19 mice-bearing human tau p301s mutation at 4, 8, and 12-14 months of age. |
2019-07-24 |
2023-08-13 |
mouse |
| Leah C Beauchamp, Jacky Chan, Lin W Hung, Benjamin S Padman, Laura J Vella, Xiang M Liu, Bradley Coleman, Ashley I Bush, Michael Lazarou, Andrew F Hill, Laura Jacobson, Kevin J Barnha. Ablation of tau causes an olfactory deficit in a murine model of Parkinson's disease. Acta neuropathologica communications. vol 6. issue 1. 2019-06-04. PMID:29976255. |
this pathological feature becomes apparent in the striatum and substantia nigra of 15-month-old tau knockout mice, suggesting the potential for a spread of disease. |
2019-06-04 |
2023-08-13 |
mouse |
| Bruno Ouimet, Élise Pépin, Yan Bergeron, Laure Chagniel, Jean Martin Beaulieu, Guy Massicotte, Michel Cy. Motor learning deficits and striatal GSK-3 hyperactivity in Akt3 knockout mice. Behavioral neuroscience. vol 133. issue 1. 2019-03-21. PMID:30688489. |
biochemical analysis in the striatum revealed modifications in the levels of both phosphorylated gsk-3 and tau in akt3-deficient mice, which are reminiscent of enhanced gsk-3 activity. |
2019-03-21 |
2023-08-13 |
mouse |
| Edna Maria Camelo Chaves, Jose Eduardo Ribeiro Honório-Júnior, Caren Nádia Soares Sousa, Valdécio Silveira Monteiro, Dayanne Terra Tenório Nonato, Leonardo Pimentel Dantas, Ana Silvia Suassuna Carneiro Lúcio, José Maria Barbosa-Filho, Manoel Cláudio Azevedo Patrocínio, Glauce Socorro Barros Viana, Silvânia Maria Mendes Vasconcelo. The anxiolytic-like effect of 6-styryl-2-pyrone in mice involves GABAergic mechanism of action. Metabolic brain disease. vol 33. issue 1. 2019-01-31. PMID:29086102. |
after behavioral tests, these animals were sacrificed and had their prefrontal cortex (pfc), hippocampus (hc) and striatum (st) dissected for assaying amino acids (aspartate- asp, glutamate- glu, glycine- gly, taurine- tau and gamma-aminobutyric acid- gaba). |
2019-01-31 |
2023-08-13 |
mouse |
| Alana Pimentel Moura, Belisa Parmeggiani, Juciano Gasparotto, Mateus Grings, Gabriela Miranda Fernandez Cardoso, Bianca Seminotti, José Cláudio Fonseca Moreira, Daniel Pens Gelain, Moacir Wajner, Guilhian Leipnit. Glycine Administration Alters MAPK Signaling Pathways and Causes Neuronal Damage in Rat Brain: Putative Mechanisms Involved in the Neurological Dysfunction in Nonketotic Hyperglycinemia. Molecular neurobiology. vol 55. issue 1. 2018-12-11. PMID:28050793. |
gly decreased tau phosphorylation in striatum and cerebral cortex 30 min and 24 h after its administration. |
2018-12-11 |
2023-08-13 |
rat |
| Kateřina Storey, Silvie Johanidesová, Radoslav Matěj, Jiří Keller, Zdeněk Rohan, Robert Rusin. FTLD-TDP and progressive supranuclear palsy in comorbidity-a report of two cases with different clinical presentations. Neurocase. vol 23. issue 1. 2018-02-20. PMID:27915581. |
neuropathological examination revealed neuronal and glial tau pathology together with ubiquitin, and phospho-tdp-43-immunoreactivities in the hippocampus, striatum, mesencephalon, and frontal and temporal cortices. |
2018-02-20 |
2023-08-13 |
Not clear |
| Denglei Ma, Yanqiu Zhu, Yanzheng Li, Cuicui Yang, Li Zhang, Yali Li, Lin Li, Lan Zhan. Beneficial effects of cornel iridoid glycoside on behavioral impairment and senescence status in SAMP8 mice at different ages. Behavioural brain research. vol 312. 2017-12-19. PMID:27283974. |
in addition, cig treatment inhibited tau hyperphosphorylation in the hippocampus and striatum of samp8 mice at different ages. |
2017-12-19 |
2023-08-13 |
mouse |
