| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| U K Rinn. Treatment of Parkinson's disease: problems with a progressing disease. Journal of neural transmission. vol 51. issue 1-2. 1981-10-25. PMID:7264627. |
post-mortem brain studies have shown that in parkinson's disease there is not only a progressive loss of dopaminergic substantia nigra neurons but there are also significant changes in the striatal dopamine receptors. |
1981-10-25 |
2023-08-12 |
Not clear |
| K Fuxe, L F Agnati, C Köhler, D Kuonen, S O Ogren, K Andersson, T Hökfel. Characterization of normal and supersensitive dopamine receptors: effects of ergot drugs and neuropeptides. Journal of neural transmission. vol 51. issue 1-2. 1981-10-25. PMID:7264628. |
actions of dopaminergic ergot drugs have been evaluated at supersensitive dopamine receptors. |
1981-10-25 |
2023-08-12 |
rat |
| K Fuxe, L F Agnati, C Köhler, D Kuonen, S O Ogren, K Andersson, T Hökfel. Characterization of normal and supersensitive dopamine receptors: effects of ergot drugs and neuropeptides. Journal of neural transmission. vol 51. issue 1-2. 1981-10-25. PMID:7264628. |
in agreement with previous work, evidence have also been presented that prolonged treatment with a potent dopaminergic drug, pergolide, can produce a down regulation of normal dopamine receptors by reducing the density of such receptors. |
1981-10-25 |
2023-08-12 |
rat |
| L György, Z Orr, G Folly, M Dód. The influence of dopamine and dopaminergic agonists on the contractions of field stimulated rat vas deferens. Archives internationales de pharmacodynamie et de therapie. vol 250. issue 1. 1981-10-14. PMID:6268006. |
the influence of dopamine and dopaminergic agonists on the contractions of field stimulated rat vas deferens. |
1981-10-14 |
2023-08-12 |
rat |
| A L Gundlach, P M Bear. Differential effects of IV and IP muscimol on central dopamine metabolism. Psychopharmacology. vol 74. issue 1. 1981-10-14. PMID:6791208. |
the effect of iv and ip muscimol on the concentrations of dopamine (da) and 3,4-dihydroxyphenylacetic acid (dopac) in both the nigrostriatal and mesolimbic dopaminergic pathways has been studied. |
1981-10-14 |
2023-08-12 |
Not clear |
| C Ferrari, P Rampini, A Malinverni, C Scarduelli, R Benco, R Caldara, C Barbieri, G Testori, P G Crosignan. Inhibition of luteinizing hormone release by dopamine infusion in healthy women and in various pathophysiological conditions. Acta endocrinologica. vol 97. issue 4. 1981-10-14. PMID:6791426. |
to investigate the effect of dopaminergic stimulation on gonadotrophin release, serum lh and fsh concentrations were measured during dopamine infusion (5 microgram/kg/min for 120 min) in 8 healthy women in the early follicular phase, in 12 patients with hyperprolactinaemic amenorrhoea, in 5 subjects with premature ovarian failure and in 8 with polycystic ovarian disease and raised serum lh levels. |
1981-10-14 |
2023-08-12 |
human |
| M J Kell. An analysis of the effects of apomorphine and haloperidol on the release of [3H]-dopamine and [3H]-noradrenaline from rabbit brain slices. Archives internationales de pharmacodynamie et de therapie. vol 250. issue 1. 1981-10-14. PMID:7271378. |
in low concentrations both compounds showed selectivity for dopaminergic receptor sites, apomorphine stimulating and haloperidol inhibiting pre-synaptic dopamine receptors. |
1981-10-14 |
2023-08-12 |
rabbit |
| A L Gundlach, P M Bear. Effect of GABAergic drugs on dopamine catabolism in the nigrostriatal and mesolimbic dopaminergic pathways of the rat. The Journal of pharmacy and pharmacology. vol 33. issue 1. 1981-09-25. PMID:6114152. |
effect of gabaergic drugs on dopamine catabolism in the nigrostriatal and mesolimbic dopaminergic pathways of the rat. |
1981-09-25 |
2023-08-12 |
rat |
| G R Hanson, L Alphs, W Wolf, R Levine, W Lovenber. Haloperidol-induced reduction of nigral substance P-like immunoreactivity: a probe for the interactions between dopamine and substance P neuronal systems. The Journal of pharmacology and experimental therapeutics. vol 218. issue 2. 1981-09-25. PMID:6166743. |
data presented in this paper suggest that 1) blockade of dopamine postsynaptic receptors alters nigral spli levels associated with the substance p striatal-nigral loop, 2) destruction of the nigral-striatal dopaminergic pathway results in changes in nigral content of spli similar to that induced by haloperidol, 3) several weeks after nigral-striatal lesions, compensatory mechanisms mediate a return of nigral spli content to control levels and 4) substance p striatal-nigral circuits continue to respond to dopaminergic input after kainic acid lesions in the anterior striatum, whereas properly placed mechanical striatal-nigral lesions appear to be effective in preventing this interaction. |
1981-09-25 |
2023-08-12 |
Not clear |
| S Bansal, L A Lee, P D Wool. Dopaminergic regulation of growth hormone (GH) secretion in normal man: correlation of L-dopa and dopamine levels with the GH response. The Journal of clinical endocrinology and metabolism. vol 53. issue 2. 1981-09-25. PMID:7251816. |
