| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shunyao Liao, Yunqiang Liu, Xiaojuan Chen, Yuande Tan, Jie Mei, Wenzhong Song, Lu Gan, Hailian Wang, Shi Yin, Xianjue Dong, Shu Chi, Shaoping Den. The Impact of Genetic Variants for Different Physiological Characterization of Type 2 Diabetes Loci on Gestational Insulin Signaling in Nondiabetic Pregnant Chinese Women. Reproductive sciences (Thousand Oaks, Calif.). vol 22. issue 11. 2016-10-05. PMID:25878199. |
by adjusting for maternal age, bmi, and the related interactions, the genetic variants in abcc8, cdkal1, cdkn2a, hnf1b, kcnj11, and mtnr1b were detected to impact gestational insulin signaling through heterogeneous mechanisms; however, compared with that in nonpregnant metabolism, the genetic effects seem to be eminently and heavily influenced by maternal age and bmi, indicating possible particular mechanisms underlying gestational metabolism and diabetic pathogenesis. |
2016-10-05 |
2023-08-13 |
Not clear |
| Omer Babiker, Sarah E Flanagan, Sian Ellard, Hesham Al Girim, Khalid Hussain, Senthil Senniappa. Protein-induced hyperinsulinaemic hypoglycaemia due to a homozygous HADH mutation in three siblings of a Saudi family. Journal of pediatric endocrinology & metabolism : JPEM. vol 28. issue 9-10. 2016-06-17. PMID:25915078. |
hyperinsulinaemic hypoglycaemia (hh) is caused by mutations in the key genes involved in regulation of insulin secretion from the pancreatic β-cells and mutations in abcc8 and kcnj11 are the most common causes of hh. |
2016-06-17 |
2023-08-13 |
Not clear |
| Klára Roženková, Maria Güemes, Pratik Shah, Khalid Hussai. The Diagnosis and Management of Hyperinsulinaemic Hypoglycaemia. Journal of clinical research in pediatric endocrinology. vol 7. issue 2. 2016-05-23. PMID:26316429. |
recent advances in genetics have linked chi to mutations in 9 genes that play a key role in regulating insulin secretion (abcc8, kcnj11, glud1, gck, hadh, slc16a1, ucp2, hnf4a and hnf1a). |
2016-05-23 |
2023-08-13 |
Not clear |
| Sofianos Andrikopoulos, Barbara C Fam, Anita Holdsworth, Sherley Visinoni, Zheng Ruan, Maria Stathopoulos, Anne W Thorburn, Christos N Joannides, Michael Cancilla, Lois Balmer, Joseph Proietto, Grant Moraha. Identification of ABCC8 as a contributory gene to impaired early-phase insulin secretion in NZO mice. The Journal of endocrinology. vol 228. issue 1. 2016-02-19. PMID:26493453. |
identification of abcc8 as a contributory gene to impaired early-phase insulin secretion in nzo mice. |
2016-02-19 |
2023-08-13 |
mouse |
| Sofianos Andrikopoulos, Barbara C Fam, Anita Holdsworth, Sherley Visinoni, Zheng Ruan, Maria Stathopoulos, Anne W Thorburn, Christos N Joannides, Michael Cancilla, Lois Balmer, Joseph Proietto, Grant Moraha. Identification of ABCC8 as a contributory gene to impaired early-phase insulin secretion in NZO mice. The Journal of endocrinology. vol 228. issue 1. 2016-02-19. PMID:26493453. |
transgenic nzo mice were generated that expressed the wt abcc8/kcnj11 genes and displayed significant improvements in early-phase glucose-mediated insulin secretion and glucose tolerance, confirming abcc8 as a causative gene. |
2016-02-19 |
2023-08-13 |
mouse |
| Sofianos Andrikopoulos, Barbara C Fam, Anita Holdsworth, Sherley Visinoni, Zheng Ruan, Maria Stathopoulos, Anne W Thorburn, Christos N Joannides, Michael Cancilla, Lois Balmer, Joseph Proietto, Grant Moraha. Identification of ABCC8 as a contributory gene to impaired early-phase insulin secretion in NZO mice. The Journal of endocrinology. vol 228. issue 1. 2016-02-19. PMID:26493453. |
this study provides evidence for a role of abcc8 in early-phase glucose-mediated insulin secretion and validates this gene as a contributor to β-cell dysfunction in t2d. |
2016-02-19 |
2023-08-13 |
mouse |