| Giulia Cisbani, Alexander Maxan, Jeffrey H Kordower, Emmanuel Planel, Thomas B Freeman, Francesca Cicchett. Presence of tau pathology within foetal neural allografts in patients with Huntington's and Parkinson's disease. Brain : a journal of neurology. vol 140. issue 11. 2017-11-07. PMID:29069396. |
while the striatum of the grafted huntington's disease patient revealed an equal amount of 3-repeat and 4-repeat isoforms of tau, the grafted tissue showed elevated 4-repeat isoforms by western blot. |
2017-11-07 |
2023-08-13 |
Not clear |
| Helen Ling, Gabor G Kovacs, Jean Paul G Vonsattel, Karen Davey, Kin Y Mok, John Hardy, Huw R Morris, Thomas T Warner, Janice L Holton, Tamas Reves. Astrogliopathy predominates the earliest stage of corticobasal degeneration pathology. Brain : a journal of neurology. vol 139. issue Pt 12. 2017-05-10. PMID:27797812. |
relatively greater tau burden in the anterior frontal cortex, striatum and subthalamic nucleus suggests the striatal afferent connection to the dorsolateral prefrontal cortex and basal ganglia circuitry are the earliest neural network connections affected by corticobasal degeneration-related tau pathology. |
2017-05-10 |
2023-08-13 |
Not clear |
| Liang Xiao-Feng, Zhu Wen-Ting, Xu Yuan-Yuan, Lai Chong-Fa, Zheng Lu, Rao Jin-Jun, Wang Wen-Y. Protective role of 6-Hydroxy-1-H-Indazole in an MPTP-induced mouse model of Parkinson's disease. European journal of pharmacology. vol 791. 2017-03-28. PMID:27614126. |
the results showed that mptp decreased the dopaminergic neurons in the substantia nigra and dopamine in the striatum, downregulated the expression of tyrosine hydroxylase (th), induced the impairment of behavior and hyperphosphorylation of tau, however, 6-hydroxy-1-h-indazole decreased the loss of dopaminergic neurons, increased dopamine concentration and th expression, alleviated the behavioral damage and level of phosphor-tau in the mptp-induced model of pd in c57bl/6 mice. |
2017-03-28 |
2023-08-13 |
mouse |
| Cheng-long Xie, Jing-Ya Lin, Mei-Hua Wang, Yu Zhang, Su-fang Zhang, Xi-Jin Wang, Zhen-Guo Li. Inhibition of Glycogen Synthase Kinase-3β (GSK-3β) as potent therapeutic strategy to ameliorates L-dopa-induced dyskinesia in 6-OHDA parkinsonian rats. Scientific reports. vol 6. 2017-01-10. PMID:26997328. |
tdzd8 reduced the phosphorylation levels of tau, darpp32, erk and pka protein, which represent molecular markers of lid, as well as reduced l-dopa-induced fosb mrna and ppeb mrna levels in the lesioned striatum. |
2017-01-10 |
2023-08-13 |
rat |
| Chul Hyoung Lyoo, Hanna Cho, Jae Yong Choi, Mi Song Hwang, Sang Kyoon Hong, Yun Joong Kim, Young Hoon Ryu, Myung Sik Le. Tau Accumulation in Primary Motor Cortex of Variant Alzheimer's Disease with Spastic Paraparesis. Journal of Alzheimer's disease : JAD. vol 51. issue 3. 2016-12-19. PMID:26890779. |
the proband showed prominently increased amyloid binding in striatum and cerebellum and asymmetrical tau binding in the primary sensorimotor cortex contralateral to the side more affected by spasticity. |
2016-12-19 |
2023-08-13 |
Not clear |
| Susanne Pirker, Laura Perju-Dumbrava, Gabor G Kovacs, Tatiana Traub-Weidinger, Walter Pirke. Progressive Dopamine Transporter Binding Loss in Autopsy-Confirmed Corticobasal Degeneration. Journal of Parkinson's disease. vol 5. issue 4. 2016-09-29. PMID:26485425. |
corticobasal degeneration (cbd) is characterized by neuronal and glial deposition of 4-repeat tau in the frontal and parietal cerebral cortex, white matter and striatum. |
2016-09-29 |
2023-08-13 |
Not clear |
