| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gabriela Henríquez, Alejandra Gomez, Erick Guerrero, Mahesh Naraya. Potential Role of Natural Polyphenols against Protein Aggregation Toxicity: In Vitro, In Vivo, and Clinical Studies. ACS chemical neuroscience. vol 11. issue 19. 2021-06-18. PMID:32822152. |
one of the main features of neurodegenerative disorders such as alzheimer's disease and parkinson's disease is the amyloidogenic behavior of disease-specific proteins including amyloid β, tau, α-synuclein, and mutant huntingtin which participate in the formation, accumulation, and deposition of toxic misfolded aggregates. |
2021-06-18 |
2023-08-13 |
Not clear |
| Gabriela Henríquez, Alejandra Gomez, Erick Guerrero, Mahesh Naraya. Potential Role of Natural Polyphenols against Protein Aggregation Toxicity: In Vitro, In Vivo, and Clinical Studies. ACS chemical neuroscience. vol 11. issue 19. 2021-06-18. PMID:32822152. |
we explore the effectiveness of the polyphenols epigallocatechin-3-gallate, oleuropein aglycone, and quercetin on their ability to inhibit aggregation of amyloid β, tau, and α-synuclein and mitigate other pathological features for alzheimer's disease and parkinson's disease. |
2021-06-18 |
2023-08-13 |
Not clear |
| Thomas K Karikari, Sophie Keeling, Emily Hill, Juan Lantero Rodrı Guez, David A Nagel, Bruno Becker, Kina Höglund, Henrik Zetterberg, Kaj Blennow, Eric J Hill, Kevin G Moffa. Extensive Plasmid Library to Prepare Tau Protein Variants and Study Their Functional Biochemistry. ACS chemical neuroscience. vol 11. issue 19. 2021-06-18. PMID:32833429. |
tau neurofibrillary tangles are key pathological features of alzheimer's disease and other tauopathies. |
2021-06-18 |
2023-08-13 |
Not clear |
| Chae Eun Heo, Jong Yoon Han, Sungsu Lim, Jeeyoung Lee, Dongjoon Im, Min Jae Lee, Yun Kyung Kim, Hugh I Ki. ATP Kinetically Modulates Pathogenic Tau Fibrillations. ACS chemical neuroscience. vol 11. issue 19. 2021-06-18. PMID:32915536. |
advanced understanding of alzheimer's disease (ad) and several tauopathies over the past decades indicates the pathological importance of tau aggregation in these diseases. |
2021-06-18 |
2023-08-13 |
human |
| Yuan Hu, Xiaochun Hu, Yonglin Lu, Shuo Shi, Danjing Yang, Tianming Ya. New Strategy for Reducing Tau Aggregation Cytologically by A Hairpinlike Molecular Inhibitor, Tannic Acid Encapsulated in Liposome. ACS chemical neuroscience. vol 11. issue 21. 2021-06-18. PMID:33048528. |
inhibition of tau protein aggregation is an attractive therapeutic target for alzheimer's disease. |
2021-06-18 |
2023-08-13 |
mouse |
| Jie Zhao, Qihui Shi, Hongda Tian, Youzhi Li, Yan Liu, Zhen Xu, Anne Robert, Qiong Liu, Bernard Meunie. TDMQ20, a Specific Copper Chelator, Reduces Memory Impairments in Alzheimer's Disease Mouse Models. ACS chemical neuroscience. vol 12. issue 1. 2021-06-18. PMID:33322892. |
besides targeting amyloid or tau metabolisms, regulation of redox metal ions is a recognized therapeutic target for alzheimer's disease (ad). |
2021-06-18 |
2023-08-13 |
mouse |
| Philip R Lindstedt, Ross J Taylor, Gonçalo J L Bernardes, Michele Vendruscol. Facile Installation of Post-translational Modifications on the Tau Protein via Chemical Mutagenesis. ACS chemical neuroscience. vol 12. issue 3. 2021-06-18. PMID:33464820. |
we illustrate this approach by performing site-specific phosphorylation and methylation of tau, a protein that stabilizes microtubules and whose aggregation is closely linked with alzheimer's disease. |
