| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tamia Phoenix, Tia M Foster, Edward J Catapane, Craig Hinkley, Margaret A Carrol. Genomic Study of GABA Receptor Ligand Binding Sites of the Bivalve Mollusc Crassostrea virginica. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35556591. |
previously our lab demonstrated in c. virginica serotonin's increase of cilia beating rates is blocked by applying gaba to the visceral or cerebral ganglia. |
2022-05-13 |
2023-08-13 |
mouse |
| Emilio Merlo Pich, Laura Cavalleri, Caterina Toma, Ginetta Coll. Involvement of DA D3 Receptors in Structural Neuroplasticity of Selected Limbic Brain Circuits: Possible Role in Treatment-Resistant Depression. Current topics in behavioral neurosciences. 2022-05-10. PMID:35538302. |
converging studies point to evidence of structural plasticity in circuits operated by glutamate, gaba, dopamine, and serotonin neurotransmitters, in concert with neurotrophic factors such as brain derived neurotrophic factor (bdnf) or insulin growth factor 1 (igf1) and a series of modulators that include circulating hormones. |
2022-05-10 |
2023-08-13 |
human |
| Lin-Ru Zhao, Pan He, Jie Li, Ya-Jun Zhang, Jing-Xing Jiang, Ying-Ru Wu, Yue Zhang, Jia Li, Cong Liu, Xu-Liang Ha. [Sleep-improving mechanism of Chaiqin Ningshen Granules in insomnia rats: based on hippocampal metabonomics]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 47. issue 7. 2022-05-09. PMID:35534263. |
the results show that the drugs can significantly improve the mental state, liver depression, and blood stasis of rats, significantly increase the content of 5-hydroxytryptamine(5-ht) and gamma aminobutyric acid(gaba) in hippocampus(except low-dose cng), and significantly reduce the content of glucose(glu)(except low-dose cng). |
2022-05-09 |
2023-08-13 |
rat |
| Mengying Wei, Yuanyuan Liu, Zifeng Pi, Kexin Yue, Shizhe Li, Mingxin Hu, Zhiqiang Liu, Fengrui Song, Zhongying Li. Investigation of plasma metabolomics and neurotransmitter dysfunction in the process of Alzheimer's disease rat induced by amyloid beta 25-35. RSC advances. vol 9. issue 32. 2022-05-06. PMID:35515227. |
the neurotransmitter dysfunction was mainly involved in γ-aminobutyric acid (gaba), acetyl choline (ach), glutamic acid (glu), 5-hydroxytryptamine (5-ht), dopamine (da) and norepinephrine (ne). |
2022-05-06 |
2023-08-13 |
rat |
| Jia-Xing Liu, Jia-Han Li, Chen-Hui DU, Yan Ya. [Metabonomic study of biochemical changes in serum of PCPA-induced insomnia rats after treatment with Suanzaoren Decoction]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 47. issue 6. 2022-03-29. PMID:35347962. |
then pathological changes of the liver and brain were observed and biochemical indexes such as 5-hydroxytryptamine(5-ht), dopamine(da), glutamate(glu), γ-aminobutyric acid(gaba), and norepinephrine(ne) in the hippocampus and prostaglandin d2(pgd2), tumor necrosis factor-α(tnf-α), interleukin-1β(il-1β), and il-6 in the serum of rats were detected. |
2022-03-29 |
2023-08-13 |
rat |
| Jia-Xing Liu, Jia-Han Li, Chen-Hui DU, Yan Ya. [Metabonomic study of biochemical changes in serum of PCPA-induced insomnia rats after treatment with Suanzaoren Decoction]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 47. issue 6. 2022-03-29. PMID:35347962. |
the results showed that szrd could improve the pathological changes of brain and liver tissues, increase the levels of neurotransmitters 5-ht, da, and gaba in hippocampus and the level of pgd2 in hypothalamic-pituitary-adrenal axis(hpa axis), and reduce the levels of il-1β and tnf-α in serum of insomnia rats. |
2022-03-29 |
2023-08-13 |
rat |
| Divya Yadav, Pravir Kuma. Restoration and targeting of aberrant neurotransmitters in Parkinson's disease therapeutics. Neurochemistry international. 2022-03-25. PMID:35331828. |
