| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T V Davydova, M A Gruden, V S Kudrin, V B Narkevich, L A Vetrile, I A Zakharova, R D E Sewel. Antibodies to Glutamate Facilitate Spatial Memory Formation in the Morris Water Maze in Aging C57BL/6 mice. Bulletin of experimental biology and medicine. vol 169. issue 1. 2021-06-01. PMID:32474668. |
in animals treated with glutamate antibodies, the content of serotonin and dopamine metabolites 3-mt and hva in the hippocampus decreased, but no changes in the metabolism of neurotransmitter acids were revealed. |
2021-06-01 |
2023-08-13 |
mouse |
| Lovedeep Singh, Anudeep Kaur, Saweta Garg, Amrit Pal Singh, Rajbir Bhatt. Protective Effect of Esculetin, Natural Coumarin in Mice Model of Fibromyalgia: Targeting Pro-Inflammatory Cytokines and MAO-A. Neurochemical research. vol 45. issue 10. 2021-06-01. PMID:32676949. |
these behavioral deficits with reserpine treatment were integrated with a reduced level of serotonin (5-ht), reduced glutathione (gsh), along with an increase in monoamine oxidase-a (mao-a) activity, pro-inflammatory cytokines (il-1β, tnf-α), thiobarbituric acid reactive substances (tbars) and glutamate level. |
2021-06-01 |
2023-08-13 |
mouse |
| Omar K Sial, Eric M Parise, Lyonna F Parise, Tamara Gnecco, Carlos A Bolaños-Guzmá. Ketamine: The final frontier or another depressing end? Behavioural brain research. vol 383. 2021-05-25. PMID:32017978. |
although the prominent understanding has been that ketamine's mode of action is mediated solely via the nmda receptor, this view has been challenged by reports implicating other glutamate receptors such as ampa, and other neurotransmitter systems such as serotonin and opioids in the antidepressant response. |
2021-05-25 |
2023-08-13 |
Not clear |
| Lucia Caffino, Francesca Mottarlini, Giorgia Targa, Michel M M Verheij, Judith Homberg, Fabio Fumagall. Long access to cocaine self-administration dysregulates the glutamate synapse in the nucleus accumbens core of serotonin transporter knockout rats. British journal of pharmacology. 2021-05-21. PMID:33880773. |
long access to cocaine self-administration dysregulates the glutamate synapse in the nucleus accumbens core of serotonin transporter knockout rats. |
2021-05-21 |
2023-08-13 |
rat |
| Zhifeng Zhong, Simin Zhou, Bin Xiang, Yu Wu, Jiaxin Xie, Peng L. Association of Peripheral Plasma Neurotransmitters with Cognitive Performance in Chronic High-altitude Exposure. Neuroscience. vol 463. 2021-05-19. PMID:33540052. |
consistent with this result, peripheral plasma dopa, dopamine, serotonin, 5-hiaa and glutamate were associated with brain neurotransmitter levels after chronic hh exposure in rats. |
2021-05-19 |
2023-08-13 |
rat |
| Joo Wung Chae, Dong Ho Kang, Yaqun Li, Seung Hoon Kim, Hyung Gon Lee, Jeong Il Choi, Myung Ha Yoon, Woong Mo Ki. Antinociceptive effects of nefopam modulating serotonergic, adrenergic, and glutamatergic neurotransmission in the spinal cord. Neuroscience letters. vol 731. 2021-05-17. PMID:32450186. |
the present study investigated the effects of intrathecal nefopam on the pain behavior and on the extracellular levels of serotonin (5-ht), norepinephrine (ne), and glutamate in the spinal cord, in a rat model of pain induced by formalin. |
2021-05-17 |
2023-08-13 |
rat |
| Joo Wung Chae, Dong Ho Kang, Yaqun Li, Seung Hoon Kim, Hyung Gon Lee, Jeong Il Choi, Myung Ha Yoon, Woong Mo Ki. Antinociceptive effects of nefopam modulating serotonergic, adrenergic, and glutamatergic neurotransmission in the spinal cord. Neuroscience letters. vol 731. 2021-05-17. PMID:32450186. |
microdialysis studies were conducted to measure the extracellular levels of 5-ht, ne, and glutamate in the spinal cord following nefopam administration. |
2021-05-17 |
2023-08-13 |
rat |
