| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tamara Romón, Anna M Planas, Albert Adel. Blockade of MK-801-induced heat shock protein 72/73 in rat brain by antipsychotic and monoaminergic agents targeting D2, 5-HT1A, 5-HT2A and α1-adrenergic receptors. CNS & neurological disorders drug targets. vol 13. issue 1. 2014-10-08. PMID:24040788. |
in addition, antagonism at dopamine d2 (raclopride), 5-ht2 (m100907) and α1- adrenoceptors (prazosin) as well as agonism at 5-ht1a receptors (bay x 3702) also diminished the mk-801-induced number of cells labeled with hsp72/73. |
2014-10-08 |
2023-08-12 |
rat |
| Tamara Romón, Anna M Planas, Albert Adel. Blockade of MK-801-induced heat shock protein 72/73 in rat brain by antipsychotic and monoaminergic agents targeting D2, 5-HT1A, 5-HT2A and α1-adrenergic receptors. CNS & neurological disorders drug targets. vol 13. issue 1. 2014-10-08. PMID:24040788. |
the results suggest that the efficacy of atypical antipsychotic drugs in the clinic may result from a combined effect on 5-ht2, 5-ht1a and α1-adrenergic receptors added to the classical dopamine d2 receptor antagonism. |
2014-10-08 |
2023-08-12 |
rat |
| Mirjana Carli, Roberto W Invernizz. Serotoninergic and dopaminergic modulation of cortico-striatal circuit in executive and attention deficits induced by NMDA receptor hypofunction in the 5-choice serial reaction time task. Frontiers in neural circuits. vol 8. 2014-09-24. PMID:24966814. |
in this review, we focus on the 5-choice serial reaction time task which is able to provide various measures of attention and executive control over performance in rodents and the ability of prefrontocortical and striatal serotonin 5-ht1a, 5-ht2a, and 5-ht2c as well as dopamine d1- and d2-like receptors to modulate different aspects of executive and attention disturbances induced by nmda receptor hypofunction in the prefrontal cortex. |
2014-09-24 |
2023-08-13 |
Not clear |
| Mirjana Carli, Roberto W Invernizz. Serotoninergic and dopaminergic modulation of cortico-striatal circuit in executive and attention deficits induced by NMDA receptor hypofunction in the 5-choice serial reaction time task. Frontiers in neural circuits. vol 8. 2014-09-24. PMID:24966814. |
these studies illustrate the control of attention selectivity by serotonin 5-ht1a, 5-ht2a, 5-ht2c, and dopamine d1- but not d2-like receptors and a distinct contribution of these cortical and striatal serotonin and dopamine receptors to the control of different aspects of executive control over performance such as impulsivity and compulsivity. |
2014-09-24 |
2023-08-13 |
Not clear |
| Na Ye, Zilan Song, Ao Zhan. Dual ligands targeting dopamine D2 and serotonin 5-HT1A receptors as new antipsychotical or anti-Parkinsonian agents. Current medicinal chemistry. vol 21. issue 4. 2014-09-17. PMID:24164194. |
dual ligands targeting dopamine d2 and serotonin 5-ht1a receptors as new antipsychotical or anti-parkinsonian agents. |
2014-09-17 |
2023-08-12 |
Not clear |
| Na Ye, Zilan Song, Ao Zhan. Dual ligands targeting dopamine D2 and serotonin 5-HT1A receptors as new antipsychotical or anti-Parkinsonian agents. Current medicinal chemistry. vol 21. issue 4. 2014-09-17. PMID:24164194. |
the present review discusses the advance of dual agents with mixed actions at the dopamine d2 and serotonin 5-ht1a receptors in the treatment of these diseases. |
2014-09-17 |
2023-08-12 |
Not clear |
| Toshio Matsud. Neuropharmacologic studies on the brain serotonin1A receptor using the selective agonist osemozotan. Biological & pharmaceutical bulletin. vol 36. issue 12. 2014-07-14. PMID:24292048. |
furthermore, we showed that osemozotan attenuates psychostimulant-induced behavioral sensitization and that prefrontal dopamine release is enhanced by functional interaction between the 5-ht1a receptor and other receptors. |
2014-07-14 |
2023-08-12 |
mouse |
