| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Stephen M Stahl, Clara Lee-Zimmerman, Sylvia Cartwright, Debbi Ann Morrissett. Serotonergic drugs for depression and beyond. Current drug targets. vol 14. issue 5. 2013-10-29. PMID:23531115. |
novel drugs in development include those that combine multiple simultaneous pharmacologic mechanisms in addition to sert inhibition within the same molecule, such as vilazodone (combining 5ht1a partial agonism with sert inhibition), triple reuptake inhibitors (combining norepinephrine and dopamine reuptake inhibition with sert inhibition), and vortioxetine, a multimodal antidepressant combining actions at the g protein receptor mode (5ht1a and 5ht1b partial agonism and 5ht7 antagonism), at the ion channel mode (5ht3 antagonism) as well as the neurotransmitter transporter mode (sert inhibition). |
2013-10-29 |
2023-08-12 |
Not clear |
| Takeshi Murai, Tomokazu Nakako, Masaru Ikejiri, Takeo Ishiyama, Mutsuo Taiji, Kazuhito Iked. Effects of lurasidone on executive function in common marmosets. Behavioural brain research. vol 246. 2013-10-28. PMID:23454675. |
lurasidone, a novel atypical antipsychotic agent with high binding affinity for dopamine d2, serotonin 5-ht7, 5-ht2a and 5-ht1a receptors has been reported to have superior efficacy in rodents' models of cognitive impairment. |
2013-10-28 |
2023-08-12 |
Not clear |
| Takafumi Mizushige, Yurina Sawashi, Ayako Yamada, Ryuhei Kanamoto, Kousaku Ohinat. Characterization of Tyr-Leu-Gly, a novel anxiolytic-like peptide released from bovine αS-casein. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 27. issue 7. 2013-09-18. PMID:23580614. |
the anxiolytic-like activity of ylg was inhibited by way100135, sch23390 or bicuculline, antagonists of serotonin 5-ht1a, dopamine d1, and gaba(a) receptors, respectively; however, ylg had no affinity for these receptors. |
2013-09-18 |
2023-08-12 |
mouse |
| Takafumi Mizushige, Norimasa Kanegawa, Ayako Yamada, Ami Ota, Ryuhei Kanamoto, Kousaku Ohinat. Aromatic amino acid-leucine dipeptides exhibit anxiolytic-like activity in young mice. Neuroscience letters. vol 543. 2013-09-06. PMID:23570730. |
similarly to yl, the anxiolytic-like activities of fl and wl were inhibited by way100135, sch-23390 and bicuculline, antagonists of serotonin 5-ht1a, dopamine d1 and gabaa receptors, respectively, implying that fl and wl activate a common anxiolytic pathway to that of yl. |
2013-09-06 |
2023-08-12 |
mouse |
| Yin Chen, Songlin Wang, Xiangqing Xu, Xin Liu, Minquan Yu, Song Zhao, Shicheng Liu, Yinli Qiu, Tan Zhang, Bi-Feng Liu, Guisen Zhan. Synthesis and biological investigation of coumarin piperazine (piperidine) derivatives as potential multireceptor atypical antipsychotics. Journal of medicinal chemistry. vol 56. issue 11. 2013-08-20. PMID:23675993. |
the discovery and synthesis of potential and novel antipsychotic coumarin derivatives, associated with potent dopamine d2, d3, and serotonin 5-ht1a and 5-ht2a receptor properties, are the focus of the present article. |
2013-08-20 |
2023-08-12 |
Not clear |
| Yin Chen, Songlin Wang, Xiangqing Xu, Xin Liu, Minquan Yu, Song Zhao, Shicheng Liu, Yinli Qiu, Tan Zhang, Bi-Feng Liu, Guisen Zhan. Synthesis and biological investigation of coumarin piperazine (piperidine) derivatives as potential multireceptor atypical antipsychotics. Journal of medicinal chemistry. vol 56. issue 11. 2013-08-20. PMID:23675993. |
this derivative possesses unique pharmacological features, including high affinity for dopamine d2 and d3 and serotonin 5-ht1a and 5-ht2a receptors. |
