| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Elif Ozsu, Dinesh Giri, Gulcan Seymen Karabulut, Senthil Senniappa. Successful transition to sulfonylurea therapy in two Iraqi siblings with neonatal diabetes mellitus and iDEND syndrome due to ABCC8 mutation. Journal of pediatric endocrinology & metabolism : JPEM. vol 29. issue 12. 2017-04-20. PMID:27849623. |
successful transition from insulin to sulphonyl urea (su) agents in patients with pndm due to kcnj11 mutations and in patients with intermediate dend syndrome due to kcnj11 mutation have been reported in the literature. |
2017-04-20 |
2023-08-13 |
Not clear |
| Valerio Costa, Antonio Federico, Carla Pollastro, Carmela Ziviello, Simona Cataldi, Pietro Formisano, Alfredo Ciccodicol. Computational Analysis of Single Nucleotide Polymorphisms Associated with Altered Drug Responsiveness in Type 2 Diabetes. International journal of molecular sciences. vol 17. issue 7. 2017-03-15. PMID:27347941. |
inter-individual variability is principally due to single nucleotide polymorphisms, and differential drug responsiveness has been correlated to alteration in genes involved in drug metabolism (cyp2c9) or insulin signaling (irs1, abcc8, kcnj11 and pparg). |
2017-03-15 |
2023-08-13 |
Not clear |
| Asma Deeb, Abdelhadi Habeb, Walid Kaplan, Salima Attia, Suha Hadi, Amani Osman, Jamal Al-Jubeh, Sarah Flanagan, Elisa DeFranco, Sian Ellar. Genetic characteristics, clinical spectrum, and incidence of neonatal diabetes in the Emirate of AbuDhabi, United Arab Emirates. American journal of medical genetics. Part A. vol 170. issue 3. 2016-12-13. PMID:26463504. |
the child with kcnj11 mutation was successfully switched from insulin to oral sulphonylurea. |
2016-12-13 |
2023-08-13 |
Not clear |
| Shunyao Liao, Yunqiang Liu, Xiaojuan Chen, Yuande Tan, Jie Mei, Wenzhong Song, Lu Gan, Hailian Wang, Shi Yin, Xianjue Dong, Shu Chi, Shaoping Den. The Impact of Genetic Variants for Different Physiological Characterization of Type 2 Diabetes Loci on Gestational Insulin Signaling in Nondiabetic Pregnant Chinese Women. Reproductive sciences (Thousand Oaks, Calif.). vol 22. issue 11. 2016-10-05. PMID:25878199. |
by adjusting for maternal age, bmi, and the related interactions, the genetic variants in abcc8, cdkal1, cdkn2a, hnf1b, kcnj11, and mtnr1b were detected to impact gestational insulin signaling through heterogeneous mechanisms; however, compared with that in nonpregnant metabolism, the genetic effects seem to be eminently and heavily influenced by maternal age and bmi, indicating possible particular mechanisms underlying gestational metabolism and diabetic pathogenesis. |
2016-10-05 |
2023-08-13 |
Not clear |
| Kelly A Hicks, Jake A Kushner, Rubina Heptulla, J Nina Ha. Permanent neonatal diabetes mellitus in monozygotic twins achieving low-dose sulfonylurea therapy. Journal of pediatric endocrinology & metabolism : JPEM. vol 27. issue 1-2. 2016-07-28. PMID:23959658. |
although kcnj11 mutations of the katp channel within the β cell are known to prevent insulin secretion and cause permanent neonatal diabetes mellitus, the genotype-phenotype correlation continues to be of clinical interest. |
2016-07-28 |
2023-08-12 |
Not clear |
| Omer Babiker, Sarah E Flanagan, Sian Ellard, Hesham Al Girim, Khalid Hussain, Senthil Senniappa. Protein-induced hyperinsulinaemic hypoglycaemia due to a homozygous HADH mutation in three siblings of a Saudi family. Journal of pediatric endocrinology & metabolism : JPEM. vol 28. issue 9-10. 2016-06-17. PMID:25915078. |
hyperinsulinaemic hypoglycaemia (hh) is caused by mutations in the key genes involved in regulation of insulin secretion from the pancreatic β-cells and mutations in abcc8 and kcnj11 are the most common causes of hh. |
2016-06-17 |
2023-08-13 |
Not clear |