| L Zhao, C-B Chu, J-F Li, Y-T Yang, S-Q Niu, W Qin, Y-G Hao, Q Dong, R Guan, W-L Hu, Y Wan. Glycogen synthase kinase-3 reduces acetylcholine level in striatum via disturbing cellular distribution of choline acetyltransferase in cholinergic interneurons in rats. Neuroscience. vol 255. 2014-08-14. PMID:24121130. |
in the present study, with combined intracerebroventricular injection of wortmannin and gf-109203x, we activated gsk-3 and demonstrated the increased phosphorylation level of microtubule-associated protein tau and neurofilaments (nfs) in the rat striatum. |
2014-08-14 |
2023-08-12 |
rat |
| Adam W Oaks, Maya Frankfurt, David I Finkelstein, Anita Sidh. Age-dependent effects of A53T alpha-synuclein on behavior and dopaminergic function. PloS one. vol 8. issue 4. 2013-09-16. PMID:23560093. |
prior to normalization of dopamine uptake, transient activation of tau kinases and hyperphosphorylation of tau in the striatum were also observed. |
2013-09-16 |
2023-08-12 |
mouse |
| Cathra Halabi, Anasheh Halabi, David L Dean, Pei-Ning Wang, Adam L Boxer, John Q Trojanowski, Stephen J Dearmond, Bruce L Miller, Joel H Kramer, William W Seele. Patterns of striatal degeneration in frontotemporal dementia. Alzheimer disease and associated disorders. vol 27. issue 1. 2013-08-12. PMID:22367382. |
at autopsy, patients with behavioral variant frontotemporal dementia and semantic dementia showed striking and severe tau or tar dna-binding protein of 43 kda pathology, especially in ventral parts of the striatum. |
2013-08-12 |
2023-08-12 |
Not clear |
| Tabea H Schauer, Maximilian Lochner, Gabor G Kovac. Nigral Tau pathology and striatal amyloid-β deposition does not correlate with striatal dopamine deficit in Alzheimer's disease. Journal of neural transmission (Vienna, Austria : 1996). vol 119. issue 12. 2013-07-22. PMID:22664779. |
in the present study, using morphometric immunohistochemistry in 34 cases with ad-related pathology, we evaluated whether nigral burden of tau pathology or striatal burden of amyloid-β deposition correlates with dopamine transporter (dat) expression in the striatum. |
2013-07-22 |
2023-08-12 |
Not clear |
| Olga M Viquez, Samuel W Caito, W Hayes McDonald, David B Friedman, William M Valentin. Electrophilic adduction of ubiquitin activating enzyme E1 by N,N-diethyldithiocarbamate inhibits ubiquitin activation and is accompanied by striatal injury in the rat. Chemical research in toxicology. vol 25. issue 11. 2013-05-07. PMID:22874009. |
our studies also delineated localized injury within the striatum as indicated by decreased levels of tyrosine hydroxylase, elevated protein carbonyl content, increased antioxidant enzyme and α-synuclein expression, and enhanced phosphorylation of tau and tyrosine hydroxylase. |
2013-05-07 |
2023-08-12 |
rat |
| Michiyo Iba, Jing L Guo, Jennifer D McBride, Bin Zhang, John Q Trojanowski, Virginia M-Y Le. Synthetic tau fibrils mediate transmission of neurofibrillary tangles in a transgenic mouse model of Alzheimer's-like tauopathy. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 3. 2013-04-01. PMID:23325240. |
interestingly, injection of tau pffs into either hippocampus or striatum together with overlaying cortex gave rise to distinct pattern of spreading. |
2013-04-01 |
2023-08-12 |
mouse |
| Shunmei Chiba, Erika Takada, Mamoru Tadokoro, Taizo Taniguchi, Keiichi Kadoyama, Mariko Takenokuchi, Seiya Kato, Noboru Suzuk. Loss of dopaminoreceptive neuron causes L-dopa resistant parkinsonism in tauopathy. Neurobiology of aging. vol 33. issue 10. 2013-01-21. PMID:22169201. |
interestingly, dopaminoreceptive (dar) neurons in the striatum showed neurofibrils degeneration and apoptosis through caspase-3 activation by mutant tau accumulation. |
2013-01-21 |
2023-08-12 |
mouse |