| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Andrew A Bremer, Sayali Ranadive, Robert H Lusti. Outpatient transition of an infant with permanent neonatal diabetes due to a KCNJ11 activating mutation from subcutaneous insulin to oral glyburide. Pediatric diabetes. vol 9. issue 3 Pt 1. 2008-08-07. PMID:18221420. |
until recently, most forms of permanent neonatal diabetes required lifelong subcutaneous insulin for management; however, permanent neonatal diabetes due to activating mutations in the kcnj11 gene, which encodes the kir6.2 protein subunit of the atp-sensitive k+ (k(atp)) channel, may be amenable to oral sulfonylurea therapy. |
2008-08-07 |
2023-08-12 |
Not clear |
| Andrew A Bremer, Sayali Ranadive, Robert H Lusti. Outpatient transition of an infant with permanent neonatal diabetes due to a KCNJ11 activating mutation from subcutaneous insulin to oral glyburide. Pediatric diabetes. vol 9. issue 3 Pt 1. 2008-08-07. PMID:18221420. |
we describe a case of an 18-month-old infant with permanent neonatal diabetes due to an activating kcnj11 mutation successfully transitioned from subcutaneous insulin therapy to oral sulfonylurea therapy in the outpatient setting. |
2008-08-07 |
2023-08-12 |
Not clear |
| E D'Amato, P Tammaro, T J Craig, A Tosi, R Giorgetti, R Lorini, F M Ashcrof. Variable phenotypic spectrum of diabetes mellitus in a family carrying a novel KCNJ11 gene mutation. Diabetic medicine : a journal of the British Diabetic Association. vol 25. issue 6. 2008-08-01. PMID:18544102. |
identification of kcnj11 mutations has important therapeutic implications, as many patients can replace insulin injections with sulphonylurea tablets. |
2008-08-01 |
2023-08-12 |
Not clear |
| Isabelle Flechtner, Martine Vaxillaire, Hélène Cavé, Raphael Scharfmann, Philippe Froguel, Michel Pola. Neonatal hyperglycaemia and abnormal development of the pancreas. Best practice & research. Clinical endocrinology & metabolism. vol 22. issue 1. 2008-05-22. PMID:18279778. |
the very recently elucidated mutations in kcnj11 and abcc8 genes, encoding the kir6.2 and sur1 subunits of the pancreatic k(atp) channel involved in regulation of insulin secretion, account for a third to a half of the pndm cases. |
2008-05-22 |
2023-08-12 |
Not clear |
| Isabelle Flechtner, Martine Vaxillaire, Hélène Cavé, Raphael Scharfmann, Philippe Froguel, Michel Pola. Neonatal hyperglycaemia and abnormal development of the pancreas. Best practice & research. Clinical endocrinology & metabolism. vol 22. issue 1. 2008-05-22. PMID:18279778. |
some patients (those with mutations in kcnj11 and abcc8) may be transferred from insulin therapy to sulphonylureas. |
2008-05-22 |
2023-08-12 |
Not clear |
| S Letha, Darly Mammen, Joseph J Valamparampi. Permanent neonatal diabetes due to KCNJ11 gene mutation. Indian journal of pediatrics. vol 74. issue 10. 2008-04-07. PMID:17978456. |
it has been recently discovered that mutation in kcnj11 gene encoding kir6.2, the pore forming subunit of atp sensitive potassium channel (k atp) is the most common cause and such patients may respond better to oral sulphonylurea drugs than insulin. |
2008-04-07 |
2023-08-12 |
Not clear |
| C G Nichols, J C Koster, M S Remed. beta-cell hyperexcitability: from hyperinsulinism to diabetes. Diabetes, obesity & metabolism. vol 9 Suppl 2. 2008-03-31. PMID:17919182. |
