| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Julian Goggi, Ian A Pullar, Stephen L Carney, Henry F Bradfor. Modulation of neurotransmitter release induced by brain-derived neurotrophic factor in rat brain striatal slices in vitro. Brain research. vol 941. issue 1-2. 2002-08-14. PMID:12031545. |
bdnf potentiated the potassium or veratrine-stimulated release of gaba, dopamine and serotonin. |
2002-08-14 |
2023-08-12 |
rat |
| I Brünig, S Penschuck, B Berninger, J Benson, J M Fritsch. BDNF reduces miniature inhibitory postsynaptic currents by rapid downregulation of GABA(A) receptor surface expression. The European journal of neuroscience. vol 13. issue 7. 2001-06-21. PMID:11298792. |
bdnf reduces miniature inhibitory postsynaptic currents by rapid downregulation of gaba(a) receptor surface expression. |
2001-06-21 |
2023-08-12 |
rat |
| I Brünig, S Penschuck, B Berninger, J Benson, J M Fritsch. BDNF reduces miniature inhibitory postsynaptic currents by rapid downregulation of GABA(A) receptor surface expression. The European journal of neuroscience. vol 13. issue 7. 2001-06-21. PMID:11298792. |
in the present study, we found that brain-derived neurotrophic factor (bdnf) acts postsynaptically to reduce gamma-aminobutyric acid (gaba)-ergic function. |
2001-06-21 |
2023-08-12 |
rat |
| M Morikawa, K Asai, M Kokubo, K Fujita, K Yoneda, N Yamamoto, Y Inoue, J Iida, T Kishimoto, T Kat. Isolation and characterization of a new immortal rat astrocyte with a high expression of NGF mRNA. Neuroscience research. vol 39. issue 2. 2001-05-03. PMID:11223466. |
none of stimulants (tpa, dibutyryl cyclic amp (db-camp), hydrocortisone, l-glutamate, carbacol, gaba, dopamine, or isoproterenol) changed the expression level of either brain-derived neurotrophic factor (bdnf) or neurotrophin-3 (nt-3). |
2001-05-03 |
2023-08-12 |
rat |
| R Katoh-Semba, I K Takeuchi, Y Inaguma, S Ichisaka, Y Hata, T Tsumoto, M Iwai, K Mikoshiba, K Kat. Induction of brain-derived neurotrophic factor by convulsant drugs in the rat brain: involvement of region-specific voltage-dependent calcium channels. Journal of neurochemistry. vol 77. issue 1. 2001-05-03. PMID:11279263. |
to elucidate possible mechanisms of endogenous bdnf increase, changes in levels of bdnf were studied in the rat brain following systemic administration of various convulsant agents; excitotoxic glutamate agonists, nmda, kainic acid and (+/-)-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (ampa); gaba receptor antagonists, picrotoxin, pentylenetetrazole (ptz) and lindane (gamma-hexachlorocyclohexane); and l-type voltage-dependent calcium channel agonist, bay-k 8644. |
2001-05-03 |
2023-08-12 |
mouse |
| C Cirelli, G Tonon. Gene expression in the brain across the sleep-waking cycle. Brain research. vol 885. issue 2. 2001-03-01. PMID:11102586. |
known genes that were upregulated in waking and sleep deprivation can be grouped into the following categories: immediate early genes/transcription factors (arc, chop, ier5, ngfi-a, ngfi-b, n-ras, stat3), genes related to energy metabolism (glucose type i transporter glut1, vgf), growth factors/adhesion molecules (bdnf, trkb, f3 adhesion molecule), chaperones/heat shock proteins (bip, erp72, grp75, hsp60, hsp70), vesicle- and synapse-related genes (chromogranin c, synaptotagmin iv), neurotransmitter/hormone receptors (adrenergic receptor alpha(1a) and beta(2), gaba(a) receptor beta(3), glutamate nmda receptor 2a, glutamate ampa receptor glur2 and glur3, nicotinic acetylcholine receptor beta(2), thyroid hormone receptor trbeta), neurotransmitter transporters (glutamate/aspartate transporter glast, na(+)/cl(-) transporter ntt4/rxt1), enzymes (aryl sulfotransferase, c-jun n-terminal kinase 1, serum/glucocorticoid-induced serine/threonine kinase), and a miscellaneous group (calmodulin, cyclin d2, lmo-4, metallothionein 3). |