dopaminergic regulation of growth hormone (gh) secretion in normal man: correlation of l-dopa and dopamine levels with the gh response. |
1981-09-25 |
2023-08-12 |
Not clear |
| P Demenge, P Mouchet, B Guerin, C Feuerstei. Identification and distribution of neuroleptic binding sites in the rat spinal cord. Journal of neurochemistry. vol 37. issue 1. 1981-09-22. PMID:6114137. |
the displacement of the labelled ligand by different dopaminergic and nondopaminergic drugs at various concentrations gave similar results in the whole striatum and the spinal cord, giving further support for the existence of a dopaminergic innervation of the spinal cord and showing that dopaminergic receptor sites are distributed through the different spinal horns, with a maximal density in the dorsal horn--as for dopamine levels. |
1981-09-22 |
2023-08-12 |
rat |
| K Anderson, A Kuruvilla, N Uretsky, D D Mille. Synthesis and pharmacological evaluation of sulfonium analogues of dopamine: nonclassical dopamine agonists. Journal of medicinal chemistry. vol 24. issue 6. 1981-09-22. PMID:7252978. |
in order to test whether the nitrogen/ammonium moiety in the dopamine molecule is required for dopaminergic activity, we have synthesized two sulfonium analogues of dopamine and tested them for biological activity in an in vivo and in an in vitro system. |
1981-09-22 |
2023-08-12 |
rat |
| K Anderson, A Kuruvilla, N Uretsky, D D Mille. Synthesis and pharmacological evaluation of sulfonium analogues of dopamine: nonclassical dopamine agonists. Journal of medicinal chemistry. vol 24. issue 6. 1981-09-22. PMID:7252978. |
this study suggests that the nitrogen atom found in th dopamine molecule is not essential for dopaminergic activity, since the nitrogen can be replaced by a sulfonium functional group for this activity. |
1981-09-22 |
2023-08-12 |
rat |
| T E Robinson, D M Camp, J B Becke. Gonadectomy attenuates turning behavior produced by electrical stimulation of the nigrostriatal dopamine system in female but not male rats. Neuroscience letters. vol 23. issue 2. 1981-09-22. PMID:7254708. |
steroid hormones influence the metabolism of many dopaminergic drugs, and therefore this approach avoids the complications inherent in drug-induced behavior models of dopamine activity. |
1981-09-22 |
2023-08-12 |
rat |
| S Kaakkol. Effect of nicotinic and muscarinic drugs on amphetamine- and apomorphine-induced circling behaviour in rats. Acta pharmacologica et toxicologica. vol 48. issue 2. 1981-09-22. PMID:7257827. |
the presynaptic nicotinic cholinergic receptors on the terminals of the nigrostriatal dopaminergic neurones, stimulation of which may increase the release of dopamine, might be involved in the action of nicotinic drugs. |
1981-09-22 |
2023-08-12 |
rat |
| A A Megens, A R Cool. Presence of a particular subpopulation of dopamine receptors within the septal nuclei: a behavioural study on cats. European journal of pharmacology. vol 71. issue 2-3. 1981-09-15. PMID:6265235. |
the behavioural effects of intraseptal administration of dopaminergic drugs (apomorphine, haloperidol, (3,4-dihydroxy-phenylamino)-2-imidazoline (dpi), ergometrine and dopamine) and alpha-noradrenergic drugs (oxymetazoline, noradrenaline and phentolamine) were analysed in cats pretreated with morphine (5 mg/kg, i.p.). |
1981-09-15 |
2023-08-12 |
Not clear |
| J Nguyen-Legros, B Berger, C Alvare. High resolution radioautography of central dopaminergic fibers labelled in vitro with [3H]dopamine or [3H]norepinephrine. Brain research. vol 213. issue 2. 1981-09-15. PMID:7248758. |
high resolution radioautography of central dopaminergic fibers labelled in vitro with [3h]dopamine or [3h]norepinephrine. |
1981-09-15 |
2023-08-12 |
human |
| P G Guyenet, J K Cran. Non-dopaminergic nigrostriatal pathway. Brain research. vol 213. issue 2. 1981-09-15. PMID:7248760. |
despite a reduction of up to 85% in the number of dopaminergic cell bodies, the substantia nigra of these rats contained the same average number of eb-labelled neurons devoid of dopamine fluorescence. |
1981-09-15 |
2023-08-12 |
rat |
| K Dishovski, I Panova, P Uzuno. [Effect of the organophosphorus compound neguvon on the dopamine content in the rat brain]. Eksperimentalna meditsina i morfologiia. vol 20. issue 2. 1981-09-15. PMID:7250022. |
they discussed the connection between the changes in the content of dopamine and modulating role of presynaptic choline receptors of h- and m- types in the dopaminergic terminals of the striatum. |
1981-09-15 |
2023-08-12 |
rat |
| K Golombiowska-Nikitin, K H Sontag, N N Osborn. 3H-Spiroperidol binding to striatal membranes of mutant Han-Wistar rats which exhibit spastic paresis. Experientia. vol 37. issue 5. 1981-09-15. PMID:7250319. |
these findings indicate that the dopamine receptors of the mutants are affected and could explain some of the previous data; it has been suggested that some of the spasticity observed in the mutants may be due to an abnormal functioning of their dopaminergic neurones. |
1981-09-15 |
2023-08-12 |
rat |