| Joo Wung Chae, Dong Ho Kang, Yaqun Li, Seung Hoon Kim, Hyung Gon Lee, Jeong Il Choi, Myung Ha Yoon, Woong Mo Ki. Antinociceptive effects of nefopam modulating serotonergic, adrenergic, and glutamatergic neurotransmission in the spinal cord. Neuroscience letters. vol 731. 2021-05-17. PMID:32450186. |
the microdialysis results revealed that intrathecal nefopam significantly increased 5-ht and ne levels and attenuated the formalin-induced release of glutamate in the spinal cord. |
2021-05-17 |
2023-08-13 |
rat |
| Joo Wung Chae, Dong Ho Kang, Yaqun Li, Seung Hoon Kim, Hyung Gon Lee, Jeong Il Choi, Myung Ha Yoon, Woong Mo Ki. Antinociceptive effects of nefopam modulating serotonergic, adrenergic, and glutamatergic neurotransmission in the spinal cord. Neuroscience letters. vol 731. 2021-05-17. PMID:32450186. |
thus, the present data suggest that the increase in the extracellular levels of 5-ht and ne, and reductions in glutamate release in the spinal cord, may have contributed to the analgesic effects of nefopam. |
2021-05-17 |
2023-08-13 |
rat |
| Swati Sahoo, Prashant S Kharkar, Niteshkumar U Sahu, Brijesh . Anxiolytic activity of Psidium guajava in mice subjected to chronic restraint stress and effect on neurotransmitters in brain. Phytotherapy research : PTR. vol 35. issue 3. 2021-04-19. PMID:33034100. |
neurotransmitters such as monoamines (serotonin, norepinephrine, and dopamine), γ-aminobutyric acid (gaba), and glutamate were estimated in different regions of the brain (cortex, hippocampus, and cerebellum and brain stem). |
2021-04-19 |
2023-08-13 |
mouse |
| Georg Northoff, Dusan Hirjak, Robert C Wolf, Paola Magioncalda, Matteo Martin. All roads lead to the motor cortex: psychomotor mechanisms and their biochemical modulation in psychiatric disorders. Molecular psychiatry. vol 26. issue 1. 2021-04-14. PMID:32555423. |
these include: (i) modulation of dopamine- and substantia nigra-based subcortical-cortical motor circuit by primarily non-motor subcortical raphe nucleus and serotonin via basal ganglia and thalamus (as well as by other neurotransmitters like glutamate and gaba); (ii) modulation of motor cortex and motor network by non-motor cortical networks like default-mode network and sensory networks; (iii) global activity in cortex may also shape regional distribution of neural activity in motor cortex. |
2021-04-14 |
2023-08-13 |
human |
| Yanbin Zhao, Jiahui Liang, Haoyu Meng, Yue Yin, Huajun Zhen, Xuehan Zheng, Haochun Shi, Xiuzhi Wu, Yao Zu, Bin Wang, Liuyin Fan, Kun Zhan. Rare Earth Elements Lanthanum and Praseodymium Adversely Affect Neural and Cardiovascular Development in Zebrafish (Danio rerio). Environmental science & technology. vol 55. issue 2. 2021-04-08. PMID:33373191. |
the kyoto encyclopedia of genes and genomes (kegg) pathways analysis revealed that among others, notch, glutamate, and serotonin signaling, as well as cardiac hypertrophy and cardiac muscle contraction, were significantly affected. |
2021-04-08 |
2023-08-13 |
zebrafish |
| Gretchen L Snyder, Kimberly E Vanover, Robert E Davis, Peng Li, Allen Fienberg, Sharon Mate. A review of the pharmacology and clinical profile of lumateperone for the treatment of schizophrenia. Advances in pharmacology (San Diego, Calif.). vol 90. 2021-04-07. PMID:33706936. |
lumateperone simultaneously modulates serotonin, dopamine and glutamate neurotransmission, three key neurotransmitters implicated in schizophrenia. |
2021-04-07 |
2023-08-13 |
Not clear |
| Dong-Qin Zhao, Hua Xue, Hai-Ji Su. Nervous mechanisms of restraint water-immersion stress-induced gastric mucosal lesion. World journal of gastroenterology. vol 26. issue 20. 2021-03-31. PMID:32523309. |