2001-03-01 |
2023-08-12 |
rat |
| J Zhou, L Iacovitt. Mechanisms governing the differentiation of a serotonergic phenotype in culture. Brain research. vol 877. issue 1. 2000-11-28. PMID:10980241. |
this effect was mimicked by co-treatment with a growth factor (afgf, bfgf or bdnf; but not gdnf, igf-1, egf or tgf) and the neurotransmitter 5-ht (but not gaba, dopamine, glutamate) and/or a protein kinase activator (ibmx, forskolin, tpa). |
2000-11-28 |
2023-08-12 |
Not clear |
| C K Kellogg, J Yao, G L Plege. Sex-specific effects of in utero manipulation of GABA(A) receptors on pre- and postnatal expression of BDNF in rats. Brain research. Developmental brain research. vol 121. issue 2. 2000-09-14. PMID:10876028. |
sex-specific effects of in utero manipulation of gaba(a) receptors on pre- and postnatal expression of bdnf in rats. |
2000-09-14 |
2023-08-12 |
rat |
| C K Kellogg, J Yao, G L Plege. Sex-specific effects of in utero manipulation of GABA(A) receptors on pre- and postnatal expression of BDNF in rats. Brain research. Developmental brain research. vol 121. issue 2. 2000-09-14. PMID:10876028. |
this study evaluated the hypothesis that late gestational exposure to dz, a positive modulator of gaba(a) receptors, affects the developmental appearance of brain-derived neurotrophic factor (bdnf), an effect that could be linked to the later consequences of the exposure. |
2000-09-14 |
2023-08-12 |
rat |
| T Numakawa, N Takei, H Hatanak. BDNF rapidly induces aspartate release from cultured CNS neurons. Neuroscience research. vol 37. issue 1. 2000-07-14. PMID:10802344. |
although high potassium evoked the release of both excitatory (glutamate and aspartate) and inhibitory (gaba and glycine) amino acid transmitters, bdnf only induced glutamate and aspartate release. |
2000-07-14 |
2023-08-12 |
Not clear |
| S Reibel, B Vivien-Roels, B T Lê, Y Larmet, J Carnahan, C Marescaux, A Depauli. Overexpression of neuropeptide Y induced by brain-derived neurotrophic factor in the rat hippocampus is long lasting. The European journal of neuroscience. vol 12. issue 2. 2000-05-25. PMID:10712639. |
our results show that bdnf does not modify levels of immunostaining for glutamic acid decarboxylase, the rate-limiting enzyme for gamma-aminobutyric acid (gaba) synthesis, and somatostatin. |
2000-05-25 |
2023-08-12 |
rat |
| K Heese, U Otten, P Mathivet, M Raiteri, C Marescaux, R Bernascon. GABA(B) receptor antagonists elevate both mRNA and protein levels of the neurotrophins nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) but not neurotrophin-3 (NT-3) in brain and spinal cord of rats. Neuropharmacology. vol 39. issue 3. 2000-05-16. PMID:10698011. |
gaba(b) receptor antagonists elevate both mrna and protein levels of the neurotrophins nerve growth factor (ngf) and brain-derived neurotrophic factor (bdnf) but not neurotrophin-3 (nt-3) in brain and spinal cord of rats. |
2000-05-16 |
2023-08-12 |
rat |
| K Heese, U Otten, P Mathivet, M Raiteri, C Marescaux, R Bernascon. GABA(B) receptor antagonists elevate both mRNA and protein levels of the neurotrophins nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) but not neurotrophin-3 (NT-3) in brain and spinal cord of rats. Neuropharmacology. vol 39. issue 3. 2000-05-16. PMID:10698011. |
