| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kevin H J Park, Tomás Barret. Gliosis Precedes Amyloid-β Deposition and Pathological Tau Accumulation in the Neuronal Cell Cycle Re-Entry Mouse Model of Alzheimer's Disease. Journal of Alzheimer's disease reports. vol 4. issue 1. 2021-06-10. PMID:32904753. |
gliosis precedes amyloid-β deposition and pathological tau accumulation in the neuronal cell cycle re-entry mouse model of alzheimer's disease. |
2021-06-10 |
2023-08-13 |
mouse |
| Kristian Steen Frederiksen, Steen Hasselbalch, Gunhild Waldema. [Analysis of cerebrospinal fluid in the diagnosis of cognitive impairment and dementia]. Ugeskrift for laeger. vol 182. issue 45. 2021-06-10. PMID:33215587. |
moreover, analysis of specific molecules such as beta-amyloid, phosphorylated tau and neurofilament light chain may contribute to the diagnosis of neurodegenerative diseases including alzheimer's disease. |
2021-06-10 |
2023-08-13 |
Not clear |
| Silvia Zampar, Oliver Wirth. Characterization of a Mouse Model of Alzheimer's Disease Expressing Aβ4-42 and Human Mutant Tau. International journal of molecular sciences. vol 22. issue 10. 2021-06-10. PMID:34069029. |
characterization of a mouse model of alzheimer's disease expressing aβ4-42 and human mutant tau. |
2021-06-10 |
2023-08-13 |
mouse |
| Silvia Zampar, Oliver Wirth. Characterization of a Mouse Model of Alzheimer's Disease Expressing Aβ4-42 and Human Mutant Tau. International journal of molecular sciences. vol 22. issue 10. 2021-06-10. PMID:34069029. |
the relationship between the two most prominent neuropathological hallmarks of alzheimer's disease (ad), extracellular amyloid-β (aβ) deposits and intracellular accumulation of hyperphosphorylated tau in neurofibrillary tangles (nft), remains at present not fully understood. |
2021-06-10 |
2023-08-13 |
mouse |
| Alexander Vaiserman, Alexander Koliada, Oleh Lushcha. Neuroinflammation in pathogenesis of Alzheimer's disease: Phytochemicals as potential therapeutics. Mechanisms of ageing and development. vol 189. 2021-06-09. PMID:32450086. |
accumulation of neurotoxic forms of amyloid-β proteins in senile plaques and hyperphosphorylated tau proteins in neurofibrillary tangles is a well-known pathophysiological hallmark of alzheimer's disease (ad). |
2021-06-09 |
2023-08-13 |
Not clear |
| Daniel Giovinazzo, Biljana Bursac, Juan I Sbodio, Sumedha Nalluru, Thibaut Vignane, Adele M Snowman, Lauren M Albacarys, Thomas W Sedlak, Roberta Torregrossa, Matthew Whiteman, Milos R Filipovic, Solomon H Snyder, Bindu D Pau. Hydrogen sulfide is neuroprotective in Alzheimer's disease by sulfhydrating GSK3β and inhibiting Tau hyperphosphorylation. Proceedings of the National Academy of Sciences of the United States of America. vol 118. issue 4. 2021-06-09. PMID:33431651. |
hydrogen sulfide is neuroprotective in alzheimer's disease by sulfhydrating gsk3β and inhibiting tau hyperphosphorylation. |
2021-06-09 |
2023-08-13 |
Not clear |
| Shiyao Wang, Yong Ku Ch. Yeast surface display of full-length human microtubule-associated protein tau. Biotechnology progress. vol 36. issue 1. 2021-06-08. PMID:31581367. |
however, in patients of neurodegeneration such as alzheimer's disease (ad), tau forms neurofibrillary deposits, which correlates well with the disease progression. |