| Kiran Kumar Sayyaparaju, Heinz Grunze, Kostas N Fountoulaki. When to start aripiprazole therapy in patients with bipolar mania. Neuropsychiatric disease and treatment. vol 10. 2014-06-24. PMID:24648740. |
it has a unique mode of action, acting as a partial agonist at dopamine d2 and d3, and serotonin 5-ht1a; and exhibiting antagonistic action at the 5-ht2a and h1 receptors. |
2014-06-24 |
2023-08-12 |
Not clear |
| Susanne Nikolaus, Hubertus Hautzel, Hans-Wilhelm Mülle. Neurochemical dysfunction in treated and nontreated schizophrenia - a retrospective analysis of in vivo imaging studies. Reviews in the neurosciences. vol 25. issue 1. 2014-06-03. PMID:24486731. |
for the pool of drug-naïve, drug-free, and acutely medicated patients, major findings were increases in neostriatal dopamine (da) synthesis and release and decreases in neostriatal da transporters and d1 receptors, neostriatal, thalamic, frontal, and parietal d2 receptors, mesencephalic/pontine and temporal 5-ht1a receptors, frontal and temporal ht2a and μ-amino butyric acid (gaba)a receptors. |
2014-06-03 |
2023-08-12 |
Not clear |
| Morteza Zendehdel, Keyvan Hasani, Vahab Babapour, Sepideh Seyedali Mortezaei, Yalda Khoshbakht, Shahin Hassanpou. Dopamine-induced hypophagia is mediated by D1 and 5HT-2c receptors in chicken. Veterinary research communications. vol 38. issue 1. 2014-05-22. PMID:24122738. |
at following, birds were icv injected using 8-oh-dpat (5-ht1a agonist; 15.25 nmol) and sb242084 (5-ht2c antagonist; 1.5 μg) prior dopamine (40 nmol) injection. |
2014-05-22 |
2023-08-12 |
chicken |
| Mei Huang, John J Panos, Sunoh Kwon, Yoshihiro Oyamada, Lakshmi Rajagopal, Herbert Y Meltze. Comparative effect of lurasidone and blonanserin on cortical glutamate, dopamine, and acetylcholine efflux: role of relative serotonin (5-HT)2A and DA D2 antagonism and 5-HT1A partial agonism. Journal of neurochemistry. vol 128. issue 6. 2014-05-14. PMID:24164459. |
comparative effect of lurasidone and blonanserin on cortical glutamate, dopamine, and acetylcholine efflux: role of relative serotonin (5-ht)2a and da d2 antagonism and 5-ht1a partial agonism. |
2014-05-14 |
2023-08-12 |
rat |
| Mei Huang, John J Panos, Sunoh Kwon, Yoshihiro Oyamada, Lakshmi Rajagopal, Herbert Y Meltze. Comparative effect of lurasidone and blonanserin on cortical glutamate, dopamine, and acetylcholine efflux: role of relative serotonin (5-HT)2A and DA D2 antagonism and 5-HT1A partial agonism. Journal of neurochemistry. vol 128. issue 6. 2014-05-14. PMID:24164459. |
more potent serotonin (5-ht)2a than dopamine (da) d2 receptors antagonism, and direct or indirect 5-ht1a agonism, characterize almost all aapds. |
2014-05-14 |
2023-08-12 |
rat |
| Edward C Lauterbach, Jeffrey L Cummings, Preetha Sharone Kuppuswam. Toward a more precise, clinically--informed pathophysiology of pathological laughing and crying. Neuroscience and biobehavioral reviews. vol 37. issue 8. 2014-05-08. PMID:23518269. |
pag activity is regulated by glutamatergic nmda, muscarinic m1-3, gaba-a, dopamine d2, norepinephrine alpha-1,2, serotonin 5ht1a, 5ht1b/d, and sigma-1 receptors, with an acetylcholine/gaba balance mediating volitional inhibition of the pag. |
2014-05-08 |
2023-08-12 |
Not clear |
| Tomiki Sumiyoshi, Yuko Higuchi, Takashi Uehar. Neural basis for the ability of atypical antipsychotic drugs to improve cognition in schizophrenia. Frontiers in behavioral neuroscience. vol 7. 2014-03-10. PMID:24137114. |
the neural network underlying the ability of 5-ht1a agonists to treat cognitive impairments of schizophrenia likely includes dopamine, glutamate, and gamma-aminobutyric acid neurons. |
2014-03-10 |
2023-08-12 |
rat |
| S Body, T H C Cheung, L Valencia-Torres, C M Olarte-Sánchez, K C F Fone, C M Bradshaw, E Szabad. Pharmacological studies of performance on the free-operant psychophysical procedure. Behavioural processes. vol 95. 2014-01-21. PMID:23428704. |
