| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhang-Ren Chen, Fa-Zhong He, Mou-Ze Liu, Jin-Lei Hu, Heng Xu, Hong-Hao Zhou, Wei Zhan. MIR4532 gene variant rs60432575 influences the expression of KCNJ11 and the sulfonylureas-stimulated insulin secretion. Endocrine. vol 63. issue 3. 2020-04-27. PMID:30242599. |
we studied whether the genetic polymorphisms of mir4532 rs60452575 would influence kcnj11 expression and sulfonylurea-stimulated insulin secretion or not. |
2020-04-27 |
2023-08-13 |
Not clear |
| Monta Ustinova, Ivars Silamikelis, Ineta Kalnina, Laura Ansone, Vita Rovite, Ilze Elbere, Ilze Radovica-Spalvina, Davids Fridmanis, Jekaterina Aladyeva, Ilze Konrade, Valdis Pirags, Janis Klovin. Metformin strongly affects transcriptome of peripheral blood cells in healthy individuals. PloS one. vol 14. issue 11. 2020-03-24. PMID:31703101. |
in addition to universal effects, 4 clusters of functionally related genes with a subject-specific differential expression were distinguished, including genes relevant to insulin production (hnf1b, hnf1a, hnf4a, gck, ins, neurod1, pax4, pdx1, abcc8, kcnj11) and cholesterol homeostasis (apob, ldlr, pcsk9). |
2020-03-24 |
2023-08-13 |
Not clear |
| T Koblas, I Leontovyc, S Loukotová, F Saude. Reprogramming of Human Pancreatic Organoid Cells into Insulin-Producing β-Like Cells by Small Molecules and in Vitro Transcribed Modified mRNA Encoding Neurogenin 3 Transcription Factor. Folia biologica. vol 65. issue 3. 2020-03-09. PMID:31638558. |
upon the reprogramming, ipcs formed 4.6 ± 1.2 % of the total cells and expressed typical markers (insulin, glucokinase, abcc8, kcnj11, slc2a2, slc30a8) and transcription factors (pdx1, neurod1, mafa, nkx2.2, nkx6.1, pax4, pax6) needed for the proper function of pancreatic β-cells. |
2020-03-09 |
2023-08-13 |
human |
| Birthe Gade-Rasmussen, Sten Madsbad, Maria Saur Svane, Christoffer Martinussen, Torben Hanse. [Successful treatment of KCNJ11 neonatal diabetes without insulin]. Ugeskrift for laeger. vol 180. issue 46. 2020-01-27. PMID:30417822. |
[successful treatment of kcnj11 neonatal diabetes without insulin]. |
2020-01-27 |
2023-08-13 |
Not clear |
| Katarzyna Walczewska-Szewc, Wieslaw Nowa. Spacial models of malfunctioned protein complexes help to elucidate signal transduction critical for insulin release. Bio Systems. vol 177. 2019-07-05. PMID:30395892. |
mutations in gene kcnj11 encoding the kir6.2 subunit of the atp-sensitive potassium channel (katp), a representative of a quite complex biosystem, may affect insulin release from pancreatic beta-cells. |
2019-07-05 |
2023-08-13 |
Not clear |
| Lisa R Letourneau, Siri Atma W Greele. Congenital forms of diabetes: the beta-cell and beyond. Current opinion in genetics & development. vol 50. 2019-03-08. PMID:29454299. |
ongoing follow-up of patients with kcnj11 and abcc8 mutations has supported the safety and efficacy of sulfonylureas, as well as the use of insulin pumps and continuous glucose monitors in infants with insulin-requiring forms of monogenic diabetes. |
2019-03-08 |
2023-08-13 |
Not clear |
| Ranee Chatterjee, Clemontina A Davenport, Laura M Raffield, Nisa Maruthur, Leslie Lange, Elizabeth Selvin, Kenneth Butler, Hsin-Chieh Yeh, James G Wilson, Adolfo Correa, David Edelman, Elizabeth Hause. KCNJ11 variants and their effect on the association between serum potassium and diabetes risk in the Atherosclerosis Risk in Communities (ARIC) Study and Jackson Heart Study (JHS) cohorts. PloS one. vol 13. issue 8. 2019-02-14. PMID:30169531. |
the kcnj11 gene encodes for a k channel that regulates insulin secretion and whose function is affected by serum k levels. |
2019-02-14 |
