| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jeong Won Heo, Sang-Wook Kim, Eun-Hee Ch. Unsuccessful switch from insulin to sulfonylurea therapy in permanent neonatal diabetes mellitus due to an R201H mutation in the KCNJ11 gene: a case report. Diabetes research and clinical practice. vol 100. issue 1. 2013-12-30. PMID:23434183. |
unsuccessful switch from insulin to sulfonylurea therapy in permanent neonatal diabetes mellitus due to an r201h mutation in the kcnj11 gene: a case report. |
2013-12-30 |
2023-08-12 |
Not clear |
| Jeong Won Heo, Sang-Wook Kim, Eun-Hee Ch. Unsuccessful switch from insulin to sulfonylurea therapy in permanent neonatal diabetes mellitus due to an R201H mutation in the KCNJ11 gene: a case report. Diabetes research and clinical practice. vol 100. issue 1. 2013-12-30. PMID:23434183. |
previously, all patients carrying an r201h mutation in the kcnj11 gene showed successful switches from insulin to sulfonylurea. |
2013-12-30 |
2023-08-12 |
Not clear |
| Roopa Kanakatti Shankar, Catherine Pihoker, Lawrence M Dolan, Debra Standiford, Angela Badaru, Dana Dabelea, Beatriz Rodriguez, Mary Helen Black, Giuseppina Imperatore, Andrew Hattersley, Sian Ellard, Lisa K Gillia. Permanent neonatal diabetes mellitus: prevalence and genetic diagnosis in the SEARCH for Diabetes in Youth Study. Pediatric diabetes. vol 14. issue 3. 2013-11-25. PMID:23050777. |
mutations in katp channel genes (kcnj11, abcc8) and the insulin gene (ins) are the most common causes of pndm. |
2013-11-25 |
2023-08-12 |
Not clear |
| Homa Ilkhanipoor, Zohreh Karamizade. Changing the Treatment of Permanent Neonatal Diabetes Mellitus from Insulin to Glibenclamide in a 4-Month-Old Infant with KCNJ11 Activating Mutation. International journal of preventive medicine. vol 4. issue 9. 2013-10-16. PMID:24130952. |
changing the treatment of permanent neonatal diabetes mellitus from insulin to glibenclamide in a 4-month-old infant with kcnj11 activating mutation. |
2013-10-16 |
2023-08-12 |
Not clear |
| Homa Ilkhanipoor, Zohreh Karamizade. Changing the Treatment of Permanent Neonatal Diabetes Mellitus from Insulin to Glibenclamide in a 4-Month-Old Infant with KCNJ11 Activating Mutation. International journal of preventive medicine. vol 4. issue 9. 2013-10-16. PMID:24130952. |
he was discharged with insulin and after 2 months, kcnj11 gene mutation was found and treatment was switched from subcutaneous insulin to oral glibenclamide. |
2013-10-16 |
2023-08-12 |
Not clear |
| Homa Ilkhanipoor, Zohreh Karamizade. Changing the Treatment of Permanent Neonatal Diabetes Mellitus from Insulin to Glibenclamide in a 4-Month-Old Infant with KCNJ11 Activating Mutation. International journal of preventive medicine. vol 4. issue 9. 2013-10-16. PMID:24130952. |
now, he is 1 year old with desirable glycemic control; therefore, genetic study is recommended for kcnj11 gene mutation in such patients because if the mutation is found, treatment can be switched from insulin to sulfonylurea. |
2013-10-16 |
2023-08-12 |
Not clear |
| S Jahnavi, V Poovazhagi, V Mohan, D Bodhini, P Raghupathy, A Amutha, P Suresh Kumar, P Adhikari, M Shriraam, T Kaur, A K Das, J Molnes, P R Njolstad, R Unnikrishnan, V Radh. Clinical and molecular characterization of neonatal diabetes and monogenic syndromic diabetes in Asian Indian children. Clinical genetics. vol 83. issue 5. 2013-09-23. PMID:22831748. |
we sequenced kcnj11, abcc8 and insulin (ins) genes in 33 unrelated indian probands with onset of diabetes below one year of age. |
2013-09-23 |
2023-08-12 |
Not clear |
