| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Frédéric Marmigère, Florence Rage, Lucia Tapia-Arancibi. GABA-glutamate interaction in the control of BDNF expression in hypothalamic neurons. Neurochemistry international. vol 42. issue 4. 2003-04-17. PMID:12470709. |
bdnf peptide content was analyzed by enzyme immunoassay (elisa).we found that picrotoxin (a gaba(a) receptor antagonist) stimulated bdnf mrna expression and that gaba decreased the glutamate-induced augmentation with no effect on the expression of mrna encoding the bdnf receptor, trk b. measurements of bdnf transcripts levels showed that transcripts containing exons i and iii were increased by picrotoxin, whereas those containing exons ii and iv were unchanged. |
2003-04-17 |
2023-08-12 |
Not clear |
| Frédéric Marmigère, Florence Rage, Lucia Tapia-Arancibi. GABA-glutamate interaction in the control of BDNF expression in hypothalamic neurons. Neurochemistry international. vol 42. issue 4. 2003-04-17. PMID:12470709. |
in addition, gaba also inhibited the stimulatory effect of glutamate on bdnf peptide content. |
2003-04-17 |
2023-08-12 |
Not clear |
| Frédéric Marmigère, Florence Rage, Lucia Tapia-Arancibi. GABA-glutamate interaction in the control of BDNF expression in hypothalamic neurons. Neurochemistry international. vol 42. issue 4. 2003-04-17. PMID:12470709. |
our findings show an interaction between glutamate and gaba on bdnf expression (mrna, transcripts and peptide) in fetal hypothalamic neurons. |
2003-04-17 |
2023-08-12 |
Not clear |
| Koichi Obata, Hiroki Yamanaka, Tetsuo Fukuoka, Dai Yi, Atsushi Tokunaga, Norio Hashimoto, Hideki Yoshikawa, Koichi Noguch. Contribution of injured and uninjured dorsal root ganglion neurons to pain behavior and the changes in gene expression following chronic constriction injury of the sciatic nerve in rats. Pain. vol 101. issue 1-2. 2003-03-31. PMID:12507701. |
in order to investigate brain-derived neurotrophic factor (bdnf) and gamma-aminobutyric acid(a)-receptor (gaba(a)-r) regulation in both intact and injured primary afferent neurons after the cci, we used a double-labeling method with immunohistochemistry and in situ hybridization, as well as double immunofluorescent staining. |
2003-03-31 |
2023-08-12 |
rat |
| Hanna M Sobkowicz, Benjamin K August, Susan M Slapnic. Influence of neurotrophins on the synaptogenesis of inner hair cells in the deaf Bronx waltzer (bv) mouse organ of Corti in culture. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 20. issue 7. 2003-03-20. PMID:12485622. |
to investigate the potential role of neurotrophins in the afferent synaptogenesis of inner hair cells, we exposed bv newborn cochleas in organotypic culture to brain-derived neurotrophic factor (bdnf), neurotrophin-3 (nt-3) and nerve growth factor (ngf), and also to gamma aminobutyric acid (gaba), for up to 8 days. |
2003-03-20 |
2023-08-12 |
mouse |
| P Baldelli, M Novara, V Carabelli, J M Hernández-Guijo, E Carbon. BDNF up-regulates evoked GABAergic transmission in developing hippocampus by potentiating presynaptic N- and P/Q-type Ca2+ channels signalling. The European journal of neuroscience. vol 16. issue 12. 2003-03-12. PMID:12492424. |
bdnf action was mediated by trkb-receptors and had no effects on: (i) the amplitude and dose-response of gaba-evoked ipscs and (ii) the number of gaba(a) receptor clusters and the total functioning synapses, suggesting that the neurotrophin unlikely acted postsynaptically. |
2003-03-12 |
2023-08-12 |
rat |
