| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| E Melamed, F Hefti, R J Wurtma. Nonaminergic striatal neurons convert exogenous L-dopa to dopamine in parkinsonism. Annals of neurology. vol 8. issue 6. 1981-05-21. PMID:6260009. |
we propose that after depletion of dopaminergic terminals, these nonaminergic striatal neurons may contain a large fraction of residual dopa decarboxylase activity and may represent an important locus for conversion of administered dopa to functional dopamine in the parkinsonian corpus striatum. |
1981-05-21 |
2023-08-12 |
Not clear |
| Sh I Magalov, E L Dadal. [Catecholamine metabolism in Huntington's chorea (in patients and their phenotypically healthy relatives)]. Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952). vol 80. issue 8. 1981-05-21. PMID:6452012. |
it is suggested that dopamine metabolism disturbances play the leading role in the disease development, and that it would be wise to use therapeutic agents acting upon the striatum small cells and dopaminergic receptors. |
1981-05-21 |
2023-08-12 |
Not clear |
| Y Nomur. The locomotor effect of clonidine and its interaction with alpha-flupenthixol or haloperidol in the developing rat. Naunyn-Schmiedeberg's archives of pharmacology. vol 313. issue 1. 1981-05-21. PMID:7207635. |
it is suggested that intact function of both alpha-adrenoceptors and dopamine receptors is involved in the control of locomotor activity in developing rats and that there is the complex interaction of noradrenergic and dopaminergic system in the control of locomotor activity. |
1981-05-21 |
2023-08-12 |
rat |
| L Krulich, S M McCann, M A Mayfiel. On the mode of the prolactin release-inhibiting action of the serotonin receptor blockers metergoline, methysergide, and cyproheptadine. Endocrinology. vol 108. issue 4. 1981-05-21. PMID:7472261. |
using animals with large electrolytic lesions of the median eminence-mediobasal hypothalamus, we confirmed earlier findings that metergoline (me) and methysergide (ms) inhibit prl secretion through activation of the dopamine receptors of the pituitary lactotrophs and established, in a quantitative manner, that their dopaminergic potencies are comparable to the potency of the dopamine receptor agonist, piribedil, with ed50 in the order of 0.35 to 0.22 mg/kg. |
1981-05-21 |
2023-08-12 |
rat |
| G Hertting, A Zumstein, R Jackisch, I Hoffmann, K Stark. Modulation by endogenous dopamine of the release of acetylcholine in the caudate nucleus of the rabbit. Naunyn-Schmiedeberg's archives of pharmacology. vol 315. issue 2. 1981-05-13. PMID:7207641. |
endogenous dopamine also acts on the receptors as shown by several manipulations with known effects on dopaminergic transmission. |
1981-05-13 |
2023-08-12 |
rabbit |
| P Maestracci, D Grimaud, N Livrelli, F Philip, C Dolis. Increase in hepatic blood flow and cardiac output during dopamine infusion in man. Critical care medicine. vol 9. issue 1. 1981-04-24. PMID:7460572. |
dopamine, therefore, increased both ehbf and co, but the existence of intrahepatic dopaminergic receptors could not be established. |
1981-04-24 |
2023-08-12 |
human |
| C Y Cheung, R W Kuhn, R I Weine. Increased responsiveness of the dopamine-mediated inhibition of prolactin synthesis after destruction of the medial basal hypothalamus. Endocrinology. vol 108. issue 3. 1981-04-24. PMID:7460839. |
long term destruction of the tuberoinfundibular dopaminergic neurons results in increased responsiveness of the anterior pituitary to the suppression of prl release by dopamine. |
1981-04-24 |
2023-08-12 |
rat |
| J J Braszko, M J Bannon, B S Bunney, R H Rot. Intrastriatal kainic acid: acute effects on electrophysiological and biochemical measures of nigrostriatal dopaminergic activity. The Journal of pharmacology and experimental therapeutics. vol 216. issue 2. 1981-04-21. PMID:6257886. |
the results are discussed in terms of the role of strionigral pathways in mediating the acute effects of kainic acid on the nigrostriatal dopaminergic system and are interpreted in light of the recently described phenomenon of presumed dopamine cell depolarization inactivation. |
1981-04-21 |
2023-08-12 |
Not clear |
| A Cheramy, V Leviel, J Glowinsk. Dendritic release of dopamine in the substantia nigra. Nature. vol 289. issue 5798. 1981-04-13. PMID:6258083. |
dopamine can be released in the substantia nigra for the dendrites of nigrostriatal dopaminergic neurones, to be involved there in the self-regulation of the dopaminergic cells, to control the release of neurotransmitters from nigral afferent fibres and to influence the activity of nigral non-dopaminergic cells. |
1981-04-13 |
2023-08-12 |
Not clear |
| O Hornykiewic. [Brain dopamine and brain disorders - and what we have learned from these studies (author's transl)]. Wiener klinische Wochenschrift. vol 92. issue 20. 1981-04-13. PMID:7467350. |