consistent with this paradigm, loss-of-function mutations in the genes (kcnj11 and abcc8) that encode the two subunits (kir6.2 and sur1, respectively) of the atp-sensitive k(+) (k(atp)) channel underlie hyperinsulinism in humans, a genetic disorder characterized by dysregulated insulin secretion. |
2008-03-31 |
2023-08-12 |
mouse |
| Yang Yi, Liu Dongmei, Dana A Phares, Edward P Weiss, Josef Brandauer, James M Hagber. Association between KCNJ11 E23K genotype and cardiovascular and glucose metabolism phenotypes in older men and women. Experimental physiology. vol 93. issue 1. 2008-03-28. PMID:17720745. |
our objective was to investigate the relationship between the e23k genetic variant in the kcnj11 gene, which encodes for the kir6.2 subunit of the inward rectifier k+ channel family, and glucose and insulin metabolism and cardiovascular (cv) function in the sedentary state and their responses to exercise training. |
2008-03-28 |
2023-08-12 |
Not clear |
| I Flechtner, M Vaxillaire, H Cavé, P Froguel, M Pola. [Neonatal diabetes: a disease linked to multiple mechanisms]. Archives de pediatrie : organe officiel de la Societe francaise de pediatrie. vol 14. issue 11. 2008-01-24. PMID:17931842. |
among those, the very recently elucidated mutations in kcnj11 and abcc8 gene, encoding the kir6.2 and sur1 subunit of the pancreatic k(atp) channel involved in regulation of insulin secretion accounts for one third to a half of the pndm cases. |
2008-01-24 |
2023-08-12 |
Not clear |
| I Flechtner, M Vaxillaire, H Cavé, P Froguel, M Pola. [Neonatal diabetes: a disease linked to multiple mechanisms]. Archives de pediatrie : organe officiel de la Societe francaise de pediatrie. vol 14. issue 11. 2008-01-24. PMID:17931842. |
this analysis also has potentially important therapeutic consequences leading to transfer some patients, those with mutations in kcnj11 and abcc8 from insulin therapy to sulfonylureas. |
2008-01-24 |
2023-08-12 |
Not clear |
| b' Michel Polak, H\\xc3\\xa9l\\xc3\\xa8ne Cav\\xc3\\xa. Neonatal diabetes mellitus: a disease linked to multiple mechanisms. Orphanet journal of rare diseases. vol 2. 2007-11-06. PMID:17349054.' |
among these, the very recently elucidated mutations in the kcnj11 and abcc8 genes, encoding the kir6.2 and sur1 subunit of the pancreatic katp channel involved in regulation of insulin secretion, account for one third to half of the pndm cases. |
2007-11-06 |
2023-08-12 |
Not clear |
| b' Michel Polak, H\\xc3\\xa9l\\xc3\\xa8ne Cav\\xc3\\xa. Neonatal diabetes mellitus: a disease linked to multiple mechanisms. Orphanet journal of rare diseases. vol 2. 2007-11-06. PMID:17349054.' |
this analysis also has potentially important therapeutic consequences leading to transfer some patients, those with mutations in kcnj11 and abcc8 genes, from insulin therapy to sulfonylureas. |
2007-11-06 |
2023-08-12 |
Not clear |
| Yee-Ming Chan, Lori M B Laffe. Transition from insulin to glyburide in a 4-month-old girl with neonatal diabetes mellitus caused by a mutation in KCNJ11. Pediatric diabetes. vol 8. issue 4. 2007-10-19. PMID:17659066. |
transition from insulin to glyburide in a 4-month-old girl with neonatal diabetes mellitus caused by a mutation in kcnj11. |
2007-10-19 |
2023-08-12 |
Not clear |
| Yee-Ming Chan, Lori M B Laffe. Transition from insulin to glyburide in a 4-month-old girl with neonatal diabetes mellitus caused by a mutation in KCNJ11. Pediatric diabetes. vol 8. issue 4. 2007-10-19. PMID:17659066. |
once a genetic diagnosis is made, most patients with neonatal diabetes caused by mutations in the kcnj11 gene can be successfully managed with a sulfonylurea agent without the need for insulin. |