| S Jahnavi, V Poovazhagi, V Mohan, D Bodhini, P Raghupathy, A Amutha, P Suresh Kumar, P Adhikari, M Shriraam, T Kaur, A K Das, J Molnes, P R Njolstad, R Unnikrishnan, V Radh. Clinical and molecular characterization of neonatal diabetes and monogenic syndromic diabetes in Asian Indian children. Clinical genetics. vol 83. issue 5. 2013-09-23. PMID:22831748. |
children carrying the kcnj11 (cys42arg, arg201cys) and abcc8 (val86ala, asp212tyr) mutations have been successfully switched over from insulin therapy to oral sulfonylurea. |
2013-09-23 |
2023-08-12 |
Not clear |
| Renata Stawerska, Małgorzata Szałapska, Maciej Borowiec, Wojciech Młynarski, Karolina Antosik, Maciej Hilczer, Andrzej Lewińsk. Frequency of the E23K polymorphism of the KCNJ11 gene in children born small for gestational age and its influence on auxological and metabolic parameters in the prepubertal period. Journal of pediatric endocrinology & metabolism : JPEM. vol 26. issue 5-6. 2013-08-20. PMID:23412854. |
the e23k variant of the kcnj11 gene is possibly responsible for changes in insulin secretion during the fetal life. |
2013-08-20 |
2023-08-12 |
Not clear |
| O Oztekin, E Durmaz, S Kalay, S E Flanagan, S Ellard, I Birca. Successful sulfonylurea treatment of a neonate with neonatal diabetes mellitus due to a novel missense mutation, p.P1199L, in the ABCC8 gene. Journal of perinatology : official journal of the California Perinatal Association. vol 32. issue 8. 2013-05-29. PMID:22842804. |
there have been several reports of the successful transition from insulin to sulfonylurea agents in patients with permanent diabetes mellitus caused by mutations in the kcnj11 gene. |
2013-05-29 |
2023-08-12 |
Not clear |
| Senthil Senniappan, Balasubramaniam Shanti, Chela James, Khalid Hussai. Hyperinsulinaemic hypoglycaemia: genetic mechanisms, diagnosis and management. Journal of inherited metabolic disease. vol 35. issue 4. 2013-02-05. PMID:22231386. |
the molecular basis of hh involves defects in key genes (abcc8, kcnj11, glud1, gck, hadh, slc16a1, hnf4a and ucp2) which regulate insulin secretion. |
2013-02-05 |
2023-08-12 |
Not clear |
| Veronica Lang, Peter E Ligh. The molecular mechanisms and pharmacotherapy of ATP-sensitive potassium channel gene mutations underlying neonatal diabetes. Pharmacogenomics and personalized medicine. vol 3. 2012-12-12. PMID:23226049. |
in the pancreatic β-cell, k(atp) channel activity couples glucose metabolism to insulin secretion via cellular excitability and mutations in either kcnj11 or abcc8 genes alter k(atp) channel activity, leading to faulty insulin secretion. |
2012-12-12 |
2023-08-12 |
Not clear |
| Veronica Lang, Peter E Ligh. The molecular mechanisms and pharmacotherapy of ATP-sensitive potassium channel gene mutations underlying neonatal diabetes. Pharmacogenomics and personalized medicine. vol 3. 2012-12-12. PMID:23226049. |
many ndm patients with kcnj11 and abcc8 mutations can be successfully treated with sulfonylureas (sus) that inhibit the k(atp) channel, thus replacing the need for daily insulin injections. |
2012-12-12 |
2023-08-12 |
Not clear |
| Anders H Rosengren, Matthias Braun, Taman Mahdi, Sofia A Andersson, Mary E Travers, Makoto Shigeto, Enming Zhang, Peter Almgren, Claes Ladenvall, Annika S Axelsson, Anna Edlund, Morten Gram Pedersen, Anna Jonsson, Reshma Ramracheya, Yunzhao Tang, Jonathan N Walker, Amy Barrett, Paul R V Johnson, Valeriya Lyssenko, Mark I McCarthy, Leif Groop, Albert Salehi, Anna L Gloyn, Erik Renström, Patrik Rorsman, Lena Eliasso. Reduced insulin exocytosis in human pancreatic β-cells with gene variants linked to type 2 diabetes. Diabetes. vol 61. issue 7. 2012-09-10. PMID:22492527. |
