| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C M Luetjens, N T Bui, B Sengpiel, G Münstermann, M Poppe, A J Krohn, E Bauerbach, J Krieglstein, J H Preh. Delayed mitochondrial dysfunction in excitotoxic neuron death: cytochrome c release and a secondary increase in superoxide production. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 15. 2000-08-10. PMID:10908611. |
we monitored intracellular superoxide production of hippocampal neurons during and after exposure to the glutamate receptor agonist nmda (300 microm). |
2000-08-10 |
2023-08-12 |
human |
| Y Adamchik, M V Frantseva, M Weisspapir, P L Carlen, J L Perez Velazque. Methods to induce primary and secondary traumatic damage in organotypic hippocampal slice cultures. Brain research. Brain research protocols. vol 5. issue 2. 2000-08-02. PMID:10775835. |
3538-3553; d.w. newell, a. barth, v. papermaster, a.t. malouf, glutamate and non-glutamate receptor mediated toxicity caused by oxygen and glucose deprivation in organotypic hippocampal cultures, j. neurosci. |
2000-08-02 |
2023-08-12 |
rat |
| Y Adamchik, M V Frantseva, M Weisspapir, P L Carlen, J L Perez Velazque. Methods to induce primary and secondary traumatic damage in organotypic hippocampal slice cultures. Brain research. Brain research protocols. vol 5. issue 2. 2000-08-02. PMID:10775835. |
carlen, in vitro ischemia promotes glutamate mediated free radical generation and intracellular calcium accumulation in pyramidal neurons of cultured hippocampal slices, j. neurosci. |
2000-08-02 |
2023-08-12 |
rat |
| G Zhao, M P Flavi. Differential sensitivity of rat hippocampal and cortical astrocytes to oxygen-glucose deprivation injury. Neuroscience letters. vol 285. issue 3. 2000-08-01. PMID:10806315. |
selective vulnerability of hippocampal neurons to ischemia is felt to relate to intense glutamatergic input and glutamate receptor expression. |
2000-08-01 |
2023-08-12 |
rat |
| J M Sulliva. Cellular and molecular mechanisms underlying learning and memory impairments produced by cannabinoids. Learning & memory (Cold Spring Harbor, N.Y.). vol 7. issue 3. 2000-08-01. PMID:10837502. |
cannabinoids reduce glutamate release through a g-protein-mediated inhibition of the calcium channels responsible for neurotransmitter release from hippocampal neurons. |
2000-08-01 |
2023-08-12 |
Not clear |
| E D Kirson, Y Yaar. Unique properties of NMDA receptors enhance synaptic excitation of radiatum giant cells in rat hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 13. 2000-07-26. PMID:10864941. |
in the hippocampus, fast excitatory synaptic transmission of principal projection neurons is mediated by non-nmda glutamate receptors, whereas nmda glutamate receptors serve a slower modulatory role. |
2000-07-26 |
2023-08-12 |
rat |
| G Hoogland, J J Hens, M De Wit, C W van Veelen, A C van Huffelen, W H Gispen, P N de Graa. Glutamate and gamma-aminobutyric acid content and release of synaptosomes from temporal lobe epilepsy patients. Journal of neuroscience research. vol 60. issue 5. 2000-07-24. PMID:10820440. |
hippocampal synaptosomes from mts-associated tle patients, unlike those from t-associated tle patients, contained about 70% less glutamate and 55% less gaba than neocortical synaptosomes. |
2000-07-24 |
2023-08-12 |
human |
| X M Gao, K Sakai, R C Roberts, R R Conley, B Dean, C A Tamming. Ionotropic glutamate receptors and expression of N-methyl-D-aspartate receptor subunits in subregions of human hippocampus: effects of schizophrenia. The American journal of psychiatry. vol 157. issue 7. 2000-07-19. PMID:10873924. |
ionotropic glutamate receptors and expression of n-methyl-d-aspartate receptor subunits in subregions of human hippocampus: effects of schizophrenia. |
2000-07-19 |
2023-08-12 |
human |
| M Lousa, S Sanchez-Alonso, R Rodriguez-Diaz, J Dalma. Status epilepticus with neuron-reactive serum antibodies: response to plasma exchange. Neurology. vol 54. issue 11. 2000-07-13. PMID:10851386. |
the patient's serum reacted with rat cerebral cortex, hippocampus, and cerebellum, but not with cells expressing the glutamate receptor glur3. |
2000-07-13 |
2023-08-12 |
rat |
| S Lankiewicz, C Marc Luetjens, N Truc Bui, A J Krohn, M Poppe, G M Cole, T C Saido, J H Preh. Activation of calpain I converts excitotoxic neuron death into a caspase-independent cell death. The Journal of biological chemistry. vol 275. issue 22. 2000-07-11. PMID:10828077. |
exposure of cultured rat hippocampal neurons to the selective glutamate receptor agonist n-methyl-d-aspartate (300 microm, 5 min) or to the apoptosis-inducing protein kinase inhibitor staurosporine (300 nm) induced a delayed neuron death. |
2000-07-11 |
2023-08-12 |
rat |