2013-08-20 |
2023-08-12 |
Not clear |
| Ahmad H Alkhatib, Anna Dvorkin-Gheva, Henry Szechtma. Quinpirole and 8-OH-DPAT induce compulsive checking behavior in male rats by acting on different functional parts of an OCD neurocircuit. Behavioural pharmacology. vol 24. issue 1. 2013-06-10. PMID:23249525. |
this study investigated whether the serotonin 5-ht1a receptor agonist 8-hydroxy-2-(di-n-propylamino) tetralin (8-oh-dpat) can induce compulsive checking in a large open field, as does the dopamine d2/d3 receptor agonist quinpirole. |
2013-06-10 |
2023-08-12 |
rat |
| Jun-Xu Li, Shutian Ju, Michelle G Baladi, Wouter Koek, Charles P Franc. Eating high fat chow increases the sensitivity of rats to 8-OH-DPAT-induced lower lip retraction. Behavioural pharmacology. vol 22. issue 8. 2013-02-05. PMID:21979831. |
sensitivity to (+)-8-hydroxy-2-(dipropylamino) tetralin hydrobromide (8-oh-dpat; 5-ht1a receptor agonist)-induced lower lip retraction was examined in separate groups (n=8-9) of rats with free access to standard (5.7% fat) or high fat (34.3% fat) chow; sensitivity to quinpirole (dopamine d3/d2 receptor agonist)-induced yawning was also examined. |
2013-02-05 |
2023-08-12 |
rat |
| Jun-Xu Li, Shutian Ju, Michelle G Baladi, Wouter Koek, Charles P Franc. Eating high fat chow increases the sensitivity of rats to 8-OH-DPAT-induced lower lip retraction. Behavioural pharmacology. vol 22. issue 8. 2013-02-05. PMID:21979831. |
these data extend previous results showing changes in sensitivity to drugs acting on dopamine systems in animals eating high fat chow to a drug acting at 5-ht1a receptors and they provide support for the notion that eating certain foods impacts sensitivity to drugs acting on monoamine systems. |
2013-02-05 |
2023-08-12 |
rat |
| Cheryl Shuang-wu Li, Liming Zhang, Taraneh Haske, Amy Dounay, David Gray, Nancy Barta, Joanne Brodfuehrer, Christopher Lepsy, Brian Campbel. Mechanism-based pharmacokinetic/pharmacodynamic modeling of rat prefrontal cortical dopamine response to dual acting norepinephrine reuptake inhibitor and 5-HT1A partial agonist. The AAPS journal. vol 14. issue 2. 2013-01-28. PMID:22454087. |
mechanism-based pharmacokinetic/pharmacodynamic modeling of rat prefrontal cortical dopamine response to dual acting norepinephrine reuptake inhibitor and 5-ht1a partial agonist. |
2013-01-28 |
2023-08-12 |
rat |
| M Brunetti, L Di Tizio, S Dezi, G Pozzi, P Grandinetti, G Martinott. Aripiprazole, alcohol and substance abuse: a review. European review for medical and pharmacological sciences. vol 16. issue 10. 2012-12-20. PMID:23104650. |
it functions as a partial agonist at dopamine d2 and 5-ht1a receptors, and as an antagonist at the 5-ht2a receptor. |
2012-12-20 |
2023-08-12 |
Not clear |
| Eiji Kirin. Efficacy and safety of aripiprazole in child and adolescent patients. European child & adolescent psychiatry. vol 21. issue 7. 2012-11-26. PMID:22447196. |
aripiprazole (apz) has a unique pharmacological profile, as a partial agonist at the dopamine d2 and serotonin 5ht1a receptors and an antagonist at the serotonin 5ht2a receptor; this drug has few side effects (such as extrapyramidal syndrome, hyperprolactinemia, weight gain, metabolic disorders, and sedation) which are typical problems with other antipsychotic drugs. |
2012-11-26 |
2023-08-12 |
Not clear |
| G T Shishkina, T S Kalinina, N N Dygal. Effects of swim stress and fluoxetine on 5-HT1A receptor gene expression and monoamine metabolism in the rat brain regions. Cellular and molecular neurobiology. vol 32. issue 5. 2012-10-17. PMID:22453856. |