| Carla Pollastro, Carmela Ziviello, Valerio Costa, Alfredo Ciccodicol. Pharmacogenomics of Drug Response in Type 2 Diabetes: Toward the Definition of Tailored Therapies? PPAR research. vol 2015. 2015-07-10. PMID:26161088. |
here, we review the relationship between drug responsiveness and polymorphisms in genes involved in drug metabolism (cyp2c9) and insulin signaling (abcc8, kcnj11, and pparg). |
2015-07-10 |
2023-08-13 |
Not clear |
| Ana Luiza R Rolim, Susan C Lindsey, Ilda S Kunii, Felipe Crispim, Regina Célia M S Moisés, Rui M B Maciel, Magnus R Dias-da-Silv. The insulin-sensitivity sulphonylurea receptor variant is associated with thyrotoxic paralysis. Journal of molecular endocrinology. vol 53. issue 2. 2015-05-22. PMID:25143473. |
the sulphonylurea receptor 1 (sur1 (abcc8)) is an essential regulatory subunit of the β-cell atp-sensitive k(+) channel that controls insulin secretion after feeding. |
2015-05-22 |
2023-08-13 |
Not clear |
| Suresh Jahnavi, Varadarajan Poovazhagi, Sekar Kanthimathi, Kandasamy Balamurugan, Dhanasekaran Bodhini, Jaivinder Yadav, Vandana Jain, Rajesh Khadgawat, Mahuya Sikdar, Ayurchelvan Bhavatharini, Ashok Kumar Das, Tanvir Kaur, Viswanathan Mohan, Venkatesan Radh. Novel ABCC8 (SUR1) gene mutations in Asian Indian children with congenital hyperinsulinemic hypoglycemia. Annals of human genetics. vol 78. issue 5. 2015-04-08. PMID:25117148. |
congenital hyperinsulinemic hypoglycemia (hi) is a heterogeneous genetic disorder of insulin secretion characterized by persistent hypoglycemia, most commonly associated with inactivating mutations of the β-cell atp-sensitive k(+) channel (k(atp) channel) genes abcc8 (encoding sur1) and kcnj11(encoding kir6.2). |
2015-04-08 |
2023-08-13 |
Not clear |
| Pratik Shah, Huseyin Demirbilek, Khalid Hussai. Persistent hyperinsulinaemic hypoglycaemia in infancy. Seminars in pediatric surgery. vol 23. issue 2. 2015-01-29. PMID:24931352. |
the molecular basis of phhi involves defects in key genes (abcc8, kcnj11, gck, slc16a1, hadh, ucp2, hnf4a and glud1) that regulate insulin secretion. |
2015-01-29 |
2023-08-13 |
Not clear |
| Ahmet Anık, Gönül Catlı, Ayhan Abacı, Uluc Yiş, Hale Oren, Handan Güleryüz, Sefa Kızıldağ, Ece Böbe. A novel activating ABCC8 mutation underlying neonatal diabetes mellitus in an infant presenting with cerebral sinovenous thrombosis. Journal of pediatric endocrinology & metabolism : JPEM. vol 27. issue 5-6. 2014-12-23. PMID:24468609. |
in this patient, after a molecular analysis of the abcc8 gene revealed a novel heterozygous missense mutation (p.d424v), a successful transition from insulin to sulfonylurea treatment was made. |
2014-12-23 |
2023-08-12 |
Not clear |
| Polin Haghvirdizadeh, Monir Sadat Haerian, Pantea Haghvirdizadeh, Batoul Sadat Haeria. ABCC8 genetic variants and risk of diabetes mellitus. Gene. vol 545. issue 2. 2014-07-18. PMID:24768178. |
sulfonylurea receptor encoded by abcc8 gene, together with inward-rectifier potassium ion channel (kir6.2) regulates insulin secretion by atp-sensitive k(+) (katp) channel located in the plasma membranes. |
2014-07-18 |
2023-08-13 |
Not clear |
| Rochelle N Naylor, Siri Atma W Greeley, Graeme I Bell, Louis H Philipso. Genetics and pathophysiology of neonatal diabetes mellitus. Journal of diabetes investigation. vol 2. issue 3. 2014-06-24. PMID:24843477. |
ndm as a result of mutations in kcnj11 and abcc8 often responds to sulfonylureas, allowing transition from insulin therapy. |
2014-06-24 |
2023-08-13 |
Not clear |
| Radha Venkatesan, Dhanasekaran Bodhini, Nagarajan Narayani, Viswanathan Moha. Association study of the ABCC8 gene variants with type 2 diabetes in south Indians. Indian journal of human genetics. vol 20. issue 1. 2014-06-24. PMID:24959012. |
the abcc8 gene which encodes the sulfonylurea receptor plays a major role in insulin secretion and is a potential candidate for type 2 diabetes. |
