| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Deblina Dey, Vipan K Parihar, Gergely G Szabo, Peter M Klein, Jenny Tran, Jonathan Moayyad, Faizy Ahmed, Quynh-Anh Nguyen, Alexandria Murry, David Merriott, Brandon Nguyen, Jodi Goldman, Maria C Angulo, Daniele Piomelli, Ivan Soltesz, Janet E Baulch, Charles L Limol. Neurological Impairments in Mice Subjected to Irradiation and Chemotherapy. Radiation research. vol 193. issue 5. 2020-09-14. PMID:32134362. |
relevant to the known roles of the serotonin axis in mood disorders, we found that 5ht1a serotonin receptor levels were decreased by ∼50% in the hippocampus at both early and late time points, and a 37% decrease in serotonin levels was observed at 15 weeks postirradiation. |
2020-09-14 |
2023-08-13 |
mouse |
| Christoph U Correl. Current Treatment Options and Emerging Agents for Schizophrenia. The Journal of clinical psychiatry. vol 81. issue 3. 2020-09-14. PMID:32297721. |
mechanisms of action that are under investigation include dopamine d3 antagonism/serotonin 5-ht1a partial agonism; combined dopamine, serotonin, and glutamate modulation; phosphodiesterase 10a inhibition; trace amine-associated receptor-1 (taar1) agonism plus 5-ht1a agonism; 5-ht2a inverse agonism; sigma-2/5-ht2a antagonism; d-amino acid oxidase (daao) inhibition; glycine transporter-1 inhibition; vesicular monoamine transporter-2 antagonism; mu opioid antagonism added to olanzapine; and novel long-acting injectable antipsychotic formulations. |
2020-09-14 |
2023-08-13 |
Not clear |
| Víctor Cervantes-Ramírez, Martha Canto-Bustos, Diana Aguilar-Magaña, Elsy Arlene Pérez-Padilla, José Luis Góngora-Alfaro, Juan Carlos Pineda, Marco Atzori, Humberto Salgad. Citalopram reduces glutamatergic synaptic transmission in the auditory cortex via activation of 5-HT1A receptors. Neuroreport. vol 30. issue 18. 2020-07-31. PMID:31714483. |
here, we characterize the modulation of excitatory post-synaptic currents by application of either 5-ht or agonists of 5-ht1a and 5-ht2 receptors, or by endogenous 5-ht evoked by citalopram on pyramidal neurons from layer ii/iii of rat auditory cortex. |
2020-07-31 |
2023-08-13 |
rat |
| Víctor Cervantes-Ramírez, Martha Canto-Bustos, Diana Aguilar-Magaña, Elsy Arlene Pérez-Padilla, José Luis Góngora-Alfaro, Juan Carlos Pineda, Marco Atzori, Humberto Salgad. Citalopram reduces glutamatergic synaptic transmission in the auditory cortex via activation of 5-HT1A receptors. Neuroreport. vol 30. issue 18. 2020-07-31. PMID:31714483. |
we observed that selective agonists of 5-ht1a and 5-ht2 receptors [8-oh-dpat (10 µm) and doi (10 µm), respectively] mimic the effect of 5-ht on the excitatory post-synaptic currents. |
2020-07-31 |
2023-08-13 |
rat |
| Muhammad Farhan, Fatima Riaz, Sana Wali, Hamna Rafi. Desensitization of 5-HT-1A Somatodentritic Receptors in Tryptophan Treated and Co-treated Rats Induced by Methylphenidate. Current clinical pharmacology. vol 14. issue 2. 2020-07-07. PMID:30417792. |
tryptophan and methylphenidate being 5-ht agonists, both increase the level of serotonin thereby causing desensitization of 5-ht1a receptors. |
2020-07-07 |
2023-08-13 |
rat |
| Louisa J. Steinberg, Mark D. Underwood, Mihran J. Bakalian, Suham A. Kassir, J. John Mann, Victoria Arang. 5-HT1A receptor, 5-HT2A receptor and serotonin transporter binding in the human auditory cortex in depression Journal of psychiatry & neuroscience : JPN. vol 44. issue 5. 2020-06-22. PMID:31120232. |
5-ht1a receptor, 5-ht2a receptor and serotonin transporter binding in the human auditory cortex in depression serotonergic system abnormalities are implicated in many psychiatric disorders, including major depression. |
