| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nicolai Franzmeier, Rik Ossenkoppele, Matthias Brendel, Anna Rubinski, Ruben Smith, Atul Kumar, Niklas Mattsson-Carlgren, Olof Strandberg, Marco Duering, Katharina Buerger, Martin Dichgans, Oskar Hansson, Michael Ewer. The BIN1 rs744373 Alzheimer's disease risk SNP is associated with faster Aβ-associated tau accumulation and cognitive decline. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2021-06-01. PMID:34060233. |
the bin1 rs744373 single nucleotide polymorphism (snp) is a key genetic risk locus for alzheimer's disease (ad) associated with tau pathology. |
2021-06-01 |
2023-08-13 |
Not clear |
| Guanghao Liu, Kimberly L Fiock, Yona Levites, Todd E Golde, Marco M Hefti, Gloria Le. Fyn depletion ameliorates tau Acta neuropathologica communications. vol 8. issue 1. 2021-05-31. PMID:32665013. |
fyn depletion ameliorates tau the src family non-receptor tyrosine kinase fyn has been implicated in neurodegeneration of alzheimer's disease through interaction with amyloid β (aβ). |
2021-05-31 |
2023-08-13 |
Not clear |
| Helen C Murray, Birger Victor Dieriks, Molly E V Swanson, Praju Vikas Anekal, Clinton Turner, Richard L M Faull, Leonardo Belluscio, Alan Koretsky, Maurice A Curti. The unfolded protein response is activated in the olfactory system in Alzheimer's disease. Acta neuropathologica communications. vol 8. issue 1. 2021-05-31. PMID:32665027. |
olfactory dysfunction is an early and prevalent symptom of alzheimer's disease (ad) and the olfactory bulb is a nexus of beta-amyloid plaque and tau neurofibrillary tangle (nft) pathology during early ad progression. |
2021-05-31 |
2023-08-13 |
Not clear |
| Sarah A Kent, Tara L Spires-Jones, Claire S Durran. The physiological roles of tau and Aβ: implications for Alzheimer's disease pathology and therapeutics. Acta neuropathologica. vol 140. issue 4. 2021-05-31. PMID:32728795. |
the physiological roles of tau and aβ: implications for alzheimer's disease pathology and therapeutics. |
2021-05-31 |
2023-08-13 |
Not clear |
| Sarah A Kent, Tara L Spires-Jones, Claire S Durran. The physiological roles of tau and Aβ: implications for Alzheimer's disease pathology and therapeutics. Acta neuropathologica. vol 140. issue 4. 2021-05-31. PMID:32728795. |
tau and amyloid beta (aβ) are the prime suspects for driving pathology in alzheimer's disease (ad) and, as such, have become the focus of therapeutic development. |
2021-05-31 |
2023-08-13 |
Not clear |
| Imran Saied, Tughrul Arslan, Siddharthan Chandran, Colin Smith, Tara Spires-Jones, Suvankar Pa. Non-Invasive RF Technique for Detecting Different Stages of Alzheimer's Disease and Imaging Beta-Amyloid Plaques and Tau Tangles in the Brain. IEEE transactions on medical imaging. vol 39. issue 12. 2021-05-31. PMID:32746147. |
non-invasive rf technique for detecting different stages of alzheimer's disease and imaging beta-amyloid plaques and tau tangles in the brain. |
2021-05-31 |
2023-08-13 |
human |
| Imran Saied, Tughrul Arslan, Siddharthan Chandran, Colin Smith, Tara Spires-Jones, Suvankar Pa. Non-Invasive RF Technique for Detecting Different Stages of Alzheimer's Disease and Imaging Beta-Amyloid Plaques and Tau Tangles in the Brain. IEEE transactions on medical imaging. vol 39. issue 12. 2021-05-31. PMID:32746147. |