| Sophie Pezet, Joanna Cunningham, Jaykumar Patel, John Grist, Isabella Gavazzi, Isobel J Lever, Marzia Malcangi. BDNF modulates sensory neuron synaptic activity by a facilitation of GABA transmission in the dorsal horn. Molecular and cellular neurosciences. vol 21. issue 1. 2002-11-19. PMID:12359151. |
bdnf modulates sensory neuron synaptic activity by a facilitation of gaba transmission in the dorsal horn. |
2002-11-19 |
2023-08-12 |
rat |
| Sophie Pezet, Joanna Cunningham, Jaykumar Patel, John Grist, Isabella Gavazzi, Isobel J Lever, Marzia Malcangi. BDNF modulates sensory neuron synaptic activity by a facilitation of GABA transmission in the dorsal horn. Molecular and cellular neurosciences. vol 21. issue 1. 2002-11-19. PMID:12359151. |
acute application of bdnf significantly increased potassium-stimulated release of gaba in the dorsal horn isolated in vitro and this effect was blocked by k-252a. |
2002-11-19 |
2023-08-12 |
rat |
| Sophie Pezet, Joanna Cunningham, Jaykumar Patel, John Grist, Isabella Gavazzi, Isobel J Lever, Marzia Malcangi. BDNF modulates sensory neuron synaptic activity by a facilitation of GABA transmission in the dorsal horn. Molecular and cellular neurosciences. vol 21. issue 1. 2002-11-19. PMID:12359151. |
these data suggest that exogenous bdnf can indirectly modulate primary sensory neuron synaptic efficacy via facilitation of the release of gaba from dorsal horn interneurons. |
2002-11-19 |
2023-08-12 |
rat |
| Christine A Richardson, Beulah Leitc. Cerebellar Golgi, Purkinje, and basket cells have reduced gamma-aminobutyric acid immunoreactivity in stargazer mutant mice. The Journal of comparative neurology. vol 453. issue 1. 2002-11-07. PMID:12357434. |
to investigate whether the stargazer mutation and lack of availability of bdnf in the granule cells compromise the phenotype of the cerebellar inhibitory neurons, specifically their immunoreactivity for gamma-aminobutyric acid (gaba); the levels of gaba neurotransmitter expressed in golgi, purkinje, and basket cells; and the density of their synaptic contacts were compared in stargazer and wild-type controls using electron microscopy and quantitative immunogold labelling. |
2002-11-07 |
2023-08-12 |
mouse |
| Christine A Richardson, Beulah Leitc. Cerebellar Golgi, Purkinje, and basket cells have reduced gamma-aminobutyric acid immunoreactivity in stargazer mutant mice. The Journal of comparative neurology. vol 453. issue 1. 2002-11-07. PMID:12357434. |
whether this reduction in gaba content and inhibitory synapse density is directly attributable to the lack of bdnf in the cerebellum of the stargazer mutant is yet to be proved. |
2002-11-07 |
2023-08-12 |
mouse |
| Christian Henneberger, René Jüttner, Thomas Rothe, Rosemarie Granty. Postsynaptic action of BDNF on GABAergic synaptic transmission in the superficial layers of the mouse superior colliculus. Journal of neurophysiology. vol 88. issue 2. 2002-09-23. PMID:12163512. |
from these results we conclude that bdnf increases spontaneous network activity by suppressing gabaergic inhibition, the site of action of bdnf is predominantly postsynaptic, bdnf-induced suppression of gabaergic synaptic transmission is caused by acute downregulation of gaba(a) receptors, and bdnf effects are mediated by its trkb receptor and require pkc activation in the postsynaptic cell. |
2002-09-23 |
2023-08-12 |
mouse |
| Karl Obrietan, Xiao-Bing Gao, Anthony N Van Den Po. Excitatory actions of GABA increase BDNF expression via a MAPK-CREB-dependent mechanism--a positive feedback circuit in developing neurons. Journal of neurophysiology. vol 88. issue 2. 2002-09-23. PMID:12163549. |