2021-06-18 |
2023-08-13 |
Not clear |
| Hongli Liu, Qin Li, Chunmei Xiong, Haiyang Zhong, Qianqian Zhang, Huanxiang Liu, Xiaojun Ya. Uncovering the Effect of pS202/pT205/pS208 Triple Phosphorylations on the Conformational Features of the Key Fragment G192-T212 of Tau Protein. ACS chemical neuroscience. vol 12. issue 6. 2021-06-18. PMID:33663205. |
microtubule-associated protein tau is abnormally phosphorylated and forms the aggregates of paired helical filaments in alzheimer's disease (ad) and other tauopathies. |
2021-06-18 |
2023-08-13 |
Not clear |
| Taylor J Fiolek, Katarina L Keel, Jetze J Tep. Fluspirilene Analogs Activate the 20S Proteasome and Overcome Proteasome Impairment by Intrinsically Disordered Protein Oligomers. ACS chemical neuroscience. vol 12. issue 8. 2021-06-18. PMID:33788542. |
oligomerization of aggregation-prone intrinsically disordered proteins (idps), such as α-synuclein, amyloid β, and tau, has been shown to be associated with the pathogenesis of several neurodegenerative diseases, including parkinson's and alzheimer's disease. |
2021-06-18 |
2023-08-13 |
Not clear |
| Segev Naveh Tassa, Shani Ben Zichri, Shiran Lacham-Hartman, Ofek Oren, Zeev Slobodnik, Ekaterina Eremenko, Debra Toiber, Raz Jelinek, Niv Pap. A Mechanism for the Inhibition of Tau Neurotoxicity: Studies with Artificial Membranes, Isolated Mitochondria, and Intact Cells. ACS chemical neuroscience. vol 12. issue 9. 2021-06-18. PMID:33904703. |
it is currently believed that molecular agents that specifically bind to and neutralize the toxic proteins/peptides, amyloid β (aβ42), tau, and the tau-derived peptide phf6, hold the key to attenuating the progression of alzheimer's disease (ad). |
2021-06-18 |
2023-08-13 |
Not clear |
| Tiago Mendes, Adrien Herledan, Florence Leroux, Benoit Deprez, Jean-Charles Lambert, Devrim Kilin. High-Content Screening for Protein-Protein Interaction Modulators Using Proximity Ligation Assay in Primary Neurons. Current protocols in cell biology. vol 86. issue 1. 2021-06-17. PMID:31876395. |
we recently developed a high-content screening model based on primary hippocampal neurons cultured in 384-well plates and screened a library of ∼1100 compounds using a pla between tau and bridging integrator 1, a genetic risk factor for alzheimer's disease. |
2021-06-17 |
2023-08-13 |
rat |
| Sunil Kumar Vimal, Hua Zuo, Zhengwu Wang, Hongrun Wang, Zhiliang Long, Sanjib Bhattacharyy. Self-Therapeutic Nanoparticle That Alters Tau Protein and Ameliorates Tauopathy Toward a Functional Nanomedicine to Tackle Alzheimer's. Small (Weinheim an der Bergstrasse, Germany). vol 16. issue 16. 2021-06-17. PMID:32191383. |
self-therapeutic nanoparticle that alters tau protein and ameliorates tauopathy toward a functional nanomedicine to tackle alzheimer's. |
2021-06-17 |
2023-08-13 |
mouse |
| Sunil Kumar Vimal, Hua Zuo, Zhengwu Wang, Hongrun Wang, Zhiliang Long, Sanjib Bhattacharyy. Self-Therapeutic Nanoparticle That Alters Tau Protein and Ameliorates Tauopathy Toward a Functional Nanomedicine to Tackle Alzheimer's. Small (Weinheim an der Bergstrasse, Germany). vol 16. issue 16. 2021-06-17. PMID:32191383. |
similarly, a high level of tau is found in macaque monkey serum and au-peg inhibits amyloidosis of alzheimer's patients and primate's serum samples ex vivo. |
2021-06-17 |
2023-08-13 |
mouse |
| Noemi Esteras, Franziska Kundel, Giuseppe F Amodeo, Evgeny V Pavlov, David Klenerman, Andrey Y Abramo. Insoluble tau aggregates induce neuronal death through modification of membrane ion conductance, activation of voltage-gated calcium channels and NADPH oxidase. The FEBS journal. vol 288. issue 1. 2021-06-17. PMID:32338825. |