parkinson's disease (pd) occurs due to extensive damage of dopamine-producing neurons; this causes dopamine deficits in the midbrain, followed by the alternation of various other neurotransmitters (glutamate, gaba, serotonin, etc.). |
2022-03-25 |
2023-08-13 |
Not clear |
| Xiaojuan Zhang, Yongli Ye, Jiadi Sun, Jia-Sheng Wang, Lili Tang, Yida Xu, Jian Ji, Xiulan Su. Abnormal neurotransmission of GABA and serotonin in Caenorhabditis elegans induced by Fumonisin B1. Environmental pollution (Barking, Essex : 1987). 2022-03-18. PMID:35301029. |
furthermore, abnormal expression of mrna levels associated with gaba and serotonin were found in nematodes treated with fb1, such as unc-30, unc-47, unc-49, exp-1, mod-5, cat-1, and tph-1. |
2022-03-18 |
2023-08-13 |
caenorhabditis_elegans |
| Xiaoyue Wei, Kezhu Wang, Jinfeng Gao, Shijian Chen, Siying Zeng, Yuhong Zha. FG7142 combined with restraint stress induces anxiogenic-like effects via downregulation gamma-aminobutyric acid type A receptor subunit alpha1 and 5-hydroxytryptamine 1A receptors expression in the hippocampus. Neuroreport. vol 33. issue 3. 2022-02-09. PMID:35139062. |
fg7142 combined with restraint stress induces anxiogenic-like effects via downregulation gamma-aminobutyric acid type a receptor subunit alpha1 and 5-hydroxytryptamine 1a receptors expression in the hippocampus. |
2022-02-09 |
2023-08-13 |
Not clear |
| Lei Cheng, Baolin Yang, Hua Du, Tong Zhou, Yang Li, Jiajie Wu, Zhenxiao Cao, An X. Moderate intensity of static magnetic fields can alter the avoidance behavior and fat storage of Caenorhabditis elegans via serotonin. Environmental science and pollution research international. 2022-01-29. PMID:35092591. |
the total serotonin level was increased by 17.08% and 16.45% with the treatment of 0.5 t and 1 t smf, compared to the control group; however, there were minimal effects of smfs on other three neurotransmitters including choline, γ-aminobutyric acid (gaba), dopamine. |
2022-01-29 |
2023-08-13 |
human |
| Moitreyee Chattopadhyay, Souvik Basak, Atish Barua, Malaya Gupta, Dibyajyoti Das, Tanushree Karmakar, Gautam Kumar Bagch. Neuropharmacological Alterations by a Rice Contaminant Stenotrophomonas maltophilia: a Detailed Bio-molecular and Mechanistic Landscape. Applied biochemistry and biotechnology. 2022-01-10. PMID:35006552. |
throughout the study, both acute and chronic exposure of the cell lysate showed a decrease in the locomotor activity and a time-dependent increase of the depression (p < 0.001-0.0001, two-way anova), supported by bioamine (dopamine, noradrenaline, adrenaline, serotonin, and gaba) depletion in rodents' brain possibly due to ufa-amino acid decarboxylase interaction favoring bioamine depletion as revealed by our study. |
2022-01-10 |
2023-08-13 |
human |
| Adam Wichniak, Aleksandra Ewa Wierzbicka, Marek Jarem. Treatment of insomnia - effect of trazodone and hypnotics on sleep. Psychiatria polska. vol 55. issue 4. 2022-01-07. PMID:34994734. |
the main mechanism through which trazodone promotes sleep is its antagonistic effect on 5-ht2 serotonin receptors, while hypnotics are agonists of gamma-aminobutyric acid gabaa receptors, and other sedative antidepressants block h1 histamine receptors. |
2022-01-07 |
2023-08-13 |
Not clear |
| Ryuji Sakakibara, Shuichi Katsuragaw. Voiding and storage symptoms in depression/anxiety. Autonomic neuroscience : basic & clinical. vol 237. 2021-12-19. PMID:34923228. |
these findings might reflect the biological changes of the depressive brain; e.g., decreases in serotonin and gaba, and possible increases in crh. |
2021-12-19 |
2023-08-13 |
Not clear |