2021-06-08 |
2023-08-13 |
human |
| Gallen Triana-Baltzer, Setareh Moughadam, Randy Slemmon, Kristof Van Kolen, Clara Theunis, Marc Mercken, Hartmuth C Kol. Development and validation of a high-sensitivity assay for measuring p217+tau in plasma. Alzheimer's & dementia (Amsterdam, Netherlands). vol 13. issue 1. 2021-06-08. PMID:34095436. |
diagnosis of alzheimer's disease (ad) based on amyloid beta (a), pathologic tau (t), and neurodegeneration (n) biomarkers in peripheral fluids promises to accelerate clinical trials and intercept disease earlier. |
2021-06-08 |
2023-08-13 |
Not clear |
| Marta Anglada-Huguet, Sara Rodrigues, Katja Hochgräfe, Eckhard Mandelkow, Eva-Maria Mandelko. Inhibition of Tau aggregation with BSc3094 reduces Tau and decreases cognitive deficits in rTg4510 mice. Alzheimer's & dementia (New York, N. Y.). vol 7. issue 1. 2021-06-08. PMID:34095439. |
one of the major hallmarks of alzheimer's disease (ad)is the aberrant modification and aggregation of the microtubule-associated protein tau . |
2021-06-08 |
2023-08-13 |
mouse |
| Heather Buchanan, Murray Mackay, Kerri Palmer, Karolína Tothová, Miroslava Katsur, Bettina Platt, David J Kos. Synaptic Loss, ER Stress and Neuro-Inflammation Emerge Late in the Lateral Temporal Cortex and Associate with Progressive Tau Pathology in Alzheimer's Disease. Molecular neurobiology. vol 57. issue 8. 2021-06-07. PMID:32514860. |
synaptic loss, er stress and neuro-inflammation emerge late in the lateral temporal cortex and associate with progressive tau pathology in alzheimer's disease. |
2021-06-07 |
2023-08-13 |
Not clear |
| Lin Wang, Na Li, Fang-Xiao Shi, Wei-Qi Xu, Yun Cao, Ying Lei, Jian-Zhi Wang, Qing Tian, Xin-Wen Zho. Upregulation of AMPK Ameliorates Alzheimer's Disease-Like Tau Pathology and Memory Impairment. Molecular neurobiology. vol 57. issue 8. 2021-06-07. PMID:32519244. |
upregulation of ampk ameliorates alzheimer's disease-like tau pathology and memory impairment. |
2021-06-07 |
2023-08-13 |
mouse |
| Lin Wang, Na Li, Fang-Xiao Shi, Wei-Qi Xu, Yun Cao, Ying Lei, Jian-Zhi Wang, Qing Tian, Xin-Wen Zho. Upregulation of AMPK Ameliorates Alzheimer's Disease-Like Tau Pathology and Memory Impairment. Molecular neurobiology. vol 57. issue 8. 2021-06-07. PMID:32519244. |
the studies have shown that 5'-adenosine monophosphate (amp)-activated protein kinase (ampk) is involved in alzheimer's disease (ad) pathology, but the effects of ampk on ad-like tau abnormal phosphorylation and its underlying mechanism remains unclear. |
2021-06-07 |
2023-08-13 |
mouse |
| Aitizaz Ul Ahsan, Vijay Lakshmi Sharma, Abubakar Wani, Mani Chopr. Naringenin Upregulates AMPK-Mediated Autophagy to Rescue Neuronal Cells From β-Amyloid Molecular neurobiology. vol 57. issue 8. 2021-06-07. PMID:32542594. |
naringenin upregulates ampk-mediated autophagy to rescue neuronal cells from β-amyloid deposition of an amyloid-β peptide is one of the first events in the pathophysiology of alzheimer's disease (ad) and is clinically characterized by aβ plaques, tau tangles, and behavioral impairments that lead to neuronal death. |
2021-06-07 |
2023-08-13 |
mouse |
