| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P M Laduron, J E Leyse. Domperidone, a specific in vitro dopamine antagonist, devoid of in vivo central dopaminergic activity. Biochemical pharmacology. vol 28. issue 14. 1979-12-18. PMID:496998. |
domperidone, a specific in vitro dopamine antagonist, devoid of in vivo central dopaminergic activity. |
1979-12-18 |
2023-08-11 |
Not clear |
| J Costenti. [Modulation of dopaminergic receptor sensitivity in the central nervous system: important parameters in synaptic function regulation]. L'Encephale. vol 5. issue 2. 1979-11-28. PMID:38958. |
three main types differing by their behavioural and biochemical characteristics are described: -- disuse hypersensitivity to dopamine agonists, induced by an interruption of dopaminergic transmission, seems to depend on an increased number of post-synaptic dopamine receptors; -- hyposensitivity to dopamine agonists, induced by an overstimulation of dopamine receptors, could depend on their qualitative or quantitative modifications; -- behavioural facilitation, elicited by a previous administration of dopaminergic agonists in low dosage, could be associated with an hyposensitivity of dopaminergic autoreceptors. |
1979-11-28 |
2023-08-11 |
Not clear |
| C Chevillard, M N Mathie. Mechanism of the depressor response to dopamine in the rat treated with phenoxybenzamine. European journal of pharmacology. vol 56. issue 4. 1979-11-28. PMID:477731. |
the data suggest that in rats the depressor component of dopamine is due to activation of both dopaminergic and beta-adrenoceptors. |
1979-11-28 |
2023-08-11 |
rat |
| L R Skirboll, A A Grace, B S Bunne. Dopamine auto- and postsynaptic receptors: electrophysiological evidence for differential sensitivity to dopamine agonists. Science (New York, N.Y.). vol 206. issue 4414. 1979-11-21. PMID:482929. |
dopaminergic cells were six to ten times more sensitive to dopamine and intravenous apomorphine than 86 percent of the caudate cells tested. |
1979-11-21 |
2023-08-11 |
Not clear |
| L R Skirboll, A A Grace, B S Bunne. Dopamine auto- and postsynaptic receptors: electrophysiological evidence for differential sensitivity to dopamine agonists. Science (New York, N.Y.). vol 206. issue 4414. 1979-11-21. PMID:482929. |
this differential sensitivity of dopamine auto- and postsynaptic receptors may explain the apparently paradoxical behavioral effects induced by small compared to large doses of some dopamine agonists and may provide a means of developing new types of drugs to antagonize dopaminergic influence in the central nervous system. |
1979-11-21 |
2023-08-11 |
Not clear |
| P D Woolf, R Lantigua, L A Le. Dopamine inhibition of stimulated growth hormone secretion: evidence for dopaminergic modulation of insulin- and L-dopa-induced growth hormone secretion in man. The Journal of clinical endocrinology and metabolism. vol 49. issue 3. 1979-10-26. PMID:468965. |
dopamine inhibition of stimulated growth hormone secretion: evidence for dopaminergic modulation of insulin- and l-dopa-induced growth hormone secretion in man. |
1979-10-26 |
2023-08-11 |
Not clear |
| G Lelord, E Callaway, J P Muh, J C Arlot, D Sauvage, B Garreau, J Domenec. [Modifications in urinary homovanillic acid after ingestion of vitamin B6; functional study in autistic children (author's transl)]. Revue neurologique. vol 134. issue 12. 1979-10-26. PMID:754238. |
basing their study on the investigations which led to the dopaminergic theory of the psychoses, the authors studied homovanillic acid (principal derivative from dopamine) levels in the urines of 37 autistic children, and 11 normal children acting as controls. |
1979-10-26 |
2023-08-11 |
Not clear |
| T L O'Donohue, W R Crowley, D M Jacobowit. Biochemical mapping of the noradrenergic ventral bundle projection sites: evidence for a noradrenergic--dopaminergic interaction. Brain research. vol 172. issue 1. 1979-10-24. PMID:466469. |
norepinephrine (ne) and dopamine (da) concentration and dopamine turnover were measured 12 days after a unilateral or bilateral noradrenergic ventral bundle (vb) transection to determine the noradrenergic projection sites and possible interactions with dopaminergic systems. |
1979-10-24 |
2023-08-11 |
Not clear |
| S M Wuerthele, N M Friedle, K E Moor. Effects of intranigral administration of dopamine agonists and antagonists and baclofen on concentrations of dopac and dopamine in the striatum and substantia nigra of the rat. Journal of neural transmission. vol 45. issue 2. 1979-10-24. PMID:469523. |
however, intranigral microinjections of high concentrations of several dopaminergic antagonists failed to mimic the biochemical effects resulting from systemic administration of these drugs; instead, they slightly increased the concentrations of both dopamine and dopac in the striatum and decreased dopamine in substantia nigra. |
1979-10-24 |
2023-08-11 |
rat |
| R Schwarcz, K Fuxe, L F Agnati, T Hökfelt, J T Coyl. Rotational behaviour in rats with unilateral striatal kainic acid lesions: a behavioural model for studies on intact dopamine receptors. Brain research. vol 170. issue 3. 1979-10-17. PMID:37986. |
since kainic acid treatment had previously been shown to reduce the number of dopamine receptors in the injected brain regions, ipsilateral turning behaviour elicited by dopaminergic drugs after these lesions seems to be due to intact receptors on the contralateral hemisphere. |