this paper describes a novel approach of detecting different stages of alzheimer's disease (ad) and imaging beta-amyloid plaques and tau tangles in the brain using rf sensors. |
2021-05-31 |
2023-08-13 |
human |
| Francesca Vitale, Jasmin Ortolan, Bruce T Volpe, Philippe Marambaud, Luca Giliberto, Cristina d'Abram. Intramuscular injection of vectorized-scFvMC1 reduces pathological tau in two different tau transgenic models. Acta neuropathologica communications. vol 8. issue 1. 2021-05-31. PMID:32762731. |
with evidence supporting the prion-like spreading of extracellular tau as a mechanism for the initiation and progression of alzheimer's disease (ad), immunotherapy has emerged as a potential disease-modifying strategy to target tau. |
2021-05-31 |
2023-08-13 |
mouse |
| Kathleen M Farmer, Gaurav Ghag, Nicha Puangmalai, Mauro Montalbano, Nemil Bhatt, Rakez Kaye. P53 aggregation, interactions with tau, and impaired DNA damage response in Alzheimer's disease. Acta neuropathologica communications. vol 8. issue 1. 2021-05-31. PMID:32778161. |
p53 aggregation, interactions with tau, and impaired dna damage response in alzheimer's disease. |
2021-05-31 |
2023-08-13 |
mouse |
| Kanta Horie, Nicolas R Barthélemy, Nipun Mallipeddi, Yan Li, Erin E Franklin, Richard J Perrin, Randall J Bateman, Chihiro Sat. Regional correlation of biochemical measures of amyloid and tau phosphorylation in the brain. Acta neuropathologica communications. vol 8. issue 1. 2021-05-31. PMID:32854776. |
alzheimer's disease (ad) neuropathologic change is characterized by amyloid plaques and neurofibrillary tangles (nfts) that consist of aggregated amyloid beta (abeta) and hyperphosphorylated tau proteins (p-tau), respectively. |
2021-05-31 |
2023-08-13 |
human |
| Wei-Ping Chen, Ge Zhang, Zhi-Juan Cheng, Xun-Hu Gu, Min Li, Xu Li. Corrigendum to "Inhibitor Kappa B Kinase β, Modulated by DJ-1/p-VHL, Reduces Phosphorylated Tau (p-Tau) Accumulation via Autophagy in Alzheimer's Disease Model" [Neuroscience 452C (2021) 1-12]. Neuroscience. vol 465. 2021-05-31. PMID:33558088. |
corrigendum to "inhibitor kappa b kinase β, modulated by dj-1/p-vhl, reduces phosphorylated tau (p-tau) accumulation via autophagy in alzheimer's disease model" [neuroscience 452c (2021) 1-12]. |
2021-05-31 |
2023-08-13 |
Not clear |
| Kirsten E J Wesenhagen, Charlotte E Teunissen, Pieter Jelle Visser, Betty M Tijm. Cerebrospinal fluid proteomics and biological heterogeneity in Alzheimer's disease: A literature review. Critical reviews in clinical laboratory sciences. vol 57. issue 2. 2021-05-28. PMID:31694431. |
alzheimer's disease (ad) is the most common cause of dementia and is characterized by aggregation of amyloid and tau proteins in the brain. |
2021-05-28 |
2023-08-13 |
Not clear |
| Daniela Monteiro-Fernandes, Joana Margarida Silva, Carina Soares-Cunha, Christina Dalla, Nikolaos Kokras, François Arnaud, Rodolphe Billiras, Viktoriya Zhuravleva, Clarissa Waites, Sylvie Bretin, Nuno Sousa, Ioannis Sotiropoulo. Allosteric modulation of AMPA receptors counteracts Tau-related excitotoxic synaptic signaling and memory deficits in stress- and Aβ-evoked hippocampal pathology. Molecular psychiatry. 2021-05-28. PMID:32467647. |
despite considerable progress in the understanding of its neuropathology, alzheimer's disease (ad) remains a complex disorder with no effective treatment that counteracts the memory deficits and the underlying synaptic malfunction triggered by the accumulation of amyloid beta (aβ) and tau protein. |
