| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yan Li, Zhi Chen, Jianting Zhao, Heming Yu, Xiangyu Chen, Yong He, Yu Tian, Yue Wang, Chong Chen, Ke Cheng, Peng Xi. Neurotransmitter and Related Metabolic Profiling in the Nucleus Accumbens of Chronic Unpredictable Mild Stress-Induced Anhedonia-Like Rats. Frontiers in behavioral neuroscience. vol 16. 2022-05-16. PMID:35571281. |
anhedonia, as a core symptom, was closely associated with altered levels of 5-hydroxytryptamine (5-ht), dopamine (da), and diverse types of glutamate (glu) receptors in the nucleus accumbens (nac). |
2022-05-16 |
2023-08-13 |
rat |
| Emilio Merlo Pich, Laura Cavalleri, Caterina Toma, Ginetta Coll. Involvement of DA D3 Receptors in Structural Neuroplasticity of Selected Limbic Brain Circuits: Possible Role in Treatment-Resistant Depression. Current topics in behavioral neurosciences. 2022-05-10. PMID:35538302. |
converging studies point to evidence of structural plasticity in circuits operated by glutamate, gaba, dopamine, and serotonin neurotransmitters, in concert with neurotrophic factors such as brain derived neurotrophic factor (bdnf) or insulin growth factor 1 (igf1) and a series of modulators that include circulating hormones. |
2022-05-10 |
2023-08-13 |
human |
| Sophie R Cohen, Michelle L Terry, Michael Coyle, Emily Wheelis, Ashley Centner, Samantha Smith, John Glinski, Natalie Lipari, Carla Budrow, Fredric P Manfredsson, Christopher Bisho. The multimodal serotonin compound Vilazodone alone, but not combined with the glutamate antagonist Amantadine, reduces l-DOPA-induced dyskinesia in hemiparkinsonian rats. Pharmacology, biochemistry, and behavior. 2022-05-05. PMID:35513119. |
the multimodal serotonin compound vilazodone alone, but not combined with the glutamate antagonist amantadine, reduces l-dopa-induced dyskinesia in hemiparkinsonian rats. |
2022-05-05 |
2023-08-13 |
rat |
| Haider Sarwar, Shafiya Imtiaz Rafiqi, Showkat Ahmad, Sruthi Jinna, Sawleha Arshi Khan, Tamanna Karim, Omar Qureshi, Zeeshan A Zahid, Jon D Elhai, Jason C Levine, Shazia J Naqvi, Juan C Jaume, Shahnawaz Ima. Hyperinsulinemia Associated Depression. Clinical medicine insights. Endocrinology and diabetes. vol 15. 2022-05-02. PMID:35494421. |
increased inflammatory cytokines have also been shown to disrupt neurotransmitter metabolism and synaptic plasticity which play a role in the development of depression via inhibiting serotonin, dopamine, melatonin, and glutamate signaling. |
2022-05-02 |
2023-08-13 |
Not clear |
| Jia-Xing Liu, Jia-Han Li, Chen-Hui DU, Yan Ya. [Metabonomic study of biochemical changes in serum of PCPA-induced insomnia rats after treatment with Suanzaoren Decoction]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 47. issue 6. 2022-03-29. PMID:35347962. |
then pathological changes of the liver and brain were observed and biochemical indexes such as 5-hydroxytryptamine(5-ht), dopamine(da), glutamate(glu), γ-aminobutyric acid(gaba), and norepinephrine(ne) in the hippocampus and prostaglandin d2(pgd2), tumor necrosis factor-α(tnf-α), interleukin-1β(il-1β), and il-6 in the serum of rats were detected. |
2022-03-29 |
2023-08-13 |
rat |
| Divya Yadav, Pravir Kuma. Restoration and targeting of aberrant neurotransmitters in Parkinson's disease therapeutics. Neurochemistry international. 2022-03-25. PMID:35331828. |
parkinson's disease (pd) occurs due to extensive damage of dopamine-producing neurons; this causes dopamine deficits in the midbrain, followed by the alternation of various other neurotransmitters (glutamate, gaba, serotonin, etc.). |
2022-03-25 |
2023-08-13 |
Not clear |
| Lucia Caffino, Francesca Mottarlini, Giorgia Targa, Michel M M Verheij, Fabio Fumagalli, Judith R Homber. Responsivity of serotonin transporter knockout rats to short and long access to cocaine: modulation of the glutamate signaling in the nucleus accumbens shell. British journal of pharmacology. 2022-02-17. PMID:35174489. |