this observation, taken together with the fact that all antipsychotically effective neuroleptics are potent blockers of brain dopamine receptors, has lead to the hypothesis that dopaminergic brain mechanisms are involved in the pathophysiology of the schizophrenic disorder(s). |
1981-04-13 |
2023-08-12 |
Not clear |
| B R Cooper, T J Hester, R A Maxwel. Behavioral and biochemical effects of the antidepressant bupropion (Wellbutrin): evidence for selective blockade of dopamine uptake in vivo. The Journal of pharmacology and experimental therapeutics. vol 215. issue 1. 1981-03-27. PMID:6778989. |
results indicate that bupropion is a selective dopamine uptake inhibitor in vivo and that dopaminergic systems play an important role in its central nervous system pharmacology. |
1981-03-27 |
2023-08-12 |
rat |
| A J Daniels, K Gysling, L Arquero. Intraneuronal site of action for imipramine in rat striatal slices. Journal of neurochemistry. vol 35. issue 3. 1981-03-27. PMID:7452282. |
it is proposed that imipramine enters the dopaminergic storage vesicles and displaces dopamine. |
1981-03-27 |
2023-08-12 |
rat |
| R Jackisch, A Zumstein, G Hertting, K Stark. Interneurones are probably not involved in the presynaptic dopaminergic control of dopamine release in rabbit caudate nucleus. Naunyn-Schmiedeberg's archives of pharmacology. vol 314. issue 2. 1981-03-27. PMID:7453832. |
interneurones are probably not involved in the presynaptic dopaminergic control of dopamine release in rabbit caudate nucleus. |
1981-03-27 |
2023-08-12 |
rabbit |
| R Jackisch, A Zumstein, G Hertting, K Stark. Interneurones are probably not involved in the presynaptic dopaminergic control of dopamine release in rabbit caudate nucleus. Naunyn-Schmiedeberg's archives of pharmacology. vol 314. issue 2. 1981-03-27. PMID:7453832. |
it is concluded that the presynaptic dopaminergic modulation of dopamine release is not mediated by a tetrodotoxin-sensitive interneuronal pathway. |
1981-03-27 |
2023-08-12 |
rabbit |
| S H Shi. Physiological evidence for the existence of prolactin releasing factor: stress-induced prolactin secretion is not linked to dopaminergic receptors. Neuroendocrinology. vol 31. issue 6. 1981-03-17. PMID:6779219. |
since the putative pif is dopamine, complete blockage of the dopaminergic pif receptors should permit demonstration of prf activity. |
1981-03-17 |
2023-08-12 |
rat |
| K T Demarest, D J Smith, A J Azzar. The presence of the type A form of monoamine oxidase within nigrostriatal dopamine-containing neurons. The Journal of pharmacology and experimental therapeutics. vol 215. issue 2. 1981-02-26. PMID:7441510. |
the nigrostriatal dopaminergic pathway was selected as a model system to determine the form (i.e., type a or b) of monoamine oxidase (mao) present within central dopamine (da)-containing neurons. |
1981-02-26 |
2023-08-12 |
rat |
| I S Hoffmann, R J Naylor, L X Cubedd. Presynaptic effects of 2-aminotetralins on striatal dopaminergic neurons. The Journal of pharmacology and experimental therapeutics. vol 215. issue 2. 1981-02-26. PMID:7441511. |
the present study evaluated whether 2-amino-5,6-dihydroxy-1,2,3,4,-tetrahydronaphthalene (a-5,6 dtn) and its 6,7-dihydroxy isomer (a-6,7 dtn) had effects on striatal dopaminergic terminals in addition to their well known action as agonists on postsynaptic dopamine (da)-receptors. |
1981-02-26 |
2023-08-12 |
rat |
| D P Goodale, D B Rusterholz, J P Long, J R Flynn, B Walsh, J G Cannon, T Le. Neurochemical and behavioral evidence for a selective presynaptic dopamine receptor agonist. Science (New York, N.Y.). vol 210. issue 4474. 1981-02-24. PMID:7444443. |
a new dopamine analog, 6,7-dihydroxy-2-dimethylaminotetralin (tl-99), was compared to apomorphine in three tests of dopaminergic function in the central nervous system. |
1981-02-24 |
2023-08-12 |
rat |
| P M Beart, A L Gundlac. 3,4-dihydroxyphenylacetic acid (DOPAC) and the rat mesolimbic dopaminergic pathway: drug effects and evidence for somatodendritic mechanisms. British journal of pharmacology. vol 69. issue 2. 1981-02-19. PMID:6108139. |
1 drug effects on dopamine catabolism of the mesolimbic dopaminergic pathway have been investigated using a sensitive radioenzymatic assay for 3,4-dihydroxyphenylacetic acid (dopac). |
1981-02-19 |
2023-08-12 |
rat |
| P M Beart, A L Gundlac. 3,4-dihydroxyphenylacetic acid (DOPAC) and the rat mesolimbic dopaminergic pathway: drug effects and evidence for somatodendritic mechanisms. British journal of pharmacology. vol 69. issue 2. 1981-02-19. PMID:6108139. |
6 similarities exist between the dopamine catabolism in somatodendritic and nerve terminal regions of mesolimbic dopaminergic neurones in the response to neuroleptic drugs, but differences in catabolism are evident following certain pharmacological treatments such as reserpine and gamma-butyrolactone. |
1981-02-19 |
2023-08-12 |
rat |