2021-05-28 |
2023-08-13 |
Not clear |
| Yuxing Xia, Stefan Prokop, Kimberly-Marie M Gorion, Justin D Kim, Zachary A Sorrentino, Brach M Bell, Alyssa N Manaois, Paramita Chakrabarty, Peter Davies, Benoit I Giasso. Tau Ser208 phosphorylation promotes aggregation and reveals neuropathologic diversity in Alzheimer's disease and other tauopathies. Acta neuropathologica communications. vol 8. issue 1. 2021-05-28. PMID:32571418. |
tau ser208 phosphorylation promotes aggregation and reveals neuropathologic diversity in alzheimer's disease and other tauopathies. |
2021-05-28 |
2023-08-13 |
mouse |
| Yuxing Xia, Stefan Prokop, Kimberly-Marie M Gorion, Justin D Kim, Zachary A Sorrentino, Brach M Bell, Alyssa N Manaois, Paramita Chakrabarty, Peter Davies, Benoit I Giasso. Tau Ser208 phosphorylation promotes aggregation and reveals neuropathologic diversity in Alzheimer's disease and other tauopathies. Acta neuropathologica communications. vol 8. issue 1. 2021-05-28. PMID:32571418. |
tau protein abnormally aggregates in tauopathies, a diverse group of neurologic diseases that includes alzheimer's disease (ad). |
2021-05-28 |
2023-08-13 |
mouse |
| Adam Briner, Jürgen Götz, Juan Carlos Polanc. Fyn Kinase Controls Tau Aggregation In Vivo. Cell reports. vol 32. issue 7. 2021-05-28. PMID:32814048. |
alzheimer's disease (ad) is a proteinopathy exhibiting aggregation of β-amyloid (aβ) as amyloid plaques and tau as neurofibrillary tangles (nfts), whereas primary tauopathies display only a tau pathology. |
2021-05-28 |
2023-08-13 |
Not clear |
| Mona-Lisa Malarte, Agneta Nordberg, Laetitia Lemoin. Characterization of MK6240, a tau PET tracer, in autopsy brain tissue from Alzheimer's disease cases. European journal of nuclear medicine and molecular imaging. vol 48. issue 4. 2021-05-28. PMID:32970217. |
characterization of mk6240, a tau pet tracer, in autopsy brain tissue from alzheimer's disease cases. |
2021-05-28 |
2023-08-13 |
Not clear |
| Mona-Lisa Malarte, Agneta Nordberg, Laetitia Lemoin. Characterization of MK6240, a tau PET tracer, in autopsy brain tissue from Alzheimer's disease cases. European journal of nuclear medicine and molecular imaging. vol 48. issue 4. 2021-05-28. PMID:32970217. |
mk6240 is a second-generation tau pet tracer designed to detect the neurofibrillary tangles in the brains of patients with alzheimer's disease (ad). |
2021-05-28 |
2023-08-13 |
Not clear |
| Kuang Gong, Paul Kyu Han, Keith A Johnson, Georges El Fakhri, Chao Ma, Quanzheng L. Attenuation correction using deep Learning and integrated UTE/multi-echo Dixon sequence: evaluation in amyloid and tau PET imaging. European journal of nuclear medicine and molecular imaging. vol 48. issue 5. 2021-05-28. PMID:33108475. |
pet measures of amyloid and tau pathologies are powerful biomarkers for the diagnosis and monitoring of alzheimer's disease (ad). |
2021-05-28 |
2023-08-13 |
Not clear |
| Hariharakrishnan Chidambaram, Subashchandrabose Chinnathamb. Role of cysteines in accelerating Tau filament formation. Journal of biomolecular structure & dynamics. 2021-05-28. PMID:33317395. |
alzheimer's disease is majorly associated with intracellular accumulation of tau into paired helical filaments and tangles. |
2021-05-28 |
2023-08-13 |
Not clear |