one of these proteins, tau, is involved in a number of pathologies including alzheimer's disease and frontotemporal dementia. |
2021-06-17 |
2023-08-13 |
Not clear |
| Tyler C Hammond, Xin Xing, Chris Wang, David Ma, Kwangsik Nho, Paul K Crane, Fanny Elahi, David A Ziegler, Gongbo Liang, Qiang Cheng, Lucille M Yanckello, Nathan Jacobs, Ai-Ling Li. β-amyloid and tau drive early Alzheimer's disease decline while glucose hypometabolism drives late decline. Communications biology. vol 3. issue 1. 2021-06-17. PMID:32632135. |
β-amyloid and tau drive early alzheimer's disease decline while glucose hypometabolism drives late decline. |
2021-06-17 |
2023-08-13 |
human |
| Tyler C Hammond, Xin Xing, Chris Wang, David Ma, Kwangsik Nho, Paul K Crane, Fanny Elahi, David A Ziegler, Gongbo Liang, Qiang Cheng, Lucille M Yanckello, Nathan Jacobs, Ai-Ling Li. β-amyloid and tau drive early Alzheimer's disease decline while glucose hypometabolism drives late decline. Communications biology. vol 3. issue 1. 2021-06-17. PMID:32632135. |
here, using the random forest machine learning method to analyze participants in the alzheimer's disease neuroimaging initiative dataset, we show that a/t/n biomarkers show varying importance in predicting ad development, with elevated biomarkers of aβ and tau better predicting early dementia status, and biomarkers of neurodegeneration, especially glucose hypometabolism, better predicting later dementia status. |
2021-06-17 |
2023-08-13 |
human |
| Xu Hun, Xiaohui Kon. An enzyme linked aptamer photoelectrochemical biosensor for Tau-381 protein using AuNPs/MoSe Journal of pharmaceutical and biomedical analysis. vol 192. 2021-06-17. PMID:33065402. |
tau protein is an important biomarker in the pathogenesis of alzheimer's disease. |
2021-06-17 |
2023-08-13 |
Not clear |
| Mengying Xu, Meiyan Lu, Wenjun Zhang, Qingwen Jin, Yun Che. Simultaneous Detection of Six Isoforms of Tau Protein in Human Cerebrospinal Fluid by Multidimensional Mass Spectrometry-Based Targeted Proteomics. Journal of proteome research. vol 20. issue 5. 2021-06-17. PMID:33843226. |
abnormal expression of tau protein can cause the development of alzheimer's disease (ad). |
2021-06-17 |
2023-08-13 |
human |
| Casimir Bamberger, Sandra Pankow, Salvador Martínez-Bartolomé, Michelle Ma, Jolene Diedrich, Robert A Rissman, John R Yate. Protein Footprinting via Covalent Protein Painting Reveals Structural Changes of the Proteome in Alzheimer's Disease. Journal of proteome research. vol 20. issue 5. 2021-06-17. PMID:33872013. |
misfolding and aggregation of amyloid-β peptide and hyperphosphorylated tau are molecular markers of alzheimer's disease (ad), and although the 3d structures of these aberrantly folded proteins have been visualized in exquisite detail, no method has been able to survey protein folding across the proteome in ad. |
2021-06-17 |
2023-08-13 |
human |
| Chan-Mi Kim, Victor Montal, Ibai Diez, William Orwig, Jorge Sepulcr. Network interdigitations of Tau and amyloid-beta deposits define cognitive levels in aging. Human brain mapping. vol 42. issue 10. 2021-06-17. PMID:33955621. |
amyloid-beta (aβ) plaques and tau neurofibrillary tangles are pathological hallmarks of alzheimer's disease (ad); their contribution to neurodegeneration and clinical manifestations are critical in understanding preclinical ad. |
2021-06-17 |
2023-08-13 |
human |