| Giulia Fiscon, Federica Conte, Susanna Amadio, Cinzia Volonté, Paola Pac. Drug Repurposing: A Network-based Approach to Amyotrophic Lateral Sclerosis. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. vol 18. issue 3. 2021-12-11. PMID:33987813. |
among catecholamine, dopamine, serotonin, histamine, and gaba receptor modulators, as well as angiotensin-converting enzymes, cyclooxygenase isozymes, and serotonin transporter inhibitors, we found some interesting no customary als drugs, including amoxapine, clomipramine, mianserin, and modafinil. |
2021-12-11 |
2023-08-13 |
human |
| Sunanjay Bajaj, Joshua A Bagley, Christoph Sommer, Abel Vertesy, Sakurako Nagumo Wong, Veronica Krenn, Julie Lévi-Strauss, Juergen A Knoblic. Neurotransmitter signaling regulates distinct phases of multimodal human interneuron migration. The EMBO journal. vol 40. issue 23. 2021-12-10. PMID:34661293. |
we use scrnaseq to reveal expression of gaba, glutamate, glycine, and serotonin receptors along distinct maturation trajectories across interneuron migration. |
2021-12-10 |
2023-08-13 |
human |
| Yanlan Chen, Nan Xiao, Yuxin Chen, Xinye Chen, Chunfei Zhong, Yuying Cheng, Bing Du, Pan L. Semen Sojae Praeparatum alters depression-like behaviors in chronic unpredictable mild stress rats via intestinal microbiota. Food research international (Ottawa, Ont.). vol 150. issue Pt B. 2021-12-05. PMID:34863499. |
in addition, semen sojae praeparatum significantly promoted the contents of norepinephrine (ne), 5-hydroxytryptamine (5-ht), brain-derived neurotrophic factor (bdnf), and gamma-aminobutyric acid (gaba) in the hippocampus and the content of bdnf in the serum (p < 0.05). |
2021-12-05 |
2023-08-13 |
rat |
| Yanlan Chen, Nan Xiao, Yuxin Chen, Xinye Chen, Chunfei Zhong, Yuying Cheng, Bing Du, Pan L. Semen Sojae Praeparatum alters depression-like behaviors in chronic unpredictable mild stress rats via intestinal microbiota. Food research international (Ottawa, Ont.). vol 150. issue Pt B. 2021-12-05. PMID:34863499. |
genus ruminococcaceae_ucg-008 was positively correlated with gaba and bdnf levels in the hippocampus; genus lactobacillus had a positive correlation with 5-ht; and genus bacteroides had negative correlations with 5-ht, bdnf, and ne. |
2021-12-05 |
2023-08-13 |
rat |
| Tabinda Salman, Rushda Afroz, Shazia Nawaz, Khalid Mahmood, Darakhshan J Haleem, Shamshad Zarin. Differential effects of memory enhancing and impairing doses of methylphenidate on serotonin metabolism and 5-HT1A, GABA, glutamate receptor expression in the rat prefrontal cortex. Biochimie. vol 191. 2021-11-29. PMID:34454977. |
differential effects of memory enhancing and impairing doses of methylphenidate on serotonin metabolism and 5-ht1a, gaba, glutamate receptor expression in the rat prefrontal cortex. |
2021-11-29 |
2023-08-13 |
rat |
| Tabinda Salman, Rushda Afroz, Shazia Nawaz, Khalid Mahmood, Darakhshan J Haleem, Shamshad Zarin. Differential effects of memory enhancing and impairing doses of methylphenidate on serotonin metabolism and 5-HT1A, GABA, glutamate receptor expression in the rat prefrontal cortex. Biochimie. vol 191. 2021-11-29. PMID:34454977. |
to understand neurochemical mechanisms and receptors involved in memory enhancing and impairing effects of mpd, the present study concerns the effects of these doses of mpd on serotonin, 5-ht1a, gaba, and nmda receptor mrna expression in the prefrontal cortex (pfc). |
2021-11-29 |
2023-08-13 |
rat |
| Gabriele Deidda, Vincenzo Crunelli, Giuseppe Di Giovann. 5-HT/GABA interaction in epilepsy. Progress in brain research. vol 259. 2021-11-24. PMID:33541679. |
here we review preclinical and human evidence showing that serotonin modulates epilepsy that this likely happens via a major modulation/interaction with gaba. |
2021-11-24 |
2023-08-13 |
human |