t50 is reduced by acute treatment with 5-hydroxytryptamine (5-ht1a, 5-ht2a) and dopamine (d1-like, d2-like) receptor agonists. |
2014-01-21 |
2023-08-12 |
Not clear |
| Man Li, Xiaofang Xue, Shuang Shao, Feng Shao, Weiwen Wan. Cognitive, emotional and neurochemical effects of repeated maternal separation in adolescent rats. Brain research. vol 1518. 2014-01-07. PMID:23623774. |
previous studies have reported that ms affected prepulse inhibition (ppi), anxiety-related behaviors, dopaminergic and serotonergic activity in adult rats, and in the present study, we investigated the effects of repeated (4h/day) maternal separation during postnatal days 1-21 on ppi and anxiety-related behaviors in an elevated plus maze, as well as dopamine d2 receptor (drd2) and 5-ht1a receptor expression in the medial prefrontal cortex (mpfc), nucleus accumbens (nac) and hippocampus in adolescent rats. |
2014-01-07 |
2023-08-12 |
rat |
| Caroline Porto Leite Teixeira, Carla Thiciane Vasconcelos de Melo, Fernando Luiz Oliveira de Araújo, Allyne Mara Rodrigues de Carvalho, Maria Izabel Gomes Silva, José Maria Barbosa-Filho, Danielle Silveira Macêdo, Glauce Socorro de Barros Viana, Francisca Cléa Florenço de Sous. Antidepressant-like effect of riparin II from Aniba riparia in mice: evidence for the involvement of the monoaminergic system. Fundamental & clinical pharmacology. vol 27. issue 2. 2013-12-03. PMID:21854446. |
the pretreatment of mice with prazosin (1 mg/kg, i.p., an α1-adrenoceptor antagonist), sch23390 (15 μg/kg, i.p., a dopamine d1 receptor antagonist), sulpiride (50 mg/kg, i.p., a dopamine d2 receptor antagonist), p-chlorophenylalanine (100 mg/kg, an inhibitor of serotonin synthesis), or nan-190 (0.5 mg/kg, a serotonin 5-ht1a receptor antagonist) completely blocked the anti-immobility effects elicited by riparin ii (50 mg/kg, p.o.) |
2013-12-03 |
2023-08-12 |
mouse |
| Katerina Zavitsanou, Victoria S Dalton, Adam K Walker, Cynthia S Weickert, Luba Sominsky, Deborah M Hodgso. Neonatal lipopolysaccharide treatment has long-term effects on monoaminergic and cannabinoid receptors in the rat. Synapse (New York, N.Y.). vol 67. issue 6. 2013-10-29. PMID:23389966. |
dopamine d1, d2, serotonin 5ht1a, 5ht2a, and serotonin transporter and cannabinoid cb1 receptor binding across several brain regions were measured autoradiographically in adulthood (pnd 85). |
2013-10-29 |
2023-08-12 |
rat |
| Katerina Zavitsanou, Victoria S Dalton, Adam K Walker, Cynthia S Weickert, Luba Sominsky, Deborah M Hodgso. Neonatal lipopolysaccharide treatment has long-term effects on monoaminergic and cannabinoid receptors in the rat. Synapse (New York, N.Y.). vol 67. issue 6. 2013-10-29. PMID:23389966. |
neonatal lps treatment caused a significant increase in dopamine d2 in the nucleus accumbens and olfactory tubercle, a decrease in 5ht1a receptor binding in the hippocampus ca1 and ventromedial hypothalamus. |
2013-10-29 |
2023-08-12 |
rat |
| Stephen M Stahl, Clara Lee-Zimmerman, Sylvia Cartwright, Debbi Ann Morrissett. Serotonergic drugs for depression and beyond. Current drug targets. vol 14. issue 5. 2013-10-29. PMID:23531115. |
the original trend to do this selectively (e.g., with ssris or selective serotonin reuptake inhibitors) has given way to combining various additional pharmacologic mechanisms with sert inhibition, including dual actions by single drugs (e.g., snris or serotonin norepinephrine reuptake inhibitors), or by augmenting ssris with a second drug of a different mechanism (e.g., bupropion with dopamine and norepinephrine reuptake inhibition; trazodone with 5ht2a antagonism; mirtazapine with 5ht2a/5ht2c/5ht3/alpha2 antagonism; buspirone or some atypical antipsychotics with 5ht1a partial agonism; other atypical antipsychotics with 5ht2c/5ht7 antagonism and other mechanisms). |
2013-10-29 |
2023-08-12 |
Not clear |