2020-06-22 |
2023-08-13 |
human |
| Jie-Cong Huang, Wei Xie, Ning Deng, Wen-Lin Liang, Dong-Rong Hu, Yu Hong, Yang Zho. [Foshouningshen decoction improves sleeping via the serotonergic system in a rat model of insomnia]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. vol 37. issue 8. 2020-06-12. PMID:28801295. |
to evaluate the sedative and hypnotic effects of foshouningshen decoction (fsnsd) and study its effects on expressions of 5-hydroxy tryptamine (5-ht) and 5-ht1a receptor (5-ht |
2020-06-12 |
2023-08-13 |
rat |
| Ashley M Cunningham, Tabia L Santos, Vanessa A Gutzeit, Heather Hamilton, René Hen, Zoe R Donaldso. Functional Interrogation of a Depression-Related Serotonergic Single Nucleotide Polymorphism, rs6295, Using a Humanized Mouse Model. ACS chemical neuroscience. vol 10. issue 7. 2020-06-11. PMID:30694044. |
the serotonin 1a receptor (5-ht1a) system has been extensively implicated in modulating mood and behavior. |
2020-06-11 |
2023-08-13 |
mouse |
| Paul R. Albert, Brice Le François, Faranak Vahid-Ansar. Genetic, epigenetic and posttranscriptional mechanisms for treatment of major depression: the 5-HT1A receptor gene as a paradigm Journal of psychiatry & neuroscience : JPN. vol 44. issue 3. 2020-06-09. PMID:30807072. |
genetic, epigenetic and posttranscriptional mechanisms for treatment of major depression: the 5-ht1a receptor gene as a paradigm major depression and anxiety are highly prevalent and involve chronic dysregulation of serotonin, but they remain poorly understood. |
2020-06-09 |
2023-08-13 |
human |
| Paul R. Albert, Brice Le François, Faranak Vahid-Ansar. Genetic, epigenetic and posttranscriptional mechanisms for treatment of major depression: the 5-HT1A receptor gene as a paradigm Journal of psychiatry & neuroscience : JPN. vol 44. issue 3. 2020-06-09. PMID:30807072. |
here, we review novel transcriptional (genetic, epigenetic) and posttranscriptional (microrna, alternative splicing) mechanisms implicated in mental illness, focusing on a key serotonin-related regulator, the serotonin 1a (5-ht1a) receptor. |
2020-06-09 |
2023-08-13 |
human |
| Le Wang, Yanming Zhang, Xia Du, Teng Ding, Weiling Gong, Feng Li. Review of antidepressants in clinic and active ingredients of traditional Chinese medicine targeting 5-HT1A receptors. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 120. 2020-04-21. PMID:31541883. |
the 5-ht1a receptor is a key protein in the brain serotonin system, modulating the release of 5-ht and other neurotransmitters. |
2020-04-21 |
2023-08-13 |
Not clear |
| Deborah J Luessen, Haiguo Sun, Molly M McGinnis, Michael Hagstrom, Glen Marrs, Brian A McCool, Rong Che. Acute ethanol exposure reduces serotonin receptor 1A internalization by increasing ubiquitination and degradation of β-arrestin2. The Journal of biological chemistry. vol 294. issue 38. 2020-04-06. PMID:31366729. |
using serotonin 5-ht1a receptors (5-ht1ars) as a model receptor system, we found that ethanol dose-dependently inhibits 5-ht1ar internalization and that mdm2 knockdown reverses this effect. |
2020-04-06 |
2023-08-13 |
rat |
| Darakhshan Jabeen Halee. Targeting Serotonin1A Receptors for Treating Chronic Pain and Depression. Current neuropharmacology. vol 17. issue 12. 2020-04-01. PMID:31418663. |
although functional responses to serotonin are mediated via the activation of multiple receptor types and subtypes, the 5-ht1a subtype is involved in the processing of nociception as well as the pathogenesis and treatment of depression. |
2020-04-01 |
2023-08-13 |
Not clear |
| Darakhshan Jabeen Halee. Targeting Serotonin1A Receptors for Treating Chronic Pain and Depression. Current neuropharmacology. vol 17. issue 12. 2020-04-01. PMID:31418663. |
