| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T L Hoffman, E Blanco, A Lane, P Galvin-Parton, I Gadi, R Santer, D DeLeón, C Stanley, T A Wilso. Glucose metabolism and insulin secretion in a patient with ABCC8 mutation and Fanconi-Bickel syndrome caused by maternal isodisomy of chromosome 3. Clinical genetics. vol 71. issue 6. 2007-07-30. PMID:17539904. |
glucose metabolism and insulin secretion in a patient with abcc8 mutation and fanconi-bickel syndrome caused by maternal isodisomy of chromosome 3. |
2007-07-30 |
2023-08-12 |
Not clear |
| Martine Vaxillaire, Aurélie Dechaume, Kanetee Busiah, Hélène Cavé, Sabrina Pereira, Raphael Scharfmann, Guiomar Perez de Nanclares, Luis Castano, Philippe Froguel, Michel Pola. New ABCC8 mutations in relapsing neonatal diabetes and clinical features. Diabetes. vol 56. issue 6. 2007-06-14. PMID:17389331. |
in our present study, we identified six new heterozygous abcc8 mutations, mainly in patients presenting the transient form of neonatal diabetes (six of eight), with a median duration of initial insulin therapy of 17 months (range 0.5-38.0). |
2007-06-14 |
2023-08-12 |
Not clear |
| Anna L Gloyn, Juveria Siddiqui, Sian Ellar. Mutations in the genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) in diabetes mellitus and hyperinsulinism. Human mutation. vol 27. issue 3. 2006-08-02. PMID:16416420. |
it has been known for some time that loss of function mutations in kcnj11, which encodes for kir6.2, and abcc8, which encodes for sur1, can cause oversecretion of insulin and result in hyperinsulinemia (hi) of infancy; however, heterozygous activating mutations in kcnj11 that result in the opposite phenotype of diabetes have recently been described. |
2006-08-02 |
2023-08-12 |
Not clear |
| Andrea Sieg, Jiping Su, Alvaro Muñoz, Michael Buchenau, Mitsuhiro Nakazaki, Lydia Aguilar-Bryan, Joseph Bryan, Susanne Ullric. Epinephrine-induced hyperpolarization of islet cells without KATP channels. American journal of physiology. Endocrinology and metabolism. vol 286. issue 3. 2004-04-21. PMID:14613926. |
this study examines the effect of epinephrine, a known physiological inhibitor of insulin secretion, on the membrane potential of pancreatic islet cells from sulfonylurea receptor-1 (abcc8)-null mice (sur1ko), which lack functional atp-sensitive k+ (katp) channels. |
2004-04-21 |
2023-08-12 |
mouse |
| Christine Sempoux, Yves Guiot, Karin Dahan, Pierre Moulin, Martine Stevens, Virginie Lambot, Pascale de Lonlay, Jean-Christophe Fournet, Claudine Junien, Francis Jaubert, Claire Nihoul-Fekete, Jean-Marie Saudubray, Jacques Rahie. The focal form of persistent hyperinsulinemic hypoglycemia of infancy: morphological and molecular studies show structural and functional differences with insulinoma. Diabetes. vol 52. issue 3. 2003-05-09. PMID:12606521. |
compared with adjacent islets, proinsulin mrna is similar and proinsulin production higher (p < or = 0.02), indicating regulation at a translational level, with slightly lower insulin stock and lower abcc8 peptide labeling (p<0.05). |
2003-05-09 |
2023-08-12 |
Not clear |
| Christine Sempoux, Yves Guiot, Karin Dahan, Pierre Moulin, Martine Stevens, Virginie Lambot, Pascale de Lonlay, Jean-Christophe Fournet, Claudine Junien, Francis Jaubert, Claire Nihoul-Fekete, Jean-Marie Saudubray, Jacques Rahie. The focal form of persistent hyperinsulinemic hypoglycemia of infancy: morphological and molecular studies show structural and functional differences with insulinoma. Diabetes. vol 52. issue 3. 2003-05-09. PMID:12606521. |
insulinomas, composed of beta-cell nests or cords, have similar proinsulin mrna compared with adjacent islets, highly variable proinsulin production, lower insulin stock (p < or = 0.02), and higher abcc8 peptide labeling (p<0.05). |
2003-05-09 |
2023-08-12 |
Not clear |
| Anna L Gloyn, Michael N Weedon, Katharine R Owen, Martina J Turner, Bridget A Knight, Graham Hitman, Mark Walker, Jonathan C Levy, Mike Sampson, Stephanie Halford, Mark I McCarthy, Andrew T Hattersley, Timothy M Fraylin. Large-scale association studies of variants in genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes. Diabetes. vol 52. issue 2. 2003-04-07. PMID:12540637. |
the genes abcc8 and kcnj11, which encode the subunits sulfonylurea receptor 1 (sur1) and inwardly rectifying potassium channel (kir6.2) of the beta-cell atp-sensitive potassium (k(atp)) channel, control insulin secretion. |
2003-04-07 |
2023-08-12 |
human |
| S C Elbein, J Sun, E Scroggin, K Teng, S J Hassted. Role of common sequence variants in insulin secretion in familial type 2 diabetic kindreds: the sulfonylurea receptor, glucokinase, and hepatocyte nuclear factor 1alpha genes. Diabetes care. vol 24. issue 3. 2001-06-14. PMID:11289470. |
in this study, we tested the primary hypotheses that previously described variants in the pancreatic sulfonylurea receptor gene (sur1 or abcc8), glucokinase (gck) gene, or hepatocyte nuclear factor 1alpha (tcf1 or hnf1alpha) gene contribute to the inherited deficiencies of insulin secretion and beta-cell compensation to insulin resistance, as well as the secondary hypotheses that these variants altered insulin sensitivity. |
2001-06-14 |
2023-08-12 |
Not clear |