excitatory actions of gaba increase bdnf expression via a mapk-creb-dependent mechanism--a positive feedback circuit in developing neurons. |
2002-09-23 |
2023-08-12 |
Not clear |
| Karl Obrietan, Xiao-Bing Gao, Anthony N Van Den Po. Excitatory actions of GABA increase BDNF expression via a MAPK-CREB-dependent mechanism--a positive feedback circuit in developing neurons. Journal of neurophysiology. vol 88. issue 2. 2002-09-23. PMID:12163549. |
to determine whether gaba(a) receptor activation during early development stimulates gene expression, we examined the inducible expression of the neurotrophin brain-derived neurotrophic factor (bdnf). |
2002-09-23 |
2023-08-12 |
Not clear |
| Karl Obrietan, Xiao-Bing Gao, Anthony N Van Den Po. Excitatory actions of GABA increase BDNF expression via a MAPK-CREB-dependent mechanism--a positive feedback circuit in developing neurons. Journal of neurophysiology. vol 88. issue 2. 2002-09-23. PMID:12163549. |
both gaba and muscimol stimulated bdnf expression, and pretreatment with u0126 attenuated gaba-induced bdnf expression. |
2002-09-23 |
2023-08-12 |
Not clear |
| Karl Obrietan, Xiao-Bing Gao, Anthony N Van Den Po. Excitatory actions of GABA increase BDNF expression via a MAPK-CREB-dependent mechanism--a positive feedback circuit in developing neurons. Journal of neurophysiology. vol 88. issue 2. 2002-09-23. PMID:12163549. |
whole cell electrophysiological recording was used to assess the effects of bdnf on gaba release. |
2002-09-23 |
2023-08-12 |
Not clear |
| Karl Obrietan, Xiao-Bing Gao, Anthony N Van Den Po. Excitatory actions of GABA increase BDNF expression via a MAPK-CREB-dependent mechanism--a positive feedback circuit in developing neurons. Journal of neurophysiology. vol 88. issue 2. 2002-09-23. PMID:12163549. |
together, these data suggest a positive excitatory feedback loop between gaba and bdnf expression during early development, where gaba facilitates bdnf expression, and bdnf facilitates the synaptic release of gaba. |
2002-09-23 |
2023-08-12 |
Not clear |
| Maki K Yamada, Kohsuke Nakanishi, Shizu Ohba, Takeshi Nakamura, Yuji Ikegaya, Nobuyoshi Nishiyama, Norio Matsuk. Brain-derived neurotrophic factor promotes the maturation of GABAergic mechanisms in cultured hippocampal neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 17. 2002-09-13. PMID:12196581. |
here we show that bdnf facilitates high k(+)-elicited release of gaba but not of glutamate and induces an increase in immunoreactive signals of glutamic acid decarboxylase, a gaba-synthesizing enzyme. |
2002-09-13 |
2023-08-12 |
Not clear |
| Maki K Yamada, Kohsuke Nakanishi, Shizu Ohba, Takeshi Nakamura, Yuji Ikegaya, Nobuyoshi Nishiyama, Norio Matsuk. Brain-derived neurotrophic factor promotes the maturation of GABAergic mechanisms in cultured hippocampal neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 17. 2002-09-13. PMID:12196581. |
bdnf also upregulated protein levels of gaba(a) receptors but not of glutamate receptors. |
2002-09-13 |
2023-08-12 |
Not clear |
| Julian Goggi, Ian A Pullar, Stephen L Carney, Henry F Bradfor. Modulation of neurotransmitter release induced by brain-derived neurotrophic factor in rat brain striatal slices in vitro. Brain research. vol 941. issue 1-2. 2002-08-14. PMID:12031545. |
this study examined the influence of brain-derived neurotrophic factor (bdnf) on the basal and depolarisation-induced release of the neurotransmitters gaba, dopamine and serotonin from rat striatal brain slices in vitro. |
2002-08-14 |
2023-08-12 |
rat |