this article targets the 5-ht1a receptors to show that indiscriminate activation of pre and postsynaptic 5-ht1a receptors is likely to produce no therapeutic benefits; biased activation of the 5-ht heteroreceptors may be a useful strategy for treating chronic pain and depression individually as well as in a comorbid condition. |
2020-04-01 |
2023-08-13 |
Not clear |
| Minxuan Cai, Liangliang Zhou, Jun Liao, Qiaoling Huang, Zhenjiang Xia, Jing Shan. IFN-γ inhibits 5-HT-induced melanin biosynthesis via downregulation of 5-HT receptors in vivo/in vitro. Journal of pharmacological sciences. vol 141. issue 1. 2020-03-11. PMID:31519333. |
in addition, we found that ifn-γ decreased serum serotonin levels as well as the cutaneous expression of tryptophan hydroxylase 1 (tph1), 5-ht1a receptor (5-ht1ar) and 5-ht1b receptor (5-ht1br) in c57bl/6 mice. |
2020-03-11 |
2023-08-13 |
mouse |
| Gregory M James, Gregor Gryglewski, Thomas Vanicek, Neydher Berroterán-Infante, Cécile Philippe, Alexander Kautzky, Lukas Nics, Chrysoula Vraka, Godber M Godbersen, Jakob Unterholzner, Helen L Sigurdardottir, Marie Spies, René Seiger, Georg S Kranz, Andreas Hahn, Markus Mitterhauser, Wolfgang Wadsak, Andreas Bauer, Marcus Hacker, Siegfried Kasper, Rupert Lanzenberge. Parcellation of the Human Cerebral Cortex Based on Molecular Targets in the Serotonin System Quantified by Positron Emission Tomography In vivo. Cerebral cortex (New York, N.Y. : 1991). vol 29. issue 1. 2020-03-03. PMID:30357321. |
positron emission tomography was carried out for the quantification of serotonin 1a (5-ht1a, n = 30) and 5-ht2a receptors (n = 22), the serotonin-degrading enzyme monoamine oxidase a (mao-a, n = 32) and the serotonin transporter (5-htt, n = 24) in healthy participants. |
2020-03-03 |
2023-08-13 |
human |
| Limin Wang, Zhenxiang Zhu, Wenjuan Hou, Xueni Zhang, Zhixiong He, Wei Yuan, Yang Yang, Siyi Zhang, Rui Jia, Fadao Ta. Serotonin Signaling Trough Prelimbic 5-HT1A Receptors Modulates CSDS-Induced Behavioral Changes in Adult Female Voles. The international journal of neuropsychopharmacology. vol 22. issue 3. 2020-01-30. PMID:30445535. |
serotonin signaling trough prelimbic 5-ht1a receptors modulates csds-induced behavioral changes in adult female voles. |
2020-01-30 |
2023-08-13 |
Not clear |
| Ting Yang Hsieh, Yi Chang, Su Jane Wan. Piperine-mediated suppression of voltage-dependent Ca Food & function. vol 10. issue 5. 2020-01-02. PMID:31033966. |
in addition, immunocytochemical analysis confirmed the presence of presynaptic 5-hydroxytryptamine 1a (5-ht1a) receptor proteins. |
2020-01-02 |
2023-08-13 |
rat |
| Joanna Sniecikowska, Adrian Newman-Tancredi, Marcin Kolaczkowsk. From Receptor Selectivity to Functional Selectivity: The Rise of Biased Agonism in 5-HT1A Receptor Drug Discovery. Current topics in medicinal chemistry. vol 19. issue 26. 2019-12-31. PMID:31544717. |
despite extensive efforts to design serotonin 5-ht1a receptor compounds, there are currently no clinically available selective agonists to explore the therapeutic potential of activating this receptor. |
2019-12-31 |
2023-08-13 |
Not clear |
| Valérie Turcotte-Cardin, Faranak Vahid-Ansari, Christine Luckhart, Mireille Daigle, Sean D Geddes, Kenji F Tanaka, René Hen, Jonathan James, Zul Merali, Jean-Claude Béïque, Paul R Alber. Loss of Adult 5-HT1A Autoreceptors Results in a Paradoxical Anxiogenic Response to Antidepressant Treatment. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 39. issue 8. 2019-12-30. PMID:30552180. |
chronic ssri treatment induces desensitization of 5-ht1a autoreceptors to enhance 5-ht neurotransmission. |
2019-12-30 |
2023-08-13 |
mouse |