| Nadeeja Wijesekara, Rafaella Araujo Gonçalves, Rosemary Ahrens, Kathy Ha, Fernanda G De Felice, Paul E Frase. Combination of human tau and islet amyloid polypeptide exacerbates metabolic dysfunction in transgenic mice. The Journal of pathology. vol 254. issue 3. 2021-06-07. PMID:33797777. |
amyloid plaques and neurofibrillary tangles composed of hyperphosphorylated tau are important contributors to alzheimer's disease (ad). |
2021-06-07 |
2023-08-13 |
mouse |
| Courtney J Mycroft-West, Anthony J Devlin, Lynsay C Cooper, Scott E Guimond, Patricia Procter, Marco Guerrini, Gavin J Miller, David G Fernig, Edwin A Yates, Marcelo A Lima, Mark A Skidmor. Glycosaminoglycans from Marine drugs. vol 19. issue 4. 2021-06-07. PMID:33916819. |
the widely used clinical anticoagulant heparin has been reported to exert beneficial effects through multiple pathophysiological pathways involved in the aetiology of alzheimer's disease, for example, amyloid peptide production and clearance, tau phosphorylation, inflammation and oxidative stress. |
2021-06-07 |
2023-08-13 |
Not clear |
| Jonathan D Cherry, Camille D Esnault, Zachary H Baucom, Yorghos Tripodis, Bertrand R Huber, Victor E Alvarez, Thor D Stein, Dennis W Dickson, Ann C McKe. Tau isoforms are differentially expressed across the hippocampus in chronic traumatic encephalopathy and Alzheimer's disease. Acta neuropathologica communications. vol 9. issue 1. 2021-06-07. PMID:33980303. |
tau isoforms are differentially expressed across the hippocampus in chronic traumatic encephalopathy and alzheimer's disease. |
2021-06-07 |
2023-08-13 |
Not clear |
| Brian D Hitt, Jaime Vaquer-Alicea, Victor A Manon, Joshua D Beaver, Omar M Kashmer, Jan N Garcia, Marc I Diamon. Ultrasensitive tau biosensor cells detect no seeding in Alzheimer's disease CSF. Acta neuropathologica communications. vol 9. issue 1. 2021-06-07. PMID:34039426. |
ultrasensitive tau biosensor cells detect no seeding in alzheimer's disease csf. |
2021-06-07 |
2023-08-13 |
human |
| Brian D Hitt, Jaime Vaquer-Alicea, Victor A Manon, Joshua D Beaver, Omar M Kashmer, Jan N Garcia, Marc I Diamon. Ultrasensitive tau biosensor cells detect no seeding in Alzheimer's disease CSF. Acta neuropathologica communications. vol 9. issue 1. 2021-06-07. PMID:34039426. |
tau protein forms self-replicating assemblies (seeds) that may underlie progression of pathology in alzheimer's disease (ad) and related tauopathies. |
2021-06-07 |
2023-08-13 |
human |
| Shweta Kishor Sonawane, Subashchandrabose Chinnathamb. Epigallocatechin-3-gallate modulates Tau Post-translational modifications and cytoskeletal network. Oncotarget. vol 12. issue 11. 2021-06-05. PMID:34084282. |
alzheimer's disease is a type of dementia denoted by progressive neuronal death due to the accumulation of proteinaceous aggregates of tau. |
2021-06-05 |
2023-08-13 |
Not clear |
| Clément Barbereau, Alaa Yehya, Michelle Silhol, Nicolas Cubedo, Jean-Michel Verdier, Tangui Maurice, Mireille Rosse. Neuroprotective brain-derived neurotrophic factor signaling in the TAU-P301L tauopathy zebrafish model. Pharmacological research. vol 158. 2021-06-04. PMID:32417505. |
in alzheimer's disease (ad), although the relationship between bdnf and amyloid load has been extensively studied, how tau pathology affects bdnf signaling remains unclear. |
2021-06-04 |
2023-08-13 |
zebrafish |