in this study we show that single, physiologically-active and non-convulsive doses of the three gaba(b) receptor antagonists cgp 36742, cgp 56433a and cgp 56999a increase ngf and bdnf mrna levels by 200-400% and protein levels by 200-250% in rat neocortex, hippocampus as well as spinal cord. |
2000-05-16 |
2023-08-12 |
rat |
| R F Bulleit, T Hsie. MEK inhibitors block BDNF-dependent and -independent expression of GABA(A) receptor subunit mRNAs in cultured mouse cerebellar granule neurons. Brain research. Developmental brain research. vol 119. issue 1. 2000-03-08. PMID:10648867. |
within 1-2 days of culture, bdnf induces the expression of granule neuron terminal differentiation markers, particularly gaba(a) receptor alpha6 subunit (gaba(a)alpha6) mrna. |
2000-03-08 |
2023-08-12 |
mouse |
| R F Bulleit, T Hsie. MEK inhibitors block BDNF-dependent and -independent expression of GABA(A) receptor subunit mRNAs in cultured mouse cerebellar granule neurons. Brain research. Developmental brain research. vol 119. issue 1. 2000-03-08. PMID:10648867. |
the expression of other gaba(a) receptor subunits, including alpha1 and gamma2, was also enhanced by exposure of developing granule neurons to bdnf. |
2000-03-08 |
2023-08-12 |
mouse |
| R F Bulleit, T Hsie. MEK inhibitors block BDNF-dependent and -independent expression of GABA(A) receptor subunit mRNAs in cultured mouse cerebellar granule neurons. Brain research. Developmental brain research. vol 119. issue 1. 2000-03-08. PMID:10648867. |
in the absence of bdnf, gaba(a)alpha6 expression occurs but not until 3-4 days of culture. |
2000-03-08 |
2023-08-12 |
mouse |
| H I Rieff, L T Raetzman, D W Sapp, H H Yeh, R E Siegel, G Corfa. Neuregulin induces GABA(A) receptor subunit expression and neurite outgrowth in cerebellar granule cells. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 24. 2000-01-06. PMID:10594059. |
we have compared the effect of ig-nrg with the effects of brain-derived neurotrophic factor (bdnf), a neurotrophin that exerts specific effects on granule cells in culture, and found that bdnf does not mimic the effects of ig-nrg on gaba(a) receptor subunit expression. |
2000-01-06 |
2023-08-12 |
Not clear |
| S Bao, L Chen, X Qiao, R F Thompso. Transgenic brain-derived neurotrophic factor modulates a developing cerebellar inhibitory synapse. Learning & memory (Cold Spring Harbor, N.Y.). vol 6. issue 3. 1999-10-19. PMID:10492009. |
in culture, bdnf accelerates the expression of gaba(a) receptor alpha6 subunit expression in granule cells. |
1999-10-19 |
2023-08-12 |
mouse |
| S Bao, L Chen, X Qiao, R F Thompso. Transgenic brain-derived neurotrophic factor modulates a developing cerebellar inhibitory synapse. Learning & memory (Cold Spring Harbor, N.Y.). vol 6. issue 3. 1999-10-19. PMID:10492009. |
here we examined synaptic gaba(a) response kinetics in bdnf transgenic mice. |
1999-10-19 |
2023-08-12 |
mouse |
| S Bao, L Chen, X Qiao, R F Thompso. Transgenic brain-derived neurotrophic factor modulates a developing cerebellar inhibitory synapse. Learning & memory (Cold Spring Harbor, N.Y.). vol 6. issue 3. 1999-10-19. PMID:10492009. |
recordings of the spontaneous gaba(a) responses indicate that the decay time constant of the gabaergic responses decreases during early postnatal development; this transition is accelerated in the bdnf transgenic mouse. |
1999-10-19 |
2023-08-12 |
mouse |