responsivity of serotonin transporter knockout rats to short and long access to cocaine: modulation of the glutamate signaling in the nucleus accumbens shell. |
2022-02-17 |
2023-08-13 |
rat |
| Jordyn M Wilcox, David C Consoli, Krista C Paffenroth, Brittany D Spitznagel, Erin S Calipari, Aaron B Bowman, Fiona E Harriso. Manganese-induced hyperactivity and dopaminergic dysfunction depend on age, sex and YAC128 genotype. Pharmacology, biochemistry, and behavior. 2022-01-22. PMID:35063467. |
the same exposure paradigm led to decreased dopamine and serotonin and metabolites (3-mt, hva and 5-hiaa) in striatum and increased glutamate in yac128 mice but not wt mice. |
2022-01-22 |
2023-08-13 |
mouse |
| Evan M Hess, Lace M Riggs, Michael Michaelides, Todd D Goul. Mechanisms of Ketamine and its Metabolites as Antidepressants. Biochemical pharmacology. 2021-12-30. PMID:34968492. |
specifically, we explore effects on glutamate neurotransmission through n-methyl d-aspartate receptors (nmdars) and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (ampars), synaptic structural changes via brain derived neurotrophic factor (bdnf) signaling, interactions with opioid receptors, and the enhancement of serotonin, norepinephrine, and dopamine signaling. |
2021-12-30 |
2023-08-13 |
Not clear |
| Sunanjay Bajaj, Joshua A Bagley, Christoph Sommer, Abel Vertesy, Sakurako Nagumo Wong, Veronica Krenn, Julie Lévi-Strauss, Juergen A Knoblic. Neurotransmitter signaling regulates distinct phases of multimodal human interneuron migration. The EMBO journal. vol 40. issue 23. 2021-12-10. PMID:34661293. |
we use scrnaseq to reveal expression of gaba, glutamate, glycine, and serotonin receptors along distinct maturation trajectories across interneuron migration. |
2021-12-10 |
2023-08-13 |
human |
| Alok Shiomurti Tripathi, Prajakta Bansod, K P Swath. Activation of 5-HT 1b/d receptor restores the cognitive function by reducing glutamate release, deposition of β-amyloid and TLR-4 pathway in the brain of scopolamine-induced dementia in rat. The Journal of pharmacy and pharmacology. vol 73. issue 12. 2021-12-08. PMID:34244776. |
activation of 5-ht 1b/d receptor restores the cognitive function by reducing glutamate release, deposition of β-amyloid and tlr-4 pathway in the brain of scopolamine-induced dementia in rat. |
2021-12-08 |
2023-08-13 |
rat |
| Tabinda Salman, Rushda Afroz, Shazia Nawaz, Khalid Mahmood, Darakhshan J Haleem, Shamshad Zarin. Differential effects of memory enhancing and impairing doses of methylphenidate on serotonin metabolism and 5-HT1A, GABA, glutamate receptor expression in the rat prefrontal cortex. Biochimie. vol 191. 2021-11-29. PMID:34454977. |
differential effects of memory enhancing and impairing doses of methylphenidate on serotonin metabolism and 5-ht1a, gaba, glutamate receptor expression in the rat prefrontal cortex. |
2021-11-29 |
2023-08-13 |
rat |
| Ankita Bhardwaj, Rishi Bhardwaj, Shweta Sharma, Suresh Kumar Sharma, Devinder Kumar Dhawan, Tanzeer Kau. AMPA induced cognitive impairment in rats: Establishing the role of endoplasmic reticulum stress inhibitor, 4-PBA. Journal of neuroscience research. vol 99. issue 10. 2021-11-18. PMID:34197000. |
the levels of neurotransmitters such as dopamine, homo vanillic acid (hva), norepinephrine, and serotonin were reduced accompanied by reduced expression of glur1 and glur4 (glutamate receptor) as well as loss of neurons in different layers of hippocampus. |
2021-11-18 |
2023-08-13 |
rat |
| Piercarlo Sarzi-Puttini, Valeria Giorgi, Simona Di Lascio, Diego Fornasar. Acetyl-L-carnitine in chronic pain: A narrative review. Pharmacological research. vol 173. 2021-11-18. PMID:34500063. |
