| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sheng Wei, Xiwen Geng, Zifa Li, Kaiyong Xu, Minghui Hu, Hongyun Wu, Wei Shi, Mingqi Qia. A forced swim-based rat model of premenstrual depression: effects of hormonal changes and drug intervention. Aging. vol 12. issue 23. 2021-04-27. PMID:33229622. |
further, the model rats showed significant changes in the serum levels of estrogen and progesterone, hippocampal levels of allopregnanolone, 5-hydroxytryptamine, norepinephrine, and γ-aminobutyric acid (gaba), and in the expression of gaba |
2021-04-27 |
2023-08-13 |
rat |
| Swati Sahoo, Prashant S Kharkar, Niteshkumar U Sahu, Brijesh . Anxiolytic activity of Psidium guajava in mice subjected to chronic restraint stress and effect on neurotransmitters in brain. Phytotherapy research : PTR. vol 35. issue 3. 2021-04-19. PMID:33034100. |
neurotransmitters such as monoamines (serotonin, norepinephrine, and dopamine), γ-aminobutyric acid (gaba), and glutamate were estimated in different regions of the brain (cortex, hippocampus, and cerebellum and brain stem). |
2021-04-19 |
2023-08-13 |
mouse |
| Georg Northoff, Dusan Hirjak, Robert C Wolf, Paola Magioncalda, Matteo Martin. All roads lead to the motor cortex: psychomotor mechanisms and their biochemical modulation in psychiatric disorders. Molecular psychiatry. vol 26. issue 1. 2021-04-14. PMID:32555423. |
these include: (i) modulation of dopamine- and substantia nigra-based subcortical-cortical motor circuit by primarily non-motor subcortical raphe nucleus and serotonin via basal ganglia and thalamus (as well as by other neurotransmitters like glutamate and gaba); (ii) modulation of motor cortex and motor network by non-motor cortical networks like default-mode network and sensory networks; (iii) global activity in cortex may also shape regional distribution of neural activity in motor cortex. |
2021-04-14 |
2023-08-13 |
human |
| Qiqi Cao, Jixiang Wang, Yanru Hao, Fangye Zhao, Rong Fu, Yanghuan Yu, Jundong Wang, Ruiyan Niu, Shengtai Bian, Zilong Su. Exercise Ameliorates Fluoride-induced Anxiety- and Depression-like Behavior in Mice: Role of GABA. Biological trace element research. 2021-04-07. PMID:33825162. |
a number of entries into and time spent in the open zone in the elevated zero maze (ezm), resting time in the tail suspension test (tst) and levels of serotonin (5-ht) and gamma-aminobutyric acid (gaba), were significantly altered in f when compared to c. meanwhile, the anxiety-like behavior in the ezm and the depression-like behavior in the tst were significantly improved in ef when compared to group f. exercise significantly enhanced fluoride-induced low gaba level, with less effect on the concentration of 5-ht. |
2021-04-07 |
2023-08-13 |
mouse |
| B Chen, Y Yang, S Li, X Zhu, Y Qi, F Hon. The critical role of hippocampal dopamine in the pathogenesis of hepatic encephalopathy. Physiological research. vol 70. issue 1. 2021-04-03. PMID:33453721. |
the pathogenesis of hepatic encephalopathy (he) has been generally linked to blood ammonia, gamma-aminobutyric acid and serotonin. |
2021-04-03 |
2023-08-13 |
rat |
| Xiao-Li Dong, Xiong Wang, Fang Liu, Xin Liu, Zhong-Rui Du, Robert W Li, Chang-Hu Xue, Ka-Hing Wong, Wing-Tak Wong, Qing Zhao, Qing-Juan Tan. Polymannuronic acid prevents dopaminergic neuronal loss via brain-gut-microbiota axis in Parkinson's disease model. International journal of biological macromolecules. vol 164. 2021-04-02. PMID:32710966. |
the results showed pm administration improved motor functions by preventing dopaminergic neuronal loss in the substantia nigra pars compacta (snpc) and enhanced contents of striatal homovanillic acid (hva), serotonin (5-ht), 5-hydroxyindole acetic acid (5-hiaa) and γ-aminobutyric acid (gaba) in pd mice. |
2021-04-02 |
2023-08-13 |
mouse |
| Marion R Desmarchelie. Clinical Psychopharmacology for the Exotic Animal Practitioner. The veterinary clinics of North America. Exotic animal practice. vol 24. issue 1. 2021-01-27. PMID:33189249. |