2023-08-13 |
human |
| J Stanik, A Dankovcikova, L Barak, M Skopkova, M Palko, J Divinec, I Klimes, D Gasperikov. Sulfonylurea vs insulin therapy in individuals with sulfonylurea-sensitive permanent neonatal diabetes mellitus, attributable to a KCNJ11 mutation, and poor glycaemic control. Diabetic medicine : a journal of the British Diabetic Association. vol 35. issue 3. 2018-12-17. PMID:29278452. |
sulfonylurea vs insulin therapy in individuals with sulfonylurea-sensitive permanent neonatal diabetes mellitus, attributable to a kcnj11 mutation, and poor glycaemic control. |
2018-12-17 |
2023-08-13 |
Not clear |
| J Stanik, A Dankovcikova, L Barak, M Skopkova, M Palko, J Divinec, I Klimes, D Gasperikov. Sulfonylurea vs insulin therapy in individuals with sulfonylurea-sensitive permanent neonatal diabetes mellitus, attributable to a KCNJ11 mutation, and poor glycaemic control. Diabetic medicine : a journal of the British Diabetic Association. vol 35. issue 3. 2018-12-17. PMID:29278452. |
therapy with sulfonylurea is preferable to insulin in the majority of individuals with kcnj11 mutations, but not all of these people achieve target levels of hba |
2018-12-17 |
2023-08-13 |
Not clear |
| Sonya Galcheva, Sara Al-Khawaga, Khalid Hussai. Diagnosis and management of hyperinsulinaemic hypoglycaemia. Best practice & research. Clinical endocrinology & metabolism. vol 32. issue 4. 2018-12-11. PMID:30086874. |
recent advances in genetics have linked congenital hh to mutations in 14 different genes that play a key role in regulating insulin secretion (abcc8, kcnj11, glud1, gck, hadh, slc16a1, ucp2, hnf4a, hnf1a, hk1, pgm1, ppm2, cacna1d, foxa2). |
2018-12-11 |
2023-08-13 |
Not clear |
| Hüseyin Demirbilek, Khalid Hussai. Congenital Hyperinsulinism: Diagnosis and Treatment Update. Journal of clinical research in pediatric endocrinology. vol 9. issue Suppl 2. 2018-08-06. PMID:29280746. |
mutations in 12 different key genes (abcc8, kcnj11, glud1, gck, hadh, slc16a1, ucp2, hnf4a, hnf1a, hk1, pgm1 and pmm2) that are involved in the regulation of insulin secretion from pancreatic β-cells have been described to be responsible for the underlying molecular mechanisms leading to congenital hh. |
2018-08-06 |
2023-08-13 |
Not clear |
| Fang Yuan, Dongsheng Guo, Ge Gao, Yanli Liu, Yingying Xu, Yuhang Wu, Fan Yang, Xinrong Ke, Keyu Lai, Liangqing Hong, Yin-Xiong L. Generation of a KCNJ11 homozygous knockout human embryonic stem cell line WAe001-A-12 using CRISPR/Cas9. Stem cell research. vol 24. 2018-07-03. PMID:29034901. |
mutations in kcnj11 result in hyperinsulinism or diabetes mellitus, associated with abnormal insulin secretion. |
2018-07-03 |
2023-08-13 |
human |
| Sorin Ioacara, Sarah Flanagan, Elke Fröhlich-Reiterer, Robin Goland, Simona Fic. First case of neonatal diabetes with KCNJ11 Q52R mutation successfully switched from insulin to sulphonylurea treatment. Journal of diabetes investigation. vol 8. issue 5. 2018-05-08. PMID:28083968. |
first case of neonatal diabetes with kcnj11 q52r mutation successfully switched from insulin to sulphonylurea treatment. |
2018-05-08 |
2023-08-13 |
Not clear |
| E Dabrowska-Zamojcin, M Tarnowski, M Szydlowski, M Romanowski, V Dziedziejko, K Safranow, L Domanski, A Pawli. KCNJ11 and KCNQ1 Gene Polymorphisms Are Not Associated with Post-Transplant Diabetes Mellitus in Kidney Allograft Recipients Treated with Tacrolimus. Folia biologica. vol 63. issue 3. 2018-05-07. PMID:28805561. |
atp-sensitive potassium channels kcnj11 and kcnq1 play an important role in the regulation of insulin secretion by β cells and development of diabetes mellitus. |
2018-05-07 |
2023-08-13 |
Not clear |