| Klára Roženková, Maria Güemes, Pratik Shah, Khalid Hussai. The Diagnosis and Management of Hyperinsulinaemic Hypoglycaemia. Journal of clinical research in pediatric endocrinology. vol 7. issue 2. 2016-05-23. PMID:26316429. |
recent advances in genetics have linked chi to mutations in 9 genes that play a key role in regulating insulin secretion (abcc8, kcnj11, glud1, gck, hadh, slc16a1, ucp2, hnf4a and hnf1a). |
2016-05-23 |
2023-08-13 |
Not clear |
| Brian W Thurber, David Carmody, Elizabeth C Tadie, Ashley N Pastore, Jazzmyne T Dickens, Kristen E Wroblewski, Rochelle N Naylor, Louis H Philipson, Siri Atma W Greele. Age at the time of sulfonylurea initiation influences treatment outcomes in KCNJ11-related neonatal diabetes. Diabetologia. vol 58. issue 7. 2016-03-10. PMID:25877689. |
individuals with heterozygous activating mutations of the kcnj11 gene encoding a subunit of the atp-sensitive potassium channel (katp) can usually be treated with oral sulfonylurea (su) pills in lieu of insulin injections. |
2016-03-10 |
2023-08-13 |
Not clear |
| Carla Pollastro, Carmela Ziviello, Valerio Costa, Alfredo Ciccodicol. Pharmacogenomics of Drug Response in Type 2 Diabetes: Toward the Definition of Tailored Therapies? PPAR research. vol 2015. 2015-07-10. PMID:26161088. |
here, we review the relationship between drug responsiveness and polymorphisms in genes involved in drug metabolism (cyp2c9) and insulin signaling (abcc8, kcnj11, and pparg). |
2015-07-10 |
2023-08-13 |
Not clear |
| Nagaraja M Phani, Vasudeva Guddattu, Ravishankara Bellampalli, Venu Seenappa, Prabha Adhikari, Shivashankara K Nagri, Sydney C D Souza, Gopinath P Mundyat, Kapaettu Satyamoorthy, Padmalatha S Ra. Population specific impact of genetic variants in KCNJ11 gene to type 2 diabetes: a case-control and meta-analysis study. PloS one. vol 9. issue 9. 2015-06-22. PMID:25247988. |
potassium inwardly rectifying channel, subfamily j, member 11 (kcnj11) gene have a key role in insulin secretion and is of substantial interest as a candidate gene for type 2 diabetes (t2d). |
2015-06-22 |
2023-08-13 |
Not clear |
| Suresh Jahnavi, Varadarajan Poovazhagi, Sekar Kanthimathi, Kandasamy Balamurugan, Dhanasekaran Bodhini, Jaivinder Yadav, Vandana Jain, Rajesh Khadgawat, Mahuya Sikdar, Ayurchelvan Bhavatharini, Ashok Kumar Das, Tanvir Kaur, Viswanathan Mohan, Venkatesan Radh. Novel ABCC8 (SUR1) gene mutations in Asian Indian children with congenital hyperinsulinemic hypoglycemia. Annals of human genetics. vol 78. issue 5. 2015-04-08. PMID:25117148. |
congenital hyperinsulinemic hypoglycemia (hi) is a heterogeneous genetic disorder of insulin secretion characterized by persistent hypoglycemia, most commonly associated with inactivating mutations of the β-cell atp-sensitive k(+) channel (k(atp) channel) genes abcc8 (encoding sur1) and kcnj11(encoding kir6.2). |
2015-04-08 |
2023-08-13 |
Not clear |
| Pratik Shah, Huseyin Demirbilek, Khalid Hussai. Persistent hyperinsulinaemic hypoglycaemia in infancy. Seminars in pediatric surgery. vol 23. issue 2. 2015-01-29. PMID:24931352. |
the molecular basis of phhi involves defects in key genes (abcc8, kcnj11, gck, slc16a1, hadh, ucp2, hnf4a and glud1) that regulate insulin secretion. |
2015-01-29 |
2023-08-13 |
Not clear |
| Parvaneh Keshavarz, Razie Habibipour, Malaeke Ghasemi, Ehsan Kazemnezhad, Maryam Alizadeh, Mohammad Hasan Hedayati Omam. Lack of genetic susceptibility of KCNJ11 E23K polymorphism with risk of type 2 diabetes in an Iranian population. Endocrine research. vol 39. issue 3. 2015-01-20. PMID:24460047. |
the kcnj11 gene has a strong effect on glucose-stimulated insulin secretion. |
2015-01-20 |
2023-08-12 |
Not clear |