psychotropic drugs acting on serotonin, dopamine, norepinephrine, and gamma-aminobutyric acid pathways work by decreasing fear and anxiety, reactivity, and hypervigilance, and by improving impulse control. |
2021-01-27 |
2023-08-13 |
Not clear |
| Samar S Elblehi, Omnia I El Euony, Yasser S El-Saye. Apoptosis and astrogliosis perturbations and expression of regulatory inflammatory factors and neurotransmitters in acrylamide-induced neurotoxicity under ω3 fatty acids protection in rats. Neurotoxicology. vol 76. 2021-01-20. PMID:31647937. |
moreover, it reduced neurotransmitters (acetylcholine, gaba, serotonin and noradrenaline levels) and increased ache activity in brain tissues. |
2021-01-20 |
2023-08-13 |
rat |
| Indrani Datta, S R Mekha, Alka Kaushal, Kavina Ganapathy, Rema Razda. Influence of intranasal exposure of MPTP in multiple doses on liver functions and transition from non-motor to motor symptoms in a rat PD model. Naunyn-Schmiedeberg's archives of pharmacology. vol 393. issue 2. 2021-01-04. PMID:31468077. |
decreases in dopamine, noradrenaline, and gaba and increase in serotonin were detected in striatum. |
2021-01-04 |
2023-08-13 |
rat |
| Mariana de Souza Aranha Garcia-Gomes, Dennis Albert Zanatto, Orfa Yineth Galvis-Alonso, Jorge Mejia, Ana Tada Fonseca Brasil Antiorio, Pedro Kenzo Yamamoto, Márcia Carolina Millán Olivato, Thaísa Meira Sandini, Jorge Camilo Flório, Ivo Lebrun, Silvia Maria Gomes Massironi, Sandra Regina Alexandre-Ribeiro, Maria Martha Bernardi, Susan Ienne, Tiago Antonio de Souza, Maria Lúcia Zaidan Dagli, Claudia Madalena Cabrera Mor. Behavioral and neurochemical characterization of the spontaneous mutation tremor, a new mouse model of audiogenic seizures. Epilepsy & behavior : E&B. vol 105. 2020-12-29. PMID:32109856. |
comparing with wild type (wt) mice, the tremor mice showed higher hippocampal gene expression of egr3 and gabra1 and increased concentrations of noradrenalin (nor; p = .0012), serotonin (5ht; p = .0083), 5-hydroxyindoleacetic acid (5-hiaa; p = .0032), γ-amino butyric acid (gaba; p = .0123), glutamate (p = .0217) and aspartate (p = .0124). |
2020-12-29 |
2023-08-13 |
mouse |
| Shakshi Sharma, Khadga Raj, Shamsher Sing. Neuroprotective Effect of Quercetin in Combination with Piperine Against Rotenone- and Iron Supplement-Induced Parkinson's Disease in Experimental Rats. Neurotoxicity research. vol 37. issue 1. 2020-12-21. PMID:31654381. |
on the 29th day, all animals were sacrificed and striatum was isolated for biochemical (lpo, nitrite, gsh, mitochondrial complexes i and iv), neuroinflammatory (tnf-α, il-1β, and il-6), and neurotransmitter (dopamine, norepinephrine, serotonin, gaba, glutamate) estimation. |
2020-12-21 |
2023-08-13 |
rat |
| Raju Paudel, Khadga Raj, Y K Gupta, Shamsher Sing. Oxiracetam and Zinc Ameliorates Autism-Like Symptoms in Propionic Acid Model of Rats. Neurotoxicity research. vol 37. issue 4. 2020-12-21. PMID:32026359. |
on 29th day, all the animals were sacrificed by cervical dislocation and the brain was preserved for biochemical (lpo, gsh, nitrite, mitochondrial complex i, iv and camp), neuroinflammatory (tnf-α, il-1β, il-6) and neurotransmitters (5-ht, gaba, glutamate and acetylcholine) analysis. |
2020-12-21 |
2023-08-13 |
rat |
| Bingli Cheng, Yanfei Liu, Jinfan Tian, Rui Gao, Yue Li. Complementary and Alternative Medicine for the Treatment of Insomnia: An Overview of Scientific Evidence from 2008 to 2018. Current vascular pharmacology. vol 18. issue 4. 2020-12-07. PMID:31057109. |
meanwhile, based on pre-clinical trial, the possible mechanisms of cam for insomnia were modulation of circadian rhythm, gaba receptor activation, antagonisms of 5-ht receptors, inhibition of glutamate-mediated pathways, and attenuation of inflammation. |
2020-12-07 |
2023-08-13 |
Not clear |