neurotransmitters/neuromodulators, such as nitric oxide, hydrogen sulfide, vasoactive intestinal peptide, calcitonin gene-related peptide, substance p, enkephalin, 5-hydroxytryptamine, acetylcholine, catecholamine, glutamate, γ-aminobutyric acid, oxytocin and arginine vasopressin, can participate in the regulation of stress. |
2021-03-31 |
2023-08-13 |
Not clear |
| Nabil Benzin. [New pathophysiological approaches to obsessive-compulsive disorder]. La Revue du praticien. vol 70. issue 7. 2021-03-23. PMID:33739728. |
while serotonin was the first to be incriminated due to the efficacy of serotonergic antidepressants, it turns out that years of research in genetics and neuroimaging have invalidated this hypothesis in favour of a new target: glutamate. |
2021-03-23 |
2023-08-13 |
Not clear |
| Tulika Shukla, Ravi Kumar Nadella, Reshma Jabeen Taj M J, Suhas Ganesh, Gerald Nestadt, Meera Purushottam, Sanjeev Jain, Y C Janardhan Reddy, Biju Viswanat. Association of SLC1A1 gene polymorphism with obsessive compulsive disorder in a sample from southern India. Experimental and clinical psychopharmacology. vol 28. issue 6. 2021-03-12. PMID:31985241. |
the glutamate transporter gene slc1a1 has been shown to have an association with obsessive-compulsive disorder (ocd), and serotonin reuptake inhibitor (sri) treatment response. |
2021-03-12 |
2023-08-13 |
human |
| Christoph U Correll, Robert E Davis, Michal Weingart, Jelena Saillard, Cedric O'Gorman, John M Kane, Jeffrey A Lieberman, Carol A Tamminga, Sharon Mates, Kimberly E Vanove. Efficacy and Safety of Lumateperone for Treatment of Schizophrenia: A Randomized Clinical Trial. JAMA psychiatry. vol 77. issue 4. 2021-02-03. PMID:31913424. |
lumateperone is a serotonin, dopamine, and glutamate modulator with the potential to treat schizophrenia with few adverse effects. |
2021-02-03 |
2023-08-13 |
Not clear |
| Mariana de Souza Aranha Garcia-Gomes, Dennis Albert Zanatto, Orfa Yineth Galvis-Alonso, Jorge Mejia, Ana Tada Fonseca Brasil Antiorio, Pedro Kenzo Yamamoto, Márcia Carolina Millán Olivato, Thaísa Meira Sandini, Jorge Camilo Flório, Ivo Lebrun, Silvia Maria Gomes Massironi, Sandra Regina Alexandre-Ribeiro, Maria Martha Bernardi, Susan Ienne, Tiago Antonio de Souza, Maria Lúcia Zaidan Dagli, Claudia Madalena Cabrera Mor. Behavioral and neurochemical characterization of the spontaneous mutation tremor, a new mouse model of audiogenic seizures. Epilepsy & behavior : E&B. vol 105. 2020-12-29. PMID:32109856. |
comparing with wild type (wt) mice, the tremor mice showed higher hippocampal gene expression of egr3 and gabra1 and increased concentrations of noradrenalin (nor; p = .0012), serotonin (5ht; p = .0083), 5-hydroxyindoleacetic acid (5-hiaa; p = .0032), γ-amino butyric acid (gaba; p = .0123), glutamate (p = .0217) and aspartate (p = .0124). |
2020-12-29 |
2023-08-13 |
mouse |
| Shakshi Sharma, Khadga Raj, Shamsher Sing. Neuroprotective Effect of Quercetin in Combination with Piperine Against Rotenone- and Iron Supplement-Induced Parkinson's Disease in Experimental Rats. Neurotoxicity research. vol 37. issue 1. 2020-12-21. PMID:31654381. |
on the 29th day, all animals were sacrificed and striatum was isolated for biochemical (lpo, nitrite, gsh, mitochondrial complexes i and iv), neuroinflammatory (tnf-α, il-1β, and il-6), and neurotransmitter (dopamine, norepinephrine, serotonin, gaba, glutamate) estimation. |
2020-12-21 |
2023-08-13 |
rat |
| Raju Paudel, Khadga Raj, Y K Gupta, Shamsher Sing. Oxiracetam and Zinc Ameliorates Autism-Like Symptoms in Propionic Acid Model of Rats. Neurotoxicity research. vol 37. issue 4. 2020-12-21. PMID:32026359. |
on 29th day, all the animals were sacrificed by cervical dislocation and the brain was preserved for biochemical (lpo, gsh, nitrite, mitochondrial complex i, iv and camp), neuroinflammatory (tnf-α, il-1β, il-6) and neurotransmitters (5-ht, gaba, glutamate and acetylcholine) analysis. |
2020-12-21 |
2023-08-13 |
rat |