variants near tcf7l2 and adra2a were associated with reduced glucose-induced insulin secretion, whereas susceptibility variants near adra2a, kcnj11, kcnq1, and tcf7l2 were associated with reduced depolarization-evoked insulin exocytosis. |
2012-09-10 |
2023-08-12 |
human |
| Bo Gong, Jing Yu, Haichuan Li, Wenjiao Li, Xinghai Ton. The effect of KCNJ11 polymorphism on the risk of type 2 diabetes: a global meta-analysis based on 49 case-control studies. DNA and cell biology. vol 31. issue 5. 2012-07-25. PMID:22082043. |
potassium inwardly rectifying channel, subfamily-j, member 11 (kcnj11) gene encodes kir6.2 subunits of the adenosine triphosphate (atp)-sensitive potassium channel involved in glucose-mediated metabolic signaling pathway and has attracted considerable attention as a candidate gene for type 2 diabetes (t2d) based on its function in glucose-stimulated insulin secretion. |
2012-07-25 |
2023-08-12 |
Not clear |
| Juliette Dupont, Carla Pereira, Ana Medeira, Rui Duarte, Sian Ellard, Lurdes Sampai. Permanent neonatal diabetes mellitus due to KCNJ11 mutation in a Portuguese family: transition from insulin to oral sulfonylureas. Journal of pediatric endocrinology & metabolism : JPEM. vol 25. issue 3-4. 2012-07-24. PMID:22768671. |
permanent neonatal diabetes mellitus due to kcnj11 mutation in a portuguese family: transition from insulin to oral sulfonylureas. |
2012-07-24 |
2023-08-12 |
Not clear |
| Juliette Dupont, Carla Pereira, Ana Medeira, Rui Duarte, Sian Ellard, Lurdes Sampai. Permanent neonatal diabetes mellitus due to KCNJ11 mutation in a Portuguese family: transition from insulin to oral sulfonylureas. Journal of pediatric endocrinology & metabolism : JPEM. vol 25. issue 3-4. 2012-07-24. PMID:22768671. |
heterozygous activation mutations in kcnj11, encoding the kir6.2 subunit of the atp-sensitive potassium (k(atp)) channel, which acts as a key role in insulin secretion regulation, account for about half of the cases of pndm. |
2012-07-24 |
2023-08-12 |
Not clear |
| Juliette Dupont, Carla Pereira, Ana Medeira, Rui Duarte, Sian Ellard, Lurdes Sampai. Permanent neonatal diabetes mellitus due to KCNJ11 mutation in a Portuguese family: transition from insulin to oral sulfonylureas. Journal of pediatric endocrinology & metabolism : JPEM. vol 25. issue 3-4. 2012-07-24. PMID:22768671. |
individuals with kcnj11 mutations have been successfully transitioned from insulin to sulfonylurea (su) therapy. |
2012-07-24 |
2023-08-12 |
Not clear |
| Beatriz Tavira, Eliecer Coto, Armando Torres, Carmen Díaz-Corte, Beatriz Díaz-Molina, Francisco Ortega, Manuel Arias, Juan M Díaz, Rafael Selgas, Carlos López-Larrea, Marta Ruiz-Ortega, Alberto Ortiz, Elena González, Josep M Campistol, Victoria Alvare. Association between a common KCNJ11 polymorphism (rs5219) and new-onset posttransplant diabetes in patients treated with Tacrolimus. Molecular genetics and metabolism. vol 105. issue 3. 2012-07-16. PMID:22264780. |
the reported effect of this kcnj11 polymorphism on insulin release by beta cells could explain this association. |
2012-07-16 |
2023-08-12 |
Not clear |
| Małgorzata Wajda-Cuszlag, Daniel Witkowski, Elżbieta Piontek, Marta Wysocka-Mincewicz, Maciej Borowiec, Wojciech Młynarski, Mieczysław Szaleck. [Glucokinase gene mutation as a causative factor of permanent neonatal diabetes mellitus]. Pediatric endocrinology, diabetes, and metabolism. vol 18. issue 1. 2012-06-07. PMID:22525692. |
one of them is neonatal diabetes identified within the first 6 months of life and often associated with the mutation in kcnj11, abcc8 or insulin gene. |
2012-06-07 |
2023-08-12 |
Not clear |