| Zhao Yuan, Zheng Hong-Xia, X U Ying, Lin N. [Network analysis and experimental verification of Qingyan Formula in treatment of perimenopausal anxiety disorder]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 45. issue 17. 2020-11-10. PMID:33164397. |
qyfe increased serum serotonin/5-hydroxytryptamine(5-ht), and gamma aminobutyric acid(gaba) levels in anxious ovx rats, significantly reduced glutamate(glu) and norepinephrine(na) levels, and reversed the disturbance of excitatory/suppressive transmitter balance caused by ovx, which may be related to its effect on alleviating anxiety disorder in ovx rats. |
2020-11-10 |
2023-08-13 |
rat |
| D Sobrido-Cameán, L A Yáñez-Guerra, D Robledo, E López-Varela, M C Rodicio, M R Elphick, R Anadón, Antón Barreiro-Iglesia. Cholecystokinin in the central nervous system of the sea lamprey Petromyzon marinus: precursor identification and neuroanatomical relationships with other neuronal signalling systems. Brain structure & function. vol 225. issue 1. 2020-11-04. PMID:31807925. |
we generated an antiserum to pmcck-8 to enable immunohistochemical analysis of cck expression, which revealed that gaba or glutamate, but not serotonin, tyrosine hydroxylase or neuropeptide y, is co-expressed in some pmcck-8-immunoreactive (ir) neurons. |
2020-11-04 |
2023-08-13 |
Not clear |
| Xin Tu, Ying-Wen Li, Qi-Liang Chen, Yan-Jun Shen, Zhi-Hao Li. Tributyltin enhanced anxiety of adult male zebrafish through elevating cortisol level and disruption in serotonin, dopamine and gamma-aminobutyric acid neurotransmitter pathways. Ecotoxicology and environmental safety. vol 203. 2020-10-14. PMID:32888589. |
in contrast, the expressions of genes responsible for the synthesis and action of serotonin (5-ht) (pet1, thp2 and htr1aa), dopamine (da) (th1, slc6a3, drd2a and drd2b) and gamma-aminobutyric acid (gaba) (gad2 and gabrg2) were all significantly inhibited. |
2020-10-14 |
2023-08-13 |
zebrafish |
| Gregers Wegener, Vallo Volk. Nitric Oxide Synthase Inhibitors as Antidepressants. Pharmaceuticals (Basel, Switzerland). vol 3. issue 1. 2020-10-01. PMID:27713253. |
moreover, several of the conventional neurotransmitters, including serotonin, glutamate and gaba, are intimately regulated by no, and distinct classes of antidepressants have been found to modulate the hippocampal no level in vivo. |
2020-10-01 |
2023-08-13 |
Not clear |
| Nicholas W DeKorver, Dustin Lichty, Marieke van der Hart, Arash Rassoulpour, Stephen J Bonaser. Increased whole cerebellar serotonin in aged C57BL/6 mice. Matters. vol 2017. 2020-10-01. PMID:28894740. |
we thus examined total cerebellar glutamate, glutamine, gaba, glycine, dopamine, norepinephrine, tryptophan, serotonin, alanine, threonine, and asparagine content from male 2-3-month (young, |
2020-10-01 |
2023-08-13 |
mouse |
| Alan L Pehrson, Christian S Pedersen, Kirstine Sloth Tølbøl, Connie Sanche. Vortioxetine Treatment Reverses Subchronic PCP Treatment-Induced Cognitive Impairments: A Potential Role for Serotonin Receptor-Mediated Regulation of GABA Neurotransmission. Frontiers in pharmacology. vol 9. 2020-10-01. PMID:29559911. |
vortioxetine treatment reverses subchronic pcp treatment-induced cognitive impairments: a potential role for serotonin receptor-mediated regulation of gaba neurotransmission. |
2020-10-01 |
2023-08-13 |
Not clear |
| Olena Lykhmus, Larysa P Voytenko, Katrin S Lips, Ivonne Bergen, Gabriela Krasteva-Christ, Douglas E Vetter, Wolfgang Kummer, Maryna Sko. Nicotinic Acetylcholine Receptor α9 and α10 Subunits Are Expressed in the Brain of Mice. Frontiers in cellular neuroscience. vol 11. 2020-09-30. PMID:28955208. |
the α9 and α10 nicotinic acetylcholine receptor (nachr) subunits are likely to be the evolutionary precursors to the entire cys-loop superfamily of ligand-gated ion channels, which includes acetylcholine, gaba, glycine and serotonin ionotropic receptors. |
2020-09-30 |
2023-08-13 |
mouse |