| Sabeen Abid Khan, Arit Parkash, Mohsina Ibrahi. Permanent Neonatal Diabetes (DEND Syndrome). Journal of the College of Physicians and Surgeons--Pakistan : JCPSP. vol 26. issue 11. 2018-01-04. PMID:28666500. |
genetic mutation testing confirmed mutations in kcnj11 gene encoding the kir6.2 subunit of the k-atpchannel, which are involved in insulin secretion. |
2018-01-04 |
2023-08-13 |
Not clear |
| Yisheng Yang, Lawrence Cha. Monogenic Diabetes: What It Teaches Us on the Common Forms of Type 1 and Type 2 Diabetes. Endocrine reviews. vol 37. issue 3. 2017-12-08. PMID:27035557. |
two of the t2d-associated monogenic diabetes genes-potassium inward-rectifying channel, subfamily j, member 11 (kcnj11), which controls glucose-stimulated insulin secretion in the β-cell; and peroxisome proliferator-activated receptor γ (pparg), which impacts multiple tissue targets in relation to inflammation and insulin sensitivity-have been developed as major antidiabetic drug targets. |
2017-12-08 |
2023-08-13 |
human |
| Tarig Babiker, Natascia Vedovato, Kashyap Patel, Nicholas Thomas, Roisin Finn, Roope Männikkö, Ali J Chakera, Sarah E Flanagan, Maggie H Shepherd, Sian Ellard, Frances M Ashcroft, Andrew T Hattersle. Successful transfer to sulfonylureas in KCNJ11 neonatal diabetes is determined by the mutation and duration of diabetes. Diabetologia. vol 59. issue 6. 2017-08-28. PMID:27033559. |
our aim was to identify factors associated with successful transfer from insulin to sulfonylureas in patients with permanent neonatal diabetes due to mutations in kcnj11 (which encodes the inwardly rectifying potassium channel kir6.2). |
2017-08-28 |
2023-08-13 |
Not clear |
| Siri Atma W Greeley, Mark C Zielinski, Ananta Poudel, Honggang Ye, Shivani Berry, Jerome B Taxy, David Carmody, Donald F Steiner, Louis H Philipson, Jamie R Wood, Manami Har. Preservation of Reduced Numbers of Insulin-Positive Cells in Sulfonylurea-Unresponsive KCNJ11-Related Diabetes. The Journal of clinical endocrinology and metabolism. vol 102. issue 1. 2017-06-20. PMID:27802092. |
the most common genetic cause of permanent neonatal diabetes mellitus is activating mutations in kcnj11, which can usually be treated using oral sulfonylureas (sus) instead of insulin injections, although some mutations are su unresponsive. |
2017-06-20 |
2023-08-13 |
Not clear |
| Opeolu O Ojo, Dinesh K Srinivasan, Bosede O Owolabi, Mary K McGahon, R Charlotte Moffett, Tim M Curtis, J Michael Conlon, Peter R Flatt, Yasser H A Abdel-Waha. Molecular mechanisms mediating the beneficial metabolic effects of [Arg4]tigerinin-1R in mice with diet-induced obesity and insulin resistance. Biological chemistry. vol 397. issue 8. 2017-06-15. PMID:26966929. |
peptide administration resulted in up-regulation of key functional genes in islets involved insulin secretion (abcc8, kcnj11, cacna1c and slc2a2) and in skeletal muscle involved with insulin action (insr, irs1, pdk1, pik3ca, and slc2a4). |
2017-06-15 |
2023-08-13 |
mouse |
| Maki Moritani, Ichiro Yokota, Reiko Horikawa, Tatsuhiko Urakami, Aki Nishii, Tomoyuki Kawamura, Nobuyuki Kikuchi, Touru Kikuchi, Tsutomu Ogata, Shigetaka Sugihara, Shin Amemiy. Identification of monogenic gene mutations in Japanese subjects diagnosed with type 1B diabetes between >5 and 15.1 years of age. Journal of pediatric endocrinology & metabolism : JPEM. vol 29. issue 9. 2017-05-04. PMID:27398945. |
monogenic mutations, such as those in the potassium inwardly-rectifying channel, subfamily j, member 11 (kcnj11) and insulin (ins) genes, are identified in young patients with type 1b diabetes (non-autoimmune-mediated). |
2017-05-04 |
2023-08-13 |
human |