1979-10-17 |
2023-08-11 |
rat |
| R Schwarcz, K Fuxe, L F Agnati, T Hökfelt, J T Coyl. Rotational behaviour in rats with unilateral striatal kainic acid lesions: a behavioural model for studies on intact dopamine receptors. Brain research. vol 170. issue 3. 1979-10-17. PMID:37986. |
thus, the present report suggests: (a) that a behavioural model for studies of drugs acting at intact dopamine receptors can be obtained by unilateral neostriatal kainate injections and (b) that development of dopaminergic supersensitivity involves increased affinity of the receptors for dopamine receptor agonists and an increase in the coupling to its biological effector mechanism. |
1979-10-17 |
2023-08-11 |
rat |
| L C Tolbert, T N Thomas, L D Middaugh, J W Zem. Ascorbate blocks amphetamine-induced turning behavior in rats with unilateral nigro-striatal lesions. Brain research bulletin. vol 4. issue 1. 1979-10-17. PMID:572739. |
thus, ascorbic acid might have a role in regulating dopaminergic transmission and could be of therapeutic value in disorders involving functional dopamine excess. |
1979-10-17 |
2023-08-11 |
rat |
| A V Christensen, I M Nielse. Dopaminergic supersensitivity: influence of dopamine agonists, cholinergics, anticholinergics, and drugs used for the treatment of tardive dyskinesia. Psychopharmacology. vol 62. issue 2. 1979-09-17. PMID:111273. |
dopaminergic supersensitivity: influence of dopamine agonists, cholinergics, anticholinergics, and drugs used for the treatment of tardive dyskinesia. |
1979-09-17 |
2023-08-11 |
Not clear |
| A J Zametkin, J R Stevens, R Pittma. Ontogeny of spontaneous blinking and of habituation of the blink reflex. Annals of neurology. vol 5. issue 5. 1979-09-17. PMID:223495. |
the inverse relationship of spontaneous blink rate and number of blink reflexes to habituation in early childhood and in disorders of dopamine transmission suggests that spontaneous blink rate and habituation of the blink reflex reflect maturation and integrity of dopaminergic circuits in the brain. |
1979-09-17 |
2023-08-11 |
Not clear |
| P Seeman, G N Woodruff, J A Poa. Similar binding of 3H-ADTN and 3H-apomorphine to calf brain dopamine receptors. European journal of pharmacology. vol 55. issue 2. 1979-09-17. PMID:456412. |
the ic50 values (nm concentrations inhibiting specific binding by 50%) were 0.9 for (+/-)-n-propyl-norapomorphine, 3.0 for dopamine, 7 for (--)-adrenaline, 60 for (--)-noradrenaline and 4000 for isoproterenol, a series of potencies compatible with properties for a dopaminergic site. |
1979-09-17 |
2023-08-11 |
Not clear |
| P Muller, P Seema. Presynaptic subsensitivity as a possible basis for sensitization by long-term dopamine mimetics. European journal of pharmacology. vol 55. issue 2. 1979-09-17. PMID:572299. |
a possible cellular basis for dopaminergic sensitization by long-term dopamine mimetics was examined in rat brain striatum. |
1979-09-17 |
2023-08-11 |
rat |
| P Muller, P Seema. Presynaptic subsensitivity as a possible basis for sensitization by long-term dopamine mimetics. European journal of pharmacology. vol 55. issue 2. 1979-09-17. PMID:572299. |
this permits less autoregulation and enhanced dopamine agonist action, possibly accounting for the dopaminergic sensitization by long-term agonists. |
1979-09-17 |
2023-08-11 |
rat |
| J M Loeb, M Vassall. Adrenergic mechanisms in postvagal tachycardia. The Journal of pharmacology and experimental therapeutics. vol 210. issue 1. 1979-09-01. PMID:448648. |
postvagal tachycardia: 1) is not affected by ventricular or atrial drive; 2) is enhanced by the application of either norepinephrine or dopamine on the sinus node area; 3) is increased in magnitude and duration by the catecholamine uptake blockers desipramine and phenoxybenzamine; 4) is significantly reduced by beta blockade with propranolol; 5) is not affected by alpha blockade with phentolamine or dopaminergic blockade with haloperidol; 6) is not affected by disulfiram, a drug which inhibits dopamine beta-hydroxylase and thereby increases endogenous dopamine; 7) rises more slowly to a smaller peak after bretylium; and 8) is enhanced by phenoxybenzamine, but not by desipramine, after destruction of sympathetic nerves by 6-hydroxydopamine. |
1979-09-01 |
2023-08-11 |
dog |
| V Leviel, A Chéramy, J Glowinsk. Role of the dendritic release of dopamine in the reciprocal control of the two nigro-striatal dopaminergic pathways. Nature. vol 280. issue 5719. 1979-09-01. PMID:450141. |
role of the dendritic release of dopamine in the reciprocal control of the two nigro-striatal dopaminergic pathways. |
1979-09-01 |
2023-08-11 |
Not clear |
| T J McKenna, D P Island, W E Nicholson, G W Liddl. Dopamine inhibits angiotensin-stimulated aldosterone biosynthesis in bovine adrenal cells. The Journal of clinical investigation. vol 64. issue 1. 1979-08-29. PMID:447857. |
the possibility that dopamine may play a role in the in vivo control of aldosterone production in man was suggested to us by reports from others; (a) that bromocriptine, a dopaminergic agonist, inhibits the aldosterone response to diuresis and to the infusion of angiotensin or acth; and (b) that metaclopramide, a dopamine blocking agent, causes elevations in plasma aldosterone levels. |
1979-08-29 |
2023-08-11 |
human |