acetyl-l-carnitine (alc) is an endogenous molecule that not only plays a role in energy metabolism, but also has antioxidant properties, protects from oxidative stress, modulates brain neurotransmitters such as acetylcholine, serotonin and dopamine, and acts on neurotrophic factors such as nerve growth factor (ngf) and metabotropic glutamate (mglu) receptors by means of epigenetic mechanisms. |
2021-11-18 |
2023-08-13 |
Not clear |
| Dasiel O Borroto-Escuela, Patrizia Ambrogini, Manuel Narvaez, Valentina Di Liberto, Sarah Beggiato, Luca Ferraro, Ramon Fores-Pons, Jose E Alvarez-Contino, Alexander Lopez-Salas, Giuseppa Mudò, Zaida Díaz-Cabiale, Kjell Fux. Serotonin Heteroreceptor Complexes and Their Integration of Signals in Neurons and Astroglia-Relevance for Mental Diseases. Cells. vol 10. issue 8. 2021-11-15. PMID:34440670. |
understanding the role of astrocytes and their allosteric receptor-receptor interactions in modulating forebrain glutamate synapses with impact on dorsal raphe-forebrain serotonin neurons is also of high relevance for research on major depressive disorder. |
2021-11-15 |
2023-08-13 |
Not clear |
| Mark B Zimering, Shree G Nadkarn. Schizophrenia Plasma Autoantibodies Promote 'Biased Agonism' at the 5-Hydroxytryptamine 2A Receptor: Neurotoxicity is Positively Modulated by Metabotropic Glutamate 2/3 Receptor Agonism. Endocrinology, diabetes and metabolism journal. vol 3. issue 4. 2021-11-12. PMID:31537990. |
schizophrenia plasma autoantibodies promote 'biased agonism' at the 5-hydroxytryptamine 2a receptor: neurotoxicity is positively modulated by metabotropic glutamate 2/3 receptor agonism. |
2021-11-12 |
2023-08-13 |
Not clear |
| Rita Cervera-Juanes, Priscila Darakjian, Megan Ball, Steven G Kohama, Henryk F Urbansk. Effects of estradiol supplementation on the brain transcriptome of old rhesus macaques maintained on an obesogenic diet. GeroScience. 2021-11-12. PMID:34642852. |
synaptogenesis, circadian rhythm, mitochondrial dysfunction, mtor, glutamate, serotonin, gaba, dopamine, epinephrine/norepinephrine, glucocorticoid receptor signaling, neuronal nos, and amyloid processing were exclusively enriched in amg. |
2021-11-12 |
2023-08-13 |
Not clear |
| Kunal Maini, Janice W Hollier, Haley Gould, Victoria Bollich, John John LaForge, Elyse M Cornett, Amber N Edinoff, Adam M Kaye, Alan D Kay. Lumateperone tosylate, A Selective and Concurrent Modulator of Serotonin, Dopamine, and Glutamate, in the Treatment of Schizophrenia. Health psychology research. vol 9. issue 1. 2021-11-10. PMID:34746489. |
lumateperone tosylate, a selective and concurrent modulator of serotonin, dopamine, and glutamate, in the treatment of schizophrenia. |
2021-11-10 |
2023-08-13 |
Not clear |
| T V Davydova, T I Nevidimova, L A Vetrile, I A Zakharova, D N Savochkina, S A Galkin, N A Bokha. Correlation of Antibodies to Neurotransmitters in the Sera of Women with Alcohol Dependence and Depressive Disorders. Bulletin of experimental biology and medicine. vol 171. issue 6. 2021-11-02. PMID:34705169. |
comparative analysis of blood sera from women with alcohol dependence and depressive disorders or from conditionally healthy women revealed reduced level of antibodies to dopamine, norepinephrine, serotonin, glutamate, and gaba in blood serum in women with dysthymic disorder and a depressive episode and their increased content in women with alcohol dependence in combination with depressive disorders. |
2021-11-02 |
2023-08-13 |
Not clear |
| Shijing Wang, Francesco Leri, Sakina J Rizv. Anhedonia as a central factor in depression: Neural mechanisms revealed from preclinical to clinical evidence. Progress in neuro-psychopharmacology & biological psychiatry. vol 110. 2021-11-01. PMID:33631251. |
as well, serotonin, norepinephrine, opioids, glutamate, gamma aminobutyric acid (gaba), and acetylcholine are also involved in anhedonia, and medications targeting these systems may also potentially normalize reward processing in depression. |
2021-11-01 |
2023-08-13 |
Not clear |