2014-06-24 |
2023-08-13 |
Not clear |
| Maria Carla Proverbio, Eleonora Mangano, Alessandra Gessi, Roberta Bordoni, Roberta Spinelli, Rosanna Asselta, Paola Sogno Valin, Stefania Di Candia, Ilaria Zamproni, Cecilia Diceglie, Stefano Mora, Manuela Caruso-Nicoletti, Alessandro Salvatoni, Gianluca De Bellis, Cristina Battagli. Whole genome SNP genotyping and exome sequencing reveal novel genetic variants and putative causative genes in congenital hyperinsulinism. PloS one. vol 8. issue 7. 2014-03-05. PMID:23869231. |
the genetic causes of chi have been found in genes regulating insulin secretion from pancreatic β-cells; recessive inactivating mutations in the abcc8 and kcnj11 genes represent the most common events. |
2014-03-05 |
2023-08-12 |
Not clear |
| Roopa Kanakatti Shankar, Catherine Pihoker, Lawrence M Dolan, Debra Standiford, Angela Badaru, Dana Dabelea, Beatriz Rodriguez, Mary Helen Black, Giuseppina Imperatore, Andrew Hattersley, Sian Ellard, Lisa K Gillia. Permanent neonatal diabetes mellitus: prevalence and genetic diagnosis in the SEARCH for Diabetes in Youth Study. Pediatric diabetes. vol 14. issue 3. 2013-11-25. PMID:23050777. |
mutations in katp channel genes (kcnj11, abcc8) and the insulin gene (ins) are the most common causes of pndm. |
2013-11-25 |
2023-08-12 |
Not clear |
| S Jahnavi, V Poovazhagi, V Mohan, D Bodhini, P Raghupathy, A Amutha, P Suresh Kumar, P Adhikari, M Shriraam, T Kaur, A K Das, J Molnes, P R Njolstad, R Unnikrishnan, V Radh. Clinical and molecular characterization of neonatal diabetes and monogenic syndromic diabetes in Asian Indian children. Clinical genetics. vol 83. issue 5. 2013-09-23. PMID:22831748. |
we sequenced kcnj11, abcc8 and insulin (ins) genes in 33 unrelated indian probands with onset of diabetes below one year of age. |
2013-09-23 |
2023-08-12 |
Not clear |
| S Jahnavi, V Poovazhagi, V Mohan, D Bodhini, P Raghupathy, A Amutha, P Suresh Kumar, P Adhikari, M Shriraam, T Kaur, A K Das, J Molnes, P R Njolstad, R Unnikrishnan, V Radh. Clinical and molecular characterization of neonatal diabetes and monogenic syndromic diabetes in Asian Indian children. Clinical genetics. vol 83. issue 5. 2013-09-23. PMID:22831748. |
children carrying the kcnj11 (cys42arg, arg201cys) and abcc8 (val86ala, asp212tyr) mutations have been successfully switched over from insulin therapy to oral sulfonylurea. |
2013-09-23 |
2023-08-12 |
Not clear |
| Akiko Saito-Hakoda, Tohru Yorifuji, Junko Kanno, Shigeo Kure, Ikuma Fujiwar. Nateglinide is Effective for Diabetes Mellitus with Reactive Hypoglycemia in a Child with a Compound Heterozygous ABCC8 Mutation. Clinical pediatric endocrinology : case reports and clinical investigations : official journal of the Japanese Society for Pediatric Endocrinology. vol 21. issue 3. 2013-08-08. PMID:23926410. |
abcc8 encodes the sulfonylurea receptor 1 (sur1) subunits of the beta-cell atp-sensitive potassium (k-atp) channel playing a critical role in the regulation of insulin secretion, and inactivating mutations in abcc8 cause congenital hyperinsulinism. |
2013-08-08 |
2023-08-12 |
Not clear |
| Akiko Saito-Hakoda, Tohru Yorifuji, Junko Kanno, Shigeo Kure, Ikuma Fujiwar. Nateglinide is Effective for Diabetes Mellitus with Reactive Hypoglycemia in a Child with a Compound Heterozygous ABCC8 Mutation. Clinical pediatric endocrinology : case reports and clinical investigations : official journal of the Japanese Society for Pediatric Endocrinology. vol 21. issue 3. 2013-08-08. PMID:23926410. |
sequencing of the abcc8 identified a compound heterozygous mutation (r1420h/f591fs604x), suggesting that this mutation may alter regulation of insulin secretion with advancing age, leading to diabetes mellitus with reactive hypoglycemia from hyperinsulinism. |
2013-08-08 |
2023-08-12 |
Not clear |