| Q Zhou, C C Petersen, R A Nicol. Effects of reduced vesicular filling on synaptic transmission in rat hippocampal neurones. The Journal of physiology. vol 525 Pt 1. 2000-07-10. PMID:10811737. |
the consequence of reduced uptake of neurotransmitters into synaptic vesicles on synaptic transmission was examined in rat hippocampal slices and culture using bafilomycin a1 (baf), a potent and specific blocker of the vacuolar-type (v-type) atpase, which eliminates the driving force for the uptake of both glutamate and gaba into synaptic vesicles. |
2000-07-10 |
2023-08-12 |
rat |
| T W Margrie, J A Rostas, P Sa. Inhibition of transmitter release and long-term depression in the avian hippocampus. Neuroscience letters. vol 284. issue 1-2. 2000-07-03. PMID:10771151. |
here using whole cell and intracellular recordings from brain slices, we show that the n-type calcium channel contributes significantly to glutamate release in the avian hippocampus. |
2000-07-03 |
2023-08-12 |
Not clear |
| b' M Schwendt, D Jezov\\xc3\\xa. Gene expression of two glutamate receptor subunits in response to repeated stress exposure in rat hippocampus. Cellular and molecular neurobiology. vol 20. issue 3. 2000-07-03. PMID:10789831.' |
gene expression of two glutamate receptor subunits in response to repeated stress exposure in rat hippocampus. |
2000-07-03 |
2023-08-12 |
rat |
| b' M Schwendt, D Jezov\\xc3\\xa. Gene expression of two glutamate receptor subunits in response to repeated stress exposure in rat hippocampus. Cellular and molecular neurobiology. vol 20. issue 3. 2000-07-03. PMID:10789831.' |
we have hypothesized that repeated stress exposure may evoke changes of hippocampal glutamate receptors at the level of gene expression. |
2000-07-03 |
2023-08-12 |
rat |
| b' M Schwendt, D Jezov\\xc3\\xa. Gene expression of two glutamate receptor subunits in response to repeated stress exposure in rat hippocampus. Cellular and molecular neurobiology. vol 20. issue 3. 2000-07-03. PMID:10789831.' |
the study was designed to analyze the levels of mrna coding for nmdar1, the essential subunit of the n-methyl-d-aspartate (nmda) receptor subtype, and for glur1, an ampa glutamate receptor subunit, after repeated immobilization stress in rat hippocampus. |
2000-07-03 |
2023-08-12 |
rat |
| b' M Schwendt, D Jezov\\xc3\\xa. Gene expression of two glutamate receptor subunits in response to repeated stress exposure in rat hippocampus. Cellular and molecular neurobiology. vol 20. issue 3. 2000-07-03. PMID:10789831.' |
these results demonstrate selective changes in the gene expression of glutamate receptor subunits, which are likely to take part in the mechanisms leading to enhanced excitability and vulnerability of hippocampal neurons and to potential damage during repeated or chronic stress exposure. |
2000-07-03 |
2023-08-12 |
rat |
| A K McAllister, C F Steven. Nonsaturation of AMPA and NMDA receptors at hippocampal synapses. Proceedings of the National Academy of Sciences of the United States of America. vol 97. issue 11. 2000-06-30. PMID:10811899. |
thus, glutamate receptors at hippocampal synapses are not generally saturated by quantal release. |
2000-06-30 |
2023-08-12 |
Not clear |
| R Popovic, R Liniger, P E Bickle. Anesthetics and mild hypothermia similarly prevent hippocampal neuron death in an in vitro model of cerebral ischemia. Anesthesiology. vol 92. issue 5. 2000-06-28. PMID:10781280. |
this study was performed to evaluate the comparative effects of isoflurane, sodium pentothal, and mild hypothermia in a hippocampal slice model of cerebral ischemia and to determine if the mechanism of neuroprotection of isoflurane involves inhibition of glutamate excitotoxicity. |
2000-06-28 |
2023-08-12 |
Not clear |
| J A St-Pierre, D Nouel, Y Dumont, A Beaudet, R Quirio. Association of neuropeptide Y Y1 receptors with glutamate-positive and NPY-positive neurons in rat hippocampal cultures. The European journal of neuroscience. vol 12. issue 4. 2000-06-21. PMID:10762361. |
these results thus provide an anatomical basis for the modulation of glutamate and npy release by the y1 receptor in the hippocampus. |
2000-06-21 |
2023-08-12 |
rat |
| J N Kew, A Koester, J L Moreau, F Jenck, A M Ouagazzal, V Mutel, J G Richards, G Trube, G Fischer, A Montkowski, W Hundt, R K Reinscheid, M Pauly-Evers, J A Kemp, H Bluethman. Functional consequences of reduction in NMDA receptor glycine affinity in mice carrying targeted point mutations in the glycine binding site. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 11. 2000-06-15. PMID:10818139. |
glycine concentration-response curves from acutely dissociated hippocampal neurons revealed a 5- and 86-fold reduction in receptor glycine affinity in mice carrying grin1(d481n) and grin1(k483q) mutations, respectively, whereas receptor glutamate affinity remained unaffected. |
2000-06-15 |
2023-08-12 |
mouse |