| Katherine Q Philla, Andrew J Bauer, Karen S Vogt, Siri Atma W Greele. Successful transition from insulin to sulfonylurea therapy in a patient with monogenic neonatal diabetes owing to a KCNJ11 F333L [corrected] mutation. Diabetes care. vol 36. issue 12. 2014-12-11. PMID:24265373. |
successful transition from insulin to sulfonylurea therapy in a patient with monogenic neonatal diabetes owing to a kcnj11 f333l [corrected] mutation. |
2014-12-11 |
2023-08-12 |
Not clear |
| Victor M Hernandez-Escalante, Edna J Nava-Gonzalez, V Saroja Voruganti, Jack W Kent, Karin Haack, Hugo A Laviada-Molina, Fernanda Molina-Segui, Esther C Gallegos-Cabriales, Juan Carlos Lopez-Alvarenga, Shelley A Cole, Marguerite J Mezzles, Anthony G Comuzzie, Raul A Bastarrache. Replication of obesity and diabetes-related SNP associations in individuals from Yucatán, México. Frontiers in genetics. vol 5. 2014-12-05. PMID:25477898. |
nominal associations were found for cnr1, slc30a8, gck, and pcsk1 snps with systolic blood pressure, insulin and glucose, and for cnr1, slc30a8, kcnj11, and pcsk1 snps with adiponectin and leptin (p < 0.05). |
2014-12-05 |
2023-08-13 |
human |
| Yi-Der Jiang, Lee-Ming Chuang, Dee Pei, Yann-Jinn Lee, Jun-Nan Wei, Fung-Chang Sung, Tien-Jyun Chan. Genetic Variations in the Kir6.2 Subunit (KCNJ11) of Pancreatic ATP-Sensitive Potassium Channel Gene Are Associated with Insulin Response to Glucose Loading and Early Onset of Type 2 Diabetes in Childhood and Adolescence in Taiwan. International journal of endocrinology. vol 2014. 2014-10-13. PMID:25309595. |
genetic variations in the kir6.2 subunit (kcnj11) of pancreatic atp-sensitive potassium channel gene are associated with insulin response to glucose loading and early onset of type 2 diabetes in childhood and adolescence in taiwan. |
2014-10-13 |
2023-08-13 |
human |
| B M Shields, R M Freathy, A T Hattersle. Genetic influences on the association between fetal growth and susceptibility to type 2 diabetes. Journal of developmental origins of health and disease. vol 1. issue 2. 2014-08-22. PMID:25143063. |
(1) studies of rare monogenic diabetes have shown mutations in a single gene, such as gck or kcnj11, can cause diabetes by reducing insulin secretion, and these mutations are also associated with reduced birth weight. |
2014-08-22 |
2023-08-13 |
Not clear |
| Rochelle N Naylor, Siri Atma W Greeley, Graeme I Bell, Louis H Philipso. Genetics and pathophysiology of neonatal diabetes mellitus. Journal of diabetes investigation. vol 2. issue 3. 2014-06-24. PMID:24843477. |
ndm as a result of mutations in kcnj11 and abcc8 often responds to sulfonylureas, allowing transition from insulin therapy. |
2014-06-24 |
2023-08-13 |
Not clear |
| Maria Carla Proverbio, Eleonora Mangano, Alessandra Gessi, Roberta Bordoni, Roberta Spinelli, Rosanna Asselta, Paola Sogno Valin, Stefania Di Candia, Ilaria Zamproni, Cecilia Diceglie, Stefano Mora, Manuela Caruso-Nicoletti, Alessandro Salvatoni, Gianluca De Bellis, Cristina Battagli. Whole genome SNP genotyping and exome sequencing reveal novel genetic variants and putative causative genes in congenital hyperinsulinism. PloS one. vol 8. issue 7. 2014-03-05. PMID:23869231. |
the genetic causes of chi have been found in genes regulating insulin secretion from pancreatic β-cells; recessive inactivating mutations in the abcc8 and kcnj11 genes represent the most common events. |
2014-03-05 |
2023-08-12 |
Not clear |
| T Babiker, M H Shepherd, A T Hattersle. Continue with long term sulfonylureas in patients with mutations in the KCNJ11 gene when there is evidence of response even if insulin treatment is still required. Diabetes research and clinical practice. vol 100. issue 3. 2014-01-10. PMID:23608551. |
continue with long term sulfonylureas in patients with mutations in the kcnj11 gene when there is evidence of response even if insulin treatment is still required. |
2014-01-10 |
2023-08-12 |
Not clear |