fst exposure also decreased the brainstem dopamine metabolism, which was unexpectedly positively correlated with 5-ht1a receptor mrna levels in the frontal cortex. |
2012-10-17 |
2023-08-12 |
rat |
| B T Carrol. The universal field hypothesis of catatonia and neuroleptic malignant syndrome. CNS spectrums. vol 5. issue 7. 2012-10-02. PMID:18197153. |
this hypothesis considers both disorders as a single entity that result from variable combinations of the following: 1) gamma-aminobutyric acid (gaba) hypoactivity at the gabaa receptor; 2) dopamine hypoactivity at the d2 receptor; 3) serotonin hyperactivity at the 5-ht1a receptor and hypoactivity at the 5-ht2a receptor; and 4) glutamate hypoactivity at the n-methyl-d-aspartate (ndma) receptor. |
2012-10-02 |
2023-08-12 |
human |
| Yoshihiro Tadori, Tetsuro Kikuch. [Pharmacology of antipsychotics at human dopamine D2 and D3 receptors]. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology. vol 32. issue 1. 2012-09-13. PMID:22568121. |
aripiprazole is a dopamine d/d3 and serotonin 5-ht1a receptor partial agonist which is approved for treatment of schizophrenia. |
2012-09-13 |
2023-08-12 |
human |
| Mark Sanford, Gillian M Keatin. Quetiapine: a review of its use in the management of bipolar depression. CNS drugs. vol 26. issue 5. 2012-08-10. PMID:22519923. |
the antidepressant effects of quetiapine are poorly understood, but may be related to antagonism of 5-ht2a receptors in cortical regions, partial agonism of 5-ht1a in the prefrontal cortex in association with increased extracellular dopamine release in the region, or to reduced synaptic reuptake of noradrenaline resulting from inhibition of the noradrenaline reuptake transporter by the quetiapine metabolite norquetiapine. |
2012-08-10 |
2023-08-12 |
Not clear |
| Mei Huang, Masakuni Horiguchi, Anna R Felix, Herbert Y Meltze. 5-HT1A and 5-HT7 receptors contribute to lurasidone-induced dopamine efflux. Neuroreport. vol 23. issue 7. 2012-08-02. PMID:22415605. |
5-ht1a and 5-ht7 receptors contribute to lurasidone-induced dopamine efflux. |
2012-08-02 |
2023-08-12 |
rat |
| Mei Huang, Masakuni Horiguchi, Anna R Felix, Herbert Y Meltze. 5-HT1A and 5-HT7 receptors contribute to lurasidone-induced dopamine efflux. Neuroreport. vol 23. issue 7. 2012-08-02. PMID:22415605. |
lurasidone is a novel, atypical antipsychotic drug with serotonin [5-hydroxytryptamine (5-ht)]2a, 5-ht7, dopamine (da) d2 antagonist, and 5-ht1a receptor partial agonist properties. |
2012-08-02 |
2023-08-12 |
rat |
| Shunsuke Tanahashi, Satoshi Yamamura, Masanori Nakagawa, Eishi Motomura, Motohiro Okad. Dopamine D2 and serotonin 5-HT1A receptors mediate the actions of aripiprazole in mesocortical and mesoaccumbens transmission. Neuropharmacology. vol 62. issue 2. 2012-07-27. PMID:21925189. |
dopamine d2 and serotonin 5-ht1a receptors mediate the actions of aripiprazole in mesocortical and mesoaccumbens transmission. |
2012-07-27 |
2023-08-12 |
Not clear |
| Shunsuke Tanahashi, Satoshi Yamamura, Masanori Nakagawa, Eishi Motomura, Motohiro Okad. Dopamine D2 and serotonin 5-HT1A receptors mediate the actions of aripiprazole in mesocortical and mesoaccumbens transmission. Neuropharmacology. vol 62. issue 2. 2012-07-27. PMID:21925189. |
the antipsychotic agent aripiprazole acts as a partial agonist of dopamine d2 and serotonin 5-ht1a receptors. |
2012-07-27 |
2023-08-12 |
Not clear |