2007-10-19 |
2023-08-12 |
Not clear |
| Yee-Ming Chan, Lori M B Laffe. Transition from insulin to glyburide in a 4-month-old girl with neonatal diabetes mellitus caused by a mutation in KCNJ11. Pediatric diabetes. vol 8. issue 4. 2007-10-19. PMID:17659066. |
we report on the transition from insulin to glyburide (glibenclamide) therapy in a 4-month-old girl with neonatal diabetes mellitus caused by a mutation in kcnj11. |
2007-10-19 |
2023-08-12 |
Not clear |
| Juraj Stanik, Daniela Gasperikova, Magdalena Paskova, Lubomir Barak, Jana Javorkova, Emilia Jancova, Miriam Ciljakova, Peter Hlava, Jozef Michalek, Sarah E Flanagan, Ewan Pearson, Andrew T Hattersley, Sian Ellard, Iwar Klime. Prevalence of permanent neonatal diabetes in Slovakia and successful replacement of insulin with sulfonylurea therapy in KCNJ11 and ABCC8 mutation carriers. The Journal of clinical endocrinology and metabolism. vol 92. issue 4. 2007-09-17. PMID:17213273. |
prevalence of permanent neonatal diabetes in slovakia and successful replacement of insulin with sulfonylurea therapy in kcnj11 and abcc8 mutation carriers. |
2007-09-17 |
2023-08-12 |
Not clear |
| Jan Skupien, Maciej T Malecki, Wojciech Mlynarski, Tomasz Klupa, Krzysztof Wanic, Agnieszka Gach, Iwona Solecka, Jacek Sieradzk. Assessment of insulin sensitivity in adults with permanent neonatal diabetes mellitus due to mutations in the KCNJ11 gene encoding Kir6.2. The review of diabetic studies : RDS. vol 3. issue 1. 2007-08-10. PMID:17491708. |
assessment of insulin sensitivity in adults with permanent neonatal diabetes mellitus due to mutations in the kcnj11 gene encoding kir6.2. |
2007-08-10 |
2023-08-12 |
mouse |
| A S Slingerland, R Nuboer, M Hadders-Algra, A T Hattersley, G J Bruinin. Improved motor development and good long-term glycaemic control with sulfonylurea treatment in a patient with the syndrome of intermediate developmental delay, early-onset generalised epilepsy and neonatal diabetes associated with the V59M mutation in the KCNJ11 gene. Diabetologia. vol 49. issue 11. 2007-07-25. PMID:17047922. |
sulfonylureas, which bind to the sulfonylurea receptor 1 subunit of the k(atp) channel, can replace insulin injections in patients with kcnj11 mutations. |
2007-07-25 |
2023-08-12 |
Not clear |
| G Tonini, C Bizzarri, R Bonfanti, M Vanelli, F Cerutti, E Faleschini, F Meschi, F Prisco, E Ciacco, M Cappa, C Torelli, V Cauvin, S Tumini, D Iafusco, F Barbett. Sulfonylurea treatment outweighs insulin therapy in short-term metabolic control of patients with permanent neonatal diabetes mellitus due to activating mutations of the KCNJ11 (KIR6.2) gene. Diabetologia. vol 49. issue 9. 2007-06-11. PMID:16816952. |
sulfonylurea treatment outweighs insulin therapy in short-term metabolic control of patients with permanent neonatal diabetes mellitus due to activating mutations of the kcnj11 (kir6.2) gene. |
2007-06-11 |
2023-08-12 |
Not clear |
| Anna L Gloyn, Sian Ellar. Defining the genetic aetiology of monogenic diabetes can improve treatment. Expert opinion on pharmacotherapy. vol 7. issue 13. 2007-04-19. PMID:16925503. |
the recent discovery that mutations in the kcnj11 gene (encoding the kir6.2 subunit of the k(atp) channel) are the most common cause of permanent neonatal diabetes, has enabled children to stop insulin injections and achieve improved glycaemic control with high doses of sulphonylurea tablets. |
2007